STRINGSTRING
KLV64188.1 KLV64188.1 mtgA mtgA murA murA KLV65437.1 KLV65437.1 uppP uppP cpdA cpdA mltC mltC KLV65738.1 KLV65738.1 mltF mltF KLV66232.1 KLV66232.1 KLV66475.1 KLV66475.1 KLV66548.1 KLV66548.1 KLV66557.1 KLV66557.1 KLV66564.1 KLV66564.1 KLV66696.1 KLV66696.1 mrdA mrdA KLV66976.1 KLV66976.1 ftsI ftsI KLV67054.1 KLV67054.1 emtA emtA KLV67071.1 KLV67071.1 KLV67088.1 KLV67088.1 KLV67227.1 KLV67227.1 ddpX ddpX KLV67324.1 KLV67324.1 KLV67363.1 KLV67363.1 nagZ nagZ mltG mltG murJ murJ KLV64675.1 KLV64675.1 KLV62754.1 KLV62754.1 KLV62756.1 KLV62756.1 KLV62835.1 KLV62835.1 KLV62946.1 KLV62946.1 mrdA-2 mrdA-2 mrdB mrdB rlpA rlpA KLV62962.1 KLV62962.1 KLV63069.1 KLV63069.1 ddl ddl KLV63304.1 KLV63304.1 KLV63307.1 KLV63307.1 KLV63337.1 KLV63337.1 uppS uppS KLV63392.1 KLV63392.1 KLV63421.1 KLV63421.1 ddl-2 ddl-2 murC murC murG murG ftsW ftsW murD murD mraY mraY murF murF murE murE ftsI-2 ftsI-2 KLV63529.1 KLV63529.1 mpl mpl glmU glmU wecA wecA murI murI murB murB
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
KLV64188.1Murein peptide amidase A. (248 aa)
mtgAMonofunctional biosynthetic peptidoglycan transglycosylase; Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors; Belongs to the glycosyltransferase 51 family. (239 aa)
murAUDP-N-acetylglucosamine 1-carboxyvinyltransferase; Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine; Belongs to the EPSP synthase family. MurA subfamily. (419 aa)
KLV65437.1Periplasmic pilin chaperone. (232 aa)
uppPUndecaprenyl-diphosphatase; Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin; Belongs to the UppP family. (272 aa)
cpdA3',5'-cyclic adenosine monophosphate phosphodiesterase CpdA; Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes. (275 aa)
mltCMembrane-bound lytic murein transglycosylase C; Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division. (361 aa)
KLV65738.1Membrane-bound lytic murein transglycosylase A; Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division. (365 aa)
mltFMembrane-bound lytic murein transglycosylase F; Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella. (516 aa)
KLV66232.1Sensor histidine kinase YpdA. (586 aa)
KLV66475.1Hypothetical protein. (244 aa)
KLV66548.1D-alanyl-D-alanine endopeptidase; Belongs to the peptidase S11 family. (315 aa)
KLV66557.1Sensor histidine kinase YehU. (561 aa)
KLV66564.1Hypothetical protein. (226 aa)
KLV66696.1D-alanyl-D-alanine carboxypeptidase DacD; Belongs to the peptidase S11 family. (388 aa)
mrdAPenicillin-binding protein 2; Catalyzes cross-linking of the peptidoglycan cell wall. Belongs to the transpeptidase family. MrdA subfamily. (645 aa)
KLV66976.1Murein DD-endopeptidase MepM. (439 aa)
ftsITranspeptidase; Catalyzes cross-linking of the peptidoglycan cell wall at the division septum. (581 aa)
KLV67054.1Murein tetrapeptide carboxypeptidase. (304 aa)
emtAEndo-type membrane-bound lytic murein transglycosylase A; Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division. Preferentially cleaves at a distance of more than two disaccharide units from the ends of the glycan chain. (203 aa)
KLV67071.1Hypothetical protein. (240 aa)
KLV67088.1Hypothetical protein. (231 aa)
KLV67227.1Hypothetical protein. (260 aa)
ddpXD-alanyl-D-alanine dipeptidase; Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide. (195 aa)
KLV67324.1Lipoprotein. (455 aa)
KLV67363.1Hypothetical protein. (237 aa)
nagZBeta-hexosaminidase; Plays a role in peptidoglycan recycling by cleaving the terminal beta-1,4-linked N-acetylglucosamine (GlcNAc) from peptide- linked peptidoglycan fragments, giving rise to free GlcNAc, anhydro-N- acetylmuramic acid and anhydro-N-acetylmuramic acid-linked peptides. Belongs to the glycosyl hydrolase 3 family. NagZ subfamily. (341 aa)
mltGAminodeoxychorismate lyase; Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation. (340 aa)
murJIntegral membrane protein MviN; Involved in peptidoglycan biosynthesis. Transports lipid- linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane. (511 aa)
KLV64675.1Inner membrane protein. (259 aa)
KLV62754.1Undecaprenyl pyrophosphate phosphatase. (202 aa)
KLV62756.1D-alanyl-D-alanine carboxypeptidase DacC; Belongs to the peptidase S11 family. (400 aa)
KLV62835.1Pectinesterase. (437 aa)
KLV62946.1Hypothetical protein. (226 aa)
mrdA-2Penicillin-binding protein 2; Catalyzes cross-linking of the peptidoglycan cell wall. Belongs to the transpeptidase family. MrdA subfamily. (633 aa)
mrdBRod shape-determining protein RodA; Peptidoglycan polymerase that is essential for cell wall elongation; Belongs to the SEDS family. MrdB/RodA subfamily. (370 aa)
rlpARare lipoprotein A; Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides. (364 aa)
KLV62962.1D-alanyl-D-alanine carboxypeptidase DacA; Belongs to the peptidase S11 family. (403 aa)
KLV63069.1Chaperone FimC. (230 aa)
ddlD-alanine-D-alanine ligase A; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. (370 aa)
KLV63304.1Hypothetical protein. (231 aa)
KLV63307.1Hypothetical protein. (225 aa)
KLV63337.1Membrane-bound lytic murein transglycosylase D. (406 aa)
uppSDitrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific); Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di- trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide. (252 aa)
KLV63392.1Penicillin-binding protein 1B; Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross- linking of the peptide subunits). (849 aa)
KLV63421.11,6-anhydro-N-acetylmuramyl-L-alanine amidase AmpD. (187 aa)
ddl-2D-alanine-D-alanine ligase B; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family. (306 aa)
murCUDP-N-acetylmuramate-L-alanine ligase; Cell wall formation; Belongs to the MurCDEF family. (491 aa)
murGUndecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II); Belongs to the glycosyltransferase 28 family. MurG subfamily. (355 aa)
ftsWLipid II flippase FtsW; Peptidoglycan polymerase that is essential for cell division. Belongs to the SEDS family. FtsW subfamily. (414 aa)
murDUDP-N-acetylmuramoylalanine-D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. (438 aa)
mraYphospho-N-acetylmuramoyl-pentapeptide- transferase; First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; Belongs to the glycosyltransferase 4 family. MraY subfamily. (360 aa)
murFUDP-N-acetylmuramoyl-tripeptide-D-alanyl-D- alanine ligase; Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein; Belongs to the MurCDEF family. MurF subfamily. (452 aa)
murEUDP-N-acetylmuramoyl-L-alanyl-D-glutamate-2, 6-diaminopimelate ligase; Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan. Belongs to the MurCDEF family. MurE subfamily. (495 aa)
ftsI-2Peptidoglycan synthase FtsI; Catalyzes cross-linking of the peptidoglycan cell wall at the division septum; Belongs to the transpeptidase family. FtsI subfamily. (588 aa)
KLV63529.1Soluble lytic murein transglycosylase. (645 aa)
mplUDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Reutilizes the intact tripeptide L-alanyl-gamma-D-glutamyl- meso-diaminopimelate by linking it to UDP-N-acetylmuramate. Belongs to the MurCDEF family. Mpl subfamily. (459 aa)
glmUGlmU protein; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. (456 aa)
wecAUndecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase; Catalyzes the transfer of the GlcNAc-1-phosphate moiety from UDP-GlcNAc onto the carrier lipid undecaprenyl phosphate (C55-P), yielding GlcNAc-pyrophosphoryl-undecaprenyl (GlcNAc-PP-C55). (367 aa)
murIGlutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. (283 aa)
murBUDP-N-acetylenolpyruvoylglucosamine reductase; Cell wall formation. (342 aa)
Your Current Organism:
Citrobacter sp. MGH106
NCBI taxonomy Id: 1686381
Other names: C. sp. MGH106
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