STRINGSTRING
rplB rplB RY69_847 RY69_847 RY69_807 RY69_807 rpsB rpsB RY69_760 RY69_760 RY69_723 RY69_723 RY69_686 RY69_686 RY69_673 RY69_673 rpmB rpmB RY69_630 RY69_630 raiA raiA RY69_583 RY69_583 rplT rplT rpmI rpmI smc smc RY69_470 RY69_470 RY69_469 RY69_469 RY69_456 RY69_456 hup hup RY69_413 RY69_413 rpmE rpmE cgtA cgtA rplU rplU RY69_297 RY69_297 RY69_264 RY69_264 RY69_2191 RY69_2191 RY69_2159 RY69_2159 RY69_2114 RY69_2114 RY69_2108 RY69_2108 RY69_2090 RY69_2090 RY69_2065 RY69_2065 RY69_2064 RY69_2064 RY69_206 RY69_206 rpmH rpmH recF recF gyrB gyrB RY69_1980 RY69_1980 RY69_1903 RY69_1903 RY69_1902 RY69_1902 RY69_1901 RY69_1901 recR recR topA topA pepD pepD RY69_1835 RY69_1835 RY69_1824 RY69_1824 dnaB dnaB rpsF rpsF rpsR rpsR nth nth rpsO rpsO rpsP rpsP rplQ rplQ rpmF rpmF rpsK rpsK RY69_1617 RY69_1617 RY69_161 RY69_161 RY69_1586 RY69_1586 RY69_1584 RY69_1584 RY69_1581 RY69_1581 rplJ rplJ rplL rplL RY69_90 RY69_90 RY69_909 RY69_909 RY69_945 RY69_945 rplO rplO rpmD rpmD RY69_1547 RY69_1547 rpsE rpsE rplR rplR rpsH rpsH rpsN-2 rpsN-2 rplE rplE recQ recQ rplX rplX dnaG dnaG pdxS pdxS rplN rplN rpsQ rpsQ rpmC rpmC rpsC rpsC rpsG rpsG RY69_864 RY69_864 rplW rplW rplC rplC rpsJ rpsJ recO recO RY69_1328 RY69_1328 recN recN rpsA rpsA rpsI rpsI rplM rplM rplY rplY rpsT rpsT rpmG rpmG
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
rplB50S ribosomal protein L2; One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome. Belongs to the universal ribosomal protein uL2 family. (276 aa)
RY69_847Hypothetical protein; Belongs to the SOS response-associated peptidase family. (230 aa)
RY69_807IstB-like ATP-binding protein. (261 aa)
rpsB30S ribosomal protein S2; Belongs to the universal ribosomal protein uS2 family. (279 aa)
RY69_760DNA topoisomerase. (719 aa)
RY69_723DNA-binding helix-turn-helix protein. (229 aa)
RY69_686IstB-like ATP-binding protein. (253 aa)
RY69_673IstB-like ATP-binding protein. (261 aa)
rpmB50S ribosomal protein L28; Belongs to the bacterial ribosomal protein bL28 family. (64 aa)
RY69_630Serine/threonine protein kinase. (707 aa)
raiARibosome-associated factor Y; Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth. (220 aa)
RY69_583Cobyrinic acid a,c-diamide synthase. (319 aa)
rplT50S ribosomal protein L20; Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit. (127 aa)
rpmI50S ribosomal protein L35. (64 aa)
smcSMC N domain containing protein; Required for chromosome condensation and partitioning. Belongs to the SMC family. (1215 aa)
RY69_470Replication-associated recombination protein A. (459 aa)
RY69_469DEAD/DEAH box helicase. (856 aa)
RY69_456ATPase involved in DNA repair. (481 aa)
hupDNA-binding protein HU; Belongs to the bacterial histone-like protein family. (93 aa)
RY69_413Primosomal protein N'. (769 aa)
rpmE50S ribosomal protein L31; Binds the 23S rRNA. (70 aa)
cgtAGTPase obg; An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. (563 aa)
rplU50S ribosomal protein L21; This protein binds to 23S rRNA in the presence of protein L20; Belongs to the bacterial ribosomal protein bL21 family. (102 aa)
RY69_297Hypothetical protein. (404 aa)
RY69_264IstB-like ATP-binding protein. (261 aa)
RY69_2191IstB-like ATP-binding protein. (253 aa)
RY69_2159Extracellular solute-binding protein, family 1. (415 aa)
RY69_2114Transcriptional regulator, Sir2 family. (251 aa)
RY69_2108Raffinose-binding protein. (429 aa)
RY69_2090Lipopolysaccharide kinase. (470 aa)
RY69_2065Stage 0 sporulation protein J; Belongs to the ParB family. (421 aa)
RY69_2064Soj family protein. (322 aa)
RY69_206Putative tetratricopeptide repeat-containing domain protein. (733 aa)
rpmH50S ribosomal protein L34; Belongs to the bacterial ribosomal protein bL34 family. (44 aa)
recFDNA replication and repair protein RecF; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP. (368 aa)
gyrBDNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. (696 aa)
RY69_1980Putative serine/threonine-protein kinase PrkC. (682 aa)
RY69_1903Type II/IV secretion system protein. (339 aa)
RY69_1902Flp pilus assembly protein. (162 aa)
RY69_1901Flp pilus assembly protein. (104 aa)
recRRecombination protein RecR; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. (200 aa)
topADNA topoisomerase; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA superc [...] (1016 aa)
pepDDipeptidase. (533 aa)
RY69_1835FMN-binding domain protein. (183 aa)
RY69_1824Dipeptidase A. (506 aa)
dnaBReplicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. Belongs to the helicase family. DnaB subfamily. (486 aa)
rpsF30S ribosomal protein S6; Binds together with S18 to 16S ribosomal RNA. (96 aa)
rpsR30S ribosomal protein S18; Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit; Belongs to the bacterial ribosomal protein bS18 family. (82 aa)
nthEndonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (222 aa)
rpsO30S ribosomal protein S15; Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome. (89 aa)
rpsP30S ribosomal protein S16; Belongs to the bacterial ribosomal protein bS16 family. (149 aa)
rplQ50S ribosomal protein L17. (174 aa)
rpmF50S ribosomal protein L32; Belongs to the bacterial ribosomal protein bL32 family. (64 aa)
rpsK30S ribosomal protein S11; Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine- Dalgarno cleft in the 70S ribosome; Belongs to the universal ribosomal protein uS11 family. (132 aa)
RY69_1617L-ribulose-5-phosphate 4-epimerase. (46 aa)
RY69_16150S ribosomal protein L36. (37 aa)
RY69_1586IstB-like ATP-binding protein. (261 aa)
RY69_1584ISPsy20, transposase IstB. (253 aa)
RY69_1581IstB domain protein ATP-binding protein. (155 aa)
rplJ50S ribosomal protein L10; Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors. Belongs to the universal ribosomal protein uL10 family. (173 aa)
rplL50S ribosomal protein L7/L12; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation; Belongs to the bacterial ribosomal protein bL12 family. (126 aa)
RY69_90FHA domain protein. (451 aa)
RY69_909ParB-like protein. (472 aa)
RY69_945IstB-like ATP-binding protein. (253 aa)
rplO50S ribosomal protein L15; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family. (150 aa)
rpmD50S ribosomal protein L30. (64 aa)
RY69_1547Hypothetical protein. (418 aa)
rpsE30S ribosomal protein S5; Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body. Belongs to the universal ribosomal protein uS5 family. (242 aa)
rplR50S ribosomal protein L18; This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. (123 aa)
rpsH30S ribosomal protein S8; One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; Belongs to the universal ribosomal protein uS8 family. (132 aa)
rpsN-230S ribosomal protein S14 type Z; Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site. (61 aa)
rplE50S ribosomal protein L5; This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. (190 aa)
recQATP-dependent DNA helicase RecQ. (652 aa)
rplX50S ribosomal protein L24; One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit. (111 aa)
dnaGDNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. (697 aa)
pdxSPyridoxal biosynthesis lyase PdxS; Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5- phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively. Belongs to the PdxS/SNZ family. (291 aa)
rplN50S ribosomal protein L14; Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome; Belongs to the universal ribosomal protein uL14 family. (122 aa)
rpsQ30S ribosomal protein S17; One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA. (86 aa)
rpmC50S ribosomal protein L29; Belongs to the universal ribosomal protein uL29 family. (83 aa)
rpsC30S ribosomal protein S3; Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation; Belongs to the universal ribosomal protein uS3 family. (266 aa)
rpsG30S ribosomal protein S7; One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA; Belongs to the universal ribosomal protein uS7 family. (156 aa)
RY69_864Type III restriction enzyme, res subunit. (862 aa)
rplW50S ribosomal protein L23; One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome; Belongs to the universal ribosomal protein uL23 family. (98 aa)
rplC50S ribosomal protein L3; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family. (213 aa)
rpsJ30S ribosomal protein S10; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family. (102 aa)
recODNA repair protein RecO; Involved in DNA repair and RecF pathway recombination. (239 aa)
RY69_1328Putative tetratricopeptide repeat-containing domain protein. (1123 aa)
recNDNA repair protein RecN. (616 aa)
rpsA30S ribosomal protein S1. (491 aa)
rpsI30S ribosomal protein S9; Belongs to the universal ribosomal protein uS9 family. (163 aa)
rplM50S ribosomal protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. (149 aa)
rplY50S ribosomal protein L25; This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance. Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily. (205 aa)
rpsT30S ribosomal protein S20; Binds directly to 16S ribosomal RNA. (86 aa)
rpmG50S ribosomal protein L33; Belongs to the bacterial ribosomal protein bL33 family. (55 aa)
Your Current Organism:
Bifidobacterium breve
NCBI taxonomy Id: 1685
Other names: AS 1.2213, ATCC 15700, B. breve, BCRC 11846, Bifidobacterium parvulorum, CCRC 11846, CCRC:11846, CCUG 18365, CCUG 30511 A, CIP 64.69, DSM 20213, HAMBI 558, LMG 11042, LMG:11042, NCAIM B.01820, NCFB 2257, NCIMB 702257, NCTC 11815
Server load: low (16%) [HD]