(29 nodes) Positive regulation of response to cytokine stimulus network (Paramormyrops kingsleyae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	rnf185	Ring finger protein 185. (191 aa)
	DDX58	DExD/H-box helicase 58. (921 aa)
	ENSPKIP00000038987	CARD_2 domain-containing protein. (454 aa)
	ENSPKIP00000038948	CARD_2 domain-containing protein. (281 aa)
	Csf1	Uncharacterized protein. (276 aa)
	UBE2K-2	Ubiquitin conjugating enzyme E2 K; Belongs to the ubiquitin-conjugating enzyme family. (118 aa)
	c1qtnf4	C1q and TNF related 4. (369 aa)
	ENSPKIP00000030443	Uncharacterized protein. (158 aa)
	gas6	Uncharacterized protein. (654 aa)
	ENSPKIP00000024557	Uncharacterized protein. (684 aa)
	ENSPKIP00000024234	Receptor-interacting serine-threonine kinase 2. (563 aa)
	dhx9	DEAH (Asp-Glu-Ala-His) box helicase 9. (1286 aa)
	supt5h	Transcription elongation factor SPT5. (1083 aa)
	prkn	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (483 aa)
	fadd	Fas associated via death domain. (226 aa)
	trim32	Tripartite motif containing 32. (670 aa)
	UBE2K	Ubiquitin conjugating enzyme E2 K; Belongs to the ubiquitin-conjugating enzyme family. (222 aa)
	LSM14A-2	LSM14A mRNA processing body assembly factor. (480 aa)
	ikbke	Inhibitor of nuclear factor kappa B kinase subunit epsilon. (710 aa)
	tbk1	TANK-binding kinase 1. (727 aa)
	Ifih1	Interferon induced with helicase C domain 1. (1009 aa)
	LSM14A	LSM14A mRNA processing body assembly factor b. (502 aa)
	trim44	Tripartite motif containing 44. (296 aa)
	Med1	Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1838 aa)
	ENSPKIP00000001459	Disintegrin domain-containing protein. (92 aa)
	ENSPKIP00000001430	Pep_M12B_propep domain-containing protein. (292 aa)
	ENSPKIP00000021895	Interferon regulatory factor 3. (436 aa)
	ENSPKIP00000017947	Adhesion G protein-coupled receptor G1. (537 aa)
	edn1	Endothelin 1. (167 aa)

Your Current Organism:

Paramormyrops kingsleyae

NCBI taxonomy Id: 1676925
Other names: Brienomyrus kingsleyae, Brienomyrus sp. CAB, Mormyrus kingsleyae, P. kingsleyae, Pollimyrus kingsleyae

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
DDX58	ENSPKIP00000021895	ENSPKIP00000040060	ENSPKIP00000021895	DExD/H-box helicase 58.	Interferon regulatory factor 3.	0.769
DDX58	ENSPKIP00000038948	ENSPKIP00000040060	ENSPKIP00000038948	DExD/H-box helicase 58.	CARD_2 domain-containing protein.	0.942
DDX58	ENSPKIP00000038987	ENSPKIP00000040060	ENSPKIP00000038987	DExD/H-box helicase 58.	CARD_2 domain-containing protein.	0.942
DDX58	Ifih1	ENSPKIP00000040060	ENSPKIP00000013751	DExD/H-box helicase 58.	Interferon induced with helicase C domain 1.	0.888
DDX58	fadd	ENSPKIP00000040060	ENSPKIP00000021485	DExD/H-box helicase 58.	Fas associated via death domain.	0.426
DDX58	ikbke	ENSPKIP00000040060	ENSPKIP00000019560	DExD/H-box helicase 58.	Inhibitor of nuclear factor kappa B kinase subunit epsilon.	0.526
DDX58	tbk1	ENSPKIP00000040060	ENSPKIP00000015737	DExD/H-box helicase 58.	TANK-binding kinase 1.	0.526
ENSPKIP00000017947	fadd	ENSPKIP00000017947	ENSPKIP00000021485	Adhesion G protein-coupled receptor G1.	Fas associated via death domain.	0.738
ENSPKIP00000017947	prkn	ENSPKIP00000017947	ENSPKIP00000016560	Adhesion G protein-coupled receptor G1.	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily.	0.514
ENSPKIP00000021895	DDX58	ENSPKIP00000021895	ENSPKIP00000040060	Interferon regulatory factor 3.	DExD/H-box helicase 58.	0.769
ENSPKIP00000021895	ENSPKIP00000038948	ENSPKIP00000021895	ENSPKIP00000038948	Interferon regulatory factor 3.	CARD_2 domain-containing protein.	0.872
ENSPKIP00000021895	ENSPKIP00000038987	ENSPKIP00000021895	ENSPKIP00000038987	Interferon regulatory factor 3.	CARD_2 domain-containing protein.	0.872
ENSPKIP00000021895	Ifih1	ENSPKIP00000021895	ENSPKIP00000013751	Interferon regulatory factor 3.	Interferon induced with helicase C domain 1.	0.739
ENSPKIP00000021895	ikbke	ENSPKIP00000021895	ENSPKIP00000019560	Interferon regulatory factor 3.	Inhibitor of nuclear factor kappa B kinase subunit epsilon.	0.924
ENSPKIP00000021895	tbk1	ENSPKIP00000021895	ENSPKIP00000015737	Interferon regulatory factor 3.	TANK-binding kinase 1.	0.951
ENSPKIP00000021895	trim32	ENSPKIP00000021895	ENSPKIP00000021166	Interferon regulatory factor 3.	Tripartite motif containing 32.	0.414
ENSPKIP00000024234	fadd	ENSPKIP00000024234	ENSPKIP00000021485	Receptor-interacting serine-threonine kinase 2.	Fas associated via death domain.	0.738
ENSPKIP00000024234	prkn	ENSPKIP00000024234	ENSPKIP00000016560	Receptor-interacting serine-threonine kinase 2.	E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily.	0.514
ENSPKIP00000024557	trim32	ENSPKIP00000024557	ENSPKIP00000021166	Uncharacterized protein.	Tripartite motif containing 32.	0.722
ENSPKIP00000038948	DDX58	ENSPKIP00000038948	ENSPKIP00000040060	CARD_2 domain-containing protein.	DExD/H-box helicase 58.	0.942