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THC_0009 THC_0009 THC_0020 THC_0020 nadA nadA ispH ispH mqnC mqnC nth nth queE queE THC_0410 THC_0410 THC_0449 THC_0449 THC_0450 THC_0450 THC_0474 THC_0474 leuC leuC THC_0658 THC_0658 THC_0674 THC_0674 THC_0695 THC_0695 THC_0718 THC_0718 THC_0777 THC_0777 rlmN rlmN THC_0802 THC_0802 ispG ispG nuoI nuoI nuoB nuoB THC_0921 THC_0921 rimO rimO thiC thiC THC_1074 THC_1074 THC_1119 THC_1119 moaA moaA THC_1169 THC_1169 THC_1208 THC_1208 THC_1259 THC_1259 THC_1271 THC_1271 queH queH nuoB-2 nuoB-2 nuoI-2 nuoI-2 THC_1361 THC_1361 THC_1375 THC_1375 THC_1378 THC_1378 THC_1380 THC_1380 THC_1483 THC_1483 THC_1484 THC_1484 THC_1522 THC_1522 THC_1560 THC_1560 THC_1625 THC_1625 miaB miaB THC_1760 THC_1760 THC_1763 THC_1763 THC_1767 THC_1767
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
THC_0009Pyruvate ferredoxin oxidoreductase. (97 aa)
THC_0020Aconitate hydratase. (645 aa)
nadAQuinolinate synthase A; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (304 aa)
ispHHydroxymethylbutenyl pyrophosphate reductase; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. (550 aa)
mqnCHypothetical protein; Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2). (357 aa)
nthEndonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (212 aa)
queE7-carboxy-7-deazaguanine synthase; Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. (212 aa)
THC_0410Sulfite reductase. (263 aa)
THC_0449Sulfite reductase. (432 aa)
THC_0450Sulfite reductase. (409 aa)
THC_0474Molybdopterin oxidoreductase; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (894 aa)
leuC3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (425 aa)
THC_0658Hypothetical protein; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. (383 aa)
THC_0674Fe-S cluster protein. (171 aa)
THC_0695Hypothetical protein. (306 aa)
THC_0718Radical SAM protein. (305 aa)
THC_0777Hypothetical protein. (181 aa)
rlmN50S rRNA methyltransferase; Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs; Belongs to the radical SAM superfamily. RlmN family. (367 aa)
THC_0802Radical SAM protein. (339 aa)
ispG4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. (364 aa)
nuoINADH-ubiquinone oxidoreductase; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. (184 aa)
nuoBNADH dehydrogenase subunit B; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. (158 aa)
THC_0921Thiosulfate reductase; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (693 aa)
rimOHypothetical protein; Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12; Belongs to the methylthiotransferase family. RimO subfamily. (434 aa)
thiCPhosphomethylpyrimidine synthase; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. Belongs to the ThiC family. (435 aa)
THC_1074Hypothetical protein. (247 aa)
THC_1119Pyruvate formate lyase-activating protein. (366 aa)
moaAMolybdenum cofactor biosynthesis protein MoeA; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate. (319 aa)
THC_1169Fumarate hydratase. (279 aa)
THC_1208Hypothetical protein. (98 aa)
THC_1259Indolepyruvate ferredoxin oxidoreductase; Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates. (518 aa)
THC_1271Fe-S cluster protein. (266 aa)
queHHypothetical protein; Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr). (193 aa)
nuoB-2NADH dehydrogenase subunit B; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. (171 aa)
nuoI-2NADH-ubiquinone oxidoreductase; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. (180 aa)
THC_1361Ni/Fe hydrogenase. (364 aa)
THC_1375Molybdopterin oxidoreductase; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (1080 aa)
THC_1378Nitrate reductase. (770 aa)
THC_1380Nitrate reductase. (158 aa)
THC_1483Hypothetical protein. (448 aa)
THC_1484Radical SAM protein. (331 aa)
THC_1522Ribonucleoside-triphosphate reductase. (230 aa)
THC_1560Radical SAM protein. (191 aa)
THC_1625Hypothetical protein. (228 aa)
miaBDimethylallyladenosine tRNA methylthiotransferase; Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6- (dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine. (448 aa)
THC_1760Zinc-finger protein. (226 aa)
THC_1763acetyl-CoA synthase subunit gamma. (456 aa)
THC_1767Formate dehydrogenase, partial; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family. (454 aa)
Your Current Organism:
Caldimicrobium thiodismutans
NCBI taxonomy Id: 1653476
Other names: C. thiodismutans, Caldimicrobium thiodismutans Kojima et al. 2016, DSM 29380, NBRC 110713, Thermodesulfobacteriaceae bacterium TF1, strain TF1
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