(83 nodes) Nuclear receptor binding network (Paramormyrops kingsleyae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	EP300	E1A binding protein p300. (2557 aa)
	LOC111843600	LisH domain-containing protein. (1558 aa)
	nr1h4	Nuclear receptor subfamily 1, group H, member 4. (482 aa)
	NR4A2-2	Nuclear receptor subfamily 4, group A, member 2b. (599 aa)
	LOC111858764	Nuclear receptor subfamily 0, group B, member 1. (261 aa)
	taf10	Transcription initiation factor TFIID subunit 10; TFIID is a multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors; Belongs to the TAF10 family. (232 aa)
	ENSPKIP00000032662	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (664 aa)
	ENSPKIP00000032667	Phorbol-ester/DAG-type domain-containing protein. (58 aa)
	PRKCB	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
	LEF1	Lymphoid enhancer binding factor 1. (373 aa)
	ENSPKIP00000033034	Lymphoid enhancer-binding factor 1. (298 aa)
	LOC111843681	NR LBD domain-containing protein. (264 aa)
	rnf6	Ring finger protein (C3H2C3 type) 6. (634 aa)
	ENSPKIP00000035086	Si:ch211-59d17.3. (903 aa)
	Kdm1a	Lysine-specific histone demethylase; Histone demethylase that demethylates both 'Lys-4' (H3K4me) and 'Lys-9' (H3K9me) of histone H3, thereby acting as a coactivator or a corepressor, depending on the context. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Acts as a corepressor by mediating demethylation of H3K4me, a specific tag for epigenetic transcriptional activation. Demethylates both mono- (H3K4me1) and di-methylated (H3K4me2) H3K4me; Belongs to the flavin monoamine oxidase family. (851 aa)
	nr4a3	Nuclear receptor subfamily 4, group A, member 3. (593 aa)
	TRERF1	Transcriptional regulating factor 1. (1153 aa)
	snw1	SNW domain containing 1. (536 aa)
	ncoa1	Nuclear receptor coactivator 1. (1357 aa)
	ENSPKIP00000037372	CTNNB1_binding domain-containing protein. (130 aa)
	Mms19	MMS19 homolog, cytosolic iron-sulfur assembly component. (1046 aa)
	LOC111847915	Nuclear receptor binding SET domain protein 1a. (2201 aa)
	NR4A1	Nuclear receptor subfamily 4, group A, member 1. (571 aa)
	bud31	BUD31 homolog. (144 aa)
	dcaf13	Ddb1 and cul4 associated factor 13. (445 aa)
	ddx54	ATP-dependent RNA helicase; Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily. (870 aa)
	ppid	Peptidylprolyl isomerase D. (373 aa)
	ENSPKIP00000001033	Nuclear receptor corepressor 1. (2337 aa)
	ENSPKIP00000001455	Peroxisome proliferator-activated receptor gamma, coactivator 1 beta. (754 aa)
	znf366	Zinc finger protein 366. (714 aa)
	daxx	Death-domain associated protein. (737 aa)
	nr0b2	Nuclear receptor subfamily 0, group B, member 2a. (262 aa)
	Med1	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1838 aa)
	BRD8	Bromodomain containing 8. (849 aa)
	med25	Mediator complex subunit 25. (749 aa)
	Tacc2	Uncharacterized protein. (3448 aa)
	NCOA3	Nuclear receptor coactivator 3. (1520 aa)
	dnaaf4	Dynein axonemal assembly factor 4. (416 aa)
	grip1	Glutamate receptor interacting protein 1. (1167 aa)
	tmf1	TATA element modulatory factor 1. (1140 aa)
	ENSPKIP00000006245	Nuclear receptor corepressor 2. (2068 aa)
	LOC111857396	ASCH domain-containing protein. (584 aa)
	CNOT1	CCR4-NOT transcription complex subunit 1. (2373 aa)
	rnf14	RBR-type E3 ubiquitin transferase. (456 aa)
	nkx3-1	NK3 homeobox 1. (226 aa)
	LOC111857468	AT rich interactive domain 5A (MRF1-like). (617 aa)
	LOC111844331	Glutamate receptor interacting protein 1. (1151 aa)
	LOC111849289	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (672 aa)
	gtf2h1	General transcription factor IIH, polypeptide 1. (544 aa)
	Pagr1	PAXIP1 associated glutamate-rich protein 1. (283 aa)
	ENSPKIP00000012944	BCAS3 microtubule associated cell migration factor. (884 aa)
	nrbf2	Nuclear receptor binding factor 2b. (254 aa)
	NR1H3	Nuclear receptor subfamily 1 group H member 3. (465 aa)
	ENSPKIP00000013921	Uncharacterized protein. (428 aa)
	Hmga1	Uncharacterized protein. (126 aa)
	LOC111848121	TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor. (360 aa)
	ENSPKIP00000016034	PPARG coactivator 1 alpha. (1119 aa)
	CNOT1-2	CCR4-NOT transcription complex subunit 1. (2438 aa)
	NR4A2	Nuclear receptor subfamily 4, group A, member 2b. (599 aa)
	ENSPKIP00000017505	Uncharacterized protein. (100 aa)
	Gtf2b	General transcription factor IIB. (321 aa)
	LOC111854407	Peroxisome proliferator-activated receptor gamma, coactivator 1 alpha. (1133 aa)
	LOC111854743	Uncharacterized protein. (579 aa)
	LOC111845232	Uncharacterized protein. (2683 aa)
	sirt1	Deacetylase sirtuin-type domain-containing protein. (735 aa)
	Prpf6	PRP6 pre-mRNA processing factor 6 homolog (S. cerevisiae). (1031 aa)
	DCAF1	DDB1 and CUL4 associated factor 1. (1540 aa)
	LOC111860889	Nuclear receptor interacting protein 1b. (1107 aa)
	PRKCA	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (690 aa)
	LOC111835928	Nucleic_acid_bd domain-containing protein. (2330 aa)
	ncoa6	Nucleic_acid_bd domain-containing protein. (1974 aa)
	ENSPKIP00000023000	Uncharacterized protein. (352 aa)
	LOC111851925	Nuclear receptor subfamily 1, group H, member 3. (449 aa)
	Lrif1	Uncharacterized protein. (358 aa)
	ncoa2	Uncharacterized protein. (1371 aa)
	LOC111837757	Transforming, acidic coiled-coil containing protein 1. (770 aa)
	SMARCE1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1. (424 aa)
	GRIP2	Glutamate receptor interacting protein 2b. (600 aa)
	LOC111843225	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (681 aa)
	LOC111853937	Nuclear receptor subfamily 1, group H, member 5. (508 aa)
	nsd1	Nuclear receptor binding SET domain protein 1b. (2140 aa)
	ENSPKIP00000027011	Thyroid hormone receptor interactor 4. (522 aa)
	nrip1	Nuclear receptor interacting protein 1a. (1128 aa)

Your Current Organism:

Paramormyrops kingsleyae

NCBI taxonomy Id: 1676925
Other names: Brienomyrus kingsleyae, Brienomyrus sp. CAB, Mormyrus kingsleyae, P. kingsleyae, Pollimyrus kingsleyae

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BRD8	snw1	ENSPKIP00000003226	ENSPKIP00000036433	Bromodomain containing 8.	SNW domain containing 1.	0.444
CNOT1	CNOT1-2	ENSPKIP00000007857	ENSPKIP00000016896	CCR4-NOT transcription complex subunit 1.	CCR4-NOT transcription complex subunit 1.	0.900
CNOT1	ddx54	ENSPKIP00000007857	ENSPKIP00000041946	CCR4-NOT transcription complex subunit 1.	ATP-dependent RNA helicase; Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily.	0.459
CNOT1-2	CNOT1	ENSPKIP00000016896	ENSPKIP00000007857	CCR4-NOT transcription complex subunit 1.	CCR4-NOT transcription complex subunit 1.	0.900
CNOT1-2	ddx54	ENSPKIP00000016896	ENSPKIP00000041946	CCR4-NOT transcription complex subunit 1.	ATP-dependent RNA helicase; Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily.	0.459
ENSPKIP00000001033	ENSPKIP00000023000	ENSPKIP00000001033	ENSPKIP00000023000	Nuclear receptor corepressor 1.	Uncharacterized protein.	0.583
ENSPKIP00000001033	EP300	ENSPKIP00000001033	ENSPKIP00000027655	Nuclear receptor corepressor 1.	E1A binding protein p300.	0.658
ENSPKIP00000001033	LOC111835928	ENSPKIP00000001033	ENSPKIP00000021739	Nuclear receptor corepressor 1.	Nucleic_acid_bd domain-containing protein.	0.587
ENSPKIP00000001033	LOC111843681	ENSPKIP00000001033	ENSPKIP00000033872	Nuclear receptor corepressor 1.	NR LBD domain-containing protein.	0.647
ENSPKIP00000001033	LOC111845232	ENSPKIP00000001033	ENSPKIP00000018215	Nuclear receptor corepressor 1.	Uncharacterized protein.	0.658
ENSPKIP00000001033	LOC111851925	ENSPKIP00000001033	ENSPKIP00000023038	Nuclear receptor corepressor 1.	Nuclear receptor subfamily 1, group H, member 3.	0.832
ENSPKIP00000001033	LOC111853937	ENSPKIP00000001033	ENSPKIP00000026750	Nuclear receptor corepressor 1.	Nuclear receptor subfamily 1, group H, member 5.	0.832
ENSPKIP00000001033	LOC111854743	ENSPKIP00000001033	ENSPKIP00000018133	Nuclear receptor corepressor 1.	Uncharacterized protein.	0.538
ENSPKIP00000001033	LOC111858764	ENSPKIP00000001033	ENSPKIP00000032295	Nuclear receptor corepressor 1.	Nuclear receptor subfamily 0, group B, member 1.	0.647
ENSPKIP00000001033	Med1	ENSPKIP00000001033	ENSPKIP00000002844	Nuclear receptor corepressor 1.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.675
ENSPKIP00000001033	NCOA3	ENSPKIP00000001033	ENSPKIP00000004740	Nuclear receptor corepressor 1.	Nuclear receptor coactivator 3.	0.583
ENSPKIP00000001033	NR1H3	ENSPKIP00000001033	ENSPKIP00000013582	Nuclear receptor corepressor 1.	Nuclear receptor subfamily 1 group H member 3.	0.832
ENSPKIP00000001033	NR4A1	ENSPKIP00000001033	ENSPKIP00000039800	Nuclear receptor corepressor 1.	Nuclear receptor subfamily 4, group A, member 1.	0.538
ENSPKIP00000001033	NR4A2	ENSPKIP00000001033	ENSPKIP00000017416	Nuclear receptor corepressor 1.	Nuclear receptor subfamily 4, group A, member 2b.	0.538
ENSPKIP00000001033	NR4A2-2	ENSPKIP00000001033	ENSPKIP00000031642	Nuclear receptor corepressor 1.	Nuclear receptor subfamily 4, group A, member 2b.	0.538