(30 nodes) Phenylalanine metabolism network (Pseudomonas sp. KG01)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	KMT53854.1	3-hydroxyacyl-CoA dehydrogenase; Converts 3-hydroxyadipyl-CoA to beta-ketoadipyl-CoA in phenylacetate degradation; Derived by automated computational analysis using gene prediction method: Protein Homology. (509 aa)
	KMT53316.1	Esterase; Derived by automated computational analysis using gene prediction method: Protein Homology. (139 aa)
	KMT53126.1	Thioesterase; Derived by automated computational analysis using gene prediction method: Protein Homology. (150 aa)
	KMT57262.1	enoyl-CoA hydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. (370 aa)
	hisC	Aspartate aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (370 aa)
	KMT56795.1	Aromatic amino acid aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (397 aa)
	phhA	Phenylalanine 4-hydroxylase; phenylalanine 4-hydroxylase; catalyzes the formation of 4a-hydroxytetrahydrobiopterin and tyrosine from phenylalanine and tetrahydrobiopterin; Derived by automated computational analysis using gene prediction method: Protein Homology. (268 aa)
	KMT57022.1	Aromatic amino acid aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (398 aa)
	lcdH	3-hydroxybutyryl-CoA dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of L-carnitine to 3- dehydrocarnitine. (321 aa)
	dadA	Amino acid dehydrogenase; Oxidative deamination of D-amino acids. (413 aa)
	KMT56347.1	Aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (360 aa)
	dadA-2	Amino acid dehydrogenase; Oxidative deamination of D-amino acids. (433 aa)
	hisC-2	Histidinol-phosphate aminotransferase; Catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. (350 aa)
	KMT55447.1	4-hydroxyphenylpyruvate dioxygenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (633 aa)
	KMT54973.1	enoyl-CoA hydratase; Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology. (263 aa)
	fdhD	Iron ABC transporter substrate-binding protein; Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH. Belongs to the FdhD family. (279 aa)
	KMT54733.1	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (127 aa)
	KMT54365.1	Metal-dependent hydrolase family protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (280 aa)
	KMT54429.1	Amidase; Catalyzes the hydrolysis of a monocarboxylic acid amid to form a monocarboxylate and ammonia; Derived by automated computational analysis using gene prediction method: Protein Homology. (568 aa)
	KMT54489.1	glutamyl-tRNA amidotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (435 aa)
	KMT54033.1	enoyl-CoA hydratase; Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology. (249 aa)
	KMT54345.1	enoyl-CoA hydratase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the enoyl-CoA hydratase/isomerase family. (270 aa)
	KMT53853.1	enoyl-CoA hydratase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the enoyl-CoA hydratase/isomerase family. (261 aa)
	KMT52835.1	FAD-dependent oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (420 aa)
	KMT52885.1	4-hydroxyphenylpyruvate dioxygenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (361 aa)
	KMT52897.1	GNAT family acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (170 aa)
	KMT52913.1	enoyl-CoA hydratase; Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the enoyl-CoA hydratase/isomerase family. (257 aa)
	KMT52915.1	Crotonase; Derived by automated computational analysis using gene prediction method: Protein Homology. (367 aa)
	KMT52452.1	enoyl-CoA hydratase; Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology. (230 aa)
	KMT52377.1	Amidase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the amidase family. (488 aa)

Your Current Organism:

Pseudomonas sp. KG01

NCBI taxonomy Id: 1674920
Other names: P. sp. KG01

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
KMT52377.1	KMT52885.1	ACR52_28705	ACR52_24895	Amidase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the amidase family.	4-hydroxyphenylpyruvate dioxygenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.626
KMT52377.1	KMT54429.1	ACR52_28705	ACR52_16480	Amidase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the amidase family.	Amidase; Catalyzes the hydrolysis of a monocarboxylic acid amid to form a monocarboxylate and ammonia; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.651
KMT52377.1	KMT55447.1	ACR52_28705	ACR52_12890	Amidase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the amidase family.	4-hydroxyphenylpyruvate dioxygenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.720
KMT52452.1	KMT52913.1	ACR52_27065	ACR52_25055	enoyl-CoA hydratase; Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology.	enoyl-CoA hydratase; Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the enoyl-CoA hydratase/isomerase family.	0.687
KMT52452.1	KMT52915.1	ACR52_27065	ACR52_25065	enoyl-CoA hydratase; Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology.	Crotonase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.750
KMT52452.1	KMT53316.1	ACR52_27065	ACR52_22550	enoyl-CoA hydratase; Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology.	Esterase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.434
KMT52452.1	KMT53853.1	ACR52_27065	ACR52_21045	enoyl-CoA hydratase; Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology.	enoyl-CoA hydratase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the enoyl-CoA hydratase/isomerase family.	0.679
KMT52452.1	KMT53854.1	ACR52_27065	ACR52_21050	enoyl-CoA hydratase; Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology.	3-hydroxyacyl-CoA dehydrogenase; Converts 3-hydroxyadipyl-CoA to beta-ketoadipyl-CoA in phenylacetate degradation; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.822
KMT52452.1	KMT54033.1	ACR52_27065	ACR52_17975	enoyl-CoA hydratase; Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology.	enoyl-CoA hydratase; Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.652
KMT52452.1	KMT54345.1	ACR52_27065	ACR52_19600	enoyl-CoA hydratase; Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology.	enoyl-CoA hydratase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the enoyl-CoA hydratase/isomerase family.	0.905
KMT52452.1	KMT54733.1	ACR52_27065	ACR52_14720	enoyl-CoA hydratase; Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.449
KMT52452.1	KMT54973.1	ACR52_27065	ACR52_14400	enoyl-CoA hydratase; Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology.	enoyl-CoA hydratase; Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.776
KMT52452.1	KMT55447.1	ACR52_27065	ACR52_12890	enoyl-CoA hydratase; Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology.	4-hydroxyphenylpyruvate dioxygenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.410
KMT52452.1	KMT57262.1	ACR52_27065	ACR52_01225	enoyl-CoA hydratase; Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology.	enoyl-CoA hydratase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.719
KMT52452.1	lcdH	ACR52_27065	ACR52_07120	enoyl-CoA hydratase; Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; Derived by automated computational analysis using gene prediction method: Protein Homology.	3-hydroxybutyryl-CoA dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of L-carnitine to 3- dehydrocarnitine.	0.776
KMT52835.1	KMT52885.1	ACR52_24615	ACR52_24895	FAD-dependent oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology.	4-hydroxyphenylpyruvate dioxygenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.524
KMT52835.1	KMT55447.1	ACR52_24615	ACR52_12890	FAD-dependent oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology.	4-hydroxyphenylpyruvate dioxygenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.676
KMT52835.1	KMT56795.1	ACR52_24615	ACR52_04215	FAD-dependent oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Aromatic amino acid aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.521
KMT52835.1	KMT57022.1	ACR52_24615	ACR52_05430	FAD-dependent oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Aromatic amino acid aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.521
KMT52885.1	KMT52377.1	ACR52_24895	ACR52_28705	4-hydroxyphenylpyruvate dioxygenase; Derived by automated computational analysis using gene prediction method: Protein Homology.	Amidase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the amidase family.	0.626