STRINGSTRING
flaA flaA lmo0705 lmo0705 lmo0707 lmo0707 lmo0732 lmo0732 lmo0801 lmo0801 lmo0835 lmo0835 lmo0880 lmo0880 lmo1076 lmo1076 lmo1215 lmo1215 lmo1216 lmo1216 lmo1291 lmo1291 lmo2203 lmo2203 lmo2186 lmo2186 lmo2185 lmo2185 lmo2179 lmo2179 lmo2821 lmo2821 lmo2714 lmo2714 lmo2691 lmo2691 lmo2178 lmo2178 lmo2027 lmo2027 lmo2026 lmo2026 inlC inlC lmo1413 lmo1413 lmo0066 lmo0066 lmo0105 lmo0105 lmo0130 lmo0130 lmo0159 lmo0159 lmo0160 lmo0160 lmo0171 lmo0171 lmo0175 lmo0175 plcA plcA hly hly mpl mpl inlG inlG inlH inlH inlE inlE lmo0327 lmo0327 lmo0333 lmo0333 lmo0409 lmo0409 lmo0415 lmo0415 inlA inlA inlB inlB lmo0438 lmo0438 lmo0576 lmo0576 iap iap tufA tufA lmo2591 lmo2591 lmo2576 lmo2576 lmo2467 lmo2467 eno eno lmo2396 lmo2396
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
flaAFlagellin protein; Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella. (287 aa)
lmo0705Similar to flagellar hook-associated protein FlgK. (506 aa)
lmo0707Flagellar hook-associated protein 2; Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end. (429 aa)
lmo0732Putative peptidoglycan bound protein (LPXTG motif). (638 aa)
lmo0801Lmo0801 protein; Similar to internalin, putative peptidoglycan bound protein (LPXTG motif). (646 aa)
lmo0835Putative peptidoglycan bound protein (LPXTG motif). (334 aa)
lmo0880Similar to wall associated protein precursor (LPXTG motif). (462 aa)
lmo1076Lmo1076 protein; Similar to autolysin (EC 3.5.1.28) (N-acetylmuramoyl-L-alanine amidase). (572 aa)
lmo1215Lmo1215 protein; Similar to N-acetylmuramoyl-L-alanine amidase (autolysin). (289 aa)
lmo1216Lmo1216 protein; Similar to N-acetylmuramoyl-L-alanine amidase (autolysin). (328 aa)
lmo1291Lmo1291 protein; Similar to acyltransferase (to B. subtilis YrhL protein). (622 aa)
lmo2203Lmo2203 protein; Similar to N-acetylmuramoyl-L-alanine amidase and to internalin B. (375 aa)
lmo2186Hemin/hemoglobin-binding protein 1; Binds both host hemin and hemoglobin with affinity in the nanomolar range and presumably directs it to membrane transporters. (207 aa)
lmo2185Hemin/hemoglobin-binding protein 2; Acts as an extracellular and cell wall-bound hemophore; scavenges host heme and hemoglobin from the environment and also serves as a cell wall receptor for both (Probable). At low hemin (Hn) and hemoglobin (Hb) concentrations adsorbs Hn/Hb and presumably directs it to membrane transporters (Probable). Soluble Hbp2 can probably pass Hn/Hb to cell wall-anchored Hbp2, and both forms can accept Hn/Hb from Hbp1. May be involved in crossing the digestive barrier in infected animals. Binds host hemin (Probable). Binds host hemoglobin with affinity in the na [...] (569 aa)
lmo2179Putative peptidoglycan bound protein (LPXTG motif). (1152 aa)
lmo2821Internalin J; Involved in several steps of L.monocytogenes infection by both intravenous and oral infection. Probably acts as an adhesion; upon ectopic expression in L.innocula bacteria adhere better to human cell lines. (851 aa)
lmo2714Peptidoglycan anchored protein (LPXTG motif). (315 aa)
lmo2691Lmo2691 protein; Similar to autolysin, N-acetylmuramidase. (590 aa)
lmo2178Putative peptidoglycan bound protein (LPXTG motif). (1612 aa)
lmo2027Putative cell surface protein, similar to internalin proteins. (367 aa)
lmo2026Putative peptidoglycan bound protein (LPXTG motif). (626 aa)
inlCInternalin C. (296 aa)
lmo1413Putative peptidoglycan bound protein (LPXTG motif). (439 aa)
lmo0066Lmo0066 protein; Similar to toxin components. (604 aa)
lmo0105Lmo0105 protein; Highly similar to chitinase B. (756 aa)
lmo0130Cell wall protein Lmo0130; Similar to 5'-nucleotidase, putative peptidoglycan bound protein (LPXTG motif). (784 aa)
lmo0159Putative peptidoglycan bound protein (LPXTG motif). (793 aa)
lmo0160Putative peptidoglycan bound protein (LPXTG motif). (571 aa)
lmo0171Similar to internalin proteins, putative peptidoglycan bound protein (LPXTG motif). (832 aa)
lmo0175Putative peptidoglycan bound protein (LPXTG motif). (415 aa)
plcAPhosphatidylinositol-specific phospholipase c; Cleaves glycosylphosphatidylinositol (GPI) and phosphatidylinositol (PI) anchors but not PI phosphates. Important factor in pathogenesis, PI-PLC activity is present only in virulent listeria species. It may participate in the lysis of the phagolysosomal membrane. (317 aa)
hlyListeriolysin O precursor; Sulfhydryl-activated pore-forming toxin, which is a major virulence factor required for the escape of bacteria from phagosomal vacuoles and entry into the host cytosol. After binding to target membranes, the protein undergoes a major conformation change, leading to its insertion in the host membrane and formation of an oligomeric pore complex. Listeriolysin O activates mitogen-activated protein (MAP) kinase activity in host cells, most likely as a result of the permeabilization of the host cell membrane. Also induces a proteasome- independent degradation of U [...] (529 aa)
mplZinc metalloproteinase precursor; Probably linked to the pathogenesis of listerial infection; Belongs to the peptidase M4 family. (510 aa)
inlGInternalin G. (490 aa)
inlHInternalin H; Contributes to systemic listeriosis in mice by decreasing host IL-6 cytokine production and thus evasion of the host immune response. Does not contribute to invasion of the host intestinal tissue. (548 aa)
inlEInternalin E. (499 aa)
lmo0327Lmo0327 protein; Similar to cell surface proteins (LPXTG motif). (1348 aa)
lmo0333Internalin I; A role in virulence could not be demonstrated. Belongs to the internalin family. (1778 aa)
lmo0409Lmo0409 protein; Similar to internalin, peptidoglycan bound protein (LPxTG motif). (821 aa)
lmo0415Lmo0415 protein; Similar to endo-1,4-beta-xylanase. (466 aa)
inlAInternalin A; Mediates the entry of L.monocytogenes into host intestinal epithelial cells; transformation with inlA alone allows L.innocua (a non-invasive species) to be taken up by host cells. Binds to human receptor cadherin-1 (E-cadherin, CDH1); the chicken homolog of cadherin-1 but not cadherin- 2 function as receptors. Mouse cadherin-1 is not a receptor, however mutating a single surface-exposed residue (Glu-172 to Pro in mouse) allows cadherin-1 to act as a receptor for InlA ; Belongs to the internalin family. (800 aa)
inlBInternalin B; Mediates the entry of L.monocytogenes into normally non- phagocytic mammalian host cells. Its host receptor is hepatocyte growth factor receptor (HGF receptor, a tyrosine kinase, MET) which is tyrosine-phosphorylated in response to InlB. Downstream targets MAPK1/MAPK3 (Erk1/2) and AKT are phosphorylated in response to InlB, which also causes cell colony scattering. Complement component 1 Q subcomponent-binding protein (gC1q-R, C1QBP) has been suggested to also act an InlB receptor, but this is less certain. Stimulation of Tyr-phosphorylation of MET by InlB is potentiated [...] (630 aa)
lmo0438Listeria nuclear targeted protein A; Relieves the repression of host cell immune response genes (interferon-stimulated genes) by blocking the recruitment of host BAHD1 to these genes. May modulate interferon-mediated immune response to control bacterial colonization of the host. (205 aa)
lmo0576Lmo0576 protein; Hypothetical cell wall associated protein. (487 aa)
iapP60 extracellular protein, invasion associated protein Iap; This major extracellular protein may be involved in the invasion of non-professional phagocytic cells by Listeria; Belongs to the peptidase C40 family. (482 aa)
tufAElongation factor Tu; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (395 aa)
lmo2591Surface protein (GW repeat) similar to N-acetylmuramidase. (508 aa)
lmo2576Peptidoglycan anchored protein (LPXTG motif). (1530 aa)
lmo2467Lmo2467 protein; Similar to chitinase and chitin binding protein. (478 aa)
enoEnolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity). Binds plasminogen when expressed on the bacterial cell surface, potentially allowing the bacterium to acquire surface-associated proteolytic activity, which in turn contributes to tissue invasion and virulence; Belongs to the enolase family. (430 aa)
lmo2396Similar to internalin proteins, putative peptidoglycan bound protein (LPXTG motif). (940 aa)
Your Current Organism:
Listeria monocytogenes
NCBI taxonomy Id: 169963
Other names: L. monocytogenes EGD-e, Listeria monocytogenes ATCC BAA-679, Listeria monocytogenes EGD-e, Listeria monocytogenes EGDe, Listeria monocytogenes str. EGD-e, Listeria monocytogenes strain EGD-e
Server load: low (18%) [HD]