STRINGSTRING
AKQ42029.1 AKQ42029.1 AKQ42828.1 AKQ42828.1 ku ku AKQ42770.1 AKQ42770.1 dinB dinB AKQ42627.1 AKQ42627.1 recF recF AKQ43416.2 AKQ43416.2 uvrC uvrC recR recR AKQ42413.2 AKQ42413.2 AKQ42385.1 AKQ42385.1 AKQ42384.1 AKQ42384.1 AKQ42374.1 AKQ42374.1 mutL mutL radA radA lexA lexA AKQ42166.1 AKQ42166.1 mfd mfd AKQ42151.1 AKQ42151.1 AKQ42137.1 AKQ42137.1 AKQ42030.2 AKQ42030.2 ligA ligA AKQ41979.2 AKQ41979.2 recA recA uvrA uvrA AKQ43252.2 AKQ43252.2 AKQ41822.1 AKQ41822.1 AKQ41791.2 AKQ41791.2 uvrB uvrB AKQ41730.1 AKQ41730.1 AKQ41673.1 AKQ41673.1 AKQ41539.1 AKQ41539.1 AKQ41530.1 AKQ41530.1 ruvB ruvB ruvA ruvA mutM mutM nth nth polA polA mutS mutS AKQ41122.1 AKQ41122.1 AKQ41088.1 AKQ41088.1 ung ung AKQ40964.1 AKQ40964.1 AKQ40961.1 AKQ40961.1 ruvC ruvC AKQ40869.2 AKQ40869.2 AKQ40859.2 AKQ40859.2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AKQ42029.1Hypothetical protein. (256 aa)
AKQ42828.1Hypothetical protein. (89 aa)
kuHypothetical protein; With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD. Belongs to the prokaryotic Ku family. (276 aa)
AKQ42770.1Hypothetical protein. (841 aa)
dinBDNA polymerase IV; Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. (378 aa)
AKQ42627.1Putative DNA-3-methyladenine glycosidase II protein. (205 aa)
recFRecombinational DNA repair ATPase; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP. (365 aa)
AKQ43416.2Uracil-DNA glycosylase superfamily. (154 aa)
uvrCExcinuclease complex nuclease subunit; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. (647 aa)
recRRecombinational DNA repair protein; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. (205 aa)
AKQ42413.2Putative ada regulatory of adaptative response protein. (342 aa)
AKQ42385.1Hypothetical protein. (414 aa)
AKQ42384.1Uracil-DNA glycosylase: Phage SPO1 DNA polymerase-related protein. (483 aa)
AKQ42374.1Single-stranded DNA-specific exonuclease. (593 aa)
mutLDNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. (613 aa)
radAPutative ATP-dependent serine protease; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function. (455 aa)
lexALexA family transcriptional regulator; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. (221 aa)
AKQ42166.1Hypothetical protein. (364 aa)
mfdTranscription-repair coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. (1164 aa)
AKQ42151.1ATP-dependent exonuclease V subunit beta; Belongs to the helicase family. UvrD subfamily. (1158 aa)
AKQ42137.1Mutator mutT protein, hypothetical. (136 aa)
AKQ42030.2Hypothetical protein. (531 aa)
ligANAD-dependent DNA ligase LigA; DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double- stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA; Belongs to the NAD-dependent DNA ligase family. LigA subfamily. (685 aa)
AKQ41979.2DNA repair protein RecN; May be involved in recombinational repair of damaged DNA. (568 aa)
recARecombinase RecA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. (355 aa)
uvrAExcinuclease ABC subunit A; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (971 aa)
AKQ43252.2Magnesium transporter ApaG. (159 aa)
AKQ41822.1Hypothetical protein; Involved in DNA repair and RecF pathway recombination. (199 aa)
AKQ41791.2A/G-specific adenine glycosylase; Adenine glycosylase active on G-A mispairs. (343 aa)
uvrBExcinuclease ABC subunit B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...] (728 aa)
AKQ41730.1Hypothetical protein. (315 aa)
AKQ41673.1Hypothetical protein. (174 aa)
AKQ41539.1Single-stranded DNA-binding protein. (132 aa)
AKQ41530.1Single-stranded DNA-binding protein. (136 aa)
ruvBHolliday junction ATP-dependent DNA helicase RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. (342 aa)
ruvAHolliday junction ATP-dependent DNA helicase RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. (200 aa)
mutM5-hydroxymethyluracil DNA glycosylase; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. (271 aa)
nthEndonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (216 aa)
polADNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (944 aa)
mutSDNA mismatch repair protein MutS; This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity. (873 aa)
AKQ41122.1ATP-dependent DNA ligase. (536 aa)
AKQ41088.1Exodeoxyribonuclease III. (257 aa)
unguracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. (227 aa)
AKQ40964.1ATP-dependent DNA helicase RecQ. (598 aa)
AKQ40961.1Exodeoxyribonuclease III. (265 aa)
ruvCCrossover junction endodeoxyribonuclease RuvC; Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group. (154 aa)
AKQ40869.2Single-stranded DNA-binding protein. (156 aa)
AKQ40859.2Hypothetical protein. (1975 aa)
Your Current Organism:
Erythrobacter atlanticus
NCBI taxonomy Id: 1648404
Other names: E. atlanticus, Erythrobacter atlanticus Zhuang et al. 2015, Erythrobacter sp. s21-N3, KCTC 42697, MCCC 1A00519, strain s21-N3
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