STRINGSTRING
AKL72691.1 AKL72691.1 AKL72788.1 AKL72788.1 gyrB gyrB menC menC gyrA gyrA truB truB dapF dapF AKL72394.1 AKL72394.1 pgi pgi AKL73256.1 AKL73256.1 pheA pheA AKL73334.1 AKL73334.1 AKL73396.1 AKL73396.1 AKL73397.1 AKL73397.1 AKL73420.1 AKL73420.1 tal tal tpiA tpiA trpF trpF hisA hisA gpmA gpmA purE purE tig tig AKL73802.1 AKL73802.1 murI murI AKL73905.1 AKL73905.1 AKL73907.1 AKL73907.1 AKL73945.1 AKL73945.1 AKL73960.1 AKL73960.1 AKL72474.1 AKL72474.1 AKL73982.1 AKL73982.1 AKL74037.1 AKL74037.1 AKL72485.1 AKL72485.1 AKL74157.1 AKL74157.1 AKL74196.1 AKL74196.1 AKL74206.1 AKL74206.1 AKL74249.1 AKL74249.1 AKL74314.1 AKL74314.1 AKL74331.1 AKL74331.1 nnrD nnrD glmM glmM truA truA AKL74398.1 AKL74398.1 hemL hemL topA topA AKL74593.1 AKL74593.1 groL groL
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AKL72691.1Parvulin-like peptidyl-prolyl isomerase; PFAM: PPIC-type PPIASE domain. (344 aa)
AKL72788.1PFAM: FKBP-type peptidyl-prolyl cis-trans isomerase. (184 aa)
gyrBDNA gyrase, B subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (633 aa)
menCO-succinylbenzoic acid synthetase; Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB). (371 aa)
gyrADNA gyrase, A subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (819 aa)
truBtRNA pseudouridine(55) synthase; Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs; Belongs to the pseudouridine synthase TruB family. Type 1 subfamily. (295 aa)
dapFDiaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (307 aa)
AKL72394.1Galactose mutarotase-like enzyme; PFAM: Aldose 1-epimerase. (292 aa)
pgiPFAM: Phosphoglucose isomerase; Belongs to the GPI family. (537 aa)
AKL73256.1Pseudouridine synthase, RluA family; Responsible for synthesis of pseudouridine from uracil. Belongs to the pseudouridine synthase RluA family. (313 aa)
pheAPFAM: Prephenate dehydratase; ACT domain. (309 aa)
AKL73334.1PFAM: Ribulose-phosphate 3 epimerase family; TIGRFAM: ribulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (218 aa)
AKL73396.1PFAM: RNA pseudouridylate synthase; S4 domain; TIGRFAM: pseudouridine synthase; Belongs to the pseudouridine synthase RsuA family. (269 aa)
AKL73397.1PFAM: Chorismate mutase type I; TIGRFAM: monofunctional chorismate mutase, gram positive type, clade 1. (122 aa)
AKL73420.1PFAM: FKBP-type peptidyl-prolyl cis-trans isomerase. (124 aa)
talTransaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 2 subfamily. (365 aa)
tpiATriosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (260 aa)
trpFPFAM: N-(5'phosphoribosyl)anthranilate (PRA) isomerase; Belongs to the TrpF family. (244 aa)
hisA1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase; PFAM: Histidine biosynthesis protein; TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. (228 aa)
gpmAPhosphoglycerate mutase, BPG-dependent, family 1; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (245 aa)
purEPhosphoribosylaminoimidazole carboxylase, PurE protein; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (154 aa)
tigTrigger factor; Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase; Belongs to the FKBP-type PPIase family. Tig subfamily. (466 aa)
AKL73802.1UDP-glucose-4-epimerase GalE; PFAM: NAD dependent epimerase/dehydratase family; UDP-glucose 4-epimerase C-term subunit; TIGRFAM: UDP-glucose-4-epimerase GalE; Belongs to the NAD(P)-dependent epimerase/dehydratase family. (316 aa)
murIGlutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. (278 aa)
AKL73905.1PFAM: Bacterial phospho-glucose isomerase C-terminal region; SIS domain; TIGRFAM: bifunctional phosphoglucose/phosphomannose isomerase. (350 aa)
AKL73907.1Phosphomannomutase; PFAM: Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III; Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II; Phosphoglucomutase/phosphomannomutase, C-terminal domain; Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I. (454 aa)
AKL73945.1PFAM: Methylmalonyl-CoA mutase; TIGRFAM: methylmalonyl-CoA mutase N-terminal domain. (532 aa)
AKL73960.1PFAM: Ribose/Galactose Isomerase; TIGRFAM: ribose 5-phosphate isomerase B; sugar-phosphate isomerase, RpiB/LacA/LacB family. (146 aa)
AKL72474.1methylmalonyl-CoA epimerase; PFAM: Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; TIGRFAM: methylmalonyl-CoA epimerase. (133 aa)
AKL73982.1PFAM: 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Metalloenzyme superfamily; TIGRFAM: phosphoglycerate mutase (2,3-diphosphoglycerate-independent), archaeal form; proposed homoserine kinase. (391 aa)
AKL74037.1Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (157 aa)
AKL72485.1Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (245 aa)
AKL74157.1Isochorismate synthase; PFAM: chorismate binding enzyme; TIGRFAM: isochorismate synthases. (426 aa)
AKL74196.1PFAM: Methylmalonyl-CoA mutase; TIGRFAM: methylmalonyl-CoA mutase N-terminal domain. (528 aa)
AKL74206.1dTDP-4-dehydrorhamnose 3,5-epimerase-like enzyme; PFAM: dTDP-4-dehydrorhamnose 3,5-epimerase; TIGRFAM: dTDP-4-dehydrorhamnose 3,5-epimerase. (188 aa)
AKL74249.1Putative dithiol-disulfide isomerase involved in polyketide biosynthesis; PFAM: DSBA-like thioredoxin domain. (185 aa)
AKL74314.1PFAM: B12 binding domain; TIGRFAM: methylmalonyl-CoA mutase C-terminal domain. (138 aa)
AKL74331.1Alanine racemase; Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids; Belongs to the alanine racemase family. (373 aa)
nnrDyjeF-like protein, hydroxyethylthiazole kinase-related; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydrata [...] (516 aa)
glmMPhosphoglucosamine mutase; Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; Belongs to the phosphohexose mutase family. (450 aa)
truAtRNA pseudouridine(38-40) synthase; Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs. (251 aa)
AKL74398.1PFAM: NAD dependent epimerase/dehydratase family. (310 aa)
hemLPFAM: Aminotransferase class-III; TIGRFAM: glutamate-1-semialdehyde-2,1-aminomutase. (425 aa)
topADNA topoisomerase I, bacterial; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removi [...] (900 aa)
AKL74593.1PFAM: Myo-inositol-1-phosphate synthase; TIGRFAM: inositol 1-phosphate synthase, Actinobacterial type. (360 aa)
groLChaperonin GroL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. (545 aa)
Your Current Organism:
Actinobacteria bacterium IMCC26256
NCBI taxonomy Id: 1650658
Other names: A. bacterium IMCC26256
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