STRINGSTRING
rnf169 rnf169 ENSPKIP00000030577 ENSPKIP00000030577 tp53bp1 tp53bp1 ENSPKIP00000038374 ENSPKIP00000038374 ENSPKIP00000038408 ENSPKIP00000038408 ENSPKIP00000038497 ENSPKIP00000038497 ENSPKIP00000038535 ENSPKIP00000038535 ENSPKIP00000038554 ENSPKIP00000038554 LOC111861095 LOC111861095 ENSPKIP00000039871 ENSPKIP00000039871 ENSPKIP00000040065 ENSPKIP00000040065 ppp5c ppp5c LOC111844327 LOC111844327 ENSPKIP00000002756 ENSPKIP00000002756 LOC111844425 LOC111844425 KDM4B KDM4B kat5 kat5 UBB UBB ENSPKIP00000000237 ENSPKIP00000000237 ENSPKIP00000034087 ENSPKIP00000034087 ENSPKIP00000033884 ENSPKIP00000033884 ENSPKIP00000033801 ENSPKIP00000033801 ENSPKIP00000033761 ENSPKIP00000033761 LOC111856488 LOC111856488 ENSPKIP00000033495 ENSPKIP00000033495 ENSPKIP00000033488 ENSPKIP00000033488 Atm Atm chek2 chek2 H2BC8 H2BC8 LOC111836641 LOC111836641 LOC111841492 LOC111841492 LOC111851430 LOC111851430 ENSPKIP00000027153 ENSPKIP00000027153 uimc1 uimc1 PWWP2A PWWP2A ANKRD11 ANKRD11 ankrd12 ankrd12 LOC111858299 LOC111858299 babam1 babam1 ENSPKIP00000025247 ENSPKIP00000025247 brcc3 brcc3 ENSPKIP00000024136 ENSPKIP00000024136 ABL1 ABL1 eya1 eya1 uba52 uba52 LOC111854492 LOC111854492 LOC111845939 LOC111845939 LOC111843474 LOC111843474 ENSPKIP00000018522 ENSPKIP00000018522 ENSPKIP00000018340 ENSPKIP00000018340 ENSPKIP00000018067 ENSPKIP00000018067 LOC111840804 LOC111840804 kxd1 kxd1 rnf8 rnf8 ube2v2 ube2v2 LOC111846432 LOC111846432 ENSPKIP00000014968 ENSPKIP00000014968 tp53 tp53 Nbn Nbn LOC111860288 LOC111860288 ube2n ube2n rad50 rad50 Eya4 Eya4 brca1 brca1 babam2 babam2 Mre11 Mre11 abraxas1 abraxas1 rps27a rps27a ENSPKIP00000004111 ENSPKIP00000004111 ENSPKIP00000004039 ENSPKIP00000004039 ENSPKIP00000003629 ENSPKIP00000003629 ENSPKIP00000003555 ENSPKIP00000003555 ENSPKIP00000003264 ENSPKIP00000003264 ENSPKIP00000003127 ENSPKIP00000003127 ENSPKIP00000003094 ENSPKIP00000003094 SMARCA5-2 SMARCA5-2 LOC111839720 LOC111839720 SMARCA5 SMARCA5 BAZ1B BAZ1B rnf168 rnf168 LOC111852171 LOC111852171 ENSPKIP00000035115 ENSPKIP00000035115
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
rnf169Ring finger protein 169. (677 aa)
ENSPKIP00000030577Histone H2B; Belongs to the histone H2B family. (113 aa)
tp53bp1Tumor protein p53 binding protein, 1. (1913 aa)
ENSPKIP00000038374Histone H2B; Belongs to the histone H2B family. (118 aa)
ENSPKIP00000038408Histone H2B; Belongs to the histone H2B family. (203 aa)
ENSPKIP00000038497Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (96 aa)
ENSPKIP00000038535Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (95 aa)
ENSPKIP00000038554Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (93 aa)
LOC111861095Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (476 aa)
ENSPKIP00000039871Uncharacterized protein. (397 aa)
ENSPKIP00000040065Reverse transcriptase domain-containing protein. (268 aa)
ppp5cSerine/threonine-protein phosphatase. (573 aa)
LOC111844327UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (154 aa)
ENSPKIP00000002756Reverse transcriptase domain-containing protein. (1051 aa)
LOC111844425Histone H2B; Belongs to the histone H2B family. (124 aa)
KDM4BLysine demethylase 4B. (1125 aa)
kat5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (558 aa)
UBBUbiquitin B. (230 aa)
ENSPKIP00000000237ANK_REP_REGION domain-containing protein. (1296 aa)
ENSPKIP00000034087SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1. (983 aa)
ENSPKIP00000033884Endo/exonuclease/phosphatase domain-containing protein. (209 aa)
ENSPKIP00000033801Uncharacterized protein. (262 aa)
ENSPKIP00000033761PHD-type domain-containing protein. (200 aa)
LOC111856488Ubiquitin-like domain-containing protein. (95 aa)
ENSPKIP00000033495Reverse transcriptase domain-containing protein. (468 aa)
ENSPKIP00000033488WW domain-containing protein. (490 aa)
AtmNon-specific serine/threonine protein kinase. (3029 aa)
chek2Checkpoint kinase 2. (507 aa)
H2BC8Histone domain-containing protein; Belongs to the histone H2B family. (117 aa)
LOC111836641Uncharacterized protein. (499 aa)
LOC111841492Bromodomain adjacent to zinc finger domain 1B. (1576 aa)
LOC111851430Ubiquitin-like domain-containing protein. (77 aa)
ENSPKIP00000027153Reverse transcriptase domain-containing protein. (231 aa)
uimc1Uncharacterized protein. (974 aa)
PWWP2APWWP domain containing 2A. (1028 aa)
ANKRD11Ankyrin repeat domain 11. (2812 aa)
ankrd12Ankyrin repeat domain 12. (2030 aa)
LOC111858299Small ubiquitin like modifier 1. (126 aa)
babam1BRISC and BRCA1 A complex member 1. (355 aa)
ENSPKIP00000025247Histone H2A; Belongs to the histone H2A family. (141 aa)
brcc3BRCA1/BRCA2-containing complex, subunit 3. (260 aa)
ENSPKIP00000024136UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (188 aa)
ABL1Tyrosine-protein kinase. (1121 aa)
eya1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (645 aa)
uba52Ubiquitin A-52 residue ribosomal protein fusion product 1. (128 aa)
LOC111854492Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (441 aa)
LOC111845939Histone H2B; Belongs to the histone H2B family. (117 aa)
LOC111843474Tyrosine-protein kinase. (1110 aa)
ENSPKIP00000018522Reverse transcriptase domain-containing protein. (425 aa)
ENSPKIP00000018340Histone H2B; Belongs to the histone H2B family. (108 aa)
ENSPKIP00000018067Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (89 aa)
LOC111840804Small ubiquitin-related modifier. (101 aa)
kxd1KxDL motif containing 1. (178 aa)
rnf8E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (655 aa)
ube2v2Ubiquitin-conjugating enzyme E2 variant 2. (180 aa)
LOC111846432Ubiquitin-conjugating enzyme E2Ia; Belongs to the ubiquitin-conjugating enzyme family. (157 aa)
ENSPKIP00000014968FHA domain-containing protein. (1811 aa)
tp53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression; Belongs to the p53 family. (431 aa)
NbnNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (777 aa)
LOC111860288Protein inhibitor of activated STAT, 4a. (500 aa)
ube2nUbiquitin conjugating enzyme E2 N; Belongs to the ubiquitin-conjugating enzyme family. (182 aa)
rad50RAD50 homolog, double strand break repair protein. (1313 aa)
Eya4Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (590 aa)
brca1Uncharacterized protein. (1439 aa)
babam2BRISC and BRCA1 A complex member 2. (395 aa)
Mre11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (713 aa)
abraxas1Abraxas 1, BRCA1 A complex subunit. (377 aa)
rps27aRibosomal protein S27a. (156 aa)
ENSPKIP00000004111Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (86 aa)
ENSPKIP00000004039Histone H2B; Belongs to the histone H2B family. (67 aa)
ENSPKIP00000003629Histone H2B; Belongs to the histone H2B family. (164 aa)
ENSPKIP00000003555Histone H2A; Belongs to the histone H2A family. (129 aa)
ENSPKIP00000003264Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (93 aa)
ENSPKIP00000003127Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (93 aa)
ENSPKIP00000003094Histone H2B; Belongs to the histone H2B family. (116 aa)
SMARCA5-2SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5. (1024 aa)
LOC111839720Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (598 aa)
SMARCA5SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5. (1025 aa)
BAZ1BBromodomain adjacent to zinc finger domain, 1B. (1606 aa)
rnf168E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and ubiquitinates histone H2A and H2AX, leading to amplify the RNF8-dependent H2A ubiquitination and promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recrui [...] (461 aa)
LOC111852171Amyloid beta (A4) precursor protein-binding, family B, member 1 (Fe65). (753 aa)
ENSPKIP00000035115Nuclear receptor binding SET domain protein 2. (476 aa)
Your Current Organism:
Paramormyrops kingsleyae
NCBI taxonomy Id: 1676925
Other names: Brienomyrus kingsleyae, Brienomyrus sp. CAB, Mormyrus kingsleyae, P. kingsleyae, Pollimyrus kingsleyae
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