(54 nodes) Heme binding network (Magnetospirillum sp. XM1)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	XM1_3047	Putative Permease; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (452 aa)
	XM1_0305	Cytochrome b/c1; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis. (665 aa)
	apaG	Protein ApaG; Function of strongly homologous gene; transporter. (130 aa)
	nirS	Nitrite reductase; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (568 aa)
	fixN	Cytochrome C oxydase, CytN subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the heme-copper respiratory oxidase family. (483 aa)
	fixO	Cytochrome C oxidase, CytO subunit; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (240 aa)
	fixP	Cytochrome C oxidase, CytP subunit; C-type cytochrome. Part of the cbb3-type cytochrome c oxidase complex. (286 aa)
	hyaC	Hydrogenase 1, b-type cytochrome subunit; Function of homologous gene experimentally demonstrated in an other organism; carrier. (240 aa)
	XM1_0703	Putative Cytochrome C4; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter. (198 aa)
	XM1_1174	Conserved protein of unknown function(Dihaem cytochrome c,69-188); Homologs of previously reported genes of unknown function. (191 aa)
	XM1_1175	Conserved membrane protein of unknown function(Cytochrome c domain,167-278); Homologs of previously reported genes of unknown function. (278 aa)
	ccmF	Heme lyase, CcmF subunit（Cytochrome c-type biogenesis protein Ccm,53-645） Function of homologous gene experimentally demonstrated in an other organism; enzyme. (659 aa)
	ccmE	Periplasmic heme chaperone（CcmE/CycJ protein,2-129） Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH. Belongs to the CcmE/CycJ family. (147 aa)
	ccmC	Heme exporter subunit; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes; Belongs to the CcmC/CycZ/HelC family. (244 aa)
	sdhD	Succinate dehydrogenase / fumarate reductase, membrane anchor subunit; Function of strongly homologous gene; membrane component. (126 aa)
	XM1_1661	Conserved protein of unknown function(Cytochrome c domain,66-185); Homologs of previously reported genes of unknown function. (329 aa)
	XM1_1700	Homologs of previously reported genes of unknown function. (431 aa)
	XM1_1879	Conserved exported protein of unknown function(Cytochrome c domain,10-223); Homologs of previously reported genes of unknown function. (243 aa)
	cycA	Cytochrome C2(Cytochrome c domain,26-121); Function of strongly homologous gene; factor. (121 aa)
	nirS-2	Nitrite reductase; Function of strongly homologous gene; enzyme. (540 aa)
	XM1_2026	Cytochrome c-552; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; transporter. (549 aa)
	nirB-2	Cytochrome c-552; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; transporter. (336 aa)
	XM1_2031	Cytochrome c, mono-and diheme variants; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; transporter. (124 aa)
	XM1_2038	Putative Nitrite reductase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (520 aa)
	XM1_2142	Putative Cytochrome C4; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter. (205 aa)
	XM1_2143	Putative Cytochrome c553; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative carrier. (252 aa)
	yedZ	Sulfoxide reductase heme-binding subunit YedZ; Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalyti [...] (220 aa)
	mamE	Magnetosome protein MamE; Function of strongly homologous gene; putative enzyme. (728 aa)
	mamE-2	Magnetosome protein MamE; Function of strongly homologous gene; putative enzyme. (582 aa)
	mamZ	Magnetosome protein MamZ; Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using [...] (649 aa)
	XM1_2525	Putative Cytochrome c-type biogenesis protein CcmF (modular protein); Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (665 aa)
	XM1_2531	Putative Quinohemoprotein amine dehydrogenase subunit alpha; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (519 aa)
	XM1_2728	Putative Cytochrome c553; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme. (101 aa)
	ctaD	Cytochrome c oxidase, subunit I; Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B. (533 aa)
	XM1_2926	Putative cytochrome c, soxE homolog; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative carrier. (97 aa)
	XM1_3029	Putative sulfite reductase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme; Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. (698 aa)
	XM1_3042	Heme/copper-type cytochrome/quinol oxidase, subunit 1; Function of strongly homologous gene; enzyme. (560 aa)
	XM1_3147	Conserved protein of unknown function(containing Cytochrome c assembly protein,62-264); Homologs of previously reported genes of unknown function. (267 aa)
	XM1_3264	Conserved protein of unknown function (containing Cytochrome c domain,6-136); Homologs of previously reported genes of unknown function. (146 aa)
	cc4	Cytochrome c4; Function of strongly homologous gene; carrier. (201 aa)
	napC	Nitrate reductase, cytochrome c-type,periplasmic; Function of homologous gene experimentally demonstrated in an other organism; carrier. (219 aa)
	torC	Cytochrome c-type protein TorC; Function of homologous gene experimentally demonstrated in an other organism; carrier; Belongs to the TorC/TorY family. (368 aa)
	ccp	Cytochrome c551 peroxidase; Function of strongly homologous gene; enzyme. (331 aa)
	norB	Nitric oxide reductase subunit B; Function of homologous gene experimentally demonstrated in an other organism; enzyme; Belongs to the heme-copper respiratory oxidase family. (446 aa)
	norC	Nitric oxide reductase subunit C; Function of homologous gene experimentally demonstrated in an other organism; enzyme. (149 aa)
	dsrA	Sulfite reductase, dissimilatory-type subunit alpha; Function of strongly homologous gene; enzyme. (417 aa)
	dsrB	Sulfite reductase, dissimilatory-type subunit beta; Function of strongly homologous gene; enzyme. (356 aa)
	XM1_4309	Cytochrome c2 iso-2; Function of strongly homologous gene; enzyme. (118 aa)
	katG	Catalase/hydroperoxidase HPI(I) katG; Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity; Belongs to the peroxidase family. Peroxidase/catalase subfamily. (735 aa)
	XM1_4453	Putative cytochrome c-552; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; regulator. (230 aa)
	XM1_4454	Putative cytochrome c-552; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter. (306 aa)
	XM1_4492	Cytochrome c' precursor; Function of strongly homologous gene; enzyme. (153 aa)
	XM1_4514	Conserved protein of unknown function (Cytochrome c/b562 46-150); Homologs of previously reported genes of unknown function. (153 aa)
	yfeX	Deferrochelatase/peroxidase YfeX; Function of strongly homologous gene; putative enzyme. (302 aa)

Your Current Organism:

Magnetospirillum sp. XM1

NCBI taxonomy Id: 1663591
Other names: M. sp. XM-1, Magnetospirillum sp. XM-1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
XM1_0305	XM1_0703	XM1_0305	XM1_0703	Cytochrome b/c1; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.	Putative Cytochrome C4; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter.	0.733
XM1_0305	XM1_1175	XM1_0305	XM1_1175	Cytochrome b/c1; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.	Conserved membrane protein of unknown function(Cytochrome c domain,167-278); Homologs of previously reported genes of unknown function.	0.927
XM1_0305	XM1_1661	XM1_0305	XM1_1661	Cytochrome b/c1; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.	Conserved protein of unknown function(Cytochrome c domain,66-185); Homologs of previously reported genes of unknown function.	0.942
XM1_0305	XM1_1700	XM1_0305	XM1_1700	Cytochrome b/c1; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.	Homologs of previously reported genes of unknown function.	0.928
XM1_0305	XM1_1879	XM1_0305	XM1_1879	Cytochrome b/c1; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.	Conserved exported protein of unknown function(Cytochrome c domain,10-223); Homologs of previously reported genes of unknown function.	0.942
XM1_0305	XM1_2031	XM1_0305	XM1_2031	Cytochrome b/c1; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.	Cytochrome c, mono-and diheme variants; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; transporter.	0.942
XM1_0305	XM1_2038	XM1_0305	XM1_2038	Cytochrome b/c1; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.	Putative Nitrite reductase; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.	0.962
XM1_0305	XM1_2142	XM1_0305	XM1_2142	Cytochrome b/c1; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.	Putative Cytochrome C4; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative transporter.	0.709
XM1_0305	XM1_2143	XM1_0305	XM1_2143	Cytochrome b/c1; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.	Putative Cytochrome c553; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative carrier.	0.646
XM1_0305	XM1_2531	XM1_0305	XM1_2531	Cytochrome b/c1; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.	Putative Quinohemoprotein amine dehydrogenase subunit alpha; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.	0.927
XM1_0305	XM1_2728	XM1_0305	XM1_2728	Cytochrome b/c1; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.	Putative Cytochrome c553; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.	0.638
XM1_0305	XM1_2926	XM1_0305	XM1_2926	Cytochrome b/c1; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.	Putative cytochrome c, soxE homolog; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative carrier.	0.591
XM1_0305	XM1_3042	XM1_0305	XM1_3042	Cytochrome b/c1; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.	Heme/copper-type cytochrome/quinol oxidase, subunit 1; Function of strongly homologous gene; enzyme.	0.991
XM1_0305	XM1_3047	XM1_0305	XM1_3047	Cytochrome b/c1; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.	Putative Permease; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; putative enzyme.	0.991
XM1_0305	XM1_3264	XM1_0305	XM1_3264	Cytochrome b/c1; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.	Conserved protein of unknown function (containing Cytochrome c domain,6-136); Homologs of previously reported genes of unknown function.	0.942
XM1_0305	XM1_4309	XM1_0305	XM1_4309	Cytochrome b/c1; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.	Cytochrome c2 iso-2; Function of strongly homologous gene; enzyme.	0.993
XM1_0305	XM1_4453	XM1_0305	XM1_4453	Cytochrome b/c1; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.	Putative cytochrome c-552; Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; regulator.	0.670
XM1_0305	cc4	XM1_0305	XM1_3443	Cytochrome b/c1; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.	Cytochrome c4; Function of strongly homologous gene; carrier.	0.764
XM1_0305	ccmC	XM1_0305	XM1_1196	Cytochrome b/c1; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.	Heme exporter subunit; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes; Belongs to the CcmC/CycZ/HelC family.	0.655
XM1_0305	ccp	XM1_0305	XM1_3671	Cytochrome b/c1; Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis.	Cytochrome c551 peroxidase; Function of strongly homologous gene; enzyme.	0.403