(26 nodes) BRCT domain superfamily network (Paramormyrops kingsleyae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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Your Input:
	Rev1	DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family. (1188 aa)
	Mcph1	Microcephalin 1. (889 aa)
	Paxip1	PAX interacting (with transcription-activation domain) protein 1. (866 aa)
	slf1	SMC5-SMC6 complex localization factor 1. (885 aa)
	Lig4	DNA ligase. (921 aa)
	ENSPKIP00000037476	DNA-directed DNA/RNA polymerase mu; Gap-filling polymerase involved in repair of DNA double- strand breaks by non-homologous end joining (NHEJ). Belongs to the DNA polymerase type-X family. (461 aa)
	tp53bp1	Tumor protein p53 binding protein, 1. (1913 aa)
	topbp1	DNA topoisomerase II binding protein 1. (1524 aa)
	LOC111846959	Uncharacterized protein. (1070 aa)
	SMARCC1	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1a. (1087 aa)
	Xrcc1	X-ray repair complementing defective repair in Chinese hamster cells 1. (617 aa)
	chd1l	Chromodomain helicase DNA binding protein 1-like. (1001 aa)
	brca1	Uncharacterized protein. (1439 aa)
	LOC111856126	DBF4-type domain-containing protein. (781 aa)
	ect2	Epithelial cell transforming 2. (913 aa)
	bard1	BRCA1 associated RING domain 1. (759 aa)
	pes1	Pescadillo homolog; Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome. (600 aa)
	Nbn	Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (777 aa)
	poll	Polymerase (DNA directed), lambda; Belongs to the DNA polymerase type-X family. (554 aa)
	ctdp1	RNA polymerase II subunit A C-terminal domain phosphatase; This promotes the activity of RNA polymerase II. (966 aa)
	rfc1	Replication factor C subunit 1. (1155 aa)
	parp1	Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1011 aa)
	Smarcc2	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2. (1102 aa)
	polm	DNA-directed DNA/RNA polymerase mu; Gap-filling polymerase involved in repair of DNA double- strand breaks by non-homologous end joining (NHEJ). Belongs to the DNA polymerase type-X family. (587 aa)
	lig3	DNA ligase. (1016 aa)
	LOC111854658	Epithelial cell transforming 2. (899 aa)

Your Current Organism:

Paramormyrops kingsleyae

NCBI taxonomy Id: 1676925
Other names: Brienomyrus kingsleyae, Brienomyrus sp. CAB, Mormyrus kingsleyae, P. kingsleyae, Pollimyrus kingsleyae

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ENSPKIP00000037476	Lig4	ENSPKIP00000037476	ENSPKIP00000030973	DNA-directed DNA/RNA polymerase mu; Gap-filling polymerase involved in repair of DNA double- strand breaks by non-homologous end joining (NHEJ). Belongs to the DNA polymerase type-X family.	DNA ligase.	0.779
ENSPKIP00000037476	Rev1	ENSPKIP00000037476	ENSPKIP00000030248	DNA-directed DNA/RNA polymerase mu; Gap-filling polymerase involved in repair of DNA double- strand breaks by non-homologous end joining (NHEJ). Belongs to the DNA polymerase type-X family.	DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family.	0.410
ENSPKIP00000037476	Xrcc1	ENSPKIP00000037476	ENSPKIP00000004872	DNA-directed DNA/RNA polymerase mu; Gap-filling polymerase involved in repair of DNA double- strand breaks by non-homologous end joining (NHEJ). Belongs to the DNA polymerase type-X family.	X-ray repair complementing defective repair in Chinese hamster cells 1.	0.815
ENSPKIP00000037476	lig3	ENSPKIP00000037476	ENSPKIP00000029789	DNA-directed DNA/RNA polymerase mu; Gap-filling polymerase involved in repair of DNA double- strand breaks by non-homologous end joining (NHEJ). Belongs to the DNA polymerase type-X family.	DNA ligase.	0.712
ENSPKIP00000037476	parp1	ENSPKIP00000037476	ENSPKIP00000021872	DNA-directed DNA/RNA polymerase mu; Gap-filling polymerase involved in repair of DNA double- strand breaks by non-homologous end joining (NHEJ). Belongs to the DNA polymerase type-X family.	Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair.	0.457
ENSPKIP00000037476	poll	ENSPKIP00000037476	ENSPKIP00000014142	DNA-directed DNA/RNA polymerase mu; Gap-filling polymerase involved in repair of DNA double- strand breaks by non-homologous end joining (NHEJ). Belongs to the DNA polymerase type-X family.	Polymerase (DNA directed), lambda; Belongs to the DNA polymerase type-X family.	0.553
LOC111846959	Smarcc2	ENSPKIP00000004743	ENSPKIP00000025977	Uncharacterized protein.	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 2.	0.428
LOC111846959	chd1l	ENSPKIP00000004743	ENSPKIP00000005560	Uncharacterized protein.	Chromodomain helicase DNA binding protein 1-like.	0.410
LOC111856126	Rev1	ENSPKIP00000006795	ENSPKIP00000030248	DBF4-type domain-containing protein.	DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family.	0.563
LOC111856126	poll	ENSPKIP00000006795	ENSPKIP00000014142	DBF4-type domain-containing protein.	Polymerase (DNA directed), lambda; Belongs to the DNA polymerase type-X family.	0.407
LOC111856126	slf1	ENSPKIP00000006795	ENSPKIP00000031745	DBF4-type domain-containing protein.	SMC5-SMC6 complex localization factor 1.	0.487
LOC111856126	topbp1	ENSPKIP00000006795	ENSPKIP00000030740	DBF4-type domain-containing protein.	DNA topoisomerase II binding protein 1.	0.539
Lig4	ENSPKIP00000037476	ENSPKIP00000030973	ENSPKIP00000037476	DNA ligase.	DNA-directed DNA/RNA polymerase mu; Gap-filling polymerase involved in repair of DNA double- strand breaks by non-homologous end joining (NHEJ). Belongs to the DNA polymerase type-X family.	0.779
Lig4	Mcph1	ENSPKIP00000030973	ENSPKIP00000037208	DNA ligase.	Microcephalin 1.	0.424
Lig4	Nbn	ENSPKIP00000030973	ENSPKIP00000012676	DNA ligase.	Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis.	0.817
Lig4	Paxip1	ENSPKIP00000030973	ENSPKIP00000033173	DNA ligase.	PAX interacting (with transcription-activation domain) protein 1.	0.441
Lig4	Rev1	ENSPKIP00000030973	ENSPKIP00000030248	DNA ligase.	DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family.	0.725
Lig4	Xrcc1	ENSPKIP00000030973	ENSPKIP00000004872	DNA ligase.	X-ray repair complementing defective repair in Chinese hamster cells 1.	0.918
Lig4	bard1	ENSPKIP00000030973	ENSPKIP00000008335	DNA ligase.	BRCA1 associated RING domain 1.	0.525
Lig4	brca1	ENSPKIP00000030973	ENSPKIP00000006458	DNA ligase.	Uncharacterized protein.	0.614