STRINGSTRING
A0A316UGS3 A0A316UGS3 A0A316U1C8 A0A316U1C8 MCM7 MCM7 A0A316UHC1 A0A316UHC1 A0A316U3D9 A0A316U3D9 KAE1 KAE1 A0A316U4U2 A0A316U4U2 A0A316U502 A0A316U502 A0A316U5X7 A0A316U5X7 A0A316U7I6 A0A316U7I6 A0A316U7P8 A0A316U7P8 A0A316U8C8 A0A316U8C8 A0A316U8P1 A0A316U8P1 A0A316U914 A0A316U914 A0A316U982 A0A316U982 A0A316UA66 A0A316UA66 A0A316UBU0 A0A316UBU0 A0A316UCM9 A0A316UCM9 A0A316UF35 A0A316UF35 A0A316UF90 A0A316UF90 A0A316UF92 A0A316UF92 A0A316UFJ5 A0A316UFJ5 A0A316UG61 A0A316UG61 A0A316TXU7 A0A316TXU7 A0A316TY07 A0A316TY07 A0A316TZS2 A0A316TZS2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
A0A316UGS3Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism. (624 aa)
A0A316U1C8DNA helicase; Belongs to the MCM family. (871 aa)
MCM7DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (875 aa)
A0A316UHC1ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily. (552 aa)
A0A316U3D9DRMBL domain-containing protein. (962 aa)
KAE1tRNA N6-adenosine threonylcarbamoyltransferase; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. KAE1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. Th [...] (428 aa)
A0A316U4U2RECA_2 domain-containing protein. (745 aa)
A0A316U502Serine/threonine-protein kinase Tel1; Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]- Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability; Belongs to the PI3/PI4-kinase family. ATM subfamily. (3130 aa)
A0A316U5X7Uncharacterized protein. (252 aa)
A0A316U7I6CUE domain-containing protein. (941 aa)
A0A316U7P8Translation factor. (545 aa)
A0A316U8C8Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (629 aa)
A0A316U8P1Telomere_reg-2 domain-containing protein. (1214 aa)
A0A316U914DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1170 aa)
A0A316U982Anti-silence-domain-containing protein. (234 aa)
A0A316UA66Cullin-domain-containing protein; Belongs to the cullin family. (846 aa)
A0A316UBU0DNA helicase; Belongs to the MCM family. (731 aa)
A0A316UCM9DHS-like NAD/FAD-binding domain-containing protein. (998 aa)
A0A316UF35SPOC domain-like protein. (917 aa)
A0A316UF90Uncharacterized protein. (1080 aa)
A0A316UF92Checkpoint protein; Belongs to the HUS1 family. (275 aa)
A0A316UFJ5Uncharacterized protein; Belongs to the CGI121/TPRKB family. (212 aa)
A0A316UG61Histone acetyltransferase type B catalytic subunit; Catalytic component of the histone acetylase B (HAT-B) complex. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair; Belongs to the HAT1 family. (461 aa)
A0A316TXU7HD domain-containing protein. (332 aa)
A0A316TY07Ku DNA-binding complex, Ku70 subunit. (660 aa)
A0A316TZS2Uncharacterized protein; Belongs to the PI3/PI4-kinase family. (2619 aa)
Your Current Organism:
Pseudomicrostroma glucosiphilum
NCBI taxonomy Id: 1684307
Other names: CBS 14053, MCA 4718, Microstromatales sp. MCA4718, NRRL 66310, P. glucosiphilum, Rhodotorula sp. MCA 4718
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