STRINGSTRING
ENSPKIP00000003264 ENSPKIP00000003264 ENSPKIP00000003127 ENSPKIP00000003127 ENSPKIP00000003094 ENSPKIP00000003094 ENSPKIP00000002756 ENSPKIP00000002756 recql4 recql4 LOC111844425 LOC111844425 CDCA7L CDCA7L kat5 kat5 rad9a rad9a ENSPKIP00000000237 ENSPKIP00000000237 LOC111844327 LOC111844327 top3a top3a ENSPKIP00000040065 ENSPKIP00000040065 ENSPKIP00000039871 ENSPKIP00000039871 rfc3 rfc3 ENSPKIP00000038554 ENSPKIP00000038554 ENSPKIP00000038535 ENSPKIP00000038535 ENSPKIP00000038497 ENSPKIP00000038497 ENSPKIP00000038408 ENSPKIP00000038408 ENSPKIP00000038374 ENSPKIP00000038374 tp53bp1 tp53bp1 tipin tipin rfc2 rfc2 rnf168 rnf168 ENSPKIP00000035115 ENSPKIP00000035115 ccna2 ccna2 ENSPKIP00000033884 ENSPKIP00000033884 ENSPKIP00000033495 ENSPKIP00000033495 LOC111843688 LOC111843688 Atm Atm ENSPKIP00000032000 ENSPKIP00000032000 rad17 rad17 rnf169 rnf169 topbp1 topbp1 H2BC8 H2BC8 ENSPKIP00000030577 ENSPKIP00000030577 LOC111836641 LOC111836641 Sirt6 Sirt6 rpa3 rpa3 ENSPKIP00000027503 ENSPKIP00000027503 ENSPKIP00000027153 ENSPKIP00000027153 uimc1 uimc1 rfc5 rfc5 LOC111858369 LOC111858369 blm blm ANKRD11 ANKRD11 ankrd12 ankrd12 babam1 babam1 DNA2 DNA2 ENSPKIP00000025247 ENSPKIP00000025247 brcc3 brcc3 rpa1 rpa1 ENSPKIP00000024136 ENSPKIP00000024136 rad9b rad9b rad1 rad1 ENSPKIP00000021462 ENSPKIP00000021462 LOC111845939 LOC111845939 cdk2 cdk2 timeless timeless rpa2 rpa2 SUMO3 SUMO3 ENSPKIP00000018522 ENSPKIP00000018522 ENSPKIP00000018340 ENSPKIP00000018340 ENSPKIP00000018067 ENSPKIP00000018067 rhno1 rhno1 rnf8 rnf8 ube2v2 ube2v2 ppp4c ppp4c LOC111846432 LOC111846432 ENSPKIP00000014968 ENSPKIP00000014968 HUS1B HUS1B Nbn Nbn LOC111860288 LOC111860288 Rbbp8 Rbbp8 ENSPKIP00000011270 ENSPKIP00000011270 ube2n ube2n Atrip Atrip rad50 rad50 ENSPKIP00000009388 ENSPKIP00000009388 LOC111834205 LOC111834205 ccna1 ccna1 rfc4 rfc4 brca1 brca1 ENSPKIP00000006289 ENSPKIP00000006289 babam2 babam2 Mre11 Mre11 Atr Atr LOC111858065 LOC111858065 ENSPKIP00000004764 ENSPKIP00000004764 abraxas1 abraxas1 ENSPKIP00000004111 ENSPKIP00000004111 ENSPKIP00000004039 ENSPKIP00000004039 ENSPKIP00000003629 ENSPKIP00000003629 ENSPKIP00000003555 ENSPKIP00000003555
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSPKIP00000003264Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (93 aa)
ENSPKIP00000003127Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (93 aa)
ENSPKIP00000003094Histone H2B; Belongs to the histone H2B family. (116 aa)
ENSPKIP00000002756Reverse transcriptase domain-containing protein. (1051 aa)
recql4RecQ helicase-like 4. (1512 aa)
LOC111844425Histone H2B; Belongs to the histone H2B family. (124 aa)
CDCA7LCell division cycle associated 7 like. (311 aa)
kat5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (558 aa)
rad9aCell cycle checkpoint control protein; Belongs to the rad9 family. (399 aa)
ENSPKIP00000000237ANK_REP_REGION domain-containing protein. (1296 aa)
LOC111844327UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (154 aa)
top3aDNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (989 aa)
ENSPKIP00000040065Reverse transcriptase domain-containing protein. (268 aa)
ENSPKIP00000039871Uncharacterized protein. (397 aa)
rfc3Replication factor C (activator 1) 3. (356 aa)
ENSPKIP00000038554Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (93 aa)
ENSPKIP00000038535Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (95 aa)
ENSPKIP00000038497Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (96 aa)
ENSPKIP00000038408Histone H2B; Belongs to the histone H2B family. (203 aa)
ENSPKIP00000038374Histone H2B; Belongs to the histone H2B family. (118 aa)
tp53bp1Tumor protein p53 binding protein, 1. (1913 aa)
tipinTIMELESS-interacting protein; Plays an important role in the control of DNA replication and the maintenance of replication fork stability. Belongs to the CSM3 family. (286 aa)
rfc2Replication factor C (activator 1) 2. (351 aa)
rnf168E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and ubiquitinates histone H2A and H2AX, leading to amplify the RNF8-dependent H2A ubiquitination and promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recrui [...] (461 aa)
ENSPKIP00000035115Nuclear receptor binding SET domain protein 2. (476 aa)
ccna2Cyclin A2; Belongs to the cyclin family. (417 aa)
ENSPKIP00000033884Endo/exonuclease/phosphatase domain-containing protein. (209 aa)
ENSPKIP00000033495Reverse transcriptase domain-containing protein. (468 aa)
LOC111843688BTB domain-containing protein. (532 aa)
AtmNon-specific serine/threonine protein kinase. (3029 aa)
ENSPKIP00000032000Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 1. (612 aa)
rad17RAD17 checkpoint clamp loader component. (681 aa)
rnf169Ring finger protein 169. (677 aa)
topbp1DNA topoisomerase II binding protein 1. (1524 aa)
H2BC8Histone domain-containing protein; Belongs to the histone H2B family. (117 aa)
ENSPKIP00000030577Histone H2B; Belongs to the histone H2B family. (113 aa)
LOC111836641Uncharacterized protein. (499 aa)
Sirt6Sirtuin 6. (386 aa)
rpa3Replication protein A3. (123 aa)
ENSPKIP00000027503Exonuclease 1. (575 aa)
ENSPKIP00000027153Reverse transcriptase domain-containing protein. (231 aa)
uimc1Uncharacterized protein. (974 aa)
rfc5Replication factor C (activator 1) 5. (336 aa)
LOC111858369Small ubiquitin-related modifier. (94 aa)
blmBLM RecQ like helicase. (1442 aa)
ANKRD11Ankyrin repeat domain 11. (2812 aa)
ankrd12Ankyrin repeat domain 12. (2030 aa)
babam1BRISC and BRCA1 A complex member 1. (355 aa)
DNA2DNA replication helicase/nuclease 2. (1345 aa)
ENSPKIP00000025247Histone H2A; Belongs to the histone H2A family. (141 aa)
brcc3BRCA1/BRCA2-containing complex, subunit 3. (260 aa)
rpa1Replication protein A subunit; As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage. (610 aa)
ENSPKIP00000024136UBIQUITIN_CONJUGAT_2 domain-containing protein; Belongs to the ubiquitin-conjugating enzyme family. (188 aa)
rad9bRAD9 checkpoint clamp component B. (416 aa)
rad1RAD1 homolog (S. pombe). (317 aa)
ENSPKIP00000021462Ubiquitin-like domain-containing protein. (159 aa)
LOC111845939Histone H2B; Belongs to the histone H2B family. (117 aa)
cdk2Cyclin-dependent kinase 2; Belongs to the protein kinase superfamily. (298 aa)
timelessTimeless circadian clock. (1246 aa)
rpa2Replication protein A2. (339 aa)
SUMO3Small ubiquitin-related modifier. (106 aa)
ENSPKIP00000018522Reverse transcriptase domain-containing protein. (425 aa)
ENSPKIP00000018340Histone H2B; Belongs to the histone H2B family. (108 aa)
ENSPKIP00000018067Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (89 aa)
rhno1Si:ch73-352p4.5. (308 aa)
rnf8E3 ubiquitin-protein ligase RNF8; E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53 [...] (655 aa)
ube2v2Ubiquitin-conjugating enzyme E2 variant 2. (180 aa)
ppp4cSerine/threonine-protein phosphatase. (307 aa)
LOC111846432Ubiquitin-conjugating enzyme E2Ia; Belongs to the ubiquitin-conjugating enzyme family. (157 aa)
ENSPKIP00000014968FHA domain-containing protein. (1811 aa)
HUS1BCheckpoint protein; Belongs to the HUS1 family. (280 aa)
NbnNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (777 aa)
LOC111860288Protein inhibitor of activated STAT, 4a. (500 aa)
Rbbp8CtIP_N domain-containing protein. (552 aa)
ENSPKIP00000011270SAE2 domain-containing protein. (94 aa)
ube2nUbiquitin conjugating enzyme E2 N; Belongs to the ubiquitin-conjugating enzyme family. (182 aa)
AtripATR interacting protein. (758 aa)
rad50RAD50 homolog, double strand break repair protein. (1313 aa)
ENSPKIP00000009388Protein phosphatase 4, regulatory subunit 2a. (406 aa)
LOC111834205Small ubiquitin-related modifier. (95 aa)
ccna1Cyclin A1; Belongs to the cyclin family. (418 aa)
rfc4Replication factor C (activator 1) 4. (357 aa)
brca1Uncharacterized protein. (1439 aa)
ENSPKIP00000006289Ig-like domain-containing protein. (136 aa)
babam2BRISC and BRCA1 A complex member 2. (395 aa)
Mre11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (713 aa)
AtrATR serine/threonine kinase; Belongs to the PI3/PI4-kinase family. (2574 aa)
LOC111858065Regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2. (618 aa)
ENSPKIP00000004764RMI1, RecQ mediated genome instability 1, homolog (S. cerevisiae). (494 aa)
abraxas1Abraxas 1, BRCA1 A complex subunit. (377 aa)
ENSPKIP00000004111Histone H4; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. (86 aa)
ENSPKIP00000004039Histone H2B; Belongs to the histone H2B family. (67 aa)
ENSPKIP00000003629Histone H2B; Belongs to the histone H2B family. (164 aa)
ENSPKIP00000003555Histone H2A; Belongs to the histone H2A family. (129 aa)
Your Current Organism:
Paramormyrops kingsleyae
NCBI taxonomy Id: 1676925
Other names: Brienomyrus kingsleyae, Brienomyrus sp. CAB, Mormyrus kingsleyae, P. kingsleyae, Pollimyrus kingsleyae
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