STRINGSTRING
secD secD ANC50445.1 ANC50445.1 ANC50328.1 ANC50328.1 ANC50327.1 ANC50327.1 AKQ42977.1 AKQ42977.1 AKQ42972.2 AKQ42972.2 AKQ43492.2 AKQ43492.2 AKQ43473.2 AKQ43473.2 AKQ42803.1 AKQ42803.1 AKQ43467.2 AKQ43467.2 AKQ42800.2 AKQ42800.2 AKQ42793.1 AKQ42793.1 AKQ42790.1 AKQ42790.1 clpX clpX clpP clpP AKQ43436.2 AKQ43436.2 AKQ42672.2 AKQ42672.2 clpB clpB AKQ42660.1 AKQ42660.1 AKQ43428.2 AKQ43428.2 AKQ42594.1 AKQ42594.1 AKQ42584.1 AKQ42584.1 AKQ43401.2 AKQ43401.2 parC parC atpD atpD atpA atpA priA priA AKQ42399.2 AKQ42399.2 AKQ42390.1 AKQ42390.1 pstB pstB mutL mutL radA radA dnaK dnaK parE parE ychF ychF gyrA gyrA AKQ42231.1 AKQ42231.1 AKQ42189.2 AKQ42189.2 AKQ42159.1 AKQ42159.1 mfd mfd secA secA AKQ42151.1 AKQ42151.1 AKQ42126.1 AKQ42126.1 AKQ43309.2 AKQ43309.2 lon lon AKQ42051.2 AKQ42051.2 secF secF AKQ41987.1 AKQ41987.1 AKQ41974.1 AKQ41974.1 AKQ43271.2 AKQ43271.2 AKQ41932.1 AKQ41932.1 recA recA uvrA uvrA AKQ43258.2 AKQ43258.2 smc smc uvrB uvrB AKQ41653.1 AKQ41653.1 AKQ41649.1 AKQ41649.1 AKQ41623.1 AKQ41623.1 AKQ41600.1 AKQ41600.1 AKQ41537.1 AKQ41537.1 AKQ41518.1 AKQ41518.1 AKQ41483.1 AKQ41483.1 AKQ41457.1 AKQ41457.1 AKQ41426.2 AKQ41426.2 ruvB ruvB ruvA ruvA AKQ41375.1 AKQ41375.1 ftsH ftsH AKQ43129.2 AKQ43129.2 groS groS groL groL AKQ41279.1 AKQ41279.1 mutS mutS AKQ41181.2 AKQ41181.2 AKQ43072.1 AKQ43072.1 AKQ43070.2 AKQ43070.2 rho rho AKQ41071.1 AKQ41071.1 AKQ41061.1 AKQ41061.1 AKQ40986.1 AKQ40986.1 AKQ40969.1 AKQ40969.1 AKQ40964.1 AKQ40964.1 gyrB gyrB AKQ40886.2 AKQ40886.2 AKQ40877.1 AKQ40877.1 AKQ40861.1 AKQ40861.1 AKQ40859.2 AKQ40859.2 AKQ40856.1 AKQ40856.1 AKQ40855.1 AKQ40855.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
secDPreprotein translocase subunit SecD; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. (532 aa)
ANC50445.1ATPase. (856 aa)
ANC50328.1ABC transporter related protein. (479 aa)
ANC50327.1Hypothetical protein. (705 aa)
AKQ42977.1Copper/silver efflux P-type ATPase. (744 aa)
AKQ42972.2Cation-transporting ATPase. (849 aa)
AKQ43492.2Hypothetical protein. (960 aa)
AKQ43473.2Hypothetical protein. (1011 aa)
AKQ42803.1ATP-dependent protease; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. (432 aa)
AKQ43467.2Permease. (604 aa)
AKQ42800.2Molecular chaperone Hsp70. (379 aa)
AKQ42793.1E1-E2 type cation ATPase. (705 aa)
AKQ42790.1DEAD/DEAH box helicase; Belongs to the DEAD box helicase family. (588 aa)
clpXATP-dependent Clp protease ATP-binding subunit ClpX; ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP. (423 aa)
clpPATP-dependent Clp protease proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. (230 aa)
AKQ43436.2Hypothetical protein. (572 aa)
AKQ42672.2Hypothetical protein. (579 aa)
clpBATP-dependent Clp protease ATP-binding subunit ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. (859 aa)
AKQ42660.1Pilus assembly protein CpaE. (434 aa)
AKQ43428.2ABC-type transport system ATPase component. (159 aa)
AKQ42594.1ATPase AAA. (442 aa)
AKQ42584.1TonB-dependent receptor domain protein. (1057 aa)
AKQ43401.2Aerobic cobaltochelatase subunit CobS. (329 aa)
parCDNA topoisomerase IV subunit A; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 1 subfamily. (765 aa)
atpDF0F1 ATP synthase subunit beta; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits. (485 aa)
atpAF0F1 ATP synthase subunit alpha; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. (509 aa)
priAPrimosome assembly protein PriA; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (714 aa)
AKQ42399.2DNA helicase. (928 aa)
AKQ42390.1Fused predicted transporter subunit of ABC superfamily: ATP-binding component. (557 aa)
pstBPhosphate ABC transporter ATP-binding protein; Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. Phosphate importer (TC 3.A.1.7) family. (289 aa)
mutLDNA mismatch repair protein MutL; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. (613 aa)
radAPutative ATP-dependent serine protease; DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function. (455 aa)
dnaKMolecular chaperone DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. (645 aa)
parEDNA topoisomerase IV subunit B; Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule; Belongs to the type II topoisomerase family. ParE type 1 subfamily. (663 aa)
ychFGTP-dependent nucleic acid-binding protein EngD; ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner. (366 aa)
gyrADNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (948 aa)
AKQ42231.1Hypothetical protein; Involved in protein export. Participates in an early event of protein translocation; Belongs to the SecG family. (131 aa)
AKQ42189.2Hypothetical protein. (355 aa)
AKQ42159.1ATP-dependent DNA helicase RecG. (690 aa)
mfdTranscription-repair coupling factor; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily. (1164 aa)
secAPreprotein translocase subunit SecA; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving both as a receptor for the preprotein-SecB complex and as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. Belongs to the SecA family. (916 aa)
AKQ42151.1ATP-dependent exonuclease V subunit beta; Belongs to the helicase family. UvrD subfamily. (1158 aa)
AKQ42126.1DEAD/DEAH box helicase. (458 aa)
AKQ43309.2TonB-denpendent receptor. (663 aa)
lonATP-dependent Lon protease; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. (813 aa)
AKQ42051.2ATP-dependent helicase. (815 aa)
secFPreprotein translocase subunit SecF; Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. (325 aa)
AKQ41987.1Hypothetical protein. (187 aa)
AKQ41974.1Hypothetical protein. (1021 aa)
AKQ43271.2DNA and RNA helicase. (781 aa)
AKQ41932.1DEAD/DEAH box helicase; Belongs to the DEAD box helicase family. (474 aa)
recARecombinase RecA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. (355 aa)
uvrAExcinuclease ABC subunit A; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. (971 aa)
AKQ43258.2TonB-denpendent receptor. (633 aa)
smcChromosome segregation protein; Required for chromosome condensation and partitioning. Belongs to the SMC family. (1140 aa)
uvrBExcinuclease ABC subunit B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...] (728 aa)
AKQ41653.1Copper/silver efflux P-type ATPase. (787 aa)
AKQ41649.1Haloacid dehalogenase. (736 aa)
AKQ41623.1Copper-translocating P-type ATPase. (803 aa)
AKQ41600.1HAD ATPase, P-type, family IC. (885 aa)
AKQ41537.1Chromosome segregation protein SMC. (834 aa)
AKQ41518.1Hypothetical protein. (301 aa)
AKQ41483.1Molybdate ABC transporter ATP-binding protein. (212 aa)
AKQ41457.1ATPase FliI/YscN family. (445 aa)
AKQ41426.2Magnesium chelatase. (320 aa)
ruvBHolliday junction ATP-dependent DNA helicase RuvB; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. (342 aa)
ruvAHolliday junction ATP-dependent DNA helicase RuvA; The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. (200 aa)
AKQ41375.1Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily. (507 aa)
ftsHATP-dependent metalloprotease; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; Belongs to the AAA ATPase family. In the central section; belongs to the AAA ATPase family. (648 aa)
AKQ43129.2Chromosome partitioning protein ParA; Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP; Belongs to the Mrp/NBP35 ATP-binding proteins family. (333 aa)
groSMolecular chaperone GroES; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. (95 aa)
groLMolecular chaperone GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. (550 aa)
AKQ41279.1Cell division cycle protein; Belongs to the AAA ATPase family. (768 aa)
mutSDNA mismatch repair protein MutS; This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity. (873 aa)
AKQ41181.2ATP-dependent RNA helicase, DEAD/DEAH box family protein. (842 aa)
AKQ43072.1ATP-dependent Clp protease ATP-binding protein; Belongs to the ClpA/ClpB family. (796 aa)
AKQ43070.2ATP-dependent helicase. (894 aa)
rhoTranscription termination factor Rho; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template. (418 aa)
AKQ41071.1AMP-dependent synthetase. (599 aa)
AKQ41061.1Metal-sulfur cluster biosynthesis protein. (174 aa)
AKQ40986.1ABC transporter ATP-binding protein. (551 aa)
AKQ40969.1ABC-type multidrug transport system ATPase component. (604 aa)
AKQ40964.1ATP-dependent DNA helicase RecQ. (598 aa)
gyrBType IIA topoisomerase B subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (848 aa)
AKQ40886.2Hypothetical protein. (271 aa)
AKQ40877.1Hypothetical protein. (875 aa)
AKQ40861.1Hypothetical protein. (1243 aa)
AKQ40859.2Hypothetical protein. (1975 aa)
AKQ40856.1Putative type I site-specific restriction-modification system, S subunit. (426 aa)
AKQ40855.1Type I restriction-modification system endonuclease, putative. (1077 aa)
Your Current Organism:
Erythrobacter atlanticus
NCBI taxonomy Id: 1648404
Other names: E. atlanticus, Erythrobacter atlanticus Zhuang et al. 2015, Erythrobacter sp. s21-N3, KCTC 42697, MCCC 1A00519, strain s21-N3
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