(71 nodes) Notch signaling pathway network (Paramormyrops kingsleyae)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	dtx2	Deltex 2, E3 ubiquitin ligase. (601 aa)
	HDAC2	Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (497 aa)
	rbpj	Recombination signal binding protein for immunoglobulin kappa J region. (487 aa)
	LOC111844438	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1230 aa)
	LOC111838096	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1220 aa)
	ENSPKIP00000001430	Pep_M12B_propep domain-containing protein. (292 aa)
	ENSPKIP00000004465	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (676 aa)
	NUMB	NUMB endocytic adaptor protein. (633 aa)
	DTX1	Deltex E3 ubiquitin ligase 1. (623 aa)
	Rbpjl	Recombination signal binding protein for immunoglobulin kappa J region-like. (484 aa)
	psen2	Presenilin; Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors. Belongs to the peptidase A22A family. (436 aa)
	Jag1	MNNL domain-containing protein. (126 aa)
	Heyl	Hes related family bHLH transcription factor with YRPW motif like. (392 aa)
	LOC111835768	Zgc:114200. (226 aa)
	LOC111854208	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (479 aa)
	LOC111840574	AXH domain-containing protein. (637 aa)
	HEY1	Hes-related family bHLH transcription factor with YRPW motif 1. (309 aa)
	LOC111850455	Ataxin 1. (806 aa)
	LOC111853133	Mastermind-like transcriptional coactivator 3. (1039 aa)
	LOC111847629	APH1B gamma secretase subunit. (258 aa)
	numbl	NUMB like endocytic adaptor protein. (632 aa)
	DLL4	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (689 aa)
	LOC111853032	Hairy-related 9. (294 aa)
	CTBP2	C-terminal binding protein 2; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (445 aa)
	kat2a	Histone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (805 aa)
	LOC111850646	Uncharacterized protein. (678 aa)
	LOC111843838	Ataxin 1a. (754 aa)
	LOC111848153	Uncharacterized protein. (256 aa)
	LOC111845232	Uncharacterized protein. (2683 aa)
	LOC111842628	Deltex E3 ubiquitin ligase 4. (685 aa)
	cir1	Corepressor interacting with RBPJ, 1. (498 aa)
	mfng	Beta-1,3-N-acetylglucosaminyltransferase. (351 aa)
	dll3	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (664 aa)
	ctbp1	C-terminal binding protein 1. (516 aa)
	HES1	Hairy-related 6. (264 aa)
	LOC111843207	CREB binding protein b. (2374 aa)
	LOC111832910	RFNG O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase. (404 aa)
	ENSPKIP00000023399	RING-type domain-containing protein. (282 aa)
	LOC111854451	Dishevelled segment polarity protein 2. (754 aa)
	ENSPKIP00000023529	ANK_REP_REGION domain-containing protein. (674 aa)
	LOC111855116	Si:dkey-3h3.3. (367 aa)
	NCSTN	Nicastrin. (702 aa)
	LOC111852005	NUMB endocytic adaptor protein. (671 aa)
	dll1	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (728 aa)
	LOC111855177	C-terminal binding protein 1; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (448 aa)
	atxn1l	Ataxin 1-like. (773 aa)
	ENSPKIP00000027054	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (666 aa)
	kat2b	Histone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily. (792 aa)
	EP300	E1A binding protein p300. (2557 aa)
	dvl1	Dishevelled segment polarity protein 1a. (721 aa)
	LFNG	Beta-1,3-N-acetylglucosaminyltransferase. (375 aa)
	LOC111845492	Beta-1,3-N-acetylglucosaminyltransferase. (386 aa)
	HDAC1	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. (480 aa)
	LOC111835477	Uncharacterized protein. (319 aa)
	hey2	Hes-related family bHLH transcription factor with YRPW motif 2. (338 aa)
	MAML3	Mastermind like transcriptional coactivator 3. (1084 aa)
	LOC111841421	MamL-1 domain-containing protein. (746 aa)
	LOC111857067	Hairy-related 2. (150 aa)
	LOC111857016	BHLH domain-containing protein. (145 aa)
	ENSPKIP00000035606	BHLH domain-containing protein. (158 aa)
	dvl3	Dishevelled segment polarity protein 3a. (687 aa)
	LOC111857015	Uncharacterized protein. (164 aa)
	ENSPKIP00000035930	Uncharacterized protein. (723 aa)
	notch1	Notch receptor 1b. (2503 aa)
	LOC111857162	Uncharacterized protein. (204 aa)
	snw1	SNW domain containing 1. (536 aa)
	ENSPKIP00000036497	Notch receptor 2. (2417 aa)
	LOC111849200	Notch receptor 3. (2447 aa)
	maml1	Mastermind-like transcriptional coactivator 1. (965 aa)
	dtx3	Zgc:66440. (373 aa)
	LOC111850269	Uncharacterized protein; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. (447 aa)

Your Current Organism:

Paramormyrops kingsleyae

NCBI taxonomy Id: 1676925
Other names: Brienomyrus kingsleyae, Brienomyrus sp. CAB, Mormyrus kingsleyae, P. kingsleyae, Pollimyrus kingsleyae

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CTBP2	EP300	ENSPKIP00000014011	ENSPKIP00000027655	C-terminal binding protein 2; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	E1A binding protein p300.	0.431
CTBP2	HDAC1	ENSPKIP00000014011	ENSPKIP00000031395	C-terminal binding protein 2; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.910
CTBP2	HDAC2	ENSPKIP00000014011	ENSPKIP00000000290	C-terminal binding protein 2; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	Histone deacetylase 2; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.910
CTBP2	LOC111845232	ENSPKIP00000014011	ENSPKIP00000018215	C-terminal binding protein 2; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	Uncharacterized protein.	0.431
CTBP2	LOC111854208	ENSPKIP00000014011	ENSPKIP00000009773	C-terminal binding protein 2; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	Histone deacetylase 1; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.	0.910
CTBP2	Rbpjl	ENSPKIP00000014011	ENSPKIP00000007133	C-terminal binding protein 2; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	Recombination signal binding protein for immunoglobulin kappa J region-like.	0.921
CTBP2	rbpj	ENSPKIP00000014011	ENSPKIP00000000406	C-terminal binding protein 2; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.	Recombination signal binding protein for immunoglobulin kappa J region.	0.921
DLL4	ENSPKIP00000023529	ENSPKIP00000013179	ENSPKIP00000023529	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	ANK_REP_REGION domain-containing protein.	0.665
DLL4	ENSPKIP00000036497	ENSPKIP00000013179	ENSPKIP00000036497	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Notch receptor 2.	0.849
DLL4	LOC111841421	ENSPKIP00000013179	ENSPKIP00000035260	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	MamL-1 domain-containing protein.	0.420
DLL4	LOC111849200	ENSPKIP00000013179	ENSPKIP00000036755	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Notch receptor 3.	0.814
DLL4	Rbpjl	ENSPKIP00000013179	ENSPKIP00000007133	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Recombination signal binding protein for immunoglobulin kappa J region-like.	0.514
DLL4	hey2	ENSPKIP00000013179	ENSPKIP00000033012	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Hes-related family bHLH transcription factor with YRPW motif 2.	0.493
DLL4	maml1	ENSPKIP00000013179	ENSPKIP00000037051	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Mastermind-like transcriptional coactivator 1.	0.424
DLL4	notch1	ENSPKIP00000013179	ENSPKIP00000036153	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Notch receptor 1b.	0.907
DLL4	rbpj	ENSPKIP00000013179	ENSPKIP00000000406	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling.	Recombination signal binding protein for immunoglobulin kappa J region.	0.602
DTX1	ENSPKIP00000023529	ENSPKIP00000006422	ENSPKIP00000023529	Deltex E3 ubiquitin ligase 1.	ANK_REP_REGION domain-containing protein.	0.719
DTX1	ENSPKIP00000036497	ENSPKIP00000006422	ENSPKIP00000036497	Deltex E3 ubiquitin ligase 1.	Notch receptor 2.	0.790
DTX1	LOC111849200	ENSPKIP00000006422	ENSPKIP00000036755	Deltex E3 ubiquitin ligase 1.	Notch receptor 3.	0.766
DTX1	notch1	ENSPKIP00000006422	ENSPKIP00000036153	Deltex E3 ubiquitin ligase 1.	Notch receptor 1b.	0.813