(28 nodes) Mixed, incl. SREBP signaling pathway, and Myc amino-terminal region network (Paramormyrops kingsleyae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	mlx	MAX dimerization protein MLX. (243 aa)
	ENSPKIP00000003228	Uncharacterized protein. (221 aa)
	INSIG1	Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family. (237 aa)
	scap	SREBF chaperone. (1270 aa)
	mlxip	MLX interacting protein. (877 aa)
	plekhb1	Pleckstrin homology domain containing B1. (186 aa)
	LOC111852927	MAX network transcriptional repressor. (515 aa)
	INSIG2	Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. (230 aa)
	NPC1L1	NPC1 like intracellular cholesterol transporter 1. (1355 aa)
	max	Myc associated factor X. (202 aa)
	mxd1	MAX dimerization protein 1. (221 aa)
	LOC111834634	Si:ch211-154o6.3. (519 aa)
	LOC111845186	BHLH domain-containing protein. (1136 aa)
	Npc2	Niemann-Pick disease, type C2. (148 aa)
	ENSPKIP00000017095	Sterol regulatory element binding transcription factor 1. (1111 aa)
	LOC111835214	Myelocytomatosis oncogene homolog. (354 aa)
	Mnt	MAX network transcriptional repressor. (641 aa)
	npc1	Niemann-Pick disease, type C1. (1281 aa)
	ENSPKIP00000024351	Sterol regulatory element binding transcription factor 2. (1109 aa)
	mxd3	MAX dimerization protein 3. (199 aa)
	Zbtb17	BTB domain-containing protein. (131 aa)
	mycn	MYCN proto-oncogene, bHLH transcription factor. (423 aa)
	insig1	Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. (252 aa)
	srebf1	Sterol regulatory element binding transcription factor 1. (1161 aa)
	LOC111846207	MYC proto-oncogene, bHLH transcription factor. (417 aa)
	mxi1	Max interactor 1, dimerization protein. (272 aa)
	ENSPKIP00000040244	MLX interacting protein like. (960 aa)
	ENSPKIP00000040453	Transcriptional regulator; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (456 aa)

Your Current Organism:

Paramormyrops kingsleyae

NCBI taxonomy Id: 1676925
Other names: Brienomyrus kingsleyae, Brienomyrus sp. CAB, Mormyrus kingsleyae, P. kingsleyae, Pollimyrus kingsleyae

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPKIP00000003228	ENSPKIP00000040453	ENSPKIP00000003228	ENSPKIP00000040453	Uncharacterized protein.	Transcriptional regulator; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes.	0.600
ENSPKIP00000003228	mycn	ENSPKIP00000003228	ENSPKIP00000032243	Uncharacterized protein.	MYCN proto-oncogene, bHLH transcription factor.	0.686
ENSPKIP00000017095	ENSPKIP00000040453	ENSPKIP00000017095	ENSPKIP00000040453	Sterol regulatory element binding transcription factor 1.	Transcriptional regulator; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes.	0.408
ENSPKIP00000017095	NPC1L1	ENSPKIP00000017095	ENSPKIP00000014148	Sterol regulatory element binding transcription factor 1.	NPC1 like intracellular cholesterol transporter 1.	0.816
ENSPKIP00000017095	npc1	ENSPKIP00000017095	ENSPKIP00000022901	Sterol regulatory element binding transcription factor 1.	Niemann-Pick disease, type C1.	0.816
ENSPKIP00000017095	scap	ENSPKIP00000017095	ENSPKIP00000005065	Sterol regulatory element binding transcription factor 1.	SREBF chaperone.	0.894
ENSPKIP00000024351	ENSPKIP00000040453	ENSPKIP00000024351	ENSPKIP00000040453	Sterol regulatory element binding transcription factor 2.	Transcriptional regulator; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes.	0.408
ENSPKIP00000024351	INSIG1	ENSPKIP00000024351	ENSPKIP00000003396	Sterol regulatory element binding transcription factor 2.	Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis. Belongs to the INSIG family.	0.458
ENSPKIP00000024351	NPC1L1	ENSPKIP00000024351	ENSPKIP00000014148	Sterol regulatory element binding transcription factor 2.	NPC1 like intracellular cholesterol transporter 1.	0.818
ENSPKIP00000024351	insig1	ENSPKIP00000024351	ENSPKIP00000033094	Sterol regulatory element binding transcription factor 2.	Insulin-induced gene protein; Mediates feedback control of cholesterol synthesis.	0.458
ENSPKIP00000024351	npc1	ENSPKIP00000024351	ENSPKIP00000022901	Sterol regulatory element binding transcription factor 2.	Niemann-Pick disease, type C1.	0.816
ENSPKIP00000024351	scap	ENSPKIP00000024351	ENSPKIP00000005065	Sterol regulatory element binding transcription factor 2.	SREBF chaperone.	0.894
ENSPKIP00000024351	srebf1	ENSPKIP00000024351	ENSPKIP00000038800	Sterol regulatory element binding transcription factor 2.	Sterol regulatory element binding transcription factor 1.	0.456
ENSPKIP00000040244	mlx	ENSPKIP00000040244	ENSPKIP00000000451	MLX interacting protein like.	MAX dimerization protein MLX.	0.932
ENSPKIP00000040244	mxd1	ENSPKIP00000040244	ENSPKIP00000015040	MLX interacting protein like.	MAX dimerization protein 1.	0.402
ENSPKIP00000040244	mxi1	ENSPKIP00000040244	ENSPKIP00000040010	MLX interacting protein like.	Max interactor 1, dimerization protein.	0.473
ENSPKIP00000040453	ENSPKIP00000003228	ENSPKIP00000040453	ENSPKIP00000003228	Transcriptional regulator; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes.	Uncharacterized protein.	0.600
ENSPKIP00000040453	ENSPKIP00000017095	ENSPKIP00000040453	ENSPKIP00000017095	Transcriptional regulator; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes.	Sterol regulatory element binding transcription factor 1.	0.408
ENSPKIP00000040453	ENSPKIP00000024351	ENSPKIP00000040453	ENSPKIP00000024351	Transcriptional regulator; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes.	Sterol regulatory element binding transcription factor 2.	0.408
ENSPKIP00000040453	LOC111835214	ENSPKIP00000040453	ENSPKIP00000020299	Transcriptional regulator; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes.	Myelocytomatosis oncogene homolog.	0.904