(23 nodes) Megakaryocyte differentiation network (Paramormyrops kingsleyae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC111838606	Sp3 transcription factor. (745 aa)
	LOC111859259	ANK_REP_REGION domain-containing protein. (126 aa)
	uba5	Ubiquitin-like modifier activating enzyme 5. (407 aa)
	ENSPKIP00000040839	Glycoprotein IX (platelet). (266 aa)
	LOC111836858	Serum response factor a. (601 aa)
	ENSPKIP00000039161	Abl interactor 1. (418 aa)
	ENSPKIP00000031300	Cyclin-dependent kinase inhibitor 2A/B (p15, inhibits CDK4). (127 aa)
	ABI1	Abl interactor 1. (524 aa)
	EP300	E1A binding protein p300. (2557 aa)
	LOC111856933	GATA binding protein 1a. (359 aa)
	ptpn6	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (588 aa)
	ENSPKIP00000019866	Homeobox domain-containing protein. (382 aa)
	SP3	Sp3 transcription factor. (730 aa)
	LOC111845232	Uncharacterized protein. (2683 aa)
	ENSPKIP00000018028	Zinc finger protein, FOG family member 1. (1126 aa)
	LOC111853334	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (593 aa)
	Gp1bb	Glycoprotein Ib platelet subunit beta. (216 aa)
	LOC111856129	Uncharacterized protein. (420 aa)
	ENSPKIP00000007905	Protein tyrosine phosphatase non-receptor type 11a. (578 aa)
	LOC111850568	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (594 aa)
	sh2b3	SH2B adaptor protein 3. (656 aa)
	LOC111835754	Serum response factor b. (598 aa)
	Med1	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1838 aa)

Your Current Organism:

Paramormyrops kingsleyae

NCBI taxonomy Id: 1676925
Other names: Brienomyrus kingsleyae, Brienomyrus sp. CAB, Mormyrus kingsleyae, P. kingsleyae, Pollimyrus kingsleyae

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPKIP00000007905	LOC111850568	ENSPKIP00000007905	ENSPKIP00000007894	Protein tyrosine phosphatase non-receptor type 11a.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.900
ENSPKIP00000007905	LOC111853334	ENSPKIP00000007905	ENSPKIP00000013653	Protein tyrosine phosphatase non-receptor type 11a.	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily.	0.901
ENSPKIP00000018028	EP300	ENSPKIP00000018028	ENSPKIP00000027655	Zinc finger protein, FOG family member 1.	E1A binding protein p300.	0.519
ENSPKIP00000018028	LOC111845232	ENSPKIP00000018028	ENSPKIP00000018215	Zinc finger protein, FOG family member 1.	Uncharacterized protein.	0.519
ENSPKIP00000018028	LOC111856129	ENSPKIP00000018028	ENSPKIP00000008633	Zinc finger protein, FOG family member 1.	Uncharacterized protein.	0.912
ENSPKIP00000018028	LOC111856933	ENSPKIP00000018028	ENSPKIP00000026015	Zinc finger protein, FOG family member 1.	GATA binding protein 1a.	0.912
ENSPKIP00000040839	Gp1bb	ENSPKIP00000040839	ENSPKIP00000009618	Glycoprotein IX (platelet).	Glycoprotein Ib platelet subunit beta.	0.907
EP300	ENSPKIP00000018028	ENSPKIP00000027655	ENSPKIP00000018028	E1A binding protein p300.	Zinc finger protein, FOG family member 1.	0.519
EP300	LOC111845232	ENSPKIP00000027655	ENSPKIP00000018215	E1A binding protein p300.	Uncharacterized protein.	0.901
EP300	LOC111856129	ENSPKIP00000027655	ENSPKIP00000008633	E1A binding protein p300.	Uncharacterized protein.	0.694
EP300	LOC111856933	ENSPKIP00000027655	ENSPKIP00000026015	E1A binding protein p300.	GATA binding protein 1a.	0.694
EP300	Med1	ENSPKIP00000027655	ENSPKIP00000002844	E1A binding protein p300.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.728
Gp1bb	ENSPKIP00000040839	ENSPKIP00000009618	ENSPKIP00000040839	Glycoprotein Ib platelet subunit beta.	Glycoprotein IX (platelet).	0.907
LOC111835754	LOC111836858	ENSPKIP00000006616	ENSPKIP00000039545	Serum response factor b.	Serum response factor a.	0.902
LOC111836858	LOC111835754	ENSPKIP00000039545	ENSPKIP00000006616	Serum response factor a.	Serum response factor b.	0.902
LOC111845232	ENSPKIP00000018028	ENSPKIP00000018215	ENSPKIP00000018028	Uncharacterized protein.	Zinc finger protein, FOG family member 1.	0.519
LOC111845232	EP300	ENSPKIP00000018215	ENSPKIP00000027655	Uncharacterized protein.	E1A binding protein p300.	0.901
LOC111845232	LOC111856129	ENSPKIP00000018215	ENSPKIP00000008633	Uncharacterized protein.	Uncharacterized protein.	0.694
LOC111845232	LOC111856933	ENSPKIP00000018215	ENSPKIP00000026015	Uncharacterized protein.	GATA binding protein 1a.	0.694
LOC111845232	Med1	ENSPKIP00000018215	ENSPKIP00000002844	Uncharacterized protein.	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.	0.728