(25 nodes) Translesion synthesis by POLK network (Paramormyrops kingsleyae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	rfc4	Replication factor C (activator 1) 4. (357 aa)
	LOC111858065	Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2. (618 aa)
	rps27a	Ribosomal protein S27a. (156 aa)
	rev3l	REV3 like, DNA directed polymerase zeta catalytic subunit. (3106 aa)
	UBB	Ubiquitin B. (230 aa)
	LOC111861157	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa)
	rfc3	Replication factor C (activator 1) 3. (356 aa)
	polk	Polymerase (DNA directed) kappa. (894 aa)
	rfc2	Replication factor C (activator 1) 2. (351 aa)
	mad2l2	Mitotic arrest deficient 2 like 2. (251 aa)
	LOC111856488	Ubiquitin-like domain-containing protein. (95 aa)
	LOC111843688	BTB domain-containing protein. (532 aa)
	ENSPKIP00000032000	Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1. (612 aa)
	Rev1	DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family. (1188 aa)
	rpa3	Replication protein A3. (123 aa)
	LOC111851430	Ubiquitin-like domain-containing protein. (77 aa)
	rfc5	Replication factor C (activator 1) 5. (336 aa)
	rpa1	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (610 aa)
	uba52	Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
	Atad5	ATPase family AAA domain containing 5a. (1761 aa)
	rpa2	Replication protein A2. (339 aa)
	rfc1	Replication factor C subunit 1. (1155 aa)
	kxd1	KxDL motif containing 1. (178 aa)
	meiob	Methionine sulfoxide reductase B1b. (468 aa)
	PCNA	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa)

Your Current Organism:

Paramormyrops kingsleyae

NCBI taxonomy Id: 1676925
Other names: Brienomyrus kingsleyae, Brienomyrus sp. CAB, Mormyrus kingsleyae, P. kingsleyae, Pollimyrus kingsleyae

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
Atad5	LOC111856488	ENSPKIP00000020118	ENSPKIP00000033649	ATPase family AAA domain containing 5a.	Ubiquitin-like domain-containing protein.	0.553
Atad5	LOC111861157	ENSPKIP00000020118	ENSPKIP00000000082	ATPase family AAA domain containing 5a.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.956
Atad5	PCNA	ENSPKIP00000020118	ENSPKIP00000013621	ATPase family AAA domain containing 5a.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.956
Atad5	Rev1	ENSPKIP00000020118	ENSPKIP00000030248	ATPase family AAA domain containing 5a.	DNA repair protein REV1; Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template- dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents; Belongs to the DNA polymerase type-Y family.	0.727
Atad5	UBB	ENSPKIP00000020118	ENSPKIP00000000715	ATPase family AAA domain containing 5a.	Ubiquitin B.	0.455
Atad5	mad2l2	ENSPKIP00000020118	ENSPKIP00000034924	ATPase family AAA domain containing 5a.	Mitotic arrest deficient 2 like 2.	0.718
Atad5	meiob	ENSPKIP00000020118	ENSPKIP00000014914	ATPase family AAA domain containing 5a.	Methionine sulfoxide reductase B1b.	0.820
Atad5	polk	ENSPKIP00000020118	ENSPKIP00000037228	ATPase family AAA domain containing 5a.	Polymerase (DNA directed) kappa.	0.712
Atad5	rev3l	ENSPKIP00000020118	ENSPKIP00000000833	ATPase family AAA domain containing 5a.	REV3 like, DNA directed polymerase zeta catalytic subunit.	0.818
Atad5	rfc1	ENSPKIP00000020118	ENSPKIP00000019044	ATPase family AAA domain containing 5a.	Replication factor C subunit 1.	0.695
Atad5	rfc2	ENSPKIP00000020118	ENSPKIP00000037198	ATPase family AAA domain containing 5a.	Replication factor C (activator 1) 2.	0.986
Atad5	rfc3	ENSPKIP00000020118	ENSPKIP00000038719	ATPase family AAA domain containing 5a.	Replication factor C (activator 1) 3.	0.991
Atad5	rfc4	ENSPKIP00000020118	ENSPKIP00000006614	ATPase family AAA domain containing 5a.	Replication factor C (activator 1) 4.	0.990
Atad5	rfc5	ENSPKIP00000020118	ENSPKIP00000026845	ATPase family AAA domain containing 5a.	Replication factor C (activator 1) 5.	0.988
Atad5	rpa1	ENSPKIP00000020118	ENSPKIP00000025037	ATPase family AAA domain containing 5a.	Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.	0.820
Atad5	rpa2	ENSPKIP00000020118	ENSPKIP00000019085	ATPase family AAA domain containing 5a.	Replication protein A2.	0.625
Atad5	rpa3	ENSPKIP00000020118	ENSPKIP00000029114	ATPase family AAA domain containing 5a.	Replication protein A3.	0.674
Atad5	rps27a	ENSPKIP00000020118	ENSPKIP00000004347	ATPase family AAA domain containing 5a.	Ribosomal protein S27a.	0.553
LOC111851430	LOC111856488	ENSPKIP00000027611	ENSPKIP00000033649	Ubiquitin-like domain-containing protein.	Ubiquitin-like domain-containing protein.	0.973
LOC111851430	LOC111861157	ENSPKIP00000027611	ENSPKIP00000000082	Ubiquitin-like domain-containing protein.	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family.	0.831