STRINGSTRING
KMT52244.1 KMT52244.1 KMT57290.1 KMT57290.1 KMT57300.1 KMT57300.1 map map KMT57527.1 KMT57527.1 cmoB cmoB KMT56659.1 KMT56659.1 KMT56668.1 KMT56668.1 KMT56697.1 KMT56697.1 KMT56765.1 KMT56765.1 cobB cobB cobD cobD KMT56769.1 KMT56769.1 cobQ cobQ KMT56771.1 KMT56771.1 cobT cobT KMT56773.1 KMT56773.1 cobS cobS KMT57040.1 KMT57040.1 gltX gltX cyoE cyoE KMT56486.1 KMT56486.1 hemF hemF KMT56012.1 KMT56012.1 pqqE pqqE KMT56231.1 KMT56231.1 KMT56337.1 KMT56337.1 cyoE-2 cyoE-2 KMT55852.1 KMT55852.1 KMT55853.1 KMT55853.1 KMT55854.1 KMT55854.1 KMT55855.1 KMT55855.1 KMT55856.1 KMT55856.1 KMT55857.1 KMT55857.1 hemE hemE KMT55780.1 KMT55780.1 KMT52246.1 KMT52246.1 rsmC rsmC hemH hemH KMT55249.1 KMT55249.1 KMT55255.1 KMT55255.1 hemA hemA hmuV hmuV gluQ gluQ rlmG rlmG hemL hemL KMT55515.1 KMT55515.1 KMT55575.1 KMT55575.1 tig tig KMT54600.1 KMT54600.1 KMT54392.1 KMT54392.1 KMT53887.1 KMT53887.1 KMT54007.1 KMT54007.1 KMT54015.1 KMT54015.1 KMT54027.1 KMT54027.1 KMT54052.1 KMT54052.1 KMT54111.1 KMT54111.1 KMT54142.1 KMT54142.1 KMT54241.1 KMT54241.1 KMT54242.1 KMT54242.1 KMT54246.1 KMT54246.1 KMT54247.1 KMT54247.1 KMT54248.1 KMT54248.1 map-2 map-2 cysG cysG KMT53836.1 KMT53836.1 KMT53473.1 KMT53473.1 KMT53492.1 KMT53492.1 KMT53493.1 KMT53493.1 hemC hemC KMT53321.1 KMT53321.1 KMT53103.1 KMT53103.1 KMT52705.1 KMT52705.1 KMT52710.1 KMT52710.1 KMT52714.1 KMT52714.1 KMT52245.1 KMT52245.1 KMT52743.1 KMT52743.1 KMT52715.1 KMT52715.1 KMT52716.1 KMT52716.1 KMT52717.1 KMT52717.1 KMT52718.1 KMT52718.1 KMT52720.1 KMT52720.1 KMT52721.1 KMT52721.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
KMT52244.1Precorrin 6A synthase; Catalyzes the formation of precorrin 6x from precorrin 5; Derived by automated computational analysis using gene prediction method: Protein Homology. (251 aa)
KMT57290.1Epimerase; Derived by automated computational analysis using gene prediction method: Protein Homology. (224 aa)
KMT57300.1Methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (405 aa)
mapMethionine aminopeptidase; Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed; Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily. (264 aa)
KMT57527.1Bacterioferritin; Iron-storage protein, whose ferroxidase center binds Fe(2+) ions, oxidizes them by dioxygen to Fe(3+), and participates in the subsequent Fe(3+) oxide mineral core formation within the central cavity of the protein complex; Belongs to the bacterioferritin family. (156 aa)
cmoBtRNA methyltransferase; Catalyzes carboxymethyl transfer from carboxy-S-adenosyl-L- methionine (Cx-SAM) to 5-hydroxyuridine (ho5U) to form 5- carboxymethoxyuridine (cmo5U) at position 34 in tRNAs. (318 aa)
KMT56659.1uroporphyrin-III methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the precorrin methyltransferase family. (247 aa)
KMT56668.1Transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (130 aa)
KMT56697.1Coproporphyrinogen III oxidase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the anaerobic coproporphyrinogen-III oxidase family. (460 aa)
KMT56765.1Cob(I)yrinic acid a,c-diamide adenosyltransferase; Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids. (203 aa)
cobBCobyrinic acid a,c-diamide synthase; Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of hydrogenobyrinate, using either L- glutamine or ammonia as the nitrogen source; Belongs to the CobB/CbiA family. (463 aa)
cobDCobalamin biosynthesis protein CobD; Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group. (302 aa)
KMT56769.1Threonine-phosphate decarboxylase; Cobalamin biosynthesis protein; decarboxylates L-threonine-O-3-phosphate to yield (R)-1-amino-2-propanol O-2-phosphate, the precursor for the linkage between the nucleotide loop and the corrin ring in cobalamin; structurally similar to histidinol phosphate aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (329 aa)
cobQCobyric acid synthase; Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. Belongs to the CobB/CobQ family. CobQ subfamily. (483 aa)
KMT56771.1Adenosylcobinamide kinase; Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate. (173 aa)
cobTNicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase; Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6-dimethylbenzimidazole (DMB). (351 aa)
KMT56773.1Alpha-ribazole phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (191 aa)
cobSCobalamin synthase; Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'- phosphate; Belongs to the CobS family. (242 aa)
KMT57040.1glcG protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (144 aa)
gltXglutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily. (493 aa)
cyoEProtoheme IX farnesyltransferase; Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group. (299 aa)
KMT56486.1Cytochrome B561; Derived by automated computational analysis using gene prediction method: Protein Homology. (359 aa)
hemFCoproporphyrinogen III oxidase; Involved in the heme biosynthesis. Catalyzes the aerobic oxidative decarboxylation of propionate groups of rings A and B of coproporphyrinogen-III to yield the vinyl groups in protoporphyrinogen- IX. (310 aa)
KMT56012.1Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (142 aa)
pqqEPyrroloquinoline quinone biosynthesis protein PqqE; Catalyzes the cross-linking of a glutamate residue and a tyrosine residue in the PqqA protein as part of the biosynthesis of pyrroloquinoline quinone (PQQ). (393 aa)
KMT56231.1Oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. (400 aa)
KMT56337.1Heme oxygenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (204 aa)
cyoE-2Protoheme IX farnesyltransferase; Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group. (295 aa)
KMT55852.1precorrin-3B C17-methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (545 aa)
KMT55853.1Precorrin-2 C20-methyltransferase; Methylates precorrin-2 at the C-20 position to produce precorrin-3A. (243 aa)
KMT55854.1Precorrin isomerase; Derived by automated computational analysis using gene prediction method: Protein Homology. (208 aa)
KMT55855.1Oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (448 aa)
KMT55856.1precorrin-6Y C5,15-methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (401 aa)
KMT55857.1cobalt-precorrin-6X reductase; CobK/CbiJ; there are 2 pathways for cobalamin (vitamin B12) production, one aerobic (ex. P. denitrificans), the other anaerobic (ex. S. typhimurium); the CobK/CbiJ perform similar reactions in both; the anaerobic pathway includes the use of a chelated cobalt ion in order for ring contraction to occur; CobK thus converts precorrin 6 into dihydro-precorrin 6 while CbiJ converts cobalt-precorrin 6 into cobalt-deihydro-precorrin 6; Derived by automated computational analysis using gene prediction method: Protein Homology. (238 aa)
hemEUroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. (355 aa)
KMT55780.1Frataxin; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the frataxin family. (110 aa)
KMT52246.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (185 aa)
rsmC16S rRNA methyltransferase; Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle; Belongs to the methyltransferase superfamily. RsmC family. (332 aa)
hemHFerrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. (341 aa)
KMT55249.1FAD-dependent oxidoreductase; Catalyzes the oxidation of the 1,2-dihydro- and 1,6- dihydro- isomeric forms of beta-NAD(P) back to beta-NAD(P)+. May serve to protect primary metabolism dehydrogenases from inhibition by the 1,2-dihydro- and 1,6-dihydro-beta-NAD(P) isomers; Belongs to the bacterial renalase family. (328 aa)
KMT55255.1Short-chain dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (260 aa)
hemAglutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). (429 aa)
hmuVHemin ABC transporter ATP-binding protein; Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system. (255 aa)
gluQglutamyl-Q tRNA(Asp) ligase; Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5-dihydroxy-2- cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon; Belongs to the class-I aminoacyl-tRNA synthetase family. GluQ subfamily. (295 aa)
rlmG50S rRNA methyltransferase; Specifically methylates the guanine in position 1835 (m2G1835) of 23S rRNA. (374 aa)
hemLGlutamate-1-semialdehyde 2,1-aminomutase; Derived by automated computational analysis using gene prediction method: Protein Homology. (427 aa)
KMT55515.1Nucleoside-diphosphate sugar epimerase; Derived by automated computational analysis using gene prediction method: Protein Homology. (213 aa)
KMT55575.1Bacterioferritin; Iron-storage protein, whose ferroxidase center binds Fe(2+) ions, oxidizes them by dioxygen to Fe(3+), and participates in the subsequent Fe(3+) oxide mineral core formation within the central cavity of the protein complex; Belongs to the bacterioferritin family. (154 aa)
tigTrigger factor; Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase; Belongs to the FKBP-type PPIase family. Tig subfamily. (436 aa)
KMT54600.1ATPase AAA; Derived by automated computational analysis using gene prediction method: Protein Homology. (281 aa)
KMT54392.1ATPase AAA; Derived by automated computational analysis using gene prediction method: Protein Homology. (319 aa)
KMT53887.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (107 aa)
KMT54007.1Ferritin; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the Dps family. (157 aa)
KMT54015.1ATP--cobalamin adenosyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the Cob(I)alamin adenosyltransferase family. (192 aa)
KMT54027.1ATPase AAA; Derived by automated computational analysis using gene prediction method: Protein Homology. (331 aa)
KMT54052.1Heme oxygenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (202 aa)
KMT54111.1Bacterioferritin; Derived by automated computational analysis using gene prediction method: Protein Homology. (176 aa)
KMT54142.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (767 aa)
KMT54241.1Precorrin-4 C11-methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (248 aa)
KMT54242.1Cobalamin biosynthesis protein CobE; Derived by automated computational analysis using gene prediction method: Protein Homology. (130 aa)
KMT54246.1Cobalamin biosynthesis protein CobN; Derived by automated computational analysis using gene prediction method: Protein Homology. (1253 aa)
KMT54247.1Magnesium chelatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (332 aa)
KMT54248.1Magnesium chelatase; Derived by automated computational analysis using gene prediction method: Protein Homology. (200 aa)
map-2Methionine aminopeptidase; Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed; Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily. (253 aa)
cysGSirohydrochlorin ferrochelatase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. Belongs to the precorrin methyltransferase family. In the N-terminal section; belongs to the precorrin-2 dehydrogenase / sirohydrochlorin ferrochelatase family. (464 aa)
KMT53836.1NAD-dependent dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology. (209 aa)
KMT53473.1Delta-aminolevulinic acid dehydratase; Catalyzes the formation of porphobilinogen from 5-aminolevulinate; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ALAD family. (337 aa)
KMT53492.1uroporphyrin-III methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (371 aa)
KMT53493.1uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. (249 aa)
hemCPorphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (313 aa)
KMT53321.1Delta-aminolevulinic acid dehydratase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the ALAD family. (324 aa)
KMT53103.1GlcG protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (146 aa)
KMT52705.1norD; Derived by automated computational analysis using gene prediction method: Protein Homology. (613 aa)
KMT52710.1ATPase AAA; Derived by automated computational analysis using gene prediction method: Protein Homology. (258 aa)
KMT52714.1AsnC family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology. (152 aa)
KMT52245.1Phosphoglycerate mutase; Derived by automated computational analysis using gene prediction method: Protein Homology. (184 aa)
KMT52743.1Protein nirL; Derived by automated computational analysis using gene prediction method: Protein Homology. (162 aa)
KMT52715.1Protein nirG; Derived by automated computational analysis using gene prediction method: Protein Homology. (147 aa)
KMT52716.1Nitrite reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. (166 aa)
KMT52717.1Radical SAM protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (393 aa)
KMT52718.1uroporphyrin-III methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the precorrin methyltransferase family. (274 aa)
KMT52720.1Coproporphyrinogen III oxidase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the anaerobic coproporphyrinogen-III oxidase family. (461 aa)
KMT52721.1Coproporphyrinogen III oxidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (439 aa)
Your Current Organism:
Pseudomonas sp. KG01
NCBI taxonomy Id: 1674920
Other names: P. sp. KG01
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