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folD folD gpt gpt XM1_0680 XM1_0680 XM1_0681 XM1_0681 XM1_0739 XM1_0739 purH purH purD purD folC folC pyrF pyrF pyrD pyrD guaB guaB XM1_1665 XM1_1665 pyrB pyrB pyrC pyrC XM1_1895 XM1_1895 pyrE pyrE folA folA thyA thyA adk adk purB purB purC purC purF purF purQ purQ purL purL purK purK purE purE glyA glyA XM1_3143 XM1_3143 mazG mazG tmk tmk XM1_3516 XM1_3516 nrd nrd XM1_3559 XM1_3559 pyrG pyrG purM purM purN purN apt apt XM1_3835 XM1_3835 grxC grxC purS purS purC-2 purC-2 dcd dcd purA purA ndk ndk XM1_4452 XM1_4452 gmk gmk guaA guaA carB carB carA carA
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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a 3D structure is known or predicted
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folDMethenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (295 aa)
gptGuanine-hypoxanthine phosphoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine. (151 aa)
XM1_0680Uncharacterized protein; Homologs of previously reported genes of unknown function. (170 aa)
XM1_0681Putative permease, inner membrane protein, Xanthine/uracil/vitamin C permease family; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; membrane component. (432 aa)
XM1_0739Putative Ribonucleoside-diphosphate reductase; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. (774 aa)
purHFused IMP cyclohydrolase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (526 aa)
purDPhosphoribosylamine--glycine ligase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the GARS family. (424 aa)
folCBifunctional folylpolyglutamate synthase and dihydrofolate synthase; Function of strongly homologous gene; putative enzyme; Belongs to the folylpolyglutamate synthase family. (434 aa)
pyrFOrotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (235 aa)
pyrDDihydro-orotate oxidase, FMN-linked（Aldolase-type TIM barrel,5-351） Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (355 aa)
guaBIMP dehydrogenase(Inosine-5'-monophosphate dehydrogenase,3-478); Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (486 aa)
XM1_1665Putative Glutamine amidotransferase(Glutamine amidotransferase type 1,44-182); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (233 aa)
pyrBAspartate carbamoyltransferase(Aspartate/ornithine carbamoyltransferase,3-313); Function of strongly homologous gene; enzyme; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (317 aa)
pyrCDihydroorotase(Dihydroorotase,26-433); Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (436 aa)
XM1_1895Putative dihydroorotase(Dihydroorotase,21-426); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (443 aa)
pyrEOrotate phosphoribosyltransferase(Orotate phosphoribosyl transferase domain,22-169); Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (230 aa)
folADihydrofolate reductase（Dihydrofolate reductase-like domain,3-162） Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. (163 aa)
thyAThymidylate synthase (TS) (TSase); Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (264 aa)
adkAdenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (217 aa)
purBAdenylosuccinate lyase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (437 aa)
purCPutative phosphoribosylaminoimidazole-succinocarboxamide synthase 2; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the SAICAR synthetase family. (325 aa)
purFAmidophosphoribosyltransferase purF; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (486 aa)
purQPhosphoribosylformylglycinamidine synthase 1; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...] (229 aa)
purLPhosphoribosylformylglycinamidine synthase 2; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...] (734 aa)
purKN5-carboxyaminoimidazole ribonucleotide synthase; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (369 aa)
purEPhosphoribosylaminoimidazole carboxylase, mutase subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (173 aa)
glyASerine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. (427 aa)
XM1_3143Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate. (329 aa)
mazGNucleoside triphosphate pyrophosphohydrolase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (278 aa)
tmkThymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (212 aa)
XM1_3516CMP/dCMP-type deaminase domain-containing protein; Homologs of previously reported genes of unknown function. (140 aa)
nrdVitamin B12-dependent ribonucleotide reductase; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. (1223 aa)
XM1_3559Putative thiol-disulfide isomerase/thioredoxins-like; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (157 aa)
pyrGCTP synthetase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (541 aa)
purMPhosphoribosylaminoimidazole synthetase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (364 aa)
purNPhosphoribosylglycinamide formyltransferase 1; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (205 aa)
aptAdenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (174 aa)
XM1_3835Putative Carbon-nitrogen hydrolase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (275 aa)
grxCGlutaredoxin 3; Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins. (87 aa)
purSFactor required for phosphoribosylformylglycinamidine synthetase activity; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and Pu [...] (80 aa)
purC-2Phosphoribosylaminoimidazole-succinocarboxamide synthase; Function of strongly homologous gene; enzyme; Belongs to the SAICAR synthetase family. (254 aa)
dcdDeoxycytidine triphosphate deaminase; Catalyzes the deamination of dCTP to dUTP. (184 aa)
purAAdenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (429 aa)
ndkNucleoside diphosphate kinase ndk; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (140 aa)
XM1_4452Homologs of previously reported genes of unknown function; Belongs to the UPF0301 (AlgH) family. (190 aa)
gmkGuanylate kinase; Essential for recycling GMP and indirectly, cGMP. (215 aa)
guaAGMP synthetase (glutamine aminotransferase); Catalyzes the synthesis of GMP from XMP. (518 aa)
carBCarbamoyl-phosphate synthase, large subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the CarB family. (1085 aa)
carACarbamoyl phosphate synthetase small subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the CarA family. (406 aa)
Your Current Organism:
Magnetospirillum sp. XM1
NCBI taxonomy Id: 1663591
Other names: M. sp. XM-1, Magnetospirillum sp. XM-1
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