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| | thiL | Thiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (334 aa) |
| | dnaN | DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] (372 aa) |
| | parA | Conserved protein of unknown function; Function of strongly homologous gene; putative factor. (786 aa) |
| | XM1_0041 | Homologs of previously reported genes of unknown function. (169 aa) |
| | XM1_0092 | Homologs of previously reported genes of unknown function. (153 aa) |
| | cobT | Nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). (339 aa) |
| | XM1_0134 | Conserved protein of unknown function （phosphoribosyltransferase fragment); Homologs of previously reported genes of unknown function. (215 aa) |
| | cobS | Putative type I secretion membrane fusion protein, HlyD family; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. (259 aa) |
| | cobB | Cobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. (441 aa) |
| | cobA | Uroporphyrinogen-III C-methyltransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the precorrin methyltransferase family. (259 aa) |
| | cobM | Precorrin-4 C(11)-methyltransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (253 aa) |
| | XM1_0169 | Conserved protein of unknown function （molybdopterin-binding domain） Homologs of previously reported genes of unknown function. (244 aa) |
| | tgt | tRNA-guanine transglycosylase; Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, - Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the [...] (375 aa) |
| | queA | S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). (344 aa) |
| | prsA | Phosphoribosylpyrophosphate synthase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (310 aa) |
| | acsA | Acetoacetyl-coenzyme A synthetase (Acetoacetate--CoA ligase 1) (Acyl-activating enzyme 1); Function of strongly homologous gene; enzyme. (651 aa) |
| | rkpK | UDP-glucose 6-dehydrogenase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (435 aa) |
| | XM1_0263 | Putative pterin-4-alpha-carbinolamine dehydratase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (101 aa) |
| | nusA | Transcription termination/antitermination L factor; Participates in both transcription termination and antitermination. (503 aa) |
| | nadD | Putative nicotinate-nucleotide adenylyltransferase NadD; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). (203 aa) |
| | dnaX | DNA polymerase III, gamma/tau subunits; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (600 aa) |
| | mtnP | S-methyl-5'-thioadenosine phosphorylase; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates; Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily. (295 aa) |
| | atpC | F1 sector of membrane-bound ATP synthase, epsilon subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. (133 aa) |
| | atpD | Membrane-bound ATP synthase, F1 sector, beta-subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits. (474 aa) |
| | atpG | ATP synthase gamma chain; Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. (294 aa) |
| | atpA | F1 sector of membrane-bound ATP synthase, alpha subunit; Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. (509 aa) |
| | atpH | ATP synthase subunit delta; F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (184 aa) |
| | priA | Primosomal protein N'(replication factor Y); Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily. (733 aa) |
| | apaG | Protein ApaG; Function of strongly homologous gene; transporter. (130 aa) |
| | folE | GTP cyclohydrolase 1; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (231 aa) |
| | polA | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. (925 aa) |
| | accA | acetyl-CoA carboxylase, carboxytransferase, alpha subunit; Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA. (317 aa) |
| | acs | acetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (645 aa) |
| | kdsB | 3-deoxy-manno-octulosonate cytidylyltransferase; Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria. (246 aa) |
| | pheA | Prephenate dehydratase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (289 aa) |
| | umuC-2 | DNA polymerase V, subunit C; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (425 aa) |
| | folD | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (295 aa) |
| | gpt | Guanine-hypoxanthine phosphoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine. (151 aa) |
| | cmk | Cytidylate kinase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (211 aa) |
| | aroA | 3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (444 aa) |
| | XM1_0644 | Homologs of previously reported genes of unknown function. (509 aa) |
| | XM1_0689 | Putative hydrolase of HD superfamily; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (199 aa) |
| | hemC | Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (315 aa) |
| | hemD | Uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. (242 aa) |
| | cobU | Adenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase; Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate. (173 aa) |
| | cobW | Protein CobW; Function of strongly homologous gene; enzyme. (335 aa) |
| | cobN | Aerobic cobaltochelatase subunit CobN; Function of strongly homologous gene; enzyme. (1233 aa) |
| | cobO | Cob(I)yrinic acid a,c-diamide adenosyltransferase; Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids. (201 aa) |
| | XM1_0801 | Putative oxygen-independent coproporphyrinogen III oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. (377 aa) |
| | dnaQ | DNA polymerase III subunit epsilon; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'- 5' exonuclease. (230 aa) |
| | coaE | Dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (211 aa) |
| | aroE | Shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (279 aa) |
| | hemE | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. (346 aa) |
| | hemH | Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. (337 aa) |
| | XM1_0836 | Homologs of previously reported genes of unknown function. (145 aa) |
| | rho | Transcription termination factor; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template. (418 aa) |
| | XM1_0872 | Putative Thiamine monophosphate synthase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (199 aa) |
| | galE | UDP-glucose 4-epimerase; Function of strongly homologous gene; enzyme. (318 aa) |
| | XM1_0903 | Conserved protein of unknown function （contain B12-binding and Radical SAM domain） Homologs of previously reported genes of unknown function. (499 aa) |
| | rfbC | dTDP-4-dehydrorhamnose 3,5-epimerase and related enzyme; Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose. Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family. (197 aa) |
| | XM1_0915 | Putative NAD-dependent epimerase/dehydratase:3-beta hydroxysteroid dehydrogenase/isomerase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (321 aa) |
| | XM1_0917 | Putative NAD-dependent epimerase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (314 aa) |
| | galE-2 | UDP-glucose 4-epimerase; Function of strongly homologous gene; enzyme. (344 aa) |
| | XM1_0923 | Putative ADP-heptose synthase; Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose. In the N-terminal section; belongs to the carbohydrate kinase PfkB family. (518 aa) |
| | XM1_0924 | Putative Nucleoside-diphosphate-sugar epimerase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (330 aa) |
| | XM1_0953 | Putative dTDP-glucose 4,6-dehydratase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. (336 aa) |
| | XM1_0959 | Putative carbamoyl phosphate synthase-like protein; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (346 aa) |
| | XM1_0962 | Conserved protein of unknown function (B12 binding domain 18-144; Homologs of previously reported genes of unknown function. (628 aa) |
| | kdsB-2 | 3-deoxy-manno-octulosonate cytidylyltransferase; Function of strongly homologous gene; enzyme. (255 aa) |
| | XM1_0974 | 3-dehydroquinate synthetase; Function of strongly homologous gene; enzyme. (356 aa) |
| | XM1_0981 | Nucleoside-diphosphate-sugar epimerase; Function of strongly homologous gene; enzyme. (342 aa) |
| | XM1_0982 | dTDP-4-dehydrorhamnose 3,5-epimerase and related enzyme; Function of strongly homologous gene; enzyme. (152 aa) |
| | XM1_0991 | Nucleoside-diphosphate-sugar epimerase; Function of strongly homologous gene; enzyme. (333 aa) |
| | purH | Fused IMP cyclohydrolase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (526 aa) |
| | XM1_1033 | Nucleoside-diphosphate-sugar epimerase; Function of strongly homologous gene; enzyme. (353 aa) |
| | XM1_1043 | Putative UDP-glucuronate decarboxylase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (317 aa) |
| | nadK | NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (255 aa) |
| | thiC | Thiamin (pyrimidine moiety) biosynthesis protein; Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. (613 aa) |
| | queE | 7-carboxy-7-deazaguanine synthase homolog(Radical SAM,45-114); Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7- deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds. (202 aa) |
| | XM1_1140 | 6-pyruvoyltetrahydropterin/6-carboxytetrahydropterin synthase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (175 aa) |
| | purD | Phosphoribosylamine--glycine ligase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the GARS family. (424 aa) |
| | dfp | Fused 4'-phosphopantothenoylcysteine decarboxylase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (401 aa) |
| | dut | Deoxyuridinetriphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. (151 aa) |
| | cbiM | Cobalt transport protein CbiM(Cobalamin (vitamin B12) biosynthesis protein CbiM,1-209); Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import. (216 aa) |
| | cbiN | Cobalt transport protein CbiN(Cobalt transport protein CbiN,6-71); Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import; Belongs to the CbiN family. (90 aa) |
| | XM1_1204 | Putative Cobalt transport protein CbiQ(ABC transporter CbiQ family,20-206); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (244 aa) |
| | cobQ | Cobyric acid synthase(Cobyric acid synthase CobQ,7-475); Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. (484 aa) |
| | cobD | Cobalamin biosynthesis protein CobD(Cobalamin biosynthesis CobD/CbiB,16-315); Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. (331 aa) |
| | XM1_1223 | Sirohydrochlorin cobaltochelatase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (328 aa) |
| | cobH | Precorrin-8X/cobalt-precorrin-8 methylmutase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (205 aa) |
| | cobL | TP_methylase domain-containing protein; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (391 aa) |
| | cobI | Precorrin-2/cobalt-factor-2 C20-methyltransferase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the precorrin methyltransferase family. (232 aa) |
| | cobJ | Uncharacterized protein; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (597 aa) |
| | queC | 7-cyano-7-deazaguanine synthase（Rossmann-like alpha/beta/alpha sandwich fold,2-225） Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). Belongs to the QueC family. (227 aa) |
| | folC | Bifunctional folylpolyglutamate synthase and dihydrofolate synthase; Function of strongly homologous gene; putative enzyme; Belongs to the folylpolyglutamate synthase family. (434 aa) |
| | accD | Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta; Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA; Belongs to the AccD/PCCB family. (308 aa) |
| | trpA | Tryptophan synthase alpha chain(Aldolase-type TIM barrel,2-265); The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (269 aa) |
| | trpB | Tryptophan synthase, beta subunit(Tryptophan synthase, beta chain,11-398); The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (407 aa) |
| | pyrF | Orotidine 5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. (235 aa) |
| | trpF | N-(5'-phosphoribosyl)anthranilate isomerase（Aldolase-type TIM barrel,4-211） Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the TrpF family. (213 aa) |
| | atpF | ATP synthase subunit b(ATPase, F0 complex, subunit B/B', bacterial/chloroplast,25-152); Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0); Belongs to the ATPase B chain family. (177 aa) |
| | atpG-2 | ATP synthase subunit b; Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0); Belongs to the ATPase B chain family. (164 aa) |
| | atpE | ATP synthase subunit c（ATPase, F0/V0 complex, subunit C,4-74） F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. (74 aa) |
| | atpB | ATP synthase subunit a（ATPase, F0 complex, subunit A,13-262） Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane. Belongs to the ATPase A chain family. (262 aa) |
| | tyrC | Protein TyrC(Prephenate dehydrogenase,23-281); Function of homologous gene experimentally demonstrated in an other organism; enzyme. (296 aa) |
| | XM1_1377 | Putative Chorismate mutase(Chorismate mutase,12-90); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (291 aa) |
| | pdxY | Pyridoxal kinase; Function of strongly homologous gene; enzyme; Belongs to the pyridoxine kinase family. (283 aa) |
| | rpoN | RNA polymerase sigma-54 factor(RNA polymerase sigma factor 54,11-496); Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (503 aa) |
| | aroK-2 | Fragment of bifunctional: shikimate kinase (N-terminal); Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (194 aa) |
| | aroB | 3-dehydroquinate synthase(3-dehydroquinate synthase AroB,18-361); Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (372 aa) |
| | cobT-2 | Aerobic cobaltochelatase subunit CobT(Cobalt chelatase, CobT subunit,19-618); Function of homologous gene experimentally demonstrated in an other organism; enzyme. (629 aa) |
| | bolA | BolA family transcriptional regulator, general stress-responsive regulator; Function of homologous gene experimentally demonstrated in an other organism; regulator; Belongs to the BolA/IbaG family. (93 aa) |
| | pduO | Corrinoid adenosyltransferase; Function of strongly homologous gene; enzyme; Belongs to the Cob(I)alamin adenosyltransferase family. (188 aa) |
| | nadB | Quinolinate synthase, L-aspartate oxidase (B protein) subunit(L-aspartate oxidase,8-515); Catalyzes the oxidation of L-aspartate to iminoaspartate. (539 aa) |
| | nadC | Quinolinate phosphoribosyltransferase(Nicotinate-nucleotide pyrophosphorylase,16-282); Function of strongly homologous gene; enzyme; Belongs to the NadC/ModD family. (284 aa) |
| | nadA | Quinolinate synthase, subunit A(Quinolinate synthetase A,26-326); Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (340 aa) |
| | pyrD | Dihydro-orotate oxidase, FMN-linked（Aldolase-type TIM barrel,5-351） Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily. (355 aa) |
| | murD | UDP-N-acetylmuramoylalanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. (457 aa) |
| | XM1_1543 | Putative Acyl-coenzyme A synthetase/AMP-(Fatty) acid ligase(AMP-dependent synthetase/ligase,58-466); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (553 aa) |
| | XM1_1547 | Aminotransferase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (255 aa) |
| | XM1_1571 | Putative Fe-S oxidoreductase(v,216-419); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (448 aa) |
| | XM1_1573 | Putative Nucleoside-diphosphate-sugar epimerase(NAD(P)-binding domain,4-299); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (360 aa) |
| | guaB | IMP dehydrogenase(Inosine-5'-monophosphate dehydrogenase,3-478); Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. (486 aa) |
| | XM1_1604 | Conserved protein of unknown function（Cytidylate kinase-like family,31-201） Homologs of previously reported genes of unknown function. (235 aa) |
| | pdxA | 4-hydroxythreonine-4-phosphate dehydrogenase; Catalyzes the NAD(P)-dependent oxidation of 4-(phosphooxy)-L- threonine (HTP) into 2-amino-3-oxo-4-(phosphooxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP). (335 aa) |
| | XM1_1619 | Aerobic carbon-monoxide dehydrogenase large subunit; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (732 aa) |
| | holC | DNA polymerase III subunit chi; Function of strongly homologous gene; enzyme. (151 aa) |
| | purU | Formyltetrahydrofolate hydrolase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (286 aa) |
| | XM1_1749 | Putative Phage-like DNA polymerase (DNA-directed DNA polymerase, family A, palm domain,221-474); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (669 aa) |
| | rfbC-2 | dTDP-4-dehydrorhamnose 3,5-epimerase(RmlC-like jelly roll fold,1-166); Function of strongly homologous gene; enzyme. (169 aa) |
| | XM1_1805 | Putative NAD-dependent epimerase/dehydratase(NAD(P)-binding domain,1-204); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (302 aa) |
| | XM1_1809 | Putative Radical SAM domain-containing protein(Radical SAM, alpha/beta horseshoe,221-414); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative structure. (500 aa) |
| | XM1_1810 | Putative Nucleoside-diphosphate-sugar epimerase(NAD-dependent epimerase/dehydratase,5-234); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (312 aa) |
| | cobB-3 | Cobyrinic acid A,C-diamide synthase（Cobyrinic acid a,c-diamide synthase CbiA,10-456） Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. (465 aa) |
| | XM1_1841 | Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (333 aa) |
| | pyrB | Aspartate carbamoyltransferase(Aspartate/ornithine carbamoyltransferase,3-313); Function of strongly homologous gene; enzyme; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. (317 aa) |
| | pyrC | Dihydroorotase(Dihydroorotase,26-433); Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily. (436 aa) |
| | aroH | Phospho-2-dehydro-3-deoxyheptonate aldolase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (462 aa) |
| | bluB | 5,6-dimethylbenzimidazole synthase(5,6-dimethylbenzimidazole synthase BluB,15-215); Function of strongly homologous gene; enzyme. (248 aa) |
| | nadE | Glutamine-dependent NAD(+) synthetase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. (551 aa) |
| | XM1_1895 | Putative dihydroorotase(Dihydroorotase,21-426); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (443 aa) |
| | gcaD | Bifunctional protein GlmU [Includes: UDP-N-acetylglucosamine pyrophosphorylase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. (449 aa) |
| | pyrE | Orotate phosphoribosyltransferase(Orotate phosphoribosyl transferase domain,22-169); Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (230 aa) |
| | folA | Dihydrofolate reductase（Dihydrofolate reductase-like domain,3-162） Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. (163 aa) |
| | thyA | Thymidylate synthase (TS) (TSase); Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. (264 aa) |
| | XM1_1987 | Putative nucleoside-diphosphate-sugar epimerase(Hopanoid-associated sugar epimerase,4-328); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (330 aa) |
| | XM1_2029 | Uroporphyrinogen-III methylase; Function of strongly homologous gene; enzyme. (266 aa) |
| | nirD-2 | Protein NirD; Function of strongly homologous gene; enzyme. (149 aa) |
| | nirL | Protein NirL; Function of strongly homologous gene; enzyme. (168 aa) |
| | nirG | Protein NirG; Function of strongly homologous gene; enzyme. (147 aa) |
| | nirH | Protein NirH; Function of strongly homologous gene; enzyme. (159 aa) |
| | XM1_2038 | Putative Nitrite reductase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (520 aa) |
| | acsA-2 | Acetyl-coenzyme A synthetase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (592 aa) |
| | nusG | Transcription termination factor; Participates in transcription elongation, termination and antitermination. (177 aa) |
| | rpoB | RNA polymerase, beta subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1391 aa) |
| | rpoC | DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1496 aa) |
| | adk | Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. (217 aa) |
| | rpoA | RNA polymerase, alpha subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (338 aa) |
| | XM1_2177 | Homologs of previously reported genes of unknown function. (91 aa) |
| | purB | Adenylosuccinate lyase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. (437 aa) |
| | XM1_2198 | Putative Ferredoxin; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (551 aa) |
| | XM1_2199 | Homologs of previously reported genes of unknown function. (563 aa) |
| | XM1_2300 | Protein of unknown function; No homology to any previously reported sequences. (119 aa) |
| | XM1_2478 | Putative xanthine dehydrogenase, molybdenum binding subunit; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (765 aa) |
| | xdhA-2 | Xanthine dehydrogenase, small subunit (fragment of part 1); Function of homologous gene experimentally demonstrated in an other organism; enzyme. (284 aa) |
| | trpB-2 | Putative Tryptophan synthase beta chain 2; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (454 aa) |
| | XM1_2620 | Putative Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily. (488 aa) |
| | XM1_2634 | Homologs of previously reported genes of unknown function. (192 aa) |
| | XM1_2654 | Putative Transketolase central region; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (655 aa) |
| | murA | UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (432 aa) |
| | paaX | DNA-binding transcriptional repressor of phenylacetic acid degradation, aryl-CoA responsive; Function of strongly homologous gene; regulator. (310 aa) |
| | hcrA | Putative 4-hydroxybenzoyl-CoA reductase subunit alpha; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (769 aa) |
| | purC | Putative phosphoribosylaminoimidazole-succinocarboxamide synthase 2; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the SAICAR synthetase family. (325 aa) |
| | dxs | 1-deoxyxylulose-5-phosphate synthase, thiamine-requiring, FAD-requiring; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (644 aa) |
| | XM1_2781 | Putative enzyme for molybdopterin cofactor synthesis required for xanthine dehydrogenase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (195 aa) |
| | bclA | Putative Benzoate--CoA ligase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (528 aa) |
| | trpC | Putative Indole-3-glycerol phosphate synthase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the TrpC family. (271 aa) |
| | trpD | Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (343 aa) |
| | umuC-3 | DNA polymerase V, subunit C; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (425 aa) |
| | purF | Amidophosphoribosyltransferase purF; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine. (486 aa) |
| | dnaB-2 | Replicative DNA helicase dnaB; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily. (505 aa) |
| | purQ | Phosphoribosylformylglycinamidine synthase 1; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...] (229 aa) |
| | purL | Phosphoribosylformylglycinamidine synthase 2; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist i [...] (734 aa) |
| | XM1_2877 | BolA-like protein; Function of strongly homologous gene; regulator; Belongs to the BolA/IbaG family. (85 aa) |
| | XM1_2914 | Putative UDP-glucose epimerase, containing with NAD(P)-binding domain; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (326 aa) |
| | XM1_2982 | Conserved protein of unknown function (TspO/MBR-related protein 1-51); Homologs of previously reported genes of unknown function. (52 aa) |
| | XM1_2983 | Conserved protein of unknown function (TspO and MBR-like protein fragment 2-108); Homologs of previously reported genes of unknown function. (125 aa) |
| | purK | N5-carboxyaminoimidazole ribonucleotide synthase; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR). (369 aa) |
| | purE | Phosphoribosylaminoimidazole carboxylase, mutase subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). (173 aa) |
| | XM1_3010 | Guanylate cyclase domain-containing protein; Homologs of previously reported genes of unknown function. (316 aa) |
| | ctaA | Heme A synthase; Catalyzes the oxidation of the C8 methyl side group on heme O porphyrin ring into a formyl group; Belongs to the COX15/CtaA family. Type 2 subfamily. (358 aa) |
| | ctaB | Protoheme IX farnesyltransferase 2; Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group. (288 aa) |
| | XM1_3049 | Putative RNA polymerase sigma factor; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter; Belongs to the sigma-70 factor family. ECF subfamily. (186 aa) |
| | XM1_3055 | Putative Adenylate cyclase 1; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (693 aa) |
| | rpoZ | DNA-directed RNA polymerase subunit omega; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. (126 aa) |
| | pdxJ | Pyridoxine 5'-phosphate synthase; Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino- 2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate. (244 aa) |
| | XM1_3077 | SnoaL-like domain-containing protein; Homologs of previously reported genes of unknown function. (140 aa) |
| | XM1_3084 | Putative AMP-dependent synthetase and ligase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme. (551 aa) |
| | nusB | Transcription antitermination factor (L factor) (N utilization substance protein B; Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. (158 aa) |
| | XM1_3143 | Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate. (329 aa) |
| | XM1_3204 | DNA polymerase III, delta prime subunit; Function of strongly homologous gene; enzyme. (363 aa) |
| | tmk | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. (212 aa) |
| | pyrH | Uridylate kinase; Catalyzes the reversible phosphorylation of UMP to UDP. (259 aa) |
| | coaD | Phosphopantetheine adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (191 aa) |
| | serS | seryl-tRNA synthetase, also charges selenocysteinyl-tRNA with serine; Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L- seryl-tRNA(Sec), which will be further converted into selenocysteinyl- tRNA(Sec). (422 aa) |
| | XM1_3313 | Putative CinA (Competence-damage inducible protein); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative factor; Belongs to the CinA family. (163 aa) |
| | acoB | Acetoin dehydrogenase E1 component (TPP-dependent beta subunit); The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. (453 aa) |
| | acoA | Acetoin dehydrogenase E1 component (TPP-dependent alpha subunit); The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). (332 aa) |
| | XM1_3347 | Putative GTPase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (348 aa) |
| | XM1_3353 | Putative propionyl-CoA synthetase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (638 aa) |
| | folK | 2-amino-4-hydroxy-6-hydroxymethyldihyropteridine pyrophosphokinase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (164 aa) |
| | ackA | Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (398 aa) |
| | XM1_3364 | Phosphotransacetylase; Function of strongly homologous gene; enzyme. (469 aa) |
| | hemB | Delta-aminolevulinic acid dehydratase; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the ALAD family. (335 aa) |
| | dnaE | DNA polymerase III subunit alpha; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (1154 aa) |
| | cobK | Precorrin-6A reductase; Function of strongly homologous gene; enzyme. (249 aa) |
| | cbiD | Putative cobalt-precorrin-6A synthase, cbiD; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. (365 aa) |
| | rpoE | ECF subfamily RNA polymerase sigma factor; Function of strongly homologous gene; factor; Belongs to the sigma-70 factor family. ECF subfamily. (168 aa) |
| | hemN | Oxygen-independent coproporphyrinogen-III oxidase; Function of strongly homologous gene; enzyme; Belongs to the anaerobic coproporphyrinogen-III oxidase family. (451 aa) |
| | accC | acetyl-CoA carboxylase, biotin carboxylase subunit; This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. (448 aa) |
| | aroQ | 3-dehydroquinate dehydratase 2; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (155 aa) |
| | thiG | Thiazole synthase; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (324 aa) |
| | coaX | Pantothenate kinase; Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis. (260 aa) |
| | pyrG | CTP synthetase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates. (541 aa) |
| | trpE | Anthranilate synthase component 1; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...] (506 aa) |
| | trpB-3 | Tryptophan synthase beta chain 2; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (452 aa) |
| | rpoH | RNA polymerase sigma factor RpoH; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is involved in regulation of expression of heat shock genes. (292 aa) |
| | rpoE-2 | RNA polymerase sigma-70 factor, ECF family protein; Function of strongly homologous gene; regulator; Belongs to the sigma-70 factor family. ECF subfamily. (198 aa) |
| | purM | Phosphoribosylaminoimidazole synthetase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (364 aa) |
| | purN | Phosphoribosylglycinamide formyltransferase 1; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. (205 aa) |
| | apt | Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis. (174 aa) |
| | thiE | Thiamine-phosphate synthase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (228 aa) |
| | hemA-2 | Glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (415 aa) |
| | aroC | Chorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (363 aa) |
| | padI | NADH-dependent phenylglyoxylate dehydrogenase subunit beta; Function of strongly homologous gene; enzyme. (469 aa) |
| | padG | NADH-dependent phenylglyoxylate dehydrogenase subunit alpha; Function of strongly homologous gene; enzyme. (406 aa) |
| | XM1_3889 | Pyruvate with ferredoxin oxidoreductase and related 2-oxoacid with ferredoxin oxidoreductase; Function of strongly homologous gene; enzyme. (89 aa) |
| | nifH | Nitrogenase iron protein, nifH; The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components: the iron protein and the molybdenum-iron protein; Belongs to the NifH/BchL/ChlL family. (295 aa) |
| | hcl | Acyl-coenzyme A synthetase/AMP-(fatty) acid ligase; Function of strongly homologous gene; enzyme. (500 aa) |
| | XM1_3964 | DNA polymerase III; Function of strongly homologous gene; enzyme. (676 aa) |
| | purS | Factor required for phosphoribosylformylglycinamidine synthetase activity; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and Pu [...] (80 aa) |
| | purC-2 | Phosphoribosylaminoimidazole-succinocarboxamide synthase; Function of strongly homologous gene; enzyme; Belongs to the SAICAR synthetase family. (254 aa) |
| | dcd | Deoxycytidine triphosphate deaminase; Catalyzes the deamination of dCTP to dUTP. (184 aa) |
| | rpoH-2 | RNA polymerase sigma factor RpoH; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is involved in regulation of expression of heat shock genes. (296 aa) |
| | purA | Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family. (429 aa) |
| | thiD | Bifunctional hydroxy-methylpyrimidine kinase and hydroxy-phosphomethylpyrimidine kinase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (270 aa) |
| | folP | Dihydropteroate synthase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (383 aa) |
| | XM1_4133 | Putative 5-formyltetrahydrofolate cyclo-ligase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; enzyme; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. (195 aa) |
| | XM1_4180 | Conserved protein of unknown function (RNA polymerase sigma factor, region 2 100-178; Homologs of previously reported genes of unknown function. (294 aa) |
| | XM1_4209 | Putative adenylate cyclase (Partial); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (1207 aa) |
| | XM1_4238 | Putative uroporphyrinogen-III methylase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the precorrin methyltransferase family. (257 aa) |
| | XM1_4239 | Conserved protein of unknown function (Cobalamin (vitamin B12) biosynthesis CbiX 12-133; Homologs of previously reported genes of unknown function. (252 aa) |
| | XM1_4359 | Putative oxidoreductase, Radical SAM; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (480 aa) |
| | ndk | Nucleoside diphosphate kinase ndk; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. (140 aa) |
| | ribF | Bifunctional riboflavin kinase and FAD synthetase ribF; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the ribF family. (329 aa) |
| | pdxH | Pyridoxine/pyridoxamine 5'-phosphate oxidase; Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP). (195 aa) |
| | XM1_4452 | Homologs of previously reported genes of unknown function; Belongs to the UPF0301 (AlgH) family. (190 aa) |
| | queG | Putative epoxyqueuosine reductase queG; Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr); Belongs to the QueG family. (351 aa) |
| | queF | NADPH-dependent 7-cyano-7-deazaguanine reductase queF; Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1). Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily. (151 aa) |
| | rfaE | Fused heptose 7-phosphate kinase; Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose. In the N-terminal section; belongs to the carbohydrate kinase PfkB family. (488 aa) |
| | gmk | Guanylate kinase; Essential for recycling GMP and indirectly, cGMP. (215 aa) |
| | ctaB-2 | Protoheme IX farnesyltransferase 1; Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group. (283 aa) |
| | dnaE-2 | Error-prone DNA polymerase dnaE; DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase. (1030 aa) |
| | XM1_4616 | Putative retron-type reverse transcriptase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (375 aa) |
| | guaA | GMP synthetase (glutamine aminotransferase); Catalyzes the synthesis of GMP from XMP. (518 aa) |
| | carB | Carbamoyl-phosphate synthase, large subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the CarB family. (1085 aa) |
| | carA | Carbamoyl phosphate synthetase small subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the CarA family. (406 aa) |
| | dnaG | DNA primase dnaG; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (624 aa) |
| | rpoD | RNA polymerase, sigma 70 (sigma D) factor; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. (682 aa) |
| | umuC-4 | DNA polymerase V, subunit C; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (425 aa) |
| | dinB | DNA polymerase IV (damage-inducible protein P); Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. (375 aa) |
| | fliI | Flagellum-specific ATP synthase; Function of strongly homologous gene; structure. (450 aa) |
