(40 nodes) RNA polymerase II, holoenzyme network (Pseudomicrostroma glucosiphilum)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	A0A316UFG5	TFIID-31kDa-domain-containing protein. (218 aa)
	A0A316U2E5	Uncharacterized protein. (1122 aa)
	A0A316U2S0	Transcription initiation factor IIA subunit 2; TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation; Belongs to the TFIIA subunit 2 family. (119 aa)
	A0A316U2S2	RNA polymerase Rpb6. (160 aa)
	A0A316U3S4	RNA polymerase II transcription factor B subunit 2; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA. Belongs to the TFB2 family. (483 aa)
	A0A316U3S5	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1252 aa)
	A0A316U468	Plus3 domain-containing protein. (560 aa)
	A0A316U525	Uncharacterized protein. (501 aa)
	A0A316U577	General transcription and DNA repair factor IIH; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II; Belongs to the GTF2H2 family. (530 aa)
	A0A316U5I8	TAF domain-containing protein. (535 aa)
	A0A316U5T1	TAFII55_N domain-containing protein. (757 aa)
	A0A316U5Y7	Uncharacterized protein. (422 aa)
	A0A316U6E4	Uncharacterized protein. (640 aa)
	A0A316U6M3	WD40 repeat-like protein. (490 aa)
	A0A316U7G6	TAFII28-domain-containing protein. (314 aa)
	A0A316U853	CDK-activating kinase assembly factor. (480 aa)
	A0A316U854	RBP11-like subunits of RNA polymerase. (201 aa)
	A0A316U9I9	TFIIE domain-containing protein. (443 aa)
	A0A316U9M3	Transcription factor Tfb4. (385 aa)
	A0A316UAC5	CDC73-domain-containing protein. (500 aa)
	A0A316UB06	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. (1801 aa)
	A0A316UBJ8	Pkinase-domain-containing protein; Belongs to the protein kinase superfamily. (430 aa)
	A0A316UBP5	TFIID_20kDa domain-containing protein. (687 aa)
	A0A316UCF7	Transcription initiation factor IIE subunit beta; Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase. (261 aa)
	A0A316UCV3	Uncharacterized protein. (87 aa)
	A0A316UCX1	Leo1-domain-containing protein. (396 aa)
	A0A316TXG5	WD_REPEATS_REGION domain-containing protein. (639 aa)
	A0A316UD53	Putative 25 kd subunit of DNA-directed RNA polymerases I, II and III. (207 aa)
	A0A316UDF5	TFIID-18kDa-domain-containing protein. (188 aa)
	A0A316UDX6	WD40 repeat-like protein. (936 aa)
	A0A316UEV6	Uncharacterized protein. (695 aa)
	A0A316U159	Transcription initiation factor TFIID subunit 10; Functions as a component of the DNA-binding general transcription factor complex TFIID and the transcription regulatory histone acetylation (HAT) complexes SAGA and SLIK. Binding of TFIID to a promoter (with or without TATA element) is the initial step in preinitiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modificati [...] (250 aa)
	A0A316UGL8	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. (133 aa)
	A0A316UGS1	Uncharacterized protein. (1757 aa)
	A0A316UJZ7	Insert subdomain of RNA polymerase alpha subunit. (281 aa)
	A0A316TY24	Uncharacterized protein. (254 aa)
	A0A316U0H1	Uncharacterized protein. (1428 aa)
	A0A316U0P9	Uncharacterized protein. (906 aa)
	A0A316TZR9	Uncharacterized protein. (65 aa)
	A0A316U020	Uncharacterized protein. (242 aa)

Your Current Organism:

Pseudomicrostroma glucosiphilum

NCBI taxonomy Id: 1684307
Other names: CBS 14053, MCA 4718, Microstromatales sp. MCA4718, NRRL 66310, P. glucosiphilum, Rhodotorula sp. MCA 4718

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
A0A316TXG5	A0A316U0H1	WD_REPEATS_REGION domain-containing protein.	Uncharacterized protein.	0.480
A0A316TXG5	A0A316U0P9	WD_REPEATS_REGION domain-containing protein.	Uncharacterized protein.	0.564
A0A316TXG5	A0A316U2S2	WD_REPEATS_REGION domain-containing protein.	RNA polymerase Rpb6.	0.603
A0A316TXG5	A0A316U3S5	WD_REPEATS_REGION domain-containing protein.	DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.639
A0A316TXG5	A0A316U5Y7	WD_REPEATS_REGION domain-containing protein.	Uncharacterized protein.	0.595
A0A316TXG5	A0A316U6M3	WD_REPEATS_REGION domain-containing protein.	WD40 repeat-like protein.	0.483
A0A316TXG5	A0A316U854	WD_REPEATS_REGION domain-containing protein.	RBP11-like subunits of RNA polymerase.	0.670
A0A316TXG5	A0A316UB06	WD_REPEATS_REGION domain-containing protein.	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.435
A0A316TXG5	A0A316UCV3	WD_REPEATS_REGION domain-containing protein.	Uncharacterized protein.	0.629
A0A316TXG5	A0A316UD53	WD_REPEATS_REGION domain-containing protein.	Putative 25 kd subunit of DNA-directed RNA polymerases I, II and III.	0.644
A0A316TXG5	A0A316UDX6	WD_REPEATS_REGION domain-containing protein.	WD40 repeat-like protein.	0.478
A0A316TXG5	A0A316UGL8	WD_REPEATS_REGION domain-containing protein.	DNA-directed RNA polymerase subunit; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.	0.629
A0A316TXG5	A0A316UJZ7	WD_REPEATS_REGION domain-containing protein.	Insert subdomain of RNA polymerase alpha subunit.	0.664
A0A316TY24	A0A316TZR9	Uncharacterized protein.	Uncharacterized protein.	0.717
A0A316TY24	A0A316U020	Uncharacterized protein.	Uncharacterized protein.	0.883
A0A316TY24	A0A316U0P9	Uncharacterized protein.	Uncharacterized protein.	0.900
A0A316TY24	A0A316U159	Uncharacterized protein.	Transcription initiation factor TFIID subunit 10; Functions as a component of the DNA-binding general transcription factor complex TFIID and the transcription regulatory histone acetylation (HAT) complexes SAGA and SLIK. Binding of TFIID to a promoter (with or without TATA element) is the initial step in preinitiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modificati [...]	0.868
A0A316TY24	A0A316U2E5	Uncharacterized protein.	Uncharacterized protein.	0.819
A0A316TY24	A0A316U2S0	Uncharacterized protein.	Transcription initiation factor IIA subunit 2; TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation; Belongs to the TFIIA subunit 2 family.	0.923
A0A316TY24	A0A316U2S2	Uncharacterized protein.	RNA polymerase Rpb6.	0.904