STRINGSTRING
KLT67246.1 KLT67246.1 KLT67346.1 KLT67346.1 KLT67348.1 KLT67348.1 hisG hisG hisD hisD hisC hisC hisB hisB hisH hisH hisA hisA KLT67475.1 KLT67475.1 hisF hisF hisI hisI KLT67498.1 KLT67498.1 KLT67568.1 KLT67568.1 aroQ aroQ KLT67126.1 KLT67126.1 KLT66869.1 KLT66869.1 KLT66876.1 KLT66876.1 KLT66877.1 KLT66877.1 dapA dapA KLT66618.1 KLT66618.1 KLT65870.1 KLT65870.1 asd asd KLT65927.1 KLT65927.1 dapB dapB KLT66068.1 KLT66068.1 KLT66122.1 KLT66122.1 KLT65356.1 KLT65356.1 KLT65357.1 KLT65357.1 aroA aroA aroC aroC KLT65364.1 KLT65364.1 KLT65428.1 KLT65428.1 trpA trpA trpB trpB trpF trpF KLT65439.1 KLT65439.1 KLT65741.1 KLT65741.1 proB proB proA proA KLT64847.1 KLT64847.1 KLT64861.1 KLT64861.1 argH argH KLT65288.1 KLT65288.1 proC proC argB argB KLT65289.1 KLT65289.1 KLT64867.1 KLT64867.1 argC argC KLT64869.1 KLT64869.1 KLT64870.1 KLT64870.1 KLT64940.1 KLT64940.1 KLT64980.1 KLT64980.1 KLT64981.1 KLT64981.1 trpC trpC dapF dapF aroE aroE KLT65193.1 KLT65193.1 aroK aroK gltD gltD KLT64276.1 KLT64276.1 KLT64486.1 KLT64486.1 KLT63664.1 KLT63664.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
KLT67246.1Glutamine synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glutamine synthetase family. (724 aa)
KLT67346.1Proline dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (395 aa)
KLT67348.13-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (352 aa)
hisGATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. (283 aa)
hisDHistidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. (431 aa)
hisCHistidinol phosphate aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (346 aa)
hisBImidazoleglycerol-phosphate dehydratase; Catalyzes the formation of 3-(imidazol-4-yl)-2-oxopropyl phosphate from D-ethythro-1-(imidazol-4-yl)glycerol 3-phosphate and histidinol from histidinol phosphate; Derived by automated computational analysis using gene prediction method: Protein Homology; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family. (377 aa)
hisHImidazole glycerol phosphate synthase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. (197 aa)
hisAPhosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology. (249 aa)
KLT67475.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+. (69 aa)
hisFImidazole glycerol phosphate synthase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. (251 aa)
hisIphosphoribosyl-ATP pyrophosphatase; Catalyzes the formation of 1-(5-phosphoribosyl)-AMP from 1-(5-phosphoribosyl)-ATP and the subsequent formation of 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino)imidazole-4- carboxamide from 1-(5-phosphoribosyl)-AMP in histidine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology; In the N-terminal section; belongs to the PRA-CH family. (200 aa)
KLT67498.1Glutamate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (473 aa)
KLT67568.12,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the transferase hexapeptide repeat family. (272 aa)
aroQ3-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (140 aa)
KLT67126.1Aspartate aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (380 aa)
KLT66869.1(2Fe-2S)-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (111 aa)
KLT66876.1Diaminopimelate decarboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (388 aa)
KLT66877.1Aspartate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aspartokinase family. (437 aa)
dapADihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (295 aa)
KLT66618.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (604 aa)
KLT65870.1Aminotransferase class III; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (397 aa)
asdAspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (329 aa)
KLT65927.1Isoaspartyl peptidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (343 aa)
dapBDihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (244 aa)
KLT66068.11-pyrroline-5-carboxylate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aldehyde dehydrogenase family. (544 aa)
KLT66122.1Prephenate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (418 aa)
KLT65356.1Prephenate dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. (277 aa)
KLT65357.1Cytochrome C4; Derived by automated computational analysis using gene prediction method: Protein Homology. (379 aa)
aroA3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (422 aa)
aroCChorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (365 aa)
KLT65364.1Aspartate aminotransferase; Catalyzes the formation of oxalozcetate and L-glutamate from L-aspartate and 2-oxoglutarate; Derived by automated computational analysis using gene prediction method: Protein Homology. (399 aa)
KLT65428.1Glutamate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glutamate synthase family. (551 aa)
trpATryptophan synthase alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. (255 aa)
trpBTryptophan synthase subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (393 aa)
trpFN-(5'-phosphoribosyl)anthranilate isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TrpF family. (210 aa)
KLT65439.1Anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). (328 aa)
KLT65741.1Aminobenzoate synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (418 aa)
proBGamma-glutamyl kinase; Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate. (359 aa)
proAGamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family. (415 aa)
KLT64847.1Asparaginase; Derived by automated computational analysis using gene prediction method: Protein Homology. (280 aa)
KLT64861.1Aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (417 aa)
argHArgininosuccinate lyase; Derived by automated computational analysis using gene prediction method: Protein Homology. (443 aa)
KLT65288.1Acetylornithine deacetylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (354 aa)
proCPyrroline-5-carboxylate reductase; Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline. (269 aa)
argBAcetylglutamate kinase; Catalyzes the ATP-dependent phosphorylation of N-acetyl-L- glutamate; Belongs to the acetylglutamate kinase family. ArgB subfamily. (262 aa)
KLT65289.1Acetylornithine carbamoyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aspartate/ornithine carbamoyltransferase superfamily. (323 aa)
KLT64867.1Acetylornithine aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (376 aa)
argCN-acetyl-gamma-glutamyl-phosphate reductase; Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde. Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. (328 aa)
KLT64869.1Argininosuccinate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the argininosuccinate synthase family. Type 1 subfamily. (396 aa)
KLT64870.1Acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (233 aa)
KLT64940.1Arginase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the arginase family. (393 aa)
KLT64980.1Anthranilate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (465 aa)
KLT64981.1Anthranilate synthase subunit II; Derived by automated computational analysis using gene prediction method: Protein Homology. (194 aa)
trpCIndole-3-glycerol phosphate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the TrpC family. (260 aa)
dapFDiaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (260 aa)
aroEAroE; catalyzes the conversion of shikimate to 3-dehydroshikimate; Derived by automated computational analysis using gene prediction method: Protein Homology. (247 aa)
KLT65193.11-alkyl-2-acetylglycerophosphocholine esterase; Derived by automated computational analysis using gene prediction method: Protein Homology. (339 aa)
aroKShikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (167 aa)
gltDGlutamate synthase is composed of subunits alpha and beta; beta subunit is a flavin adenine dinucleotide-NADPH dependent oxidoreductase; provides electrons to the alpha subunit, which binds L-glutamine and 2-oxoglutarate and forms L-glutamate; Derived by automated computational analysis using gene prediction method: Protein Homology. (488 aa)
KLT64276.1Glutamate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (1499 aa)
KLT64486.1Acetylornithine deacetylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (384 aa)
KLT63664.1Aspartate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aspartokinase family. (423 aa)
Your Current Organism:
Pedobacter sp. BMA
NCBI taxonomy Id: 1663685
Other names: P. sp. BMA
Server load: low (28%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.