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gabD2 gabD2 AKT50207.1 AKT50207.1 sdhA sdhA AKT50209.1 AKT50209.1 AKT50230.1 AKT50230.1 AKT50261.1 AKT50261.1 ldh ldh AKT50429.1 AKT50429.1 AKT50443.1 AKT50443.1 AKT52529.1 AKT52529.1 AKT50446.1 AKT50446.1 AKT50447.1 AKT50447.1 AKT50448.1 AKT50448.1 AKT50450.1 AKT50450.1 acsA acsA AKT50481.1 AKT50481.1 AKT52542.1 AKT52542.1 AKT50536.1 AKT50536.1 pckG pckG AKT50567.1 AKT50567.1 AKT50568.1 AKT50568.1 AKT50569.1 AKT50569.1 AKT50746.1 AKT50746.1 AKT52589.1 AKT52589.1 AKT52590.1 AKT52590.1 AKT50747.1 AKT50747.1 AKT50748.1 AKT50748.1 AKT50749.1 AKT50749.1 AKT50860.1 AKT50860.1 AKT50906.1 AKT50906.1 AKT51020.1 AKT51020.1 gltA gltA AKT51066.1 AKT51066.1 AKT51247.1 AKT51247.1 AKT51259.1 AKT51259.1 AKT51317.1 AKT51317.1 AKT51318.1 AKT51318.1 AKT51319.1 AKT51319.1 AKT51324.1 AKT51324.1 ilvD ilvD AKT51373.1 AKT51373.1 kgd kgd AKT51463.1 AKT51463.1 AKT51539.1 AKT51539.1 fumC fumC AKT51944.1 AKT51944.1 ackA ackA acnA acnA AKT52016.1 AKT52016.1 AKT52099.1 AKT52099.1 AKT52100.1 AKT52100.1 AKT52124.1 AKT52124.1 AKT52137.1 AKT52137.1 leuA leuA prpE prpE AKT52259.1 AKT52259.1 leuD leuD leuC leuC AKT52281.1 AKT52281.1 AKT52283.1 AKT52283.1 AKT52292.1 AKT52292.1 AKT52298.1 AKT52298.1 leuB leuB ilvC ilvC AKT52313.1 AKT52313.1 AKT52314.1 AKT52314.1 AKT52347.1 AKT52347.1 AKT52927.1 AKT52927.1 AKT52349.1 AKT52349.1 AKT52350.1 AKT52350.1 AKT52352.1 AKT52352.1 AKT52359.1 AKT52359.1 AKT52403.1 AKT52403.1 AKT52412.1 AKT52412.1 AKT52414.1 AKT52414.1 AKT52439.1 AKT52439.1 AKT52953.1 AKT52953.1 mdh mdh sucD sucD sucC sucC
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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gabD2NADP-dependent semialdehyde dehydrogenase; part of alternative pathway from alpha-ketoglutarate to succinate; Derived by automated computational analysis using gene prediction method: Protein Homology. (520 aa)
AKT50207.1Succinate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (247 aa)
sdhAPart of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; Derived by automated computational analysis using gene prediction method: Protein Homology. (665 aa)
AKT50209.1Succinate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (243 aa)
AKT50230.1Citrate synthase 2; Forms citrate from oxaloacetate and acetyl-CoA; functions in TCA cycle; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the citrate synthase family. (355 aa)
AKT50261.1acetyl-CoA hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (504 aa)
ldhLactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family. (316 aa)
AKT50429.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (215 aa)
AKT50443.1Aspartate aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (398 aa)
AKT52529.1Converts oxaloacetate to phosphoenolpyruvate using ATP as an energy source; Derived by automated computational analysis using gene prediction method: Protein Homology. (480 aa)
AKT50446.1methylmalonyl-CoA carboxyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (522 aa)
AKT50447.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (86 aa)
AKT50448.1methylmalonyl-CoA carboxyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (121 aa)
AKT50450.1Pyruvate dehydrogenase; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (790 aa)
acsAacetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (653 aa)
AKT50481.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the citrate synthase family. (402 aa)
AKT52542.1Citrate (Si)-synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the citrate synthase family. (376 aa)
AKT50536.1Malate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (402 aa)
pckGPhosphoenolpyruvate carboxykinase; Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle; Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. (598 aa)
AKT50567.1Branched-chain alpha-keto acid dehydrogenase subunit E2; Derived by automated computational analysis using gene prediction method: Protein Homology. (501 aa)
AKT50568.12-oxoisovalerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (326 aa)
AKT50569.1Pyruvate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (392 aa)
AKT50746.1Acetylornithine deacetylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (406 aa)
AKT52589.1Aspartate aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (415 aa)
AKT52590.1Creatinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (391 aa)
AKT50747.1Succinate-semialdehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aldehyde dehydrogenase family. (498 aa)
AKT50748.14-aminobutyrate aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (418 aa)
AKT50749.12-hydroxyacid dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (325 aa)
AKT50860.1GntR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (436 aa)
AKT50906.1Methylmalonate-semialdehyde dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (499 aa)
AKT51020.1Thiamine pyrophosphate-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TPP enzyme family. (572 aa)
gltAType II enzyme; in Escherichia coli this enzyme forms a trimer of dimers which is allosterically inhibited by NADH and competitively inhibited by alpha-ketoglutarate; allosteric inhibition is lost when Cys206 is chemically modified which also affects hexamer formation; forms oxaloacetate and acetyl-CoA and water from citrate and coenzyme A; functions in TCA cycle, glyoxylate cycle and respiration; enzyme from Helicobacter pylori is not inhibited by NADH; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the citrate synthase family. (429 aa)
AKT51066.1Leucine dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (343 aa)
AKT51247.1Malate dehydrogenase; Malic enzyme; oxaloacetate-decarboxylating; NAD-dependent; catalyzes the formation of pyruvate form malate; Derived by automated computational analysis using gene prediction method: Protein Homology. (571 aa)
AKT51259.12-oxoacid:ferredoxin oxidoreductase subunit beta; Derived by automated computational analysis using gene prediction method: Protein Homology. (359 aa)
AKT51317.1Pyruvate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (403 aa)
AKT51318.12-oxoisovalerate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (356 aa)
AKT51319.1Branched-chain alpha-keto acid dehydrogenase subunit E2; Derived by automated computational analysis using gene prediction method: Protein Homology. (475 aa)
AKT51324.1Fumarate hydratase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family. (568 aa)
ilvDDihydroxy-acid dehydratase; Catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the IlvD/Edd family. (613 aa)
AKT51373.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the citrate synthase family. (434 aa)
kgdAlpha-ketoglutarate decarboxylase; Kgd; produces succinic semialdehyde; part of alternative pathway from alpha-ketoglutarate to succinate; essential for normal growth; Derived by automated computational analysis using gene prediction method: Protein Homology. (1288 aa)
AKT51463.1Pyruvate carboxylase; Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. (1128 aa)
AKT51539.1Dihydrolipoyl dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (465 aa)
fumCFumarate hydratase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (467 aa)
AKT51944.1Phosphate acetyltransferase; Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family. (700 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (400 aa)
acnAAconitate hydratase; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate. (927 aa)
AKT52016.1Pyruvate phosphate dikinase; Catalyzes the formation of phosphoenolpyruvate from pyruvate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the PEP-utilizing enzyme family. (900 aa)
AKT52099.1Dihydrolipoamide dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (456 aa)
AKT52100.1Dihydrolipoamide acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (635 aa)
AKT52124.1Pyruvate dehydrogenase; Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (917 aa)
AKT52137.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (288 aa)
leuA2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. (573 aa)
prpECatalyzes the formation of propionyl-CoA using propionate as a substrate; PrpE from Ralstonia solanacearum can produce acetyl-, propionyl-, butyryl- and acrylyl-coenzyme A, and Salmonella enterica produces propionyl- and butyryl-coenzyme A; not expressed in Escherichia coli when grown on propionate/minimal media; ATP-dependent; Derived by automated computational analysis using gene prediction method: Protein Homology. (634 aa)
AKT52259.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (112 aa)
leuDIsopropylmalate isomerase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. (199 aa)
leuCIsopropylmalate isomerase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. (463 aa)
AKT52281.1AMP-dependent synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (567 aa)
AKT52283.14-hydroxybutyrate CoA-transferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (431 aa)
AKT52292.1Transferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the alpha-IPM synthase/homocitrate synthase family. (528 aa)
AKT52298.1Catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids; Derived by automated computational analysis using gene prediction method: Protein Homology. (367 aa)
leuB3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily. (356 aa)
ilvCKetol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. (343 aa)
AKT52313.1Acetolactate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (168 aa)
AKT52314.1Acetolactate synthase large subunit; catalyzes the formation of 2-acetolactate from pyruvate; Derived by automated computational analysis using gene prediction method: Protein Homology. (616 aa)
AKT52347.1methylmalonyl-CoA mutase; Derived by automated computational analysis using gene prediction method: Protein Homology. (604 aa)
AKT52927.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (103 aa)
AKT52349.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (255 aa)
AKT52350.1Transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. (319 aa)
AKT52352.1Glyoxalase; Derived by automated computational analysis using gene prediction method: Protein Homology. (148 aa)
AKT52359.1Protein meaA; Derived by automated computational analysis using gene prediction method: Protein Homology. (711 aa)
AKT52403.1methylmalonyl-CoA carboxyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (536 aa)
AKT52412.1acetyl-COA carboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (593 aa)
AKT52414.1Flavoprotein disulfide reductase; Catalyzes the reduction of nonspecific electron acceptors such as 2,6-dimethyl-1,4-benzoquinone and 5-hydroxy-1,4-naphthaquinone; does not have lipoamide dehydrogenase activity; Derived by automated computational analysis using gene prediction method: Protein Homology. (478 aa)
AKT52439.1methylmalonyl-CoA mutase; Derived by automated computational analysis using gene prediction method: Protein Homology. (534 aa)
AKT52953.1Isocitrate dehydrogenase; NADP-specific, catalyzes the formation of 2-oxoglutarate from isocitrate or oxalosuccinate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the monomeric-type IDH family. (740 aa)
mdhMalate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 2 family. (325 aa)
sucDsuccinyl-CoA synthetase subunit alpha; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. (295 aa)
sucCsuccinyl-CoA synthetase subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. (393 aa)
Your Current Organism:
Arsenicicoccus
NCBI taxonomy Id: 1658671
Other names: A. sp. oral taxon 190, Arsenicicoccus sp. oral taxon 190
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