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KMT57670.1 KMT57670.1 KMT56005.1 KMT56005.1 KMT55952.1 KMT55952.1 hutU hutU KMT55946.1 KMT55946.1 ppc ppc KMT57569.1 KMT57569.1 aroA aroA prpB prpB KMT56795.1 KMT56795.1 lpxL lpxL aroC aroC fumC fumC aroQ aroQ KMT57022.1 KMT57022.1 aroE aroE KMT56049.1 KMT56049.1 KMT56050.1 KMT56050.1 KMT56196.1 KMT56196.1 kynU kynU aroQ-2 aroQ-2 KMT55874.1 KMT55874.1 gltB gltB aroB aroB aroK aroK KMT55899.1 KMT55899.1 KMT55923.1 KMT55923.1 hutI hutI hutH hutH dapE dapE dapD dapD KMT57423.1 KMT57423.1 KMT57251.1 KMT57251.1 KMT57249.1 KMT57249.1 KMT57221.1 KMT57221.1 KMT57056.1 KMT57056.1 asd asd aspA-2 aspA-2 garD garD KMT55155.1 KMT55155.1 KMT55207.1 KMT55207.1 KMT55356.1 KMT55356.1 folP folP dapB dapB KMT55415.1 KMT55415.1 KMT55418.1 KMT55418.1 aroQ-3 aroQ-3 aroE-2 aroE-2 dapA dapA KMT54394.1 KMT54394.1 nadA nadA KMT54087.1 KMT54087.1 KMT54221.1 KMT54221.1 putA putA aroA-2 aroA-2 KMT53523.1 KMT53523.1 dapF-2 dapF-2 KMT53285.1 KMT53285.1 KMT53334.1 KMT53334.1 KMT53356.1 KMT53356.1 KMT53370.1 KMT53370.1 KMT53153.1 KMT53153.1 dapA-2 dapA-2 KMT52621.1 KMT52621.1 KMT52660.1 KMT52660.1 astE astE astB astB astD astD KMT52668.1 KMT52668.1 KMT52669.1 KMT52669.1 gudD gudD KMT52174.1 KMT52174.1 KMT52183.1 KMT52183.1 KMT52319.1 KMT52319.1 KMT52341.1 KMT52341.1 KMT52355.1 KMT52355.1 KMT52359.1 KMT52359.1 aspA aspA dapF dapF lysA lysA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
KMT57670.1Prephenate dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. (364 aa)
KMT56005.1Chorismate mutase; Catalyzes the Claisen rearrangement of chorismate to prephenate. (181 aa)
KMT55952.1Histidine utilization repressor; Derived by automated computational analysis using gene prediction method: Protein Homology. (249 aa)
hutUUrocanate hydratase; Catalyzes the conversion of urocanate to 4-imidazolone-5- propionate. (562 aa)
KMT55946.1Histidine ammonia-lyase; Derived by automated computational analysis using gene prediction method: Protein Homology. (507 aa)
ppcPhosphoenolpyruvate carboxylase; Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle; Belongs to the PEPCase type 1 family. (881 aa)
KMT57569.1Glutamate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glutamate synthase family. (539 aa)
aroA3-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (736 aa)
prpB2-methylisocitrate lyase; Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate. Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family. (302 aa)
KMT56795.1Aromatic amino acid aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (397 aa)
lpxLLipid A biosynthesis lauroyl acyltransferase; Catalyzes the transfer of laurate from lauroyl-acyl carrier protein (ACP) to Kdo(2)-lipid IV(A) to form Kdo(2)-(lauroyl)-lipid IV(A). (311 aa)
aroCChorismate synthase; Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system. (363 aa)
fumCFumarate hydratase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (458 aa)
aroQ3-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (146 aa)
KMT57022.1Aromatic amino acid aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (398 aa)
aroEShikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (273 aa)
KMT56049.12-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (172 aa)
KMT56050.1Dihydroneopterin aldolase; Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin. (117 aa)
KMT56196.1LysR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the LysR transcriptional regulatory family. (300 aa)
kynUKynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. (416 aa)
aroQ-23-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (151 aa)
KMT55874.1Histidine ammonia-lyase; Derived by automated computational analysis using gene prediction method: Protein Homology. (513 aa)
gltBCatalyzes the formation of glutamate from glutamine and alpha-ketoglutarate; Derived by automated computational analysis using gene prediction method: Protein Homology. (1481 aa)
aroB3-dehydroquinate synthase; Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ). (366 aa)
aroKShikimate kinase; Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate; Belongs to the shikimate kinase family. (172 aa)
KMT55899.1Malate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (422 aa)
KMT55923.1Sterol-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (207 aa)
hutIImidazolonepropionase; Catalyzing the hydrolysis of 4-imidazolone-5-propionate to N-formimidoyl-L-glutamate, the third step in the histidine degradation pathway; Derived by automated computational analysis using gene prediction method: Protein Homology. (401 aa)
hutHCatalyzes the degradation of histidine to urocanate and ammmonia; Derived by automated computational analysis using gene prediction method: Protein Homology. (512 aa)
dapESuccinyl-diaminopimelate desuccinylase; Catalyzes the hydrolysis of N-succinyl-L,L-diaminopimelic acid (SDAP), forming succinate and LL-2,6-diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls; Belongs to the peptidase M20A family. DapE subfamily. (383 aa)
dapD2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA. (344 aa)
KMT57423.1Catalyzes the formation of succinyldiaminopimelate from N-succinyl-2-amino-6-ketopimelate; Derived by automated computational analysis using gene prediction method: Protein Homology. (399 aa)
KMT57251.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (84 aa)
KMT57249.1L-aspartate oxidase; Catalyzes the oxidation of L-aspartate to iminoaspartate. (538 aa)
KMT57221.1Branched-chain amino acid aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (339 aa)
KMT57056.1Folylpolyglutamate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the folylpolyglutamate synthase family. (435 aa)
asdAspartate-semialdehyde dehydrogenase; Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl- 4-phosphate; Belongs to the aspartate-semialdehyde dehydrogenase family. (370 aa)
aspA-2Aspartate ammonia-lyase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (460 aa)
garDGalactarate dehydrogenase; Catalyzes the formation of 5-dehydro-4-deoxy-D-glucarate from D-galactarate; Derived by automated computational analysis using gene prediction method: Protein Homology. (517 aa)
KMT55155.15-dehydro-4-deoxyglucarate dehydratase; Catalyzes the formation of 2,5-dioxopentanoate from 5-dehydro-4-deoxy-D-glucarate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the DapA family. (303 aa)
KMT55207.1Nicotinate-nucleotide pyrophosphorylase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the NadC/ModD family. (282 aa)
KMT55356.12-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (162 aa)
folPDihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. (283 aa)
dapBDihydrodipicolinate reductase; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate; Belongs to the DapB family. (268 aa)
KMT55415.1Chorismate mutase; Derived by automated computational analysis using gene prediction method: Protein Homology. (101 aa)
KMT55418.1Converts 2-oxoglutarate to glutamate; in Escherichia coli this enzyme plays a role in glutamate synthesis when the cell is under energy restriction; uses NADPH; forms a homohexamer; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the Glu/Leu/Phe/Val dehydrogenases family. (445 aa)
aroQ-33-dehydroquinate dehydratase; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the type-II 3-dehydroquinase family. (149 aa)
aroE-2Shikimate dehydrogenase; Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). (282 aa)
dapADihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (292 aa)
KMT54394.1NAD-glutamate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (1622 aa)
nadAQuinolinate synthase A; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate; Belongs to the quinolinate synthase A family. Type 1 subfamily. (352 aa)
KMT54087.1Homoserine dehydrogenase; Catalyzes the formation of L-aspartate 4-semialdehyde from L-homoserine; Derived by automated computational analysis using gene prediction method: Protein Homology. (434 aa)
KMT54221.1Proline:sodium symporter PutP; Catalyzes the sodium-dependent uptake of extracellular L- proline; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family. (494 aa)
putATranscriptional regulator; Oxidizes proline to glutamate for use as a carbon and nitrogen source; In the C-terminal section; belongs to the aldehyde dehydrogenase family. (1317 aa)
aroA-23-phosphoshikimate 1-carboxyvinyltransferase; Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate. (418 aa)
KMT53523.1Phospho-2-dehydro-3-deoxyheptonate aldolase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (358 aa)
dapF-2Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (267 aa)
KMT53285.1Phospho-2-dehydro-3-deoxyheptonate aldolase; Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino- heptulosonate-7-phosphate (DAHP). (358 aa)
KMT53334.1Shikimate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (272 aa)
KMT53356.1DeoR faimly transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (328 aa)
KMT53370.1Diacylglycerol kinase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. (170 aa)
KMT53153.1Dipeptidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (579 aa)
dapA-2Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA). (287 aa)
KMT52621.14-amino-4-deoxychorismate lyase; Derived by automated computational analysis using gene prediction method: Protein Homology. (271 aa)
KMT52660.1Aspartate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aspartokinase family. (413 aa)
astESuccinylglutamate desuccinylase; Transforms N(2)-succinylglutamate into succinate and glutamate; Belongs to the AspA/AstE family. Succinylglutamate desuccinylase subfamily. (334 aa)
astBN-succinylarginine dihydrolase; Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)- succinylornithine, ammonia and CO(2). (448 aa)
astDSuccinylglutamate-semialdehyde dehydrogenase; Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate. (488 aa)
KMT52668.1Arginine N-succinyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (341 aa)
KMT52669.1Arginine N-succinyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (339 aa)
gudDGlucarate dehydratase; Catalyzes the formation of 5-keto-4-deoxy-D-glucarate from glucarate; Derived by automated computational analysis using gene prediction method: Protein Homology. (449 aa)
KMT52174.1LysR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the LysR transcriptional regulatory family. (302 aa)
KMT52183.1Glutamate carboxypeptidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (409 aa)
KMT52319.1Oxaloacetate decarboxylase; Catalyzes the decarboxylation of oxaloacetate into pyruvate. Seems to play a role in maintaining cellular concentrations of bicarbonate and pyruvate; Belongs to the isocitrate lyase family. Oxaloacetate decarboxylase subfamily. (289 aa)
KMT52341.1Aspartate aminotransferase; Catalyzes the formation of oxalozcetate and L-glutamate from L-aspartate and 2-oxoglutarate; Derived by automated computational analysis using gene prediction method: Protein Homology. (402 aa)
KMT52355.1Isochorismate-pyruvate lyase; Catalyzes the second reaction in the pyochelin biosynthetic pathway, the conversion of isochorismate to salicylate and pyruvate; Derived by automated computational analysis using gene prediction method: Protein Homology. (107 aa)
KMT52359.15-dehydro-4-deoxyglucarate dehydratase; Catalyzes the formation of 2,5-dioxopentanoate from 5-dehydro-4-deoxy-D-glucarate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the DapA family. (303 aa)
aspAAspartate ammonia-lyase; Catalyzes the formation of fumarate from aspartate; Derived by automated computational analysis using gene prediction method: Protein Homology. (474 aa)
dapFDiaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. (276 aa)
lysADiaminopimelate decarboxylase; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine. (415 aa)
Your Current Organism:
Pseudomonas sp. KG01
NCBI taxonomy Id: 1674920
Other names: P. sp. KG01
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