STRINGSTRING
ENSPKIP00000000237 ENSPKIP00000000237 kat5 kat5 LOC111844425 LOC111844425 ENSPKIP00000002756 ENSPKIP00000002756 ENSPKIP00000003094 ENSPKIP00000003094 ENSPKIP00000003127 ENSPKIP00000003127 ENSPKIP00000003264 ENSPKIP00000003264 ENSPKIP00000003555 ENSPKIP00000003555 ENSPKIP00000003629 ENSPKIP00000003629 ENSPKIP00000004039 ENSPKIP00000004039 ENSPKIP00000004111 ENSPKIP00000004111 Mre11 Mre11 LOC111855495 LOC111855495 brca1 brca1 rad50 rad50 LOC111842420 LOC111842420 ube2n ube2n LOC111860288 LOC111860288 Nbn Nbn ENSPKIP00000012927 ENSPKIP00000012927 nhej1 nhej1 slc23a3 slc23a3 poll poll ENSPKIP00000014968 ENSPKIP00000014968 ube2v2 ube2v2 rnf8 rnf8 ENSPKIP00000018067 ENSPKIP00000018067 ENSPKIP00000018340 ENSPKIP00000018340 xrcc6 xrcc6 ENSPKIP00000018522 ENSPKIP00000018522 rif1 rif1 LOC111845939 LOC111845939 xrcc4 xrcc4 xrcc5 xrcc5 tdp2 tdp2 cnppd1 cnppd1 ENSPKIP00000025247 ENSPKIP00000025247 ankrd12 ankrd12 ANKRD11 ANKRD11 tdp1 tdp1 polm polm ENSPKIP00000027153 ENSPKIP00000027153 Tmem182 Tmem182 LOC111836641 LOC111836641 ENSPKIP00000030577 ENSPKIP00000030577 H2BC8 H2BC8 rnf169 rnf169 Lig4 Lig4 Atm Atm ENSPKIP00000032643 ENSPKIP00000032643 Paxip1 Paxip1 ENSPKIP00000033495 ENSPKIP00000033495 ENSPKIP00000033884 ENSPKIP00000033884 ENSPKIP00000035115 ENSPKIP00000035115 ENSPKIP00000035840 ENSPKIP00000035840 rnf168 rnf168 ENSPKIP00000037476 ENSPKIP00000037476 tp53bp1 tp53bp1 ENSPKIP00000038374 ENSPKIP00000038374 ENSPKIP00000038408 ENSPKIP00000038408 ENSPKIP00000038497 ENSPKIP00000038497 ENSPKIP00000038535 ENSPKIP00000038535 ENSPKIP00000038554 ENSPKIP00000038554 ENSPKIP00000039871 ENSPKIP00000039871 ENSPKIP00000040065 ENSPKIP00000040065 LOC111844327 LOC111844327
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSPKIP00000000237ANK_REP_REGION domain-containing protein. (1296 aa)
kat5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (558 aa)
LOC111844425Histone H2B; Belongs to the histone H2B family. (124 aa)
ENSPKIP00000002756Reverse transcriptase domain-containing protein. (1051 aa)
ENSPKIP00000003094Histone H2B; Belongs to the histone H2B family. (116 aa)
ENSPKIP00000003127Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (93 aa)
ENSPKIP00000003264Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (93 aa)
ENSPKIP00000003555Histone H2A; Belongs to the histone H2A family. (129 aa)
ENSPKIP00000003629Histone H2B; Belongs to the histone H2B family. (164 aa)
ENSPKIP00000004039Histone H2B; Belongs to the histone H2B family. (67 aa)
ENSPKIP00000004111Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (86 aa)
Mre11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (713 aa)
LOC111855495Uncharacterized protein. (252 aa)
brca1Uncharacterized protein. (1439 aa)
rad50RAD50 homolog, double strand break repair protein. (1313 aa)
LOC111842420DNA cross-link repair 1C, PSO2 homolog (S. cerevisiae). (640 aa)
ube2nUbiquitin conjugating enzyme E2 N; Belongs to the ubiquitin-conjugating enzyme family. (182 aa)
LOC111860288Protein inhibitor of activated STAT, 4a. (500 aa)
NbnNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (777 aa)
ENSPKIP00000012927Uncharacterized protein. (982 aa)
nhej1Nonhomologous end-joining factor 1. (334 aa)
slc23a3Solute carrier family 23 member 3. (631 aa)
pollPolymerase (DNA directed), lambda; Belongs to the DNA polymerase type-X family. (554 aa)
ENSPKIP00000014968FHA domain-containing protein. (1811 aa)
ube2v2Ubiquitin-conjugating enzyme E2 variant 2. (180 aa)
rnf8E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (655 aa)
ENSPKIP00000018067Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (89 aa)
ENSPKIP00000018340Histone H2B; Belongs to the histone H2B family. (108 aa)
xrcc6X-ray repair complementing defective repair in Chinese hamster cells 6. (610 aa)
ENSPKIP00000018522Reverse transcriptase domain-containing protein. (425 aa)
rif1Replication timing regulatory factor 1. (2285 aa)
LOC111845939Histone H2B; Belongs to the histone H2B family. (117 aa)
xrcc4X-ray repair complementing defective repair in Chinese hamster cells 4. (344 aa)
xrcc5X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Belongs to the ku80 family. (727 aa)
tdp2Tyrosyl-DNA phosphodiesterase 2b. (368 aa)
cnppd1Cyclin Pas1/PHO80 domain containing 1. (417 aa)
ENSPKIP00000025247Histone H2A; Belongs to the histone H2A family. (141 aa)
ankrd12Ankyrin repeat domain 12. (2030 aa)
ANKRD11Ankyrin repeat domain 11. (2812 aa)
tdp1Tyrosyl-DNA phosphodiesterase 1. (686 aa)
polmDNA-directed DNA/RNA polymerase mu; Gap-filling polymerase involved in repair of DNA double- strand breaks by non-homologous end joining (NHEJ). Belongs to the DNA polymerase type-X family. (587 aa)
ENSPKIP00000027153Reverse transcriptase domain-containing protein. (231 aa)
Tmem182Transmembrane protein 182a. (294 aa)
LOC111836641Uncharacterized protein. (499 aa)
ENSPKIP00000030577Histone H2B; Belongs to the histone H2B family. (113 aa)
H2BC8Histone domain-containing protein; Belongs to the histone H2B family. (117 aa)
rnf169Ring finger protein 169. (677 aa)
Lig4DNA ligase. (921 aa)
AtmNon-specific serine/threonine protein kinase. (3029 aa)
ENSPKIP00000032643Protein kinase, DNA-activated, catalytic subunit; Belongs to the PI3/PI4-kinase family. (3873 aa)
Paxip1PAX interacting (with transcription-activation domain) protein 1. (866 aa)
ENSPKIP00000033495Reverse transcriptase domain-containing protein. (468 aa)
ENSPKIP00000033884Endo/exonuclease/phosphatase domain-containing protein. (209 aa)
ENSPKIP00000035115Nuclear receptor binding SET domain protein 2. (476 aa)
ENSPKIP00000035840Uncharacterized protein. (553 aa)
rnf168E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and ubiquitinates histone H2A and H2AX, leading to amplify the RNF8-dependent H2A ubiquitination and promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recrui [...] (461 aa)
ENSPKIP00000037476DNA-directed DNA/RNA polymerase mu; Gap-filling polymerase involved in repair of DNA double- strand breaks by non-homologous end joining (NHEJ). Belongs to the DNA polymerase type-X family. (461 aa)
tp53bp1Tumor protein p53 binding protein, 1. (1913 aa)
ENSPKIP00000038374Histone H2B; Belongs to the histone H2B family. (118 aa)
ENSPKIP00000038408Histone H2B; Belongs to the histone H2B family. (203 aa)
ENSPKIP00000038497Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (96 aa)
ENSPKIP00000038535Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (95 aa)
ENSPKIP00000038554Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (93 aa)
ENSPKIP00000039871Uncharacterized protein. (397 aa)
ENSPKIP00000040065Reverse transcriptase domain-containing protein. (268 aa)
LOC111844327UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (154 aa)
Your Current Organism:
Paramormyrops kingsleyae
NCBI taxonomy Id: 1676925
Other names: Brienomyrus kingsleyae, Brienomyrus sp. CAB, Mormyrus kingsleyae, P. kingsleyae, Pollimyrus kingsleyae
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