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AB675_7410 AB675_7410 AB675_10155 AB675_10155 AB675_4409 AB675_4409 AB675_1589 AB675_1589 AIM41 AIM41 AB675_10232 AB675_10232 NBP35 NBP35 AB675_12009 AB675_12009 AB675_4132 AB675_4132 AB675_4212 AB675_4212 AB675_5758 AB675_5758 AB675_4708 AB675_4708 AB675_3477 AB675_3477 AB675_11520 AB675_11520 AB675_8152 AB675_8152 AB675_9322 AB675_9322 AB675_5709 AB675_5709 AB675_1972 AB675_1972 AB675_6431 AB675_6431 AB675_6433 AB675_6433 AB675_6478 AB675_6478 AB675_6432 AB675_6432 AB675_8531 AB675_8531 ALA1 ALA1 AB675_478 AB675_478 CFD1 CFD1 AB675_10995 AB675_10995 TRM5 TRM5 AB675_6021 AB675_6021 AB675_1016 AB675_1016 AB675_1394 AB675_1394 AB675_1347 AB675_1347 AB675_1436 AB675_1436 AB675_8075 AB675_8075 NCS2 NCS2 AB675_4559 AB675_4559 URM1 URM1 AB675_1047 AB675_1047 AB675_4097 AB675_4097 AB675_6448 AB675_6448 AB675_4201 AB675_4201 AB675_10681 AB675_10681 AB675_8006 AB675_8006 AB675_5664 AB675_5664 AB675_9742 AB675_9742 AB675_6937 AB675_6937 AB675_2344 AB675_2344 AB675_743 AB675_743 AB675_8914 AB675_8914 NAT10 NAT10 AB675_10102 AB675_10102 AB675_218 AB675_218 AB675_206 AB675_206 AB675_7844 AB675_7844 AB675_9361 AB675_9361 AB675_9324 AB675_9324 AB675_3285 AB675_3285 AB675_9760 AB675_9760 AB675_9112 AB675_9112 AB675_2307 AB675_2307 AB675_332 AB675_332 AB675_8577 AB675_8577 AB675_444 AB675_444 AB675_1298 AB675_1298 AB675_1017 AB675_1017 AB675_5857 AB675_5857 AB675_8918 AB675_8918 AB675_3135 AB675_3135 AB675_3463 AB675_3463 AB675_9283 AB675_9283 AB675_4688 AB675_4688 AB675_11408 AB675_11408 AB675_9678 AB675_9678 AB675_4709 AB675_4709 AB675_8022 AB675_8022 AB675_7130 AB675_7130 AB675_5342 AB675_5342 AB675_9572 AB675_9572 AB675_7908 AB675_7908 AB675_914 AB675_914 TRM8 TRM8
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
AB675_7410Uncharacterized protein. (265 aa)
AB675_10155tRNA-specific adenosine deaminase 1. (288 aa)
AB675_4409Methionyl-tRNA formyltransferase, mitochondrial. (410 aa)
AB675_1589Multisite-specific tRNA:(Cytosine-C(5))-methyltransferase trm4a; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (866 aa)
AIM41Altered inheritance of mitochondria protein 41. (140 aa)
AB675_10232Uncharacterized protein. (322 aa)
NBP35Cytosolic Fe-S cluster assembly factor NBP35; Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NBP35-CFD1 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins; Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NBP35 subfamily. (342 aa)
AB675_12009tRNA(His) guanylyltransferase; Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage. (307 aa)
AB675_4132Alanine--tRNA ligase. (276 aa)
AB675_4212Elongator complex protein 4. (409 aa)
AB675_5758Uncharacterized protein. (279 aa)
AB675_4708S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase. (460 aa)
AB675_3477Regulator of Ty1 transposition protein 10. (1106 aa)
AB675_11520tRNA pseudouridine synthase 1. (571 aa)
AB675_8152Methyltransf_25 domain-containing protein. (306 aa)
AB675_9322tRNA dimethylallyltransferase, mitochondrial. (489 aa)
AB675_5709Queuine tRNA-ribosyltransferase accessory subunit 2; Non-catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine); Belongs to the queuine tRNA-ribosyltransferase family. QTRT2 subfamily. (485 aa)
AB675_1972Putative tRNA pseudouridine synthase C25B8.05. (632 aa)
AB675_6431Elongator complex protein 1. (317 aa)
AB675_6433Elongator complex protein 1. (170 aa)
AB675_6478Multisubstrate pseudouridine synthase 7. (738 aa)
AB675_6432Elongator complex protein 1. (784 aa)
AB675_8531Mitochondrial translation optimization protein 1. (701 aa)
ALA1Alanine--tRNA ligase; Catalyzes the attachment of alanine to tRNA(Ala) in a two- step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain. Belongs to the class-II aminoacyl-tRNA synthetase family. (963 aa)
AB675_478Uncharacterized protein. (145 aa)
CFD1Cytosolic Fe-S cluster assembly factor CFD1; Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NBP35-CFD1 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins; Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD1 subfamily. (320 aa)
AB675_10995tRNA (Uracil(54)-C(5))-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. (592 aa)
TRM5tRNA (guanine(37)-N1)-methyltransferase; Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding; Belongs to the TRM5 / TYW2 family. (471 aa)
AB675_6021Elongator complex protein 5. (349 aa)
AB675_1016Queuosine salvage protein; Involved in salvaging queuosine. (158 aa)
AB675_1394Threonylcarbamoyl-AMP synthase. (467 aa)
AB675_1347tRNA threonylcarbamoyladenosine dehydratase 2. (518 aa)
AB675_1436tRNA N6-adenosine threonylcarbamoyltransferase. (254 aa)
AB675_8075Queuine tRNA-ribosyltransferase catalytic subunit 1; Catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2- cyclopenten-1-yl)amino)methyl)-7-deazaguanosine). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, formi [...] (448 aa)
NCS2Cytoplasmic tRNA 2-thiolation protein 2; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation. (407 aa)
AB675_4559tRNA wybutosine-synthesizing protein 2; S-adenosyl-L-methionine-dependent transferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S- adenosyl-L-methionine to the C-7 position of 4-demethylwyosine (imG-14) to produce wybutosine-86. (370 aa)
URM1Ubiquitin-related modifier 1; Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by the MOCS3 homolog UBA4. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target pr [...] (146 aa)
AB675_1047tRNA pseudouridine(32) synthase, mitochondrial. (590 aa)
AB675_4097Putative tRNA(Ile)-lysidine synthase. (642 aa)
AB675_6448HD_domain domain-containing protein. (232 aa)
AB675_4201Putative tRNA pseudouridine synthase 4. (441 aa)
AB675_10681Uncharacterized protein. (386 aa)
AB675_8006RCC1 repeat-containing protein C10F6.04. (347 aa)
AB675_5664tRNA (Guanine(10)-N2)-methyltransferase. (611 aa)
AB675_9742Uncharacterized protein. (199 aa)
AB675_6937tRNA (Guanine-N(7)-)-methyltransferase non-catalytic subunit trm82. (677 aa)
AB675_2344Uncharacterized protein. (131 aa)
AB675_743Adenylyltransferase and sulfurtransferase uba4. (573 aa)
AB675_8914tRNA-dihydrouridine(20) synthase [NAD(P)+]. (268 aa)
NAT10RNA cytidine acetyltransferase; RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA- binding adapter protein TAN1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation. (1099 aa)
AB675_10102tRNA (Carboxymethyluridine(34)-5-O)-methyltransferase. (314 aa)
AB675_218Alpha-ketoglutarate-dependent dioxygenase abh1. (321 aa)
AB675_206Uncharacterized protein. (508 aa)
AB675_7844tRNA-dihydrouridine(47) synthase [NAD(P)(+)]; Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Specifically modifies U47 in cytoplasmic tRNAs. (741 aa)
AB675_9361Thioredoxin domain-containing protein plp1. (214 aa)
AB675_9324Elongator complex protein 2. (741 aa)
AB675_3285Diphthamide biosynthesis protein 4. (170 aa)
AB675_9760tRNA wybutosine-synthesizing protein 3. (332 aa)
AB675_9112Modification methylase HphIA; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (686 aa)
AB675_2307Diphthamide biosynthesis protein 3. (135 aa)
AB675_332Methyltransferase-like protein; Belongs to the methyltransferase superfamily. METL family. (344 aa)
AB675_8577tRNA (Guanine(9)-N1)-methyltransferase. (501 aa)
AB675_444DPBB_1 domain-containing protein. (206 aa)
AB675_1298tRNA acetyltransferase TAN1. (367 aa)
AB675_1017Queuosine salvage protein; Involved in salvaging queuosine. (445 aa)
AB675_5857tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]. (703 aa)
AB675_8918Uncharacterized protein. (441 aa)
AB675_3135Uncharacterized protein. (264 aa)
AB675_34632OG-FeII_Oxy_2 domain-containing protein. (257 aa)
AB675_9283tRNA (Uracil-O(2)-)-methyltransferase. (634 aa)
AB675_4688tRNA modification GTPase GTPBP3, mitochondrial. (637 aa)
AB675_11408Putative tRNA (cytidine(32)/guanosine(34)-2'-O)-methyltransferase; Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs. (379 aa)
AB675_9678tRNA (Adenine(58)-N(1))-methyltransferase catalytic subunit trm61. (485 aa)
AB675_4709S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase. (284 aa)
AB675_8022Allergen Asp f 7. (259 aa)
AB675_7130tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance. (480 aa)
AB675_5342tRNA (Adenine(58)-N(1))-methyltransferase non-catalytic subunit trm6. (606 aa)
AB675_9572tRNA-specific adenosine deaminase subunit tad2. (195 aa)
AB675_7908tRNA (Guanine(26)-N(2))-dimethyltransferase, mitochondrial; Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family. (762 aa)
AB675_914Uncharacterized protein. (240 aa)
TRM8tRNA (guanine-N(7)-)-methyltransferase; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. (333 aa)
Your Current Organism:
Phialophora attae
NCBI taxonomy Id: 1664694
Other names: CBS 131958, P. attae, Phialophora attae Attili-Angelis, Duarte, Stielow & de Hoog, 2014
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