(32 nodes) Nuclear DNA replication network (Pseudomicrostroma glucosiphilum)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	A0A316TXC8	CBFD_NFYB_HMF domain-containing protein. (381 aa)
	A0A316TZE3	Kinase-like protein. (414 aa)
	A0A316U1C8	DNA helicase; Belongs to the MCM family. (871 aa)
	MCM7	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] (875 aa)
	A0A316U221	DNA helicase; Belongs to the MCM family. (971 aa)
	A0A316U2W2	Uncharacterized protein. (853 aa)
	A0A316U328	ATP-dependent DNA ligase. (1009 aa)
	A0A316U3T0	DNA helicase; Belongs to the MCM family. (910 aa)
	A0A316U444	ORC_WH_C domain-containing protein. (574 aa)
	A0A316U5V3	Uncharacterized protein. (206 aa)
	A0A316U6H4	WD40 repeat-like protein. (976 aa)
	A0A316U6X2	DNA ligase. (905 aa)
	A0A316U744	DNA polymerase. (1644 aa)
	A0A316U884	Proliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (271 aa)
	A0A316U912	CDC45-like protein. (804 aa)
	A0A316U914	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (1170 aa)
	A0A316U943	DUF602-domain-containing protein. (349 aa)
	A0A316U9N0	DUF862-domain-containing protein. (648 aa)
	A0A316UA94	Vezatin domain-containing protein. (1370 aa)
	A0A316UAE6	DNA_pol_E_B domain-containing protein. (621 aa)
	A0A316UB24	Uncharacterized protein. (722 aa)
	A0A316UB61	Uncharacterized protein. (638 aa)
	A0A316UBU0	DNA helicase; Belongs to the MCM family. (731 aa)
	A0A316UD98	Uncharacterized protein. (247 aa)
	A0A316UDG1	MT-A70-domain-containing protein; Belongs to the MT-A70-like family. (395 aa)
	A0A316UDG3	Uncharacterized protein. (733 aa)
	A0A316UDQ8	Uncharacterized protein. (682 aa)
	A0A316UEN1	DNA helicase; Belongs to the MCM family. (1003 aa)
	A0A316UET1	Rad51-domain-containing protein. (170 aa)
	A0A316UFI0	Sld5 domain-containing protein. (245 aa)
	A0A316UFQ9	Uncharacterized protein. (619 aa)
	A0A316UGD6	P-loop containing nucleoside triphosphate hydrolase protein. (714 aa)

Your Current Organism:

Pseudomicrostroma glucosiphilum

NCBI taxonomy Id: 1684307
Other names: CBS 14053, MCA 4718, Microstromatales sp. MCA4718, NRRL 66310, P. glucosiphilum, Rhodotorula sp. MCA 4718

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
A0A316TXC8	A0A316U744	A0A316TXC8	A0A316U744	CBFD_NFYB_HMF domain-containing protein.	DNA polymerase.	0.489
A0A316TXC8	A0A316UAE6	A0A316TXC8	A0A316UAE6	CBFD_NFYB_HMF domain-containing protein.	DNA_pol_E_B domain-containing protein.	0.709
A0A316TZE3	A0A316U1C8	A0A316TZE3	A0A316U1C8	Kinase-like protein.	DNA helicase; Belongs to the MCM family.	0.995
A0A316TZE3	A0A316U221	A0A316TZE3	A0A316U221	Kinase-like protein.	DNA helicase; Belongs to the MCM family.	0.995
A0A316TZE3	A0A316U2W2	A0A316TZE3	A0A316U2W2	Kinase-like protein.	Uncharacterized protein.	0.410
A0A316TZE3	A0A316U3T0	A0A316TZE3	A0A316U3T0	Kinase-like protein.	DNA helicase; Belongs to the MCM family.	0.998
A0A316TZE3	A0A316U444	A0A316TZE3	A0A316U444	Kinase-like protein.	ORC_WH_C domain-containing protein.	0.797
A0A316TZE3	A0A316U744	A0A316TZE3	A0A316U744	Kinase-like protein.	DNA polymerase.	0.725
A0A316TZE3	A0A316U912	A0A316TZE3	A0A316U912	Kinase-like protein.	CDC45-like protein.	0.892
A0A316TZE3	A0A316UAE6	A0A316TZE3	A0A316UAE6	Kinase-like protein.	DNA_pol_E_B domain-containing protein.	0.718
A0A316TZE3	A0A316UB61	A0A316TZE3	A0A316UB61	Kinase-like protein.	Uncharacterized protein.	0.900
A0A316TZE3	A0A316UBU0	A0A316TZE3	A0A316UBU0	Kinase-like protein.	DNA helicase; Belongs to the MCM family.	0.996
A0A316TZE3	A0A316UDG3	A0A316TZE3	A0A316UDG3	Kinase-like protein.	Uncharacterized protein.	0.836
A0A316TZE3	A0A316UDQ8	A0A316TZE3	A0A316UDQ8	Kinase-like protein.	Uncharacterized protein.	0.799
A0A316TZE3	A0A316UEN1	A0A316TZE3	A0A316UEN1	Kinase-like protein.	DNA helicase; Belongs to the MCM family.	0.998
A0A316TZE3	A0A316UFI0	A0A316TZE3	A0A316UFI0	Kinase-like protein.	Sld5 domain-containing protein.	0.485
A0A316TZE3	A0A316UFQ9	A0A316TZE3	A0A316UFQ9	Kinase-like protein.	Uncharacterized protein.	0.501
A0A316TZE3	A0A316UGD6	A0A316TZE3	A0A316UGD6	Kinase-like protein.	P-loop containing nucleoside triphosphate hydrolase protein.	0.845
A0A316TZE3	MCM7	A0A316TZE3	A0A316U1S8	Kinase-like protein.	DNA replication licensing factor MCM7; Acts as component of the mcm2-7 complex (mcm complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the mcm2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...]	0.994
A0A316U1C8	A0A316TZE3	A0A316U1C8	A0A316TZE3	DNA helicase; Belongs to the MCM family.	Kinase-like protein.	0.995