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| | pola2 | DNA polymerase alpha subunit B; Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis. (604 aa) |
| | dscc1 | DNA replication and sister chromatid cohesion 1. (394 aa) |
| | rad9a | Cell cycle checkpoint control protein; Belongs to the rad9 family. (399 aa) |
| | ENSPKIP00000000392 | AAA domain-containing protein. (944 aa) |
| | rev3l | REV3 like, DNA directed polymerase zeta catalytic subunit. (3106 aa) |
| | CDCA7L | Cell division cycle associated 7 like. (311 aa) |
| | recql4 | RecQ helicase-like 4. (1512 aa) |
| | pold1 | DNA polymerase. (1105 aa) |
| | rad52 | RAD52 homolog, DNA repair protein. (448 aa) |
| | polh | Polymerase (DNA directed), eta. (713 aa) |
| | Mlh1 | MutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli). (776 aa) |
| | ctc1 | Uncharacterized protein. (1337 aa) |
| | ENSPKIP00000004764 | RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae). (494 aa) |
| | chtf8 | CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae). (155 aa) |
| | Atr | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2574 aa) |
| | mcm3 | DNA helicase; Belongs to the MCM family. (808 aa) |
| | Mre11 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (713 aa) |
| | ENSPKIP00000006289 | Ig-like domain-containing protein. (136 aa) |
| | brca1 | Uncharacterized protein. (1439 aa) |
| | rfc4 | Replication factor C (activator 1) 4. (357 aa) |
| | LOC111856126 | DBF4-type domain-containing protein. (781 aa) |
| | cdc6 | Cell division control protein; Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated; Belongs to the CDC6/cdc18 family. (559 aa) |
| | recql5 | ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (997 aa) |
| | pole2 | DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (527 aa) |
| | bard1 | BRCA1 associated RING domain 1. (759 aa) |
| | prim1 | DNA primase; Belongs to the eukaryotic-type primase small subunit family. (461 aa) |
| | ENSPKIP00000009032 | DNA primase large subunit; Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. (506 aa) |
| | cdc45 | CDC45 cell division cycle 45 homolog (S. cerevisiae). (568 aa) |
| | mcm2 | DNA helicase; Belongs to the MCM family. (899 aa) |
| | poli | Polymerase (DNA directed) iota. (660 aa) |
| | rad50 | RAD50 homolog, double strand break repair protein. (1313 aa) |
| | Pole | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2251 aa) |
| | ENSPKIP00000010323 | DNA polymerase. (1377 aa) |
| | Atrip | ATR interacting protein. (758 aa) |
| | ENSPKIP00000011013 | WRN RecQ like helicase. (1122 aa) |
| | fbh1 | F-box DNA helicase 1. (1055 aa) |
| | ENSPKIP00000011270 | SAE2 domain-containing protein. (94 aa) |
| | Rbbp8 | CtIP_N domain-containing protein. (552 aa) |
| | ENSPKIP00000011404 | Polymerase (DNA-directed), delta 3, accessory subunit. (395 aa) |
| | pole3 | Polymerase (DNA directed), epsilon 3 (p17 subunit). (148 aa) |
| | pole4 | Polymerase (DNA-directed), epsilon 4, accessory subunit. (122 aa) |
| | orc5 | Origin recognition complex, subunit 5. (443 aa) |
| | dbf4 | DBF4 zinc finger. (596 aa) |
| | Gins2 | GINS complex subunit 2. (273 aa) |
| | Nbn | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (777 aa) |
| | mcm10 | Minichromosome maintenance 10 replication initiation factor. (821 aa) |
| | brip1 | BRCA1 interacting protein C-terminal helicase 1. (1442 aa) |
| | stn1 | CST complex subunit STN1; Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication. (377 aa) |
| | Fancm | ERCC4 domain-containing protein. (508 aa) |
| | ENSPKIP00000013407 | Helicase ATP-binding domain-containing protein. (434 aa) |
| | PCNA | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa) |
| | brca2 | BRCA2 DNA repair associated. (2995 aa) |
| | Msh4 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (867 aa) |
| | pold2 | Polymerase (DNA directed), delta 2, regulatory subunit. (470 aa) |
| | HUS1B | Checkpoint protein; Belongs to the HUS1 family. (280 aa) |
| | LOC111834000 | DNA helicase; Belongs to the MCM family. (815 aa) |
| | meiob | Methionine sulfoxide reductase B1b. (468 aa) |
| | ENSPKIP00000014968 | FHA domain-containing protein. (1811 aa) |
| | mcm4 | DNA helicase; Belongs to the MCM family. (861 aa) |
| | ENSPKIP00000016002 | Uncharacterized protein. (385 aa) |
| | msh6 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1374 aa) |
| | mcm7 | DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (727 aa) |
| | LOC111845217 | Si:ch211-141o9.10. (520 aa) |
| | mlh3 | MutL homolog 3 (E. coli). (1346 aa) |
| | NTHL1 | Endonuclease III-like protein 1; Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines; Belongs to the Nth/MutY family. (287 aa) |
| | Bivm | Basic, immunoglobulin-like variable motif containing. (497 aa) |
| | rad51 | DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (338 aa) |
| | apex1 | DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (314 aa) |
| | rhno1 | Si:ch73-352p4.5. (308 aa) |
| | orc4 | Origin recognition complex subunit 4; Component of the origin recognition complex (ORC) that binds origins of replication; Belongs to the ORC4 family. (479 aa) |
| | orc2 | Origin recognition complex, subunit 2. (541 aa) |
| | ENSPKIP00000018352 | Cell division cycle 7 homolog (S. cerevisiae); Belongs to the protein kinase superfamily. (469 aa) |
| | rfc1 | Replication factor C subunit 1. (1155 aa) |
| | rpa2 | Replication protein A2. (339 aa) |
| | timeless | Timeless circadian clock. (1246 aa) |
| | orc6 | Origin recognition complex, subunit 6. (277 aa) |
| | wdhd1 | WD repeat and HMG-box DNA binding protein 1. (1122 aa) |
| | Atad5 | ATPase family AAA domain containing 5a. (1761 aa) |
| | LOC111834097 | Zgc:110269. (346 aa) |
| | mcmbp | Minichromosome maintenance complex binding protein. (664 aa) |
| | rad1 | RAD1 homolog (S. pombe). (317 aa) |
| | gmnn | Geminin DNA replication inhibitor. (230 aa) |
| | ENSPKIP00000022716 | DNA helicase; Belongs to the MCM family. (664 aa) |
| | gins4 | DNA replication complex GINS protein SLD5; The GINS complex plays an essential role in the initiation of DNA replication; Belongs to the GINS4/SLD5 family. (222 aa) |
| | Gen1 | Uncharacterized protein. (928 aa) |
| | ENSPKIP00000023299 | TEN1 subunit of CST complex. (131 aa) |
| | rad9b | RAD9 checkpoint clamp component B. (416 aa) |
| | ENSPKIP00000023362 | Uncharacterized protein. (578 aa) |
| | ENSPKIP00000023394 | Uncharacterized protein. (302 aa) |
| | ENSPKIP00000023558 | Piezo-type mechanosensitive ion channel component. (2585 aa) |
| | rad51b | RAD51 paralog B. (384 aa) |
| | apex2 | DNA-(apurinic or apyrimidinic site) lyase; Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. (560 aa) |
| | LOC111850128 | DNA helicase; Belongs to the MCM family. (806 aa) |
| | ercc1 | Excision repair cross-complementation group 1. (325 aa) |
| | Exd2 | Exonuclease 3'-5' domain containing 2. (630 aa) |
| | fen1 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa) |
| | rpa1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (610 aa) |
| | ENSPKIP00000025196 | Piezo-type mechanosensitive ion channel component. (2347 aa) |
| | cdt1 | Chromatin licensing and DNA replication factor 1. (655 aa) |
| | DNA2 | DNA replication helicase/nuclease 2. (1345 aa) |
| | PIEZO2 | Piezo-type mechanosensitive ion channel component. (2715 aa) |
| | pms2 | PMS1 homolog 2, mismatch repair system component. (855 aa) |
| | pif1 | ATP-dependent DNA helicase PIF1; DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. (716 aa) |
| | ANKRD11 | Ankyrin repeat domain 11. (2812 aa) |
| | tdrd3 | Tudor domain containing 3. (704 aa) |
| | msh2 | MutS homolog 2 (E. coli); Component of the post-replicative DNA mismatch repair system (MMR). (786 aa) |
| | ercc5 | Excision repair cross-complementation group 5. (1172 aa) |
| | blm | BLM RecQ like helicase. (1442 aa) |
| | rfc5 | Replication factor C (activator 1) 5. (336 aa) |
| | ENSPKIP00000027017 | Chemokine (C-C motif) ligand 44. (257 aa) |
| | PWWP2A | PWWP domain containing 2A. (1028 aa) |
| | mcmdc2 | Uncharacterized protein. (731 aa) |
| | xrcc3 | DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (357 aa) |
| | ENSPKIP00000027503 | Exonuclease 1. (575 aa) |
| | gins1 | GINS complex subunit 1 (Psf1 homolog). (206 aa) |
| | rpa3 | Replication protein A3. (123 aa) |
| | mcm6 | DNA helicase; Belongs to the MCM family. (815 aa) |
| | rad51d | RAD51 paralog D. (342 aa) |
| | Rev1 | DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family. (1188 aa) |
| | topbp1 | DNA topoisomerase II binding protein 1. (1524 aa) |
| | orc1 | Origin recognition complex subunit 1; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. (909 aa) |
| | slf1 | SMC5-SMC6 complex localization factor 1. (885 aa) |
| | rad17 | RAD17 checkpoint clamp loader component. (681 aa) |
| | chek2 | Checkpoint kinase 2. (507 aa) |
| | Atm | Non-specific serine/threonine protein kinase. (3029 aa) |
| | msh5 | MutS homolog 5. (810 aa) |
| | palb2 | PALB2_WD40 domain-containing protein. (1433 aa) |
| | top3b | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (863 aa) |
| | rad51c | RAD51 paralog C. (374 aa) |
| | mcm9 | Minichromosome maintenance 9 homologous recombination repair factor; Belongs to the MCM family. (1146 aa) |
| | mad2l2 | Mitotic arrest deficient 2 like 2. (251 aa) |
| | msh3 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1092 aa) |
| | pms1 | PMS1 homolog 1, mismatch repair system component. (874 aa) |
| | Pold4 | Si:dkey-28b4.7. (121 aa) |
| | gins3 | GINS complex subunit 3. (211 aa) |
| | rfc2 | Replication factor C (activator 1) 2. (351 aa) |
| | Mcph1 | Microcephalin 1. (889 aa) |
| | polk | Polymerase (DNA directed) kappa. (894 aa) |
| | tipin | TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (286 aa) |
| | mcm8 | Minichromosome maintenance 8 homologous recombination repair factor; Belongs to the MCM family. (866 aa) |
| | tp53bp1 | Tumor protein p53 binding protein, 1. (1913 aa) |
| | Lig1 | DNA ligase. (964 aa) |
| | orc3 | Origin recognition complex, subunit 3. (723 aa) |
| | ercc4 | Excision repair cross-complementation group 4. (893 aa) |
| | rfc3 | Replication factor C (activator 1) 3. (356 aa) |
| | ercc6 | Excision repair cross-complementation group 6. (1376 aa) |
| | top3a | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (989 aa) |
| | XRCC2 | X-ray repair cross complementing 2. (284 aa) |
| | Xpa | Xeroderma pigmentosum, complementation group A. (272 aa) |
