Your Input: | |
| | rfc3 | Replication factor C (activator 1) 3. (356 aa) |
| | ENSPKIP00000039871 | Uncharacterized protein. (397 aa) |
| | ENSPKIP00000040065 | Reverse transcriptase domain-containing protein. (268 aa) |
| | top3a | DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (989 aa) |
| | RAD51AP1 | RAD51 associated protein 1. (351 aa) |
| | XRCC2 | X-ray repair cross complementing 2. (284 aa) |
| | LOC111844327 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (154 aa) |
| | ABL1 | Tyrosine-protein kinase. (1121 aa) |
| | rad51b | RAD51 paralog B. (384 aa) |
| | LOC111854468 | Structure-specific endonuclease subunit SLX1; Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. (273 aa) |
| | ENSPKIP00000024136 | UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (188 aa) |
| | Exd2 | Exonuclease 3'-5' domain containing 2. (630 aa) |
| | parp2 | Poly [ADP-ribose] polymerase. (572 aa) |
| | fen1 | Flap endonuclease 1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site- terminated flap. Acts as [...] (380 aa) |
| | rpa1 | Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (610 aa) |
| | brcc3 | BRCA1/BRCA2-containing complex, subunit 3. (260 aa) |
| | ENSPKIP00000025247 | Histone H2A; Belongs to the histone H2A family. (141 aa) |
| | DNA2 | DNA replication helicase/nuclease 2. (1345 aa) |
| | EME2 | Essential meiotic structure-specific endonuclease subunit 2. (443 aa) |
| | babam1 | BRISC and BRCA1 A complex member 1. (355 aa) |
| | ankrd12 | Ankyrin repeat domain 12. (2030 aa) |
| | ANKRD11 | Ankyrin repeat domain 11. (2812 aa) |
| | tdrd3 | Tudor domain containing 3. (704 aa) |
| | blm | BLM RecQ like helicase. (1442 aa) |
| | LOC111858369 | Small ubiquitin-related modifier. (94 aa) |
| | rfc5 | Replication factor C (activator 1) 5. (336 aa) |
| | PWWP2A | PWWP domain containing 2A. (1028 aa) |
| | uimc1 | Uncharacterized protein. (974 aa) |
| | ENSPKIP00000027153 | Reverse transcriptase domain-containing protein. (231 aa) |
| | xrcc3 | DNA repair protein; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions; Belongs to the RecA family. RAD51 subfamily. (357 aa) |
| | ENSPKIP00000027503 | Exonuclease 1. (575 aa) |
| | LOC111851430 | Ubiquitin-like domain-containing protein. (77 aa) |
| | sirt7 | Sirtuin 7. (408 aa) |
| | rpa3 | Replication protein A3. (123 aa) |
| | lig3 | DNA ligase. (1016 aa) |
| | rad51d | RAD51 paralog D. (342 aa) |
| | LOC111860945 | Essential meiotic structure-specific endonuclease 1. (561 aa) |
| | Sirt6 | Sirtuin 6. (386 aa) |
| | LOC111836641 | Uncharacterized protein. (499 aa) |
| | ENSPKIP00000030577 | Histone H2B; Belongs to the histone H2B family. (113 aa) |
| | H2BC8 | Histone domain-containing protein; Belongs to the histone H2B family. (117 aa) |
| | topbp1 | DNA topoisomerase II binding protein 1. (1524 aa) |
| | LOC111861157 | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa) |
| | ENSPKIP00000000237 | ANK_REP_REGION domain-containing protein. (1296 aa) |
| | rad9a | Cell cycle checkpoint control protein; Belongs to the rad9 family. (399 aa) |
| | UBB | Ubiquitin B. (230 aa) |
| | kat5 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (558 aa) |
| | CDCA7L | Cell division cycle associated 7 like. (311 aa) |
| | LOC111844425 | Histone H2B; Belongs to the histone H2B family. (124 aa) |
| | recql4 | RecQ helicase-like 4. (1512 aa) |
| | pold1 | DNA polymerase. (1105 aa) |
| | ENSPKIP00000002756 | Reverse transcriptase domain-containing protein. (1051 aa) |
| | ENSPKIP00000003094 | Histone H2B; Belongs to the histone H2B family. (116 aa) |
| | ENSPKIP00000003127 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (93 aa) |
| | ENSPKIP00000003264 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (93 aa) |
| | rad52 | RAD52 homolog, DNA repair protein. (448 aa) |
| | ENSPKIP00000003555 | Histone H2A; Belongs to the histone H2A family. (129 aa) |
| | ENSPKIP00000003629 | Histone H2B; Belongs to the histone H2B family. (164 aa) |
| | polh | Polymerase (DNA directed), eta. (713 aa) |
| | ENSPKIP00000004039 | Histone H2B; Belongs to the histone H2B family. (67 aa) |
| | ENSPKIP00000004111 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (86 aa) |
| | rps27a | Ribosomal protein S27a. (156 aa) |
| | abraxas1 | Abraxas 1, BRCA1 A complex subunit. (377 aa) |
| | ENSPKIP00000004764 | RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae). (494 aa) |
| | Xrcc1 | X-ray repair complementing defective repair in Chinese hamster cells 1. (617 aa) |
| | LOC111858065 | Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2. (618 aa) |
| | Atr | ATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2574 aa) |
| | Mre11 | Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (713 aa) |
| | babam2 | BRISC and BRCA1 A complex member 2. (395 aa) |
| | ENSPKIP00000006289 | Ig-like domain-containing protein. (136 aa) |
| | brca1 | Uncharacterized protein. (1439 aa) |
| | rfc4 | Replication factor C (activator 1) 4. (357 aa) |
| | ccna1 | Cyclin A1; Belongs to the cyclin family. (418 aa) |
| | LOC111834205 | Small ubiquitin-related modifier. (95 aa) |
| | pole2 | DNA polymerase epsilon subunit; Participates in DNA repair and in chromosomal DNA replication; Belongs to the DNA polymerase epsilon subunit B family. (527 aa) |
| | ENSPKIP00000009388 | Protein phosphatase 4, regulatory subunit 2a. (406 aa) |
| | rad50 | RAD50 homolog, double strand break repair protein. (1313 aa) |
| | ENSPKIP00000009746 | MUS81 structure-specific endonuclease subunit. (543 aa) |
| | Pole | DNA polymerase epsilon catalytic subunit; DNA polymerase II participates in chromosomal DNA replication; Belongs to the DNA polymerase type-B family. (2251 aa) |
| | Slx4 | SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae). (1799 aa) |
| | Atrip | ATR interacting protein. (758 aa) |
| | ube2n | Ubiquitin conjugating enzyme E2 N; Belongs to the ubiquitin-conjugating enzyme family. (182 aa) |
| | ENSPKIP00000011013 | WRN RecQ like helicase. (1122 aa) |
| | ENSPKIP00000011270 | SAE2 domain-containing protein. (94 aa) |
| | Rbbp8 | CtIP_N domain-containing protein. (552 aa) |
| | ENSPKIP00000011404 | Polymerase (DNA-directed), delta 3, accessory subunit. (395 aa) |
| | pole3 | Polymerase (DNA directed), epsilon 3 (p17 subunit). (148 aa) |
| | LOC111860288 | Protein inhibitor of activated STAT, 4a. (500 aa) |
| | pole4 | Polymerase (DNA-directed), epsilon 4, accessory subunit. (122 aa) |
| | Nbn | Nibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (777 aa) |
| | PCNA | Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (260 aa) |
| | brca2 | BRCA2 DNA repair associated. (2995 aa) |
| | pold2 | Polymerase (DNA directed), delta 2, regulatory subunit. (470 aa) |
| | HUS1B | Checkpoint protein; Belongs to the HUS1 family. (280 aa) |
| | meiob | Methionine sulfoxide reductase B1b. (468 aa) |
| | rad9b | RAD9 checkpoint clamp component B. (416 aa) |
| | ENSPKIP00000014968 | FHA domain-containing protein. (1811 aa) |
| | LOC111846432 | Ubiquitin-conjugating enzyme E2Ia; Belongs to the ubiquitin-conjugating enzyme family. (157 aa) |
| | ppp4c | Serine/threonine-protein phosphatase. (307 aa) |
| | ube2v2 | Ubiquitin-conjugating enzyme E2 variant 2. (180 aa) |
| | ENSPKIP00000016002 | Uncharacterized protein. (385 aa) |
| | Spidr | Uncharacterized protein. (883 aa) |
| | rnf8 | E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (655 aa) |
| | kxd1 | KxDL motif containing 1. (178 aa) |
| | rad51 | DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (338 aa) |
| | rhno1 | Si:ch73-352p4.5. (308 aa) |
| | ENSPKIP00000018067 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (89 aa) |
| | ENSPKIP00000018340 | Histone H2B; Belongs to the histone H2B family. (108 aa) |
| | ENSPKIP00000018522 | Reverse transcriptase domain-containing protein. (425 aa) |
| | SUMO3 | Small ubiquitin-related modifier. (106 aa) |
| | LOC111843474 | Tyrosine-protein kinase. (1110 aa) |
| | rfc1 | Replication factor C subunit 1. (1155 aa) |
| | rpa2 | Replication protein A2. (339 aa) |
| | timeless | Timeless circadian clock. (1246 aa) |
| | parp3 | Poly [ADP-ribose] polymerase. (531 aa) |
| | cdk2 | Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa) |
| | LOC111845939 | Histone H2B; Belongs to the histone H2B family. (117 aa) |
| | LOC111834097 | Zgc:110269. (346 aa) |
| | ENSPKIP00000021462 | Ubiquitin-like domain-containing protein. (159 aa) |
| | rad1 | RAD1 homolog (S. pombe). (317 aa) |
| | uba52 | Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa) |
| | parp1 | Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1011 aa) |
| | Gen1 | Uncharacterized protein. (928 aa) |
| | rnf169 | Ring finger protein 169. (677 aa) |
| | slf1 | SMC5-SMC6 complex localization factor 1. (885 aa) |
| | rad17 | RAD17 checkpoint clamp loader component. (681 aa) |
| | ENSPKIP00000032000 | Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1. (612 aa) |
| | Atm | Non-specific serine/threonine protein kinase. (3029 aa) |
| | palb2 | PALB2_WD40 domain-containing protein. (1433 aa) |
| | LOC111843688 | BTB domain-containing protein. (532 aa) |
| | ENSPKIP00000033495 | Reverse transcriptase domain-containing protein. (468 aa) |
| | LOC111856488 | Ubiquitin-like domain-containing protein. (95 aa) |
| | ENSPKIP00000033884 | Endo/exonuclease/phosphatase domain-containing protein. (209 aa) |
| | rad51c | RAD51 paralog C. (374 aa) |
| | ccna2 | Cyclin A2; Belongs to the cyclin family. (417 aa) |
| | ENSPKIP00000035115 | Nuclear receptor binding SET domain protein 2. (476 aa) |
| | rnf168 | E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and ubiquitinates histone H2A and H2AX, leading to amplify the RNF8-dependent H2A ubiquitination and promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recrui [...] (461 aa) |
| | ENSPKIP00000036487 | Zgc:110224. (404 aa) |
| | Pold4 | Si:dkey-28b4.7. (121 aa) |
| | rfc2 | Replication factor C (activator 1) 2. (351 aa) |
| | polq | Polymerase (DNA directed), theta. (2372 aa) |
| | polk | Polymerase (DNA directed) kappa. (894 aa) |
| | tipin | TIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (286 aa) |
| | tp53bp1 | Tumor protein p53 binding protein, 1. (1913 aa) |
| | ENSPKIP00000038374 | Histone H2B; Belongs to the histone H2B family. (118 aa) |
| | chek1 | Checkpoint kinase 1; Belongs to the protein kinase superfamily. (469 aa) |
| | ENSPKIP00000038408 | Histone H2B; Belongs to the histone H2B family. (203 aa) |
| | ENSPKIP00000038497 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (96 aa) |
| | ENSPKIP00000038535 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (95 aa) |
| | ENSPKIP00000038554 | Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (93 aa) |
