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| | THC_0002 | FAD-binding protein. (459 aa) |
| | glyA | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (412 aa) |
| | THC_0008 | Pyruvate synthase. (183 aa) |
| | THC_0009 | Pyruvate ferredoxin oxidoreductase. (97 aa) |
| | THC_0010 | 2-ketoisovalerate ferredoxin oxidoreductase subunit alpha. (389 aa) |
| | THC_0011 | Pyruvate synthase. (319 aa) |
| | ispD | 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). (224 aa) |
| | THC_0020 | Aconitate hydratase. (645 aa) |
| | purC | Phosphoribosylaminoimidazole-succinocarboxamide synthase; Belongs to the SAICAR synthetase family. (292 aa) |
| | gltX | glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. (464 aa) |
| | purD | Phosphoribosylamine--glycine ligase; Belongs to the GARS family. (425 aa) |
| | purE | N5-carboxyaminoimidazole ribonucleotide mutase; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (170 aa) |
| | purK | Phosphoribosylaminoimidazole carboxylase, ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (376 aa) |
| | purM | Phosphoribosylaminoimidazole synthetase. (348 aa) |
| | acsA | acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (660 aa) |
| | THC_0133 | Alcohol dehydrogenase. (340 aa) |
| | THC_0161 | Purine nucleoside phosphorylase; The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. (274 aa) |
| | hisC | Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (365 aa) |
| | fbp | Fructose-1 6-bisphosphatase; Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3- phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P). (379 aa) |
| | ispF | 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2- C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP). (161 aa) |
| | ilvD | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. (551 aa) |
| | THC_0203 | Phosphoribosylformylglycinamidine synthase. (270 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (364 aa) |
| | THC_0212 | Threonine synthase. (409 aa) |
| | mqnC | Hypothetical protein; Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2). (357 aa) |
| | THC_0243 | Hypothetical protein. (408 aa) |
| | mqnA | Hypothetical protein; Catalyzes the dehydration of chorismate into 3-[(1- carboxyvinyl)oxy]benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2). (281 aa) |
| | menG | Hypothetical protein; Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2). (241 aa) |
| | THC_0256 | Homoserine dehydrogenase. (431 aa) |
| | acpP | Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis. (77 aa) |
| | THC_0264 | Ribose 5-phosphate isomerase. (147 aa) |
| | eno | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family. (425 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (345 aa) |
| | THC_0322 | Acetyltransferase; Belongs to the acetyltransferase family. (153 aa) |
| | THC_0331 | Prephenate dehydrogenase. (274 aa) |
| | THC_0335 | Phosphatidylserine decarboxylase. (214 aa) |
| | THC_0336 | CDP-diacylglycerol--serine O-phosphatidyltransferase; Belongs to the CDP-alcohol phosphatidyltransferase class-I family. (239 aa) |
| | metK | S-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (387 aa) |
| | plsY | Hypothetical protein; Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP. (202 aa) |
| | THC_0454 | Transketolase. (648 aa) |
| | THC_0455 | Acetolactate synthase. (165 aa) |
| | THC_0456 | Acetolactate synthase. (567 aa) |
| | THC_0496 | Hypothetical protein. (185 aa) |
| | THC_0497 | Siroheme synthase. (226 aa) |
| | THC_0500 | 3-oxoacyl-ACP synthase; Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis. Belongs to the short-chain dehydrogenases/reductases (SDR) family. (247 aa) |
| | THC_0542 | Nitrogen utilization protein B; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (412 aa) |
| | THC_0543 | Pyruvate, phosphate dikinase. (1370 aa) |
| | THC_0544 | Glyceraldehyde-3-phosphate dehydrogenase; Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. (335 aa) |
| | leuD | 3-isopropylmalate dehydratase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 2 subfamily. (167 aa) |
| | leuC | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (425 aa) |
| | dxs | 1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (623 aa) |
| | THC_0583 | Hypothetical protein; Belongs to the FPP/GGPP synthase family. (300 aa) |
| | THC_0619 | Magnesium chelatase. (345 aa) |
| | THC_0620 | Hypothetical protein. (612 aa) |
| | THC_0626 | Aminotransferase. (403 aa) |
| | THC_0631 | Threonine synthase. (463 aa) |
| | argB | Acetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (302 aa) |
| | THC_0658 | Hypothetical protein; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. (383 aa) |
| | hemC | Porphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (307 aa) |
| | THC_0671 | uroporphyrin-III C-methyltransferase. (505 aa) |
| | THC_0689 | UDP pyrophosphate synthase; Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids. (248 aa) |
| | THC_0690 | Phosphatidate cytidylyltransferase; Belongs to the CDS family. (269 aa) |
| | hisH | Imidazole glycerol phosphate synthase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (208 aa) |
| | apgM | Phosphoglycerate mutase; Catalyzes the interconversion of 2-phosphoglycerate and 3- phosphoglycerate. (408 aa) |
| | asd | Semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (340 aa) |
| | THC_0744 | Hypothetical protein. (230 aa) |
| | plsX | Phosphate acyltransferase; Catalyzes the reversible formation of acyl-phosphate (acyl- PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA. (335 aa) |
| | leuA | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. (543 aa) |
| | THC_0776 | Riboflavin synthase subunit alpha. (219 aa) |
| | trpF | N-(5'-phosphoribosyl)anthranilate isomerase; Belongs to the TrpF family. (216 aa) |
| | THC_0800 | 3-phosphoglycerate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (526 aa) |
| | dxr | 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. (389 aa) |
| | ispE | 4-diphosphocytidyl-2C-methyl-D-erythritol kinase; Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. (281 aa) |
| | prs | Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (315 aa) |
| | THC_0839 | Branched-chain amino acid aminotransferase; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (358 aa) |
| | THC_0845 | UTP--glucose-1-phosphate uridylyltransferase. (290 aa) |
| | THC_0862 | Proposed homoserine kinase. (407 aa) |
| | argH | Argininosuccinate lyase. (462 aa) |
| | THC_0893 | Alpha-amylase. (399 aa) |
| | THC_0894 | Alpha-glucan phosphorylase. (844 aa) |
| | ispG | 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. (364 aa) |
| | proB | Gamma-glutamyl kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (370 aa) |
| | panD | Aspartate decarboxylase; Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine. (118 aa) |
| | panC | Pantoate--beta-alanine ligase; Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate. Belongs to the pantothenate synthetase family. (281 aa) |
| | THC_0940 | 4-hydroxybenzoate polyprenyltransferase; Belongs to the UbiA prenyltransferase family. (286 aa) |
| | miaA | tRNA delta(2)-isopentenylpyrophosphate transferase; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A); Belongs to the IPP transferase family. (307 aa) |
| | mdh | Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family. (307 aa) |
| | THC_0948 | Adenylosuccinate lyase; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (440 aa) |
| | proA | Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (420 aa) |
| | hemA | glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (457 aa) |
| | THC_0976 | Inositol monophosphatase. (401 aa) |
| | hisA | 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino) methylideneamino] imidazole-4-carboxamide isomerase. (241 aa) |
| | THC_0989 | Diaminopimelate aminotransferase. (386 aa) |
| | THC_0990 | Inositol-3-phosphate synthase. (368 aa) |
| | THC_0992 | Hypothetical protein; Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. (235 aa) |
| | trpE | Anthranilate synthase subunit I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrat [...] (495 aa) |
| | trpB | Tryptophan synthase subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (430 aa) |
| | THC_1017 | Phosphoglucose isomerase; Belongs to the GPI family. (572 aa) |
| | THC_1018 | Delta-aminolevulinic acid dehydratase; Belongs to the ALAD family. (325 aa) |
| | THC_1056 | Glucokinase; Belongs to the bacterial glucokinase family. (316 aa) |
| | THC_1064 | Adenylate kinase. (207 aa) |
| | THC_1077 | Hypothetical protein. (261 aa) |
| | THC_1103 | Hypothetical protein; Belongs to the UbiD family. (486 aa) |
| | purF | Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (459 aa) |
| | trpB-2 | Tryptophan synthase subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (398 aa) |
| | trpA | Tryptophan synthase subunit alpha; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (268 aa) |
| | aroB | 3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (362 aa) |
| | dapF | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (287 aa) |
| | dapA | Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (296 aa) |
| | THC_1132 | DeoR faimly transcriptional regulator; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. (379 aa) |
| | purL | Phosphoribosylformylglycinamidine synthase; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist in [...] (1021 aa) |
| | hisD | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (437 aa) |
| | pfkA | Diphosphate--fructose-6-phosphate 1-phosphotransferase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis; Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Atypical ATP-dependent clade 'X' sub-subfamily. (449 aa) |
| | THC_1169 | Fumarate hydratase. (279 aa) |
| | hisF | Imidazole glycerol phosphate synthase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (259 aa) |
| | THC_1187 | Asparagine synthase. (635 aa) |
| | THC_1194 | Hypothetical protein. (350 aa) |
| | THC_1199 | Asparagine synthase. (392 aa) |
| | tal | Transaldolase; Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway; Belongs to the transaldolase family. Type 3B subfamily. (218 aa) |
| | argG | Argininosuccinate synthase; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (396 aa) |
| | THC_1224 | Riboflavin biosynthesis protein RibF; Belongs to the ribF family. (307 aa) |
| | surE | Stationary phase survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family. (252 aa) |
| | argJ | Arginine biosynthesis bifunctional protein ArgJ; Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate. Belongs to the ArgJ family. (382 aa) |
| | THC_1234 | Radical SAM protein. (359 aa) |
| | ilvC | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (330 aa) |
| | hemL | Glutamate-1-semialdehyde aminotransferase. (428 aa) |
| | proC | Pyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (274 aa) |
| | THC_1277 | Hypothetical protein. (207 aa) |
| | mqnD | 1,4-dihydroxy-6-naphthoate synthase; Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2); Belongs to the MqnA/MqnD family. MqnD subfamily. (280 aa) |
| | THC_1286 | NAD(P)H quinone oxidoreductase; Belongs to the WrbA family. (203 aa) |
| | THC_1289 | Phosphoenolpyruvate synthase; Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate; Belongs to the PEP-utilizing enzyme family. (812 aa) |
| | ribH | 6,7-dimethyl-8-ribityllumazine synthase; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. (159 aa) |
| | pgk | Phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family. (386 aa) |
| | tpiA | Triosephosphate isomerase; Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D- glyceraldehyde-3-phosphate (G3P); Belongs to the triosephosphate isomerase family. (253 aa) |
| | THC_1309 | Sulfate adenylyltransferase. (458 aa) |
| | ribBA | 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. (400 aa) |
| | gpsA | Glycerol-3-phosphate dehydrogenase; Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. (339 aa) |
| | dapB | Dihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (270 aa) |
| | THC_1439 | 2-oxoacid ferredoxin oxidoreductase subunit beta. (283 aa) |
| | THC_1440 | 2-oxoacid ferredoxin oxidoreductase subunit alpha. (572 aa) |
| | THC_1442 | Hypoxanthine phosphoribosyltransferase; Belongs to the purine/pyrimidine phosphoribosyltransferase family. (174 aa) |
| | THC_1454 | Ribulose-phosphate 3-epimerase; Belongs to the ribulose-phosphate 3-epimerase family. (224 aa) |
| | argD | Acetylornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily. (395 aa) |
| | THC_1484 | Radical SAM protein. (331 aa) |
| | THC_1505 | Hypothetical protein. (432 aa) |
| | lysA | Diaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (418 aa) |
| | panB | 3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (280 aa) |
| | THC_1526 | Phosphomannomutase. (457 aa) |
| | THC_1527 | 3-deoxy-7-phosphoheptulonate synthase. (370 aa) |
| | THC_1535 | Transcriptional regulator. (146 aa) |
| | THC_1541 | IMP cyclohydrolase. (430 aa) |
| | THC_1543 | Isocitrate dehydrogenase. (406 aa) |
| | THC_1557 | Hypothetical protein. (513 aa) |
| | THC_1560 | Radical SAM protein. (191 aa) |
| | ndk | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (141 aa) |
| | hisB | Imidazoleglycerol-phosphate dehydratase. (194 aa) |
| | THC_1592 | Alpha-isopropylmalate/homocitrate synthase family transferase; Belongs to the alpha-IPM synthase/homocitrate synthase family. (529 aa) |
| | THC_1593 | Aspartokinase; Belongs to the aspartokinase family. (409 aa) |
| | THC_1605 | 3-isopropylmalate dehydrogenase. (366 aa) |
| | THC_1612 | Beta-phosphoglucomutase. (209 aa) |
| | THC_1613 | Hypothetical protein; Belongs to the FPP/GGPP synthase family. (321 aa) |
| | THC_1616 | Fe-S oxidoreductase. (394 aa) |
| | aroD | 3-dehydroquinate dehydratase; Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis- dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate. Belongs to the type-I 3-dehydroquinase family. (228 aa) |
| | aroE | Shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (276 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (432 aa) |
| | aroK | Shikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (177 aa) |
| | THC_1642 | Hypothetical protein. (335 aa) |
| | guaB | Inosine 5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (489 aa) |
| | THC_1668 | Fumarate hydratase. (187 aa) |
| | THC_1672 | Histone-lysine N-methyltransferase. (599 aa) |
| | adk | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (215 aa) |
| | ubiX | Aromatic acid decarboxylase; Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN; Belongs to the UbiX/PAD1 family. (188 aa) |
| | THC_1736 | Glycine cleavage system protein H. (142 aa) |
| | THC_1737 | Malonyl CoA-ACP transacylase. (312 aa) |
| | THC_1738 | Tungsten formylmethanofuran dehydrogenase. (68 aa) |
| | THC_1739 | 2-ketoisovalerate ferredoxin oxidoreductase. (360 aa) |
| | THC_1740 | 2-oxoglutarate oxidoreductase. (244 aa) |
| | THC_1741 | 2-oxoacid:ferredoxin oxidoreductase subunit gamma. (189 aa) |
| | argC | N-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (344 aa) |
| | THC_1748 | Aspartate aminotransferase. (399 aa) |
| | THC_1761 | Hypothetical protein. (839 aa) |
| | THC_1768 | Prephenate dehydratase. (358 aa) |
| | THC_1774 | Aspartate aminotransferase. (395 aa) |
| | THC_1800 | acetyl-CoA carboxylase. (738 aa) |
| | trpC | Indole-3-glycerol phosphate synthase; Belongs to the TrpC family. (258 aa) |
| | hisI | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. (128 aa) |
| | hisG | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (291 aa) |
| | THC_1820 | Ornithine carbamoyltransferase; Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. (303 aa) |
