(22 nodes) PTEN Regulation network (Phialophora attae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	GUF1	Translation factor GUF1, mitochondrial; Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner. (660 aa)
	AB675_6379	E3 ubiquitin-protein ligase CHIP. (281 aa)
	AB675_428	Uncharacterized protein. (1101 aa)
	AB675_4858	Polycomb protein eed. (574 aa)
	AB675_1338	OTU domain-containing protein 3. (398 aa)
	AB675_4356	MYND-type domain-containing protein. (275 aa)
	AB675_10347	Uncharacterized protein. (406 aa)
	AB675_12027	Ubiquitin-60S ribosomal protein L40. (465 aa)
	AB675_4545	Uncharacterized protein. (374 aa)
	AB675_5137	Uncharacterized protein. (191 aa)
	AB675_8977	Putative transcriptional regulatory protein. (700 aa)
	AB675_1491	Casein kinase II subunit beta; Plays a complex role in regulating the basal catalytic activity of the alpha subunit; Belongs to the casein kinase 2 subunit beta family. (407 aa)
	AB675_10348	Uncharacterized protein. (255 aa)
	MDM34	Mitochondrial distribution and morphology protein 34; Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. MDM34 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10. (593 aa)
	AB675_7789	Putative transcriptional regulatory protein. (720 aa)
	AB675_5943	BZIP domain-containing protein. (260 aa)
	AB675_5236	Uncharacterized protein. (146 aa)
	AB675_8094	PHD domain-containing protein. (1000 aa)
	AB675_8819	Ubiquitin-40S ribosomal protein S27a. (158 aa)
	AB675_2147	Protein cps3. (570 aa)
	AB675_3445	Histone-lysine N-methyltransferase EZH2. (276 aa)
	AB675_8332	Chromatin remodeling factor mit1. (1573 aa)

Your Current Organism:

Phialophora attae

NCBI taxonomy Id: 1664694
Other names: CBS 131958, P. attae, Phialophora attae Attili-Angelis, Duarte, Stielow & de Hoog, 2014

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AB675_10347	AB675_10348	A0A0N0NK07	A0A0N1H0N1	Uncharacterized protein.	Uncharacterized protein.	0.873
AB675_10347	AB675_12027	A0A0N0NK07	A0A0N0NKU8	Uncharacterized protein.	Ubiquitin-60S ribosomal protein L40.	0.542
AB675_10347	AB675_5943	A0A0N0NK07	A0A0N1HMW7	Uncharacterized protein.	BZIP domain-containing protein.	0.542
AB675_10347	AB675_8819	A0A0N0NK07	A0A0N1HWA1	Uncharacterized protein.	Ubiquitin-40S ribosomal protein S27a.	0.542
AB675_10348	AB675_10347	A0A0N1H0N1	A0A0N0NK07	Uncharacterized protein.	Uncharacterized protein.	0.873
AB675_10348	AB675_12027	A0A0N1H0N1	A0A0N0NKU8	Uncharacterized protein.	Ubiquitin-60S ribosomal protein L40.	0.542
AB675_10348	AB675_5943	A0A0N1H0N1	A0A0N1HMW7	Uncharacterized protein.	BZIP domain-containing protein.	0.542
AB675_10348	AB675_8819	A0A0N1H0N1	A0A0N1HWA1	Uncharacterized protein.	Ubiquitin-40S ribosomal protein S27a.	0.542
AB675_10348	GUF1	A0A0N1H0N1	A0A0N1HZW7	Uncharacterized protein.	Translation factor GUF1, mitochondrial; Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner.	0.670
AB675_12027	AB675_10347	A0A0N0NKU8	A0A0N0NK07	Ubiquitin-60S ribosomal protein L40.	Uncharacterized protein.	0.542
AB675_12027	AB675_10348	A0A0N0NKU8	A0A0N1H0N1	Ubiquitin-60S ribosomal protein L40.	Uncharacterized protein.	0.542
AB675_12027	AB675_1338	A0A0N0NKU8	A0A0N0NI83	Ubiquitin-60S ribosomal protein L40.	OTU domain-containing protein 3.	0.542
AB675_12027	AB675_2147	A0A0N0NKU8	A0A0N1P0A0	Ubiquitin-60S ribosomal protein L40.	Protein cps3.	0.593
AB675_12027	AB675_3445	A0A0N0NKU8	A0A0N1P0X9	Ubiquitin-60S ribosomal protein L40.	Histone-lysine N-methyltransferase EZH2.	0.594
AB675_12027	AB675_4356	A0A0N0NKU8	A0A0N0NJ54	Ubiquitin-60S ribosomal protein L40.	MYND-type domain-containing protein.	0.593
AB675_12027	AB675_4545	A0A0N0NKU8	A0A0N0NLG2	Ubiquitin-60S ribosomal protein L40.	Uncharacterized protein.	0.619
AB675_12027	AB675_4858	A0A0N0NKU8	A0A0N0NHQ8	Ubiquitin-60S ribosomal protein L40.	Polycomb protein eed.	0.568
AB675_12027	AB675_6379	A0A0N0NKU8	A0A0N1HZE0	Ubiquitin-60S ribosomal protein L40.	E3 ubiquitin-protein ligase CHIP.	0.696
AB675_12027	AB675_8094	A0A0N0NKU8	A0A0N1HV79	Ubiquitin-60S ribosomal protein L40.	PHD domain-containing protein.	0.564
AB675_12027	AB675_8332	A0A0N0NKU8	A0A0N1P1Y1	Ubiquitin-60S ribosomal protein L40.	Chromatin remodeling factor mit1.	0.545