(15 nodes) Mixed, incl. Synuclein, and Seven in absentia protein family network (Paramormyrops kingsleyae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TPPP	Tubulin polymerization promoting protein. (260 aa)
	slc6a2	Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (626 aa)
	LOC111848108	E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (286 aa)
	sncb	Beta-synuclein; Belongs to the synuclein family. (129 aa)
	cacybp	Calcyclin binding protein. (245 aa)
	siah1	E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (337 aa)
	LOC111838250	Uncharacterized protein; Belongs to the synuclein family. (141 aa)
	LOC111859648	ArfGAP with SH3 domain, ankyrin repeat and PH domain 3. (962 aa)
	cyhr1	Cysteine/histidine-rich 1. (382 aa)
	SNCG	Gamma-synuclein; Belongs to the synuclein family. (127 aa)
	LOC111848512	Synuclein, gamma b (breast cancer-specific protein 1); Belongs to the synuclein family. (244 aa)
	syngr3	Synaptogyrin. (228 aa)
	SIAH2	E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. (301 aa)
	FASTKD5	FAST kinase domains 5. (741 aa)
	sncaip	Synuclein, alpha interacting protein. (862 aa)

Your Current Organism:

Paramormyrops kingsleyae

NCBI taxonomy Id: 1676925
Other names: Brienomyrus kingsleyae, Brienomyrus sp. CAB, Mormyrus kingsleyae, P. kingsleyae, Pollimyrus kingsleyae

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC111838250	LOC111848108	ENSPKIP00000022156	ENSPKIP00000005156	Uncharacterized protein; Belongs to the synuclein family.	E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.	0.623
LOC111838250	SIAH2	ENSPKIP00000022156	ENSPKIP00000035926	Uncharacterized protein; Belongs to the synuclein family.	E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.	0.623
LOC111838250	TPPP	ENSPKIP00000022156	ENSPKIP00000000722	Uncharacterized protein; Belongs to the synuclein family.	Tubulin polymerization promoting protein.	0.739
LOC111838250	cyhr1	ENSPKIP00000022156	ENSPKIP00000029655	Uncharacterized protein; Belongs to the synuclein family.	Cysteine/histidine-rich 1.	0.403
LOC111838250	siah1	ENSPKIP00000022156	ENSPKIP00000016661	Uncharacterized protein; Belongs to the synuclein family.	E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.	0.623
LOC111838250	slc6a2	ENSPKIP00000022156	ENSPKIP00000004557	Uncharacterized protein; Belongs to the synuclein family.	Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.	0.697
LOC111838250	sncaip	ENSPKIP00000022156	ENSPKIP00000041489	Uncharacterized protein; Belongs to the synuclein family.	Synuclein, alpha interacting protein.	0.958
LOC111838250	sncb	ENSPKIP00000022156	ENSPKIP00000006163	Uncharacterized protein; Belongs to the synuclein family.	Beta-synuclein; Belongs to the synuclein family.	0.527
LOC111838250	syngr3	ENSPKIP00000022156	ENSPKIP00000034473	Uncharacterized protein; Belongs to the synuclein family.	Synaptogyrin.	0.530
LOC111848108	LOC111838250	ENSPKIP00000005156	ENSPKIP00000022156	E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.	Uncharacterized protein; Belongs to the synuclein family.	0.623
LOC111848108	LOC111848512	ENSPKIP00000005156	ENSPKIP00000031621	E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.	Synuclein, gamma b (breast cancer-specific protein 1); Belongs to the synuclein family.	0.443
LOC111848108	SNCG	ENSPKIP00000005156	ENSPKIP00000030763	E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.	Gamma-synuclein; Belongs to the synuclein family.	0.443
LOC111848108	cacybp	ENSPKIP00000005156	ENSPKIP00000008447	E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.	Calcyclin binding protein.	0.970
LOC111848108	siah1	ENSPKIP00000005156	ENSPKIP00000016661	E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.	E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.	0.900
LOC111848108	sncaip	ENSPKIP00000005156	ENSPKIP00000041489	E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.	Synuclein, alpha interacting protein.	0.497
LOC111848512	LOC111848108	ENSPKIP00000031621	ENSPKIP00000005156	Synuclein, gamma b (breast cancer-specific protein 1); Belongs to the synuclein family.	E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.	0.443
LOC111848512	SIAH2	ENSPKIP00000031621	ENSPKIP00000035926	Synuclein, gamma b (breast cancer-specific protein 1); Belongs to the synuclein family.	E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.	0.443
LOC111848512	TPPP	ENSPKIP00000031621	ENSPKIP00000000722	Synuclein, gamma b (breast cancer-specific protein 1); Belongs to the synuclein family.	Tubulin polymerization promoting protein.	0.513
LOC111848512	cyhr1	ENSPKIP00000031621	ENSPKIP00000029655	Synuclein, gamma b (breast cancer-specific protein 1); Belongs to the synuclein family.	Cysteine/histidine-rich 1.	0.403
LOC111848512	siah1	ENSPKIP00000031621	ENSPKIP00000016661	Synuclein, gamma b (breast cancer-specific protein 1); Belongs to the synuclein family.	E3 ubiquitin-protein ligase; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.	0.443