(91 nodes) Intrinsic apoptotic signaling pathway network (Paramormyrops kingsleyae)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	fnip2	Si:ch211-42i9.8. (1027 aa)
	apopt1	Cytochrome c oxidase assembly factor 8. (201 aa)
	LOC111839152	Zgc:73226. (192 aa)
	WHAMM	WASP homolog associated with actin, golgi membranes and microtubules. (774 aa)
	LOC111834507	G_PROTEIN_RECEP_F1_2 domain-containing protein; Belongs to the G-protein coupled receptor 1 family. (354 aa)
	skil	SKI-like proto-oncogene a. (703 aa)
	cdip1	Cell death-inducing p53 target 1. (192 aa)
	ENSPKIP00000003758	Bclx_interact domain-containing protein. (190 aa)
	znf385b	Zinc finger protein 385B. (542 aa)
	Mlh1	MutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli). (776 aa)
	Bax	BCL2 associated X, apoptosis regulator a. (194 aa)
	LOC111841778	Bradykinin receptor B2; Belongs to the G-protein coupled receptor 1 family. (356 aa)
	brca1	Uncharacterized protein. (1439 aa)
	tmem117	Transmembrane protein 117. (518 aa)
	fhit	Bis(5'-adenosyl)-triphosphatase. (160 aa)
	e2f1	E2F transcription factor 1. (433 aa)
	LOC111835171	BCL2 like 1. (237 aa)
	rrp8	Ribosomal RNA-processing protein 8; Probable methyltransferase required to silence rDNA. Belongs to the methyltransferase superfamily. RRP8 family. (564 aa)
	LOC111856806	Diablo, IAP-binding mitochondrial protein a. (261 aa)
	rps19	Ribosomal protein S19. (145 aa)
	arl6ip5	PRA1 family protein. (190 aa)
	LOC111856855	PYD and CARD domain containing. (207 aa)
	bad	BCL2 associated agonist of cell death b. (169 aa)
	casp2	Caspase 2, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (435 aa)
	LOC111860667	MCL1 apoptosis regulator, BCL2 family member a. (271 aa)
	brca2	BRCA2 DNA repair associated. (2995 aa)
	Ier3	Zgc:158343. (155 aa)
	PHLDA3	Pleckstrin homology like domain family A member 3. (138 aa)
	msh6	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (1374 aa)
	ddit3	DNA-damage-inducible transcript 3. (288 aa)
	LOC111849410	BCL2 family apoptosis regulator BOK a. (167 aa)
	LOC111845833	BCL2 apoptosis regulator b. (219 aa)
	ENSPKIP00000017302	Cytochrome P450, family 1, subfamily C, polypeptide 2; Belongs to the cytochrome P450 family. (519 aa)
	aifm1	Apoptosis inducing factor mitochondrion associated 1. (675 aa)
	LOC111845232	Uncharacterized protein. (2683 aa)
	LOC111835869	Glutamine-rich 1. (706 aa)
	ENSPKIP00000018370	Uncharacterized protein. (297 aa)
	ENSPKIP00000019240	Uncharacterized protein. (192 aa)
	ATF4	Activating transcription factor 4a. (403 aa)
	sirt1	Deacetylase sirtuin-type domain-containing protein. (735 aa)
	Atad5	ATPase family AAA domain containing 5a. (1761 aa)
	BAK1	BCL2 antagonist/killer 1. (300 aa)
	ern1	Endoplasmic reticulum to nucleus signaling 1. (993 aa)
	LOC111851814	Zgc:153993. (202 aa)
	IVNS1ABP	Influenza virus NS1A binding protein. (640 aa)
	LOC111855657	CCAAT/enhancer-binding protein. (286 aa)
	TP63	Tumor protein p63. (478 aa)
	LOC111841368	Uncharacterized protein. (389 aa)
	LOC111835975	BZIP domain-containing protein. (406 aa)
	ENSPKIP00000024784	Nuclear factor of activated T cells 4. (853 aa)
	znf622	Zinc finger protein 622. (468 aa)
	pdx1	Pancreatic and duodenal homeobox 1. (280 aa)
	ENSPKIP00000025838	CASPASE_P20 domain-containing protein; Belongs to the peptidase C14A family. (176 aa)
	LOC111855875	Caspase 9, apoptosis-related cysteine peptidase; Belongs to the peptidase C14A family. (426 aa)
	LOC111855646	Uncharacterized protein; Belongs to the peptidase C14A family. (637 aa)
	msh2	MutS homolog 2 (E. coli); Component of the post-replicative DNA mismatch repair system (MMR). (786 aa)
	LOC111849531	Cytochrome P450, family 1, subfamily B, polypeptide 1; Belongs to the cytochrome P450 family. (534 aa)
	EP300	E1A binding protein p300. (2557 aa)
	Usp47	Ubiquitin specific peptidase 47; Belongs to the peptidase C19 family. (1386 aa)
	Stk11	Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (445 aa)
	ENSPKIP00000029729	MCL1 apoptosis regulator, BCL2 family member b. (295 aa)
	bag6	BCL2 associated athanogene 6, like. (1217 aa)
	LOC111855255	Pleckstrin homology-like domain, family A, member 3. (129 aa)
	qrich1	Glutamine-rich 1. (754 aa)
	LOC111859073	Uncharacterized protein. (379 aa)
	flcn	Folliculin. (614 aa)
	LOC111839033	BCL2 associated athanogene 6. (1194 aa)
	chek2	Checkpoint kinase 2. (507 aa)
	Atm	Non-specific serine/threonine protein kinase. (3029 aa)
	ENSPKIP00000032643	Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (3873 aa)
	eda2r	Ectodysplasin A2 receptor. (365 aa)
	ern2	Endoplasmic reticulum to nucleus signaling 2. (963 aa)
	LOC111857110	Tumor necrosis factor receptor superfamily, member 1B. (375 aa)
	LOC111837934	Uncharacterized protein. (259 aa)
	tp73	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (657 aa)
	casp6	Caspase 6, apoptosis-related cysteine peptidase a; Belongs to the peptidase C14A family. (296 aa)
	LOC111839110	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (637 aa)
	snw1	SNW domain containing 1. (536 aa)
	JMY	Junction mediating and regulatory protein, p53 cofactor. (901 aa)
	LOC111861108	Tribbles pseudokinase 3. (358 aa)
	ENSPKIP00000039051	Nuclear protein 1a. (77 aa)
	LOC111841041	Influenza virus NS1A binding protein b. (639 aa)
	ercc6	Excision repair cross-complementation group 6. (1376 aa)
	ENSPKIP00000040002	Im:7152348. (134 aa)
	LOC111851660	BCL2 apoptosis regulator a. (230 aa)
	JMY-2	Junction mediating and regulatory protein, p53 cofactor. (909 aa)
	LOC111853470	SKI-like proto-oncogene b. (715 aa)
	bnip3	BCL2 interacting protein 3. (191 aa)
	ENSPKIP00000041220	Uncharacterized protein. (250 aa)
	ENSPKIP00000041258	BH4_2 domain-containing protein. (226 aa)
	LOC111846716	BCL2 like 10. (176 aa)

Your Current Organism:

Paramormyrops kingsleyae

NCBI taxonomy Id: 1676925
Other names: Brienomyrus kingsleyae, Brienomyrus sp. CAB, Mormyrus kingsleyae, P. kingsleyae, Pollimyrus kingsleyae

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ATF4	EP300	ENSPKIP00000019346	ENSPKIP00000027655	Activating transcription factor 4a.	E1A binding protein p300.	0.541
ATF4	LOC111835975	ENSPKIP00000019346	ENSPKIP00000023812	Activating transcription factor 4a.	BZIP domain-containing protein.	0.904
ATF4	LOC111845232	ENSPKIP00000019346	ENSPKIP00000018215	Activating transcription factor 4a.	Uncharacterized protein.	0.541
ATF4	LOC111855657	ENSPKIP00000019346	ENSPKIP00000023114	Activating transcription factor 4a.	CCAAT/enhancer-binding protein.	0.898
ATF4	LOC111861108	ENSPKIP00000019346	ENSPKIP00000038317	Activating transcription factor 4a.	Tribbles pseudokinase 3.	0.774
ATF4	ddit3	ENSPKIP00000019346	ENSPKIP00000016444	Activating transcription factor 4a.	DNA-damage-inducible transcript 3.	0.980
Atad5	Atm	ENSPKIP00000020118	ENSPKIP00000032528	ATPase family AAA domain containing 5a.	Non-specific serine/threonine protein kinase.	0.625
Atad5	Mlh1	ENSPKIP00000020118	ENSPKIP00000004259	ATPase family AAA domain containing 5a.	MutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli).	0.403
Atad5	brca1	ENSPKIP00000020118	ENSPKIP00000006458	ATPase family AAA domain containing 5a.	Uncharacterized protein.	0.709
Atad5	brca2	ENSPKIP00000020118	ENSPKIP00000013632	ATPase family AAA domain containing 5a.	BRCA2 DNA repair associated.	0.728
Atad5	chek2	ENSPKIP00000020118	ENSPKIP00000032063	ATPase family AAA domain containing 5a.	Checkpoint kinase 2.	0.616
Atad5	msh2	ENSPKIP00000020118	ENSPKIP00000026384	ATPase family AAA domain containing 5a.	MutS homolog 2 (E. coli); Component of the post-replicative DNA mismatch repair system (MMR).	0.491
Atad5	msh6	ENSPKIP00000020118	ENSPKIP00000016214	ATPase family AAA domain containing 5a.	DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR).	0.569
Atm	Atad5	ENSPKIP00000032528	ENSPKIP00000020118	Non-specific serine/threonine protein kinase.	ATPase family AAA domain containing 5a.	0.625
Atm	ENSPKIP00000032643	ENSPKIP00000032528	ENSPKIP00000032643	Non-specific serine/threonine protein kinase.	Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family.	0.785
Atm	EP300	ENSPKIP00000032528	ENSPKIP00000027655	Non-specific serine/threonine protein kinase.	E1A binding protein p300.	0.428
Atm	LOC111839110	ENSPKIP00000032528	ENSPKIP00000034849	Non-specific serine/threonine protein kinase.	Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes.	0.743
Atm	LOC111845232	ENSPKIP00000032528	ENSPKIP00000018215	Non-specific serine/threonine protein kinase.	Uncharacterized protein.	0.428
Atm	Mlh1	ENSPKIP00000032528	ENSPKIP00000004259	Non-specific serine/threonine protein kinase.	MutL homolog 1, colon cancer, nonpolyposis type 2 (E. coli).	0.853
Atm	Stk11	ENSPKIP00000032528	ENSPKIP00000029484	Non-specific serine/threonine protein kinase.	Serine/threonine kinase 11; Belongs to the protein kinase superfamily.	0.633