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coaE coaE ABM71299.1 ABM71299.1 nadB nadB nadK nadK nadC nadC dfp dfp lytB lytB folK folK nrdR nrdR mutM mutM mqo mqo birA birA ribE ribE ispD ispD folE folE ABM71821.1 ABM71821.1 folB folB sds sds gcpE gcpE nadA nadA folP folP coaD coaD ribB ribB dxs dxs ispE ispE ispA ispA uppS uppS bioB bioB dxr dxr ABM72516.1 ABM72516.1 pntB pntB pntA-2 pntA-2 pntA pntA ABM72520.1 ABM72520.1 ABM72521.1 ABM72521.1 ABM72633.1 ABM72633.1 nadK-2 nadK-2 ribF ribF folC folC panB panB ABM72827.1 ABM72827.1 pepP pepP ABM72829.1 ABM72829.1 ABM72830.1 ABM72830.1 nadD nadD nadE nadE ABM72850.1 ABM72850.1 ABM72851.1 ABM72851.1 fumC fumC ABM72854.1 ABM72854.1 bioF bioF ABM72856.1 ABM72856.1 ABM72857.1 ABM72857.1 bioD bioD bioA bioA cmk cmk ribH ribH rnj rnj purU purU
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query proteins and first shell of interactors
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second shell of interactors
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proteins of unknown 3D structure
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a 3D structure is known or predicted
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coaEPutative dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family. (204 aa)
ABM71299.1COG1521 Putative transcriptional regulator, homolog of Bvg accessory factor [Transcription]. (226 aa)
nadBL-aspartate oxidase; Catalyzes the oxidation of L-aspartate to iminoaspartate. (555 aa)
nadKPredicted inorganic polyphosphate / ATP-NAD+ kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (299 aa)
nadCNicotinate-nucleotide pyrophosphorylase:Quinolinate phosphoriobsyl transferase; COG157 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Belongs to the NadC/ModD family. (288 aa)
dfpPutative p-pantothenate cysteine ligase and p-pantothenenoylcysteine decarboxylase; Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4- phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine; In the C-terminal section; belongs to the PPC synthetase family. (418 aa)
lytBLytB; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family. (398 aa)
folKPossible 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase. (192 aa)
nrdRPredicted transcriptional regulator, consists of a Zn-ribbon and ATP-cone domains; Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes; Belongs to the NrdR family. (159 aa)
mutMFormamidopyrimidine-DNA glycolase (FAPY-DNA glycolase); Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. (293 aa)
mqoPutative malate/quinone oxidoreductase; COG579 Predicted dehydrogenase [General function prediction only]. (497 aa)
birAPutative Biotin--acetyl-CoA-carboxylase ligase. (249 aa)
ribECOG307 Riboflavin synthase alpha chain [Coenzyme metabolism]. (219 aa)
ispDPutative 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase; Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D- erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). (223 aa)
folECOG302 GTP cyclohydrolase I [Coenzyme metabolism]. (248 aa)
ABM71821.1HAM1 family protein; COG127 Xanthosine triphosphate pyrophosphatase [Nucleotide transport and metabolism]. (194 aa)
folBCOG1539 Dihydroneopterin aldolase [Coenzyme metabolism]. (120 aa)
sdsPolyprenyl synthetase; COG142 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Belongs to the FPP/GGPP synthase family. (323 aa)
gcpEGcpE protein; Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME- 2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. Belongs to the IspG family. (405 aa)
nadAQuinolinate synthetase A protein; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (304 aa)
folPPutative dihydropteroate synthase; Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8- dihydropteroate (H2Pte), the immediate precursor of folate derivatives. (280 aa)
coaDPutative pantetheine-phosphate adenylyltransferase; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family. (159 aa)
ribBPossible GTP cyclohydrolase II / 3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family. (577 aa)
dxs1-deoxy-D-xylulose 5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (631 aa)
ispEPutative 4-diphosphocytidyl-2C-methyl-D-erythritol kinase (CMK); Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. (312 aa)
ispAPolyprenyl synthetase; COG142 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Belongs to the FPP/GGPP synthase family. (300 aa)
uppSUndecaprenyl pyrophosphate synthetase (UPPS); Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids. (267 aa)
bioBBiotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (335 aa)
dxr1-deoxy-D-xylulose 5-phosphate reductoisomerase; Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4- phosphate (MEP); Belongs to the DXR family. (409 aa)
ABM72516.1COG429 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]. (355 aa)
pntBPutative nicotinamide nucleotide transhydrogenase, subunit beta; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the PNT beta subunit family. (478 aa)
pntA-2Putative nicotinamide nucleotide transhydrogenase, subunit alpha 2 (A2). (97 aa)
pntAPutative nicotinamide nucleotide transhydrogenase, subunit alpha 1 (A1); COG3288 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]. (376 aa)
ABM72520.1Possible EF-1 guanine nucleotide exchange domain-containing protein. (192 aa)
ABM72521.1Conserved hypothetical protein. (78 aa)
ABM72633.1Diaminohydroxyphosphoribosylaminopyrimidine deaminase; Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'- phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'- phosphate; In the C-terminal section; belongs to the HTP reductase family. (368 aa)
nadK-2Predicted sugar kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (302 aa)
ribFPutative riboflavin kinase/FAD synthase; COG196 FAD synthase [Coenzyme metabolism]; Belongs to the ribF family. (307 aa)
folCPutative bifunctional Dihydrofolate/Folylpolyglutamate synthase; COG285 Folylpolyglutamate synthase [Coenzyme metabolism]; Belongs to the folylpolyglutamate synthase family. (410 aa)
panBPutative Ketopantoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family. (257 aa)
ABM72827.1Hypothetical protein. (52 aa)
pepPCOG6 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Belongs to the peptidase M24B family. (441 aa)
ABM72829.1Domain of unknown function DUF21; COG1253 Hemolysins and related proteins containing CBS domains [General function prediction only]. (325 aa)
ABM72830.1GTPase SAR1 and related small G proteins; COG1159 GTPase [General function prediction only]. (413 aa)
nadDPutative nicotinate-nucleotide adenylyltransferase; COG1057 Nicotinic acid mononucleotide adenylyltransferase [Coenzyme metabolism]; Belongs to the NadD family. (193 aa)
nadECarbon-nitrogen hydrolase:NAD+ synthase; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source. (565 aa)
ABM72850.1FtsJ cell division protein:S4 domain:Hemolysin A; COG1189 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]. (270 aa)
ABM72851.1Hypothetical protein. (58 aa)
fumCFumarate lyase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. (461 aa)
ABM72854.1COG4581 Superfamily II RNA helicase [DNA replication, recombination, and repair]. (908 aa)
bioFPutative 8-amino-7-oxononanoate synthase; COG156 7-keto-8-aminopelargonate synthetase and related enzymes [Coenzyme metabolism]. (381 aa)
ABM72856.1Conserved hypothetical protein. (238 aa)
ABM72857.1COG2226 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]. (252 aa)
bioDPutative Dethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. (221 aa)
bioAPutative diaminopelargonic acid synthase; COG161 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (433 aa)
cmkPutative bifunctional enzyme; COG283 Cytidylate kinase [Nucleotide transport and metabolism]. (509 aa)
ribHPutative 6,7-dimethyl-8-ribityllumazine synthase or riboflavin synthase beta chain; Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2- butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. (158 aa)
rnjPredicted hydrolase of the metallo-beta-lactamase superfamily; An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay. (667 aa)
purUFormyltetrahydrofolate deformylase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). (284 aa)
Your Current Organism:
Prochlorococcus marinus MIT9515
NCBI taxonomy Id: 167542
Other names: P. marinus str. MIT 9515, Prochlorococcus marinus str. MIT 9515
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