(13 nodes) TRAF6 mediated IRF7 activation, and Carbon catabolite regulation of transcription network (Paramormyrops kingsleyae)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

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a 3D structure is known or predicted

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

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textmining

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protein homology

Your Input:
	usf1	Upstream transcription factor 1. (299 aa)
	ENSPKIP00000010184	CREB binding protein a. (2348 aa)
	ENSPKIP00000011845	Estrogen receptor 1. (558 aa)
	USF2	Upstream transcription factor 2, c-fos interacting. (345 aa)
	tp53	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (431 aa)
	Sp1	Sp1 transcription factor. (676 aa)
	LOC111843885	BHLH domain-containing protein. (410 aa)
	LOC111845232	Uncharacterized protein. (2683 aa)
	ENSPKIP00000021895	Interferon regulatory factor 3. (436 aa)
	LOC111843207	CREB binding protein b. (2374 aa)
	EP300	E1A binding protein p300. (2557 aa)
	ENSPKIP00000037368	Rho-GAP domain-containing protein. (73 aa)
	ENSPKIP00000039446	Cyclic AMP-dependent transcription factor ATF-7; Plays important functions in early cell signaling. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]-3'), a sequence present in many viral and cellular promoters. (469 aa)

Your Current Organism:

Paramormyrops kingsleyae

NCBI taxonomy Id: 1676925
Other names: Brienomyrus kingsleyae, Brienomyrus sp. CAB, Mormyrus kingsleyae, P. kingsleyae, Pollimyrus kingsleyae

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPKIP00000010184	ENSPKIP00000011845	ENSPKIP00000010184	ENSPKIP00000011845	CREB binding protein a.	Estrogen receptor 1.	0.739
ENSPKIP00000010184	ENSPKIP00000021895	ENSPKIP00000010184	ENSPKIP00000021895	CREB binding protein a.	Interferon regulatory factor 3.	0.965
ENSPKIP00000010184	ENSPKIP00000037368	ENSPKIP00000010184	ENSPKIP00000037368	CREB binding protein a.	Rho-GAP domain-containing protein.	0.559
ENSPKIP00000010184	ENSPKIP00000039446	ENSPKIP00000010184	ENSPKIP00000039446	CREB binding protein a.	Cyclic AMP-dependent transcription factor ATF-7; Plays important functions in early cell signaling. Binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AG][AG]-3'), a sequence present in many viral and cellular promoters.	0.621
ENSPKIP00000010184	EP300	ENSPKIP00000010184	ENSPKIP00000027655	CREB binding protein a.	E1A binding protein p300.	0.940
ENSPKIP00000010184	LOC111843885	ENSPKIP00000010184	ENSPKIP00000017117	CREB binding protein a.	BHLH domain-containing protein.	0.515
ENSPKIP00000010184	LOC111845232	ENSPKIP00000010184	ENSPKIP00000018215	CREB binding protein a.	Uncharacterized protein.	0.940
ENSPKIP00000010184	Sp1	ENSPKIP00000010184	ENSPKIP00000015713	CREB binding protein a.	Sp1 transcription factor.	0.874
ENSPKIP00000010184	USF2	ENSPKIP00000010184	ENSPKIP00000012178	CREB binding protein a.	Upstream transcription factor 2, c-fos interacting.	0.516
ENSPKIP00000010184	tp53	ENSPKIP00000010184	ENSPKIP00000014805	CREB binding protein a.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.899
ENSPKIP00000010184	usf1	ENSPKIP00000010184	ENSPKIP00000002321	CREB binding protein a.	Upstream transcription factor 1.	0.655
ENSPKIP00000011845	ENSPKIP00000010184	ENSPKIP00000011845	ENSPKIP00000010184	Estrogen receptor 1.	CREB binding protein a.	0.739
ENSPKIP00000011845	ENSPKIP00000037368	ENSPKIP00000011845	ENSPKIP00000037368	Estrogen receptor 1.	Rho-GAP domain-containing protein.	0.445
ENSPKIP00000011845	EP300	ENSPKIP00000011845	ENSPKIP00000027655	Estrogen receptor 1.	E1A binding protein p300.	0.808
ENSPKIP00000011845	LOC111843207	ENSPKIP00000011845	ENSPKIP00000022792	Estrogen receptor 1.	CREB binding protein b.	0.739
ENSPKIP00000011845	LOC111843885	ENSPKIP00000011845	ENSPKIP00000017117	Estrogen receptor 1.	BHLH domain-containing protein.	0.403
ENSPKIP00000011845	LOC111845232	ENSPKIP00000011845	ENSPKIP00000018215	Estrogen receptor 1.	Uncharacterized protein.	0.808
ENSPKIP00000011845	Sp1	ENSPKIP00000011845	ENSPKIP00000015713	Estrogen receptor 1.	Sp1 transcription factor.	0.835
ENSPKIP00000011845	USF2	ENSPKIP00000011845	ENSPKIP00000012178	Estrogen receptor 1.	Upstream transcription factor 2, c-fos interacting.	0.454
ENSPKIP00000011845	tp53	ENSPKIP00000011845	ENSPKIP00000014805	Estrogen receptor 1.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family.	0.563