STRINGSTRING
deoA deoA deoD deoD carA carA carB carB ORJ27255.1 ORJ27255.1 ORJ27311.1 ORJ27311.1 pyrG pyrG surE-2 surE-2 pyrB pyrB pyrI pyrI ORJ26971.1 ORJ26971.1 ORJ27029.1 ORJ27029.1 ORJ27063.1 ORJ27063.1 ORJ26806.1 ORJ26806.1 nrdR nrdR tgt tgt ppnP ppnP ORJ26651.1 ORJ26651.1 ORJ26741.1 ORJ26741.1 ORJ26520.1 ORJ26520.1 ndk ndk ORJ26373.1 ORJ26373.1 ORJ26392.1 ORJ26392.1 udk udk dcd dcd ORJ26439.1 ORJ26439.1 ORJ26333.1 ORJ26333.1 ORJ26259.1 ORJ26259.1 rutE rutE ORJ26134.1 ORJ26134.1 ORJ26159.1 ORJ26159.1 ORJ26026.1 ORJ26026.1 ORJ25921.1 ORJ25921.1 ORJ25756.1 ORJ25756.1 ORJ25788.1 ORJ25788.1 pyrC pyrC tmk tmk ORJ25664.1 ORJ25664.1 ORJ25686.1 ORJ25686.1 ORJ25705.1 ORJ25705.1 ORJ25739.1 ORJ25739.1 ORJ25745.1 ORJ25745.1 ORJ25614.1 ORJ25614.1 ORJ25499.1 ORJ25499.1 ORJ25519.1 ORJ25519.1 ORJ25385.1 ORJ25385.1 ORJ25402.1 ORJ25402.1 ORJ25253.1 ORJ25253.1 thyA thyA ORJ25327.1 ORJ25327.1 tdk tdk groES groES ORJ25136.1 ORJ25136.1 cdd cdd cmk cmk pyrE pyrE dut dut ORJ24806.1 ORJ24806.1 ORJ24807.1 ORJ24807.1 ORJ24835.1 ORJ24835.1 ORJ24698.1 ORJ24698.1 ORJ24607.1 ORJ24607.1 ORJ24608.1 ORJ24608.1 nrdI nrdI ORJ24536.1 ORJ24536.1 ORJ24511.1 ORJ24511.1 ORJ24386.1 ORJ24386.1 rutA rutA rutB rutB rutD rutD rutE-2 rutE-2 rlmI rlmI rlmL rlmL pyrD pyrD ORJ24163.1 ORJ24163.1 ORJ24119.1 ORJ24119.1 ORJ24052.1 ORJ24052.1 pyrH pyrH ORJ23762.1 ORJ23762.1 ORJ23779.1 ORJ23779.1 ORJ23786.1 ORJ23786.1 surE surE upp upp ORJ23581.1 ORJ23581.1 ORJ23598.1 ORJ23598.1 pyrF pyrF
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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from curated databases
experimentally determined
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gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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deoAThymidine phosphorylase; The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis. Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. (445 aa)
deoDPurine-nucleoside phosphorylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (239 aa)
carACarbamoyl phosphate synthase small subunit; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the CarA family. (382 aa)
carBCarbamoyl phosphate synthase large subunit; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the CarB family. (1074 aa)
ORJ27255.1MFS transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (483 aa)
ORJ27311.1Nucleoside triphosphate pyrophosphohydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (271 aa)
pyrGCTP synthase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (545 aa)
surE-25'/3'-nucleotidase SurE; Nucleotidase with a broad substrate specificity as it can dephosphorylate various ribo- and deoxyribonucleoside 5'-monophosphates and ribonucleoside 3'-monophosphates with highest affinity to 3'-AMP. Also hydrolyzes polyphosphate (exopolyphosphatase activity) with the preference for short-chain-length substrates (P20-25). Might be involved in the regulation of dNTP and NTP pools, and in the turnover of 3'-mononucleotides produced by numerous intracellular RNases (T1, T2, and F) during the degradation of various RNAs. (596 aa)
pyrBAspartate carbamoyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (311 aa)
pyrIAspartate carbamoyltransferase regulatory subunit; Involved in allosteric regulation of aspartate carbamoyltransferase. (154 aa)
ORJ26971.1Reactive intermediate/imine deaminase; Has endoribonuclease activity on mRNA; Derived by automated computational analysis using gene prediction method: Protein Homology. (128 aa)
ORJ27029.1Dihydroorotase; Derived by automated computational analysis using gene prediction method: Protein Homology. (379 aa)
ORJ27063.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (231 aa)
ORJ26806.1Oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (258 aa)
nrdRTranscriptional regulator NrdR; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. (149 aa)
tgttRNA guanosine(34) transglycosylase Tgt; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose t [...] (374 aa)
ppnPHypothetical protein; Catalyzes the phosphorolysis of diverse nucleosides, yielding D-ribose 1-phosphate and the respective free bases. Can use uridine, adenosine, guanosine, cytidine, thymidine, inosine and xanthosine as substrates. Also catalyzes the reverse reactions. (96 aa)
ORJ26651.1Oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (249 aa)
ORJ26741.1Monooxygenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (439 aa)
ORJ26520.1Cytosine deaminase; Derived by automated computational analysis using gene prediction method: Protein Homology. (433 aa)
ndkNucleoside-diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (141 aa)
ORJ26373.1SDR family oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (263 aa)
ORJ26392.1Reactive intermediate/imine deaminase; Derived by automated computational analysis using gene prediction method: Protein Homology. (130 aa)
udkUridine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (213 aa)
dcddCTP deaminase; Catalyzes the deamination of dCTP to dUTP. (193 aa)
ORJ26439.1Cysteine hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (183 aa)
ORJ26333.15,10-methylene tetrahydromethanopterin reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (469 aa)
ORJ26259.1N5,N10-methylene tetrahydromethanopterin reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (449 aa)
rutEMalonic semialdehyde reductase; May reduce toxic product malonic semialdehyde to 3- hydroxypropionic acid, which is excreted. (196 aa)
ORJ26134.1Allantoate amidohydrolase and N-carbamoyl-L-amino acid amidohydrolase are very similar; the allantoate amidohydrolase from Escherichia coli forms a dimer and binds zinc ions for catalytic activity and catalyzes the conversion of allantoate to (S)-ureidoglycolate and ammonia; carbamoyl amidohydrolase from Bacillus sp. converts N-carbamoyl amino acids to amino acids, ammonia, and carbon dioxide; Derived by automated computational analysis using gene prediction method: Protein Homology. (425 aa)
ORJ26159.1HNH endonuclease; Derived by automated computational analysis using gene prediction method: Protein Homology. (114 aa)
ORJ26026.1NADP-dependent 3-hydroxy acid dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (249 aa)
ORJ25921.1Metabolite-proton symporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (425 aa)
ORJ25756.1MFS transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (438 aa)
ORJ25788.1Proline/betaine transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (497 aa)
pyrCDihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate. (349 aa)
tmkdTMP kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (216 aa)
ORJ25664.13-ketoacyl-ACP reductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (232 aa)
ORJ25686.1Monooxygenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (449 aa)
ORJ25705.1CTP synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (400 aa)
ORJ25739.1Oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (265 aa)
ORJ25745.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (405 aa)
ORJ25614.1Uridine phosphorylase; Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Belongs to the PNP/UDP phosphorylase family. (253 aa)
ORJ25499.1Nitrilotriacetate monooxygenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (434 aa)
ORJ25519.1Monooxygenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (448 aa)
ORJ25385.1GMP/IMP nucleotidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (221 aa)
ORJ25402.1Cytosine deaminase; Catalyzes the deamination of cytosine to uracil and ammonia; Derived by automated computational analysis using gene prediction method: Protein Homology. (427 aa)
ORJ25253.1LOG family protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (454 aa)
thyAPrepilin-type N-terminal cleavage/methylation domain-containing protein; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (264 aa)
ORJ25327.1MFS transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (530 aa)
tdkThymidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (192 aa)
groESCo-chaperone GroES; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. (106 aa)
ORJ25136.12',3'-cyclic-nucleotide 2'-phosphodiesterase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the 5'-nucleotidase family. (653 aa)
cddCytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. (294 aa)
cmkCytidylate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (233 aa)
pyrEOrotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (213 aa)
dutDeoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (152 aa)
ORJ24806.1Ribonucleotide-diphosphate reductase subunit beta; B2 or R2 protein; type 1a enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdA; Derived by automated computational analysis using gene prediction method: Protein Homology. (376 aa)
ORJ24807.1Ribonucleoside-diphosphate reductase subunit alpha; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (759 aa)
ORJ24835.1MFS transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (525 aa)
ORJ24698.1Hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (202 aa)
ORJ24607.1Class 1b ribonucleoside-diphosphate reductase subunit beta; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (327 aa)
ORJ24608.1Ribonucleotide-diphosphate reductase subunit alpha; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. (716 aa)
nrdIRibonucleotide reductase assembly protein NrdI; Probably involved in ribonucleotide reductase function. (134 aa)
ORJ24536.1Glutamine amidotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (429 aa)
ORJ24511.15'-deoxynucleotidase; Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates. (199 aa)
ORJ24386.1Thymidylate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (202 aa)
rutAPyrimidine utilization protein A; Catalyzes the pyrimidine ring opening between N-3 and C-4 by an unusual flavin hydroperoxide-catalyzed mechanism to yield ureidoacrylate peracid. It cleaves pyrmidine rings directly by adding oxygen atoms, making a toxic ureidoacrylate peracid product which can be spontaneously reduced to ureidoacrylate. (366 aa)
rutBPyrimidine utilization protein B; In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2; Belongs to the isochorismatase family. RutB subfamily. (250 aa)
rutDPyrimidine utilization protein D; May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation. Belongs to the AB hydrolase superfamily. Hydrolase RutD family. (276 aa)
rutE-2Malonic semialdehyde reductase; May reduce toxic product malonic semialdehyde to 3- hydroxypropionic acid, which is excreted. (196 aa)
rlmI23S rRNA (cytosine(1962)-C(5))-methyltransferase; Specifically methylates the cytosine at position 1962 (m5C1962) of 23S rRNA. (397 aa)
rlmL23S rRNA (guanine(2445)-N(2))/(guanine(2069)-N(7))- methyltransferase; Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA. Belongs to the methyltransferase superfamily. RlmKL family. (706 aa)
pyrDDihydroorotate dehydrogenase (quinone); Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (336 aa)
ORJ24163.1Hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (191 aa)
ORJ24119.1Anaerobic ribonucleoside-triphosphate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (710 aa)
ORJ24052.1Isochorismatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (172 aa)
pyrHUMP kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (243 aa)
ORJ23762.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (348 aa)
ORJ23779.1MFS transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (507 aa)
ORJ23786.1Bcr/CflA family drug resistance efflux transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (397 aa)
surE5'/3'-nucleotidase SurE; Broad specificity 5'(3')-nucleotidase and polyphosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (141 aa)
uppUracil phosphoribosyltransferase; Catalyzes the conversion of uracil and 5-phospho-alpha-D- ribose 1-diphosphate (PRPP) to UMP and diphosphate. (208 aa)
ORJ23581.1Oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (246 aa)
ORJ23598.1DUF179 domain-containing protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the UPF0301 (AlgH) family. (187 aa)
pyrFOrotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (242 aa)
Your Current Organism:
Rouxiella badensis
NCBI taxonomy Id: 1646377
Other names: CIP 111153, DSM 100043, R. badensis, Rouxiella badensis Le Fleche-Mateos et al. 2017, Rouxiella sp. 323, Rouxiella sp. 421, Rouxiella sp. DSM 100043, strain 323
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