STRINGSTRING
A0A316U2S0 A0A316U2S0 KAE1 KAE1 A0A316U3R4 A0A316U3R4 A0A316U3S4 A0A316U3S4 A0A316U4E0 A0A316U4E0 A0A316U4G9 A0A316U4G9 A0A316U4Y1 A0A316U4Y1 A0A316U4Y5 A0A316U4Y5 A0A316U577 A0A316U577 A0A316U5U9 A0A316U5U9 A0A316U6B2 A0A316U6B2 A0A316U702 A0A316U702 A0A316U7B4 A0A316U7B4 A0A316U7C3 A0A316U7C3 A0A316U7E0 A0A316U7E0 A0A316U7S1 A0A316U7S1 A0A316U7W6 A0A316U7W6 A0A316U8D3 A0A316U8D3 MED17 MED17 A0A316U9Q3 A0A316U9Q3 A0A316UA89 A0A316UA89 A0A316UAF9 A0A316UAF9 A0A316UAG7 A0A316UAG7 A0A316UAN5 A0A316UAN5 A0A316UBA3 A0A316UBA3 A0A316UC25 A0A316UC25 MED10 MED10 A0A316UCF7 A0A316UCF7 A0A316UCN2 A0A316UCN2 MED5 MED5 A0A316UDH5 A0A316UDH5 A0A316UDK6 A0A316UDK6 A0A316UDR5 A0A316UDR5 A0A316UEA8 A0A316UEA8 MED4 MED4 A0A316UES4 A0A316UES4 SUS1 SUS1 A0A316UGH3 A0A316UGH3 A0A316UGX9 A0A316UGX9 A0A316UHX4 A0A316UHX4 A0A316UI52 A0A316UI52 MED6 MED6 A0A316UIF4 A0A316UIF4 A0A316U0I4 A0A316U0I4 A0A316U159 A0A316U159 A0A316TX45 A0A316TX45 A0A316TXC6 A0A316TXC6 A0A316TY67 A0A316TY67 A0A316TYT0 A0A316TYT0 A0A316U1T5 A0A316U1T5 A0A316U051 A0A316U051 A0A316U0H6 A0A316U0H6
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
A0A316U2S0Transcription initiation factor IIA subunit 2; TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation; Belongs to the TFIIA subunit 2 family. (119 aa)
KAE1tRNA N6-adenosine threonylcarbamoyltransferase; Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. KAE1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. Th [...] (428 aa)
A0A316U3R4Transcription elongation factor 1 homolog; Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions. Belongs to the ELOF1 family. (83 aa)
A0A316U3S4RNA polymerase II transcription factor B subunit 2; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA. Belongs to the TFB2 family. (483 aa)
A0A316U4E0Zn(2)-C6 fungal-type domain-containing protein. (941 aa)
A0A316U4G9SRF-like protein. (54 aa)
A0A316U4Y1Uncharacterized protein. (1347 aa)
A0A316U4Y5RuvB-like helicase; DNA helicase participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. (508 aa)
A0A316U577General transcription and DNA repair factor IIH; Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II; Belongs to the GTF2H2 family. (530 aa)
A0A316U5U9Enhancer of polycomb-like protein. (1227 aa)
A0A316U6B2Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (506 aa)
A0A316U702Protein HIR; Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle; Belongs to the WD repeat HIR1 family. (1006 aa)
A0A316U7B4Zn(2)-C6 fungal-type domain-containing protein. (1408 aa)
A0A316U7C3FACT complex subunit POB3; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of [...] (593 aa)
A0A316U7E0Zn(2)-C6 fungal-type domain-containing protein. (1230 aa)
A0A316U7S1Elongator complex protein 3; Catalytic tRNA acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. (564 aa)
A0A316U7W6Zn(2)-C6 fungal-type domain-containing protein. (1157 aa)
A0A316U8D3Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (446 aa)
MED17Mediator of RNA polymerase II transcription subunit 17; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (769 aa)
A0A316U9Q3Zn(2)-C6 fungal-type domain-containing protein. (989 aa)
A0A316UA89Zn(2)-C6 fungal-type domain-containing protein. (1268 aa)
A0A316UAF9Uncharacterized protein. (1141 aa)
A0A316UAG7Mediator of RNA polymerase II transcription subunit 7; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. (201 aa)
A0A316UAN5Actin-related protein 8; Probably involved in transcription regulation via its interaction with the INO80 complex, a chromatin remodeling complex. Belongs to the actin family. (812 aa)
A0A316UBA3SRF-TF-domain-containing protein. (246 aa)
A0A316UC25Mediator of RNA polymerase II transcription subunit 13; Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. (1792 aa)
MED10Mediator of RNA polymerase II transcription subunit 10; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (257 aa)
A0A316UCF7Transcription initiation factor IIE subunit beta; Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase. (261 aa)
A0A316UCN2Uncharacterized protein. (171 aa)
MED5Mediator of RNA polymerase II transcription subunit 5; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (314 aa)
A0A316UDH5Adenylate kinase isoenzyme 6 homolog; Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has also ATPase activity. May be involved in rRNA maturation and transcription regulation. (212 aa)
A0A316UDK6Zn(2)-C6 fungal-type domain-containing protein. (1191 aa)
A0A316UDR5Uncharacterized protein. (536 aa)
A0A316UEA8ARID domain-containing protein. (1346 aa)
MED4Mediator of RNA polymerase II transcription subunit 4; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (405 aa)
A0A316UES4Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1118 aa)
SUS1Transcription and mRNA export factor SUS1; Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction and promoter selectivity, interaction with transcription activators, and chromatin modification through histone acetylation and deubiquitination. Within the SAGA complex, participates to a subcomplex required for deubiquitination of [...] (103 aa)
A0A316UGH3Zn(2)-C6 fungal-type domain-containing protein. (1059 aa)
A0A316UGX9Zn(2)-C6 fungal-type domain-containing protein. (627 aa)
A0A316UHX4Zn(2)-C6 fungal-type domain-containing protein. (1125 aa)
A0A316UI52Histone deacetylase; Belongs to the histone deacetylase family. HD Type 1 subfamily. (514 aa)
MED6Mediator of RNA polymerase II transcription subunit 6; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (280 aa)
A0A316UIF4Mediator of RNA polymerase II transcription subunit 31; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (150 aa)
A0A316U0I4Mediator of RNA polymerase II transcription subunit 14; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1305 aa)
A0A316U159Transcription initiation factor TFIID subunit 10; Functions as a component of the DNA-binding general transcription factor complex TFIID and the transcription regulatory histone acetylation (HAT) complexes SAGA and SLIK. Binding of TFIID to a promoter (with or without TATA element) is the initial step in preinitiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modificati [...] (250 aa)
A0A316TX45Nascent polypeptide-associated complex subunit beta. (172 aa)
A0A316TXC6Zn(2)-C6 fungal-type domain-containing protein. (1238 aa)
A0A316TY67Zn(2)-C6 fungal-type domain-containing protein. (1101 aa)
A0A316TYT0Zn(2)-C6 fungal-type domain-containing protein. (852 aa)
A0A316U1T5RuvB-like helicase; DNA helicase participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. (472 aa)
A0A316U051Zn(2)-C6 fungal-type domain-containing protein. (652 aa)
A0A316U0H6Zn(2)-C6 fungal-type domain-containing protein. (780 aa)
Your Current Organism:
Pseudomicrostroma glucosiphilum
NCBI taxonomy Id: 1684307
Other names: CBS 14053, MCA 4718, Microstromatales sp. MCA4718, NRRL 66310, P. glucosiphilum, Rhodotorula sp. MCA 4718
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