Your Input: | |
| | iscS | Cysteine desulfurase; Master enzyme that delivers sulfur to a number of partners involved in Fe-S cluster assembly, tRNA modification or cofactor biosynthesis. Catalyzes the removal of elemental sulfur atoms from cysteine to produce alanine. Functions as a sulfur delivery protein for Fe-S cluster synthesis onto IscU, an Fe-S scaffold assembly protein, as well as other S acceptor proteins. (404 aa) |
| | KLV65340.1 | Ribonuclease G. (489 aa) |
| | argR | Arginine repressor; Regulates arginine biosynthesis genes. (156 aa) |
| | mtgA | Monofunctional biosynthetic peptidoglycan transglycosylase; Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors; Belongs to the glycosyltransferase 51 family. (239 aa) |
| | lptA | Lipopolysaccharide export system protein LptA; Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm. (184 aa) |
| | lptC | Lipopolysaccharide export system protein LptC; Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. Facilitates the transfer of LPS from the inner membrane to the periplasmic protein LptA. Could be a docking site for LptA. Belongs to the LptC family. (191 aa) |
| | KLV65392.1 | Transcriptional regulator; Belongs to the BolA/IbaG family. (105 aa) |
| | murA | UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (419 aa) |
| | obg | GTPase Obg; An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control. Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. (390 aa) |
| | KLV65402.1 | RNA-binding protein YhbY. (110 aa) |
| | rlmE | Ribosomal RNA large subunit methyltransferase E; Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit. (209 aa) |
| | rimP | Ribosome maturation factor RimP; Required for maturation of 30S ribosomal subunits. Belongs to the RimP family. (150 aa) |
| | rbfA | Ribosome-binding factor A; One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA. (134 aa) |
| | deaD | ATP-dependent RNA helicase DeaD; DEAD-box RNA helicase involved in various cellular processes at low temperature, including ribosome biogenesis, mRNA degradation and translation initiation. (643 aa) |
| | lpoA | Penicillin-binding protein activator LpoA; Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a). Belongs to the LpoA family. (684 aa) |
| | rsmI | Ribosomal RNA small subunit methyltransferase I; Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA. (287 aa) |
| | KLV65436.1 | Outer membrane protein. (839 aa) |
| | rlmG | Ribosomal RNA large subunit methyltransferase G; Specifically methylates the guanine in position 1835 (m2G1835) of 23S rRNA. (378 aa) |
| | ureE | Urease accessory protein UreE; Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly. Belongs to the UreE family. (152 aa) |
| | uppP | Undecaprenyl-diphosphatase; Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin; Belongs to the UppP family. (272 aa) |
| | KLV65593.1 | Hypothetical protein. (108 aa) |
| | yqgF | YqgF family RNAse H domain-containing protein; Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA; Belongs to the YqgF HJR family. (138 aa) |
| | KLV65605.1 | Ribosomal RNA small subunit methyltransferase E; Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit. (243 aa) |
| | zapA | Cell division protein ZapA; Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division. (109 aa) |
| | KLV65741.1 | Cysteine desulfurase CsdA. (401 aa) |
| | rlmM | Ribosomal RNA large subunit methyltransferase M; Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily. (366 aa) |
| | rlmD | 23S rRNA (uracil(1939)-C(5))-methyltransferase RlmD; Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmD subfamily. (432 aa) |
| | KLV65851.1 | Formate hydrogenlyase maturation protein HycH. (136 aa) |
| | KLV65919.1 | Hypothetical protein. (403 aa) |
| | bamE | Outer membrane protein assembly factor BamE; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. (114 aa) |
| | KLV66019.1 | Inner membrane protein YpjD. (288 aa) |
| | rimM | Ribosome maturation factor RimM; An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes; Belongs to the RimM family. (182 aa) |
| | bamD | Outer membrane protein assembly factor BamD; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. Constitutes, with BamA, the core component of the assembly machinery. (245 aa) |
| | KLV66036.1 | Ribosomal large subunit pseudouridine synthase D; Responsible for synthesis of pseudouridine from uracil. Belongs to the pseudouridine synthase RluA family. (326 aa) |
| | srmB | ATP-dependent RNA helicase SrmB; DEAD-box RNA helicase involved in the assembly of the 50S ribosomal subunit at low temperature. Exhibits RNA-stimulated ATP hydrolysis and RNA unwinding activity; Belongs to the DEAD box helicase family. SrmB subfamily. (442 aa) |
| | rnc | Ribonuclease 3; Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism. (239 aa) |
| | era | GTPase Era; An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism. (301 aa) |
| | KLV66102.1 | NifU-like protein; A scaffold on which IscS assembles Fe-S clusters. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters. (128 aa) |
| | iscA | Iron-binding protein IscA; Is able to transfer iron-sulfur clusters to apo-ferredoxin. Multiple cycles of [2Fe2S] cluster formation and transfer are observed, suggesting that IscA acts catalytically. Recruits intracellular free iron so as to provide iron for the assembly of transient iron-sulfur cluster in IscU in the presence of IscS, L-cysteine and the thioredoxin reductase system TrxA/TrxB. (107 aa) |
| | hscB | Co-chaperone HscB; Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA; Belongs to the HscB family. (171 aa) |
| | hscA | Chaperone HscA; Chaperone involved in the maturation of iron-sulfur cluster- containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB. Involved in the maturation of IscU. (616 aa) |
| | KLV66107.1 | Protein IscX. (66 aa) |
| | KLV66112.1 | Penicillin-binding protein 1C. (770 aa) |
| | rlmN | Dual-specificity RNA methyltransferase RlmN; Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity; Belongs to the radical SAM superfamily. RlmN family. (388 aa) |
| | bamB | Outer membrane protein assembly factor BamB; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. (392 aa) |
| | der | GTPase Der; GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family. (490 aa) |
| | bamC | Outer membrane protein assembly factor BamC; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. (344 aa) |
| | zipA | Cell division protein ZipA; Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for the recruitment to the septal ring of downstream cell division proteins. (328 aa) |
| | KLV66308.1 | Hypothetical protein. (160 aa) |
| | ccmA | Cytochrome c biogenesis ATP-binding export protein CcmA; Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. CcmA exporter (TC 3.A.1.107) family. (208 aa) |
| | KLV66462.1 | Heme exporter protein B; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes; Belongs to the CcmB/CycW/HelB family. (219 aa) |
| | ccmC | Heme exporter protein C; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes; Belongs to the CcmC/CycZ/HelC family. (245 aa) |
| | KLV66464.1 | Heme exporter protein D; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes; Belongs to the CcmD/CycX/HelD family. (70 aa) |
| | ccmE | Cytochrome c-type biogenesis protein CcmE; Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH. Belongs to the CcmE/CycJ family. (159 aa) |
| | KLV66466.1 | Cytochrome c-type biogenesis protein CcmF. (651 aa) |
| | KLV66467.1 | Thiol:disulfide interchange protein DsbE. (185 aa) |
| | KLV66468.1 | Cytochrome c-type biogenesis protein CcmH; Possible subunit of a heme lyase. (349 aa) |
| | KLV66474.1 | Hypothetical protein. (774 aa) |
| | KLV66498.1 | Ribosomal small subunit pseudouridine synthase A; Belongs to the pseudouridine synthase RsuA family. (235 aa) |
| | lpxT | Inner membrane protein YeiU; Involved in the modification of the lipid A domain of lipopolysaccharides (LPS). Transfers a phosphate group from undecaprenyl pyrophosphate (C55-PP) to lipid A to form lipid A 1- diphosphate. Contributes to the recycling of undecaprenyl phosphate (C55-P); Belongs to the LpxT phosphotransferase family. (237 aa) |
| | torD | Hypothetical protein; Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor; Belongs to the TorD/DmsD family. TorD subfamily. (210 aa) |
| | KLV66548.1 | D-alanyl-D-alanine endopeptidase; Belongs to the peptidase S11 family. (315 aa) |
| | KLV66561.1 | Protein mrp; Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP; Belongs to the Mrp/NBP35 ATP-binding proteins family. (369 aa) |
| | KLV66565.1 | Outer membrane protein. (827 aa) |
| | KLV66696.1 | D-alanyl-D-alanine carboxypeptidase DacD; Belongs to the peptidase S11 family. (388 aa) |
| | KLV66744.1 | L,D-transpeptidase linking Lpp to murein. (309 aa) |
| | KLV66823.1 | Flagellar biosynthetic protein FliR; Role in flagellar biosynthesis. Belongs to the FliR/MopE/SpaR family. (264 aa) |
| | fliQ | Flagellar biosynthetic protein FliQ; Role in flagellar biosynthesis. Belongs to the FliQ/MopD/SpaQ family. (89 aa) |
| | KLV66830.1 | Hypothetical protein. (404 aa) |
| | KLV66832.1 | Flagellum-specific ATP synthase. (456 aa) |
| | KLV66842.1 | Flagellar protein FliS. (135 aa) |
| | flhD | Flagellar transcriptional regulator FlhD; Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non- flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways; Belongs to the FlhD family. (113 aa) |
| | flhB | Flagellar biosynthetic protein FlhB; Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin; Belongs to the type III secretion exporter family. (383 aa) |
| | flhA | Flagellar biosynthesis protein FlhA; Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin; Belongs to the FHIPEP (flagella/HR/invasion proteins export pore) family. (692 aa) |
| | mrdA | Penicillin-binding protein 2; Catalyzes cross-linking of the peptidoglycan cell wall. Belongs to the transpeptidase family. MrdA subfamily. (645 aa) |
| | cutC | Copper homeostasis protein CutC; Participates in the control of copper homeostasis. Belongs to the CutC family. (248 aa) |
| | rsmF | Ribosomal RNA small subunit methyltransferase F; Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA. (462 aa) |
| | ftsI | Transpeptidase; Catalyzes cross-linking of the peptidoglycan cell wall at the division septum. (581 aa) |
| | KLV67041.1 | Septum site-determining protein MinD. (270 aa) |
| | minC | Septum site-determining protein MinC; Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization; Belongs to the MinC family. (235 aa) |
| | KLV67054.1 | Murein tetrapeptide carboxypeptidase. (304 aa) |
| | KLV67070.1 | Hypothetical protein. (759 aa) |
| | KLV67087.1 | Hypothetical protein. (830 aa) |
| | KLV67133.1 | Nitrate reductase molybdenum cofactor assembly chaperone NarJ. (236 aa) |
| | KLV67177.1 | Protein TrpH. (292 aa) |
| | KLV67179.1 | Ribosomal large subunit pseudouridine synthase B; Belongs to the pseudouridine synthase RsuA family. (291 aa) |
| | KLV67226.1 | Hypothetical protein. (859 aa) |
| | KLV67287.1 | Nitrate reductase molybdenum cofactor assembly chaperone. (231 aa) |
| | dbpA | ATP-dependent RNA helicase DbpA; DEAD-box RNA helicase involved in the assembly of the 50S ribosomal subunit. Has an RNA-dependent ATPase activity, which is specific for 23S rRNA, and a 3' to 5' RNA helicase activity that uses the energy of ATP hydrolysis to destabilize and unwind short rRNA duplexes. (457 aa) |
| | KLV67357.1 | ATP-dependent RNA helicase HrpA. (1300 aa) |
| | KLV67358.1 | Protein YdcF. (263 aa) |
| | KLV67364.1 | Hypothetical protein. (826 aa) |
| | KLV64191.1 | Glutaredoxin-4; Belongs to the glutaredoxin family. Monothiol subfamily. (115 aa) |
| | KLV64271.1 | Murein L,D-transpeptidase. (334 aa) |
| | sufE | Cysteine desulfuration protein SufE; Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L- alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process; Belongs to the SufE family. (138 aa) |
| | KLV64274.1 | FeS cluster assembly protein SufD. (423 aa) |
| | KLV64275.1 | FeS assembly ATPase SufC. (248 aa) |
| | KLV64276.1 | FeS cluster assembly protein SufB. (495 aa) |
| | KLV64277.1 | Protein SufA; Belongs to the HesB/IscA family. (122 aa) |
| | rplT | 50S ribosomal protein L20; Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit. (118 aa) |
| | KLV64333.1 | Osmotically-inducible lipoprotein E. (113 aa) |
| | KLV64368.1 | MltA-interacting protein. (247 aa) |
| | KLV64411.1 | Ribosomal large subunit pseudouridine synthase E; Belongs to the pseudouridine synthase RsuA family. (207 aa) |
| | KLV64433.1 | L,D-transpeptidase linking Lpp to murein. (321 aa) |
| | nagZ | Beta-hexosaminidase; Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide- linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N- acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides. Belongs to the glycosyl hydrolase 3 family. NagZ subfamily. (341 aa) |
| | lpoB | Penicillin-binding protein activator LpoB; Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b). Belongs to the LpoB family. (213 aa) |
| | mltG | Aminodeoxychorismate lyase; Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation. (340 aa) |
| | KLV64462.1 | Hypothetical protein. (173 aa) |
| | KLV64464.1 | Ribosomal large subunit pseudouridine synthase C; Responsible for synthesis of pseudouridine from uracil. Belongs to the pseudouridine synthase RluA family. (331 aa) |
| | rne | Ribonuclease E; Endoribonuclease that plays a central role in RNA processing and decay. Required for the maturation of 5S and 16S rRNAs and the majority of tRNAs. Also involved in the degradation of most mRNAs. Belongs to the RNase E/G family. RNase E subfamily. (1082 aa) |
| | flgK | Flagellar hook-associated protein 1. (552 aa) |
| | KLV64470.1 | Peptidoglycan hydrolase FlgJ. (316 aa) |
| | KLV64479.1 | Flagella basal body P-ring formation protein FlgA; Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P- ring assembly; Belongs to the FlgA family. (219 aa) |
| | KLV64481.1 | Flagella synthesis protein FlgN. (140 aa) |
| | murJ | Integral membrane protein MviN; Involved in peptidoglycan biosynthesis. Transports lipid- linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane. (511 aa) |
| | KLV64485.1 | Ribosomal-protein-alanine acetyltransferase. (194 aa) |
| | KLV64510.1 | Curli production assembly/transport component CsgE. (130 aa) |
| | KLV64511.1 | Curli production assembly/transport component CsgF. (137 aa) |
| | KLV64512.1 | Curli production assembly/transport component CsgG. (277 aa) |
| | torD-2 | Chaperone; Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor; Belongs to the TorD/DmsD family. TorD subfamily. (203 aa) |
| | KLV64553.1 | Hypothetical protein. (626 aa) |
| | rlmI | Ribosomal RNA large subunit methyltransferase I; Specifically methylates the cytosine at position 1962 (m5C1962) of 23S rRNA. (403 aa) |
| | sulA | Cell division inhibitor SulA; Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1:1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division. (169 aa) |
| | rlmL | Ribosomal RNA large subunit methyltransferase K/L; Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA. Belongs to the methyltransferase superfamily. RlmKL family. (702 aa) |
| | zapC | Cell division protein ZapC; Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ. (180 aa) |
| | KLV64670.1 | Murein L,D-transpeptidase. (599 aa) |
| | rlmC | 23S rRNA (uracil(747)-C(5))-methyltransferase RlmC; Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA; Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. RlmC subfamily. (375 aa) |
| | KLV62739.1 | Oxidoreductase. (158 aa) |
| | KLV62754.1 | Undecaprenyl pyrophosphate phosphatase. (202 aa) |
| | KLV62756.1 | D-alanyl-D-alanine carboxypeptidase DacC; Belongs to the peptidase S11 family. (400 aa) |
| | KLV62781.1 | L,D-transpeptidase linking Lpp to murein. (306 aa) |
| | rlmF | Ribosomal RNA large subunit methyltransferase F; Specifically methylates the adenine in position 1618 of 23S rRNA. (308 aa) |
| | rhlE | ATP-dependent RNA helicase RhlE; DEAD-box RNA helicase involved in ribosome assembly. Has RNA- dependent ATPase activity and unwinds double-stranded RNA. (448 aa) |
| | cpoB | Tol-pal system protein YbgF; Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division; Belongs to the CpoB family. (262 aa) |
| | ybeY | Endoribonuclease YbeY; Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA. (155 aa) |
| | KLV62947.1 | Hypothetical protein. (857 aa) |
| | lptE | LPS-assembly lipoprotein LptE; Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane. (197 aa) |
| | rsfS | Ribosomal silencing factor RsfS; Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation. (105 aa) |
| | rlmH | Ribosomal RNA large subunit methyltransferase H; Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA; Belongs to the RNA methyltransferase RlmH family. (155 aa) |
| | mrdA-2 | Penicillin-binding protein 2; Catalyzes cross-linking of the peptidoglycan cell wall. Belongs to the transpeptidase family. MrdA subfamily. (633 aa) |
| | mrdB | Rod shape-determining protein RodA; Peptidoglycan polymerase that is essential for cell wall elongation; Belongs to the SEDS family. MrdB/RodA subfamily. (370 aa) |
| | KLV62962.1 | D-alanyl-D-alanine carboxypeptidase DacA; Belongs to the peptidase S11 family. (403 aa) |
| | KLV63040.1 | Hypothetical protein. (391 aa) |
| | KLV63068.1 | Outer membrane usher protein FimD. (873 aa) |
| | ddl | D-alanine-D-alanine ligase A; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. (370 aa) |
| | KLV63306.1 | Hypothetical protein. (830 aa) |
| | KLV63322.1 | Hypothetical protein. (246 aa) |
| | bamA | Outer membrane protein assembly factor BamA; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. Constitutes, with BamD, the core component of the assembly machinery. (804 aa) |
| | uppS | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific); Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di- trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide. (252 aa) |
| | erpA | Iron-sulfur cluster insertion protein ErpA; Required for insertion of 4Fe-4S clusters for at least IspG. (114 aa) |
| | KLV63392.1 | Penicillin-binding protein 1B; Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross- linking of the peptide subunits). (849 aa) |
| | KLV63393.1 | ATP-dependent RNA helicase HrpB. (810 aa) |
| | KLV63423.1 | Prepilin peptidase-dependent protein D; Belongs to the N-Me-Phe pilin family. (145 aa) |
| | zapD | Cell division protein ZapD; Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity. (247 aa) |
| | ftsZ | Cell division protein FtsZ; Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity. (383 aa) |
| | ftsQ | Cell division protein FtsQ; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly. (277 aa) |
| | ddl-2 | D-alanine-D-alanine ligase B; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. (306 aa) |
| | murC | UDP-N-acetylmuramate-L-alanine ligase; Cell wall formation; Belongs to the MurCDEF family. (491 aa) |
| | murG | Undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily. (355 aa) |
| | ftsW | Lipid II flippase FtsW; Peptidoglycan polymerase that is essential for cell division. Belongs to the SEDS family. FtsW subfamily. (414 aa) |
| | murD | UDP-N-acetylmuramoylalanine-D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. (438 aa) |
| | mraY | phospho-N-acetylmuramoyl-pentapeptide- transferase; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. (360 aa) |
| | murF | UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D- alanine ligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. (452 aa) |
| | murE | UDP-N-acetylmuramoyl-L-alanyl-D-glutamate-2, 6-diaminopimelate ligase; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. (495 aa) |
| | ftsI-2 | Peptidoglycan synthase FtsI; Catalyzes cross-linking of the peptidoglycan cell wall at the division septum; Belongs to the transpeptidase family. FtsI subfamily. (588 aa) |
| | rsmH | Ribosomal RNA small subunit methyltransferase H; Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA. (313 aa) |
| | KLV63471.1 | Ribosomal large subunit pseudouridine synthase A; Responsible for synthesis of pseudouridine from uracil. Belongs to the pseudouridine synthase RluA family. (219 aa) |
| | lptD | LPS-assembly protein LptD; Together with LptE, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. (786 aa) |
| | surA | Chaperone SurA; Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation. (428 aa) |
| | rsmA | Ribosomal RNA small subunit methyltransferase A; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. (273 aa) |
| | rsmC | Ribosomal RNA small subunit methyltransferase C; Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle; Belongs to the methyltransferase superfamily. RsmC family. (343 aa) |
| | argR-2 | Arginine repressor; Regulates arginine biosynthesis genes. (159 aa) |
| | mpl | UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Reutilizes the intact tripeptide L-alanyl-gamma-D-glutamyl- meso-diaminopimelate by linking it to UDP-N-acetylmuramate. Belongs to the MurCDEF family. Mpl subfamily. (459 aa) |
| | rlmB | 23S rRNA (guanosine-2'-O-)-methyltransferase RlmB; Specifically methylates the ribose of guanosine 2251 in 23S rRNA; Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. RlmB subfamily. (243 aa) |
| | rsgA | Ribosome small subunit-dependent GTPase A; One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit; Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily. (358 aa) |
| | frdC | Fumarate reductase subunit C; Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane. (131 aa) |
| | dsbD | Thiol:disulfide interchange protein DsbD; Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps. Belongs to the thioredoxin family. DsbD subfamily. (567 aa) |
| | KLV63829.1 | Heme lyase (NrfEFG) for insertion for heme into c552, subunit NrfG. (243 aa) |
| | KLV63830.1 | Cytochrome c-type biogenesis protein NrfE; Possible subunit of a heme lyase. (767 aa) |
| | KLV63892.1 | Ribosomal large subunit pseudouridine synthase F; Belongs to the pseudouridine synthase RsuA family. (291 aa) |
| | rsmB | Ribosomal RNA small subunit methyltransferase B; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. (429 aa) |
| | KLV62117.1 | Hypothetical protein. (180 aa) |
| | KLV62119.1 | Penicillin-binding protein 1A. (850 aa) |
| | nfuA | Fe/S biogenesis protein NfuA; Involved in iron-sulfur cluster biogenesis. Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins. Could also act as a scaffold/chaperone for damaged Fe/S proteins. (191 aa) |
| | KLV62178.1 | Ribosomal RNA small subunit methyltransferase D; Specifically methylates the guanine in position 966 of 16S rRNA in the assembled 30S particle; Belongs to the methyltransferase superfamily. RsmD family. (198 aa) |
| | rsmJ | Ribosomal RNA small subunit methyltransferase J; Specifically methylates the guanosine in position 1516 of 16S rRNA. (253 aa) |
| | rlmJ | Ribosomal RNA large subunit methyltransferase J; Specifically methylates the adenine in position 2030 of 23S rRNA. (280 aa) |
| | KLV62279.1 | Bax protein. (274 aa) |
| | KLV62283.1 | Outer membrane protein. (246 aa) |
| | secB | Protein-export protein SecB; One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA. (155 aa) |
| | rph | Ribonuclease PH; Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation. (238 aa) |
| | KLV62341.1 | Hypothetical protein. (287 aa) |
| | KLV62425.1 | Chromate reductase, Class I, flavoprotein. (188 aa) |
| | glmU | GlmU protein; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. (456 aa) |
| | rsmG | Ribosomal RNA small subunit methyltransferase G; Specifically methylates the N7 position of guanine in position 527 of 16S rRNA. (207 aa) |
| | wecA | Undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase; Catalyzes the transfer of the GlcNAc-1-phosphate moiety from UDP-GlcNAc onto the carrier lipid undecaprenyl phosphate (C55-P), yielding GlcNAc-pyrophosphoryl-undecaprenyl (GlcNAc-PP-C55). (367 aa) |
| | cyaY | Protein CyaY; Involved in iron-sulfur (Fe-S) cluster assembly. May act as a regulator of Fe-S biogenesis. (106 aa) |
| | engB | Ribosome biogenesis GTP-binding protein YsxC; Necessary for normal cell division and for the maintenance of normal septation; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family. (210 aa) |
| | yihI | Der GTPase-activating protein YihI; A GTPase-activating protein (GAP) that modifies Der/EngA GTPase function. May play a role in ribosome biogenesis. Belongs to the YihI family. (170 aa) |
| | KLV60897.1 | GTP-binding protein TypA/BipA. (607 aa) |
| | KLV60955.1 | ferredoxin-NADP reductase. (248 aa) |
| | zapB | Cell division protein ZapB; Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA. (79 aa) |
| | ftsN | Cell division protein FtsN; Essential cell division protein that activates septal peptidoglycan synthesis and constriction of the cell. Acts on both sides of the membrane, via interaction with FtsA in the cytoplasm and interaction with the FtsQBL complex in the periplasm. These interactions may induce a conformational switch in both FtsA and FtsQBL, leading to septal peptidoglycan synthesis by FtsI and associated synthases. (301 aa) |
| | murI | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. (283 aa) |
| | murB | UDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation. (342 aa) |
