Your Input: | |||||
lmo1799 | Putative peptidoglycan bound protein (LPXTG motif). (903 aa) | ||||
lmo2821 | Internalin J; Involved in several steps of L.monocytogenes infection by both intravenous and oral infection. Probably acts as an adhesion; upon ectopic expression in L.innocula bacteria adhere better to human cell lines. (851 aa) | ||||
lmo2714 | Peptidoglycan anchored protein (LPXTG motif). (315 aa) | ||||
tufA | Elongation factor Tu; This protein promotes the GTP-dependent binding of aminoacyl- tRNA to the A-site of ribosomes during protein biosynthesis. (395 aa) | ||||
lmo2576 | Peptidoglycan anchored protein (LPXTG motif). (1530 aa) | ||||
eno | Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity). Binds plasminogen when expressed on the bacterial cell surface, potentially allowing the bacterium to acquire surface-associated proteolytic activity, which in turn contributes to tissue invasion and virulence; Belongs to the enolase family. (430 aa) | ||||
lmo2186 | Hemin/hemoglobin-binding protein 1; Binds both host hemin and hemoglobin with affinity in the nanomolar range and presumably directs it to membrane transporters. (207 aa) | ||||
lmo2185 | Hemin/hemoglobin-binding protein 2; Acts as an extracellular and cell wall-bound hemophore; scavenges host heme and hemoglobin from the environment and also serves as a cell wall receptor for both (Probable). At low hemin (Hn) and hemoglobin (Hb) concentrations adsorbs Hn/Hb and presumably directs it to membrane transporters (Probable). Soluble Hbp2 can probably pass Hn/Hb to cell wall-anchored Hbp2, and both forms can accept Hn/Hb from Hbp1. May be involved in crossing the digestive barrier in infected animals. Binds host hemin (Probable). Binds host hemoglobin with affinity in the na [...] (569 aa) | ||||
lmo2179 | Putative peptidoglycan bound protein (LPXTG motif). (1152 aa) | ||||
lmo2178 | Putative peptidoglycan bound protein (LPXTG motif). (1612 aa) | ||||
lmo2085 | Putative peptidoglycan bound protein (LPXTG motif). (562 aa) | ||||
lmo1413 | Putative peptidoglycan bound protein (LPXTG motif). (439 aa) | ||||
lmo1290 | Similar to internalin proteins, putative peptidoglycan bound protein (LPXTG motif). (598 aa) | ||||
lmo1136 | Lmo1136 protein; Similar to internalin, putative peptidoglycan bound protein (LPXTG motif). (539 aa) | ||||
lmo0130 | Cell wall protein Lmo0130; Similar to 5'-nucleotidase, putative peptidoglycan bound protein (LPXTG motif). (784 aa) | ||||
lmo0159 | Putative peptidoglycan bound protein (LPXTG motif). (793 aa) | ||||
lmo0160 | Putative peptidoglycan bound protein (LPXTG motif). (571 aa) | ||||
lmo0171 | Similar to internalin proteins, putative peptidoglycan bound protein (LPXTG motif). (832 aa) | ||||
lmo0175 | Putative peptidoglycan bound protein (LPXTG motif). (415 aa) | ||||
plcA | Phosphatidylinositol-specific phospholipase c; Cleaves glycosylphosphatidylinositol (GPI) and phosphatidylinositol (PI) anchors but not PI phosphates. Important factor in pathogenesis, PI-PLC activity is present only in virulent listeria species. It may participate in the lysis of the phagolysosomal membrane. (317 aa) | ||||
hly | Listeriolysin O precursor; Sulfhydryl-activated pore-forming toxin, which is a major virulence factor required for the escape of bacteria from phagosomal vacuoles and entry into the host cytosol. After binding to target membranes, the protein undergoes a major conformation change, leading to its insertion in the host membrane and formation of an oligomeric pore complex. Listeriolysin O activates mitogen-activated protein (MAP) kinase activity in host cells, most likely as a result of the permeabilization of the host cell membrane. Also induces a proteasome- independent degradation of U [...] (529 aa) | ||||
mpl | Zinc metalloproteinase precursor; Probably linked to the pathogenesis of listerial infection; Belongs to the peptidase M4 family. (510 aa) | ||||
inlH | Internalin H; Contributes to systemic listeriosis in mice by decreasing host IL-6 cytokine production and thus evasion of the host immune response. Does not contribute to invasion of the host intestinal tissue. (548 aa) | ||||
inlE | Internalin E. (499 aa) | ||||
lmo0320 | Similar to surface protein (peptidoglycan bound,LPXTG motif). (399 aa) | ||||
lmo0331 | Lmo0331 protein; Similar to internalin, putative peptidoglycan bound protein (LPXTG motif). (633 aa) | ||||
lmo0333 | Internalin I; A role in virulence could not be demonstrated. Belongs to the internalin family. (1778 aa) | ||||
lmo0409 | Lmo0409 protein; Similar to internalin, peptidoglycan bound protein (LPxTG motif). (821 aa) | ||||
inlA | Internalin A; Mediates the entry of L.monocytogenes into host intestinal epithelial cells; transformation with inlA alone allows L.innocua (a non-invasive species) to be taken up by host cells. Binds to human receptor cadherin-1 (E-cadherin, CDH1); the chicken homolog of cadherin-1 but not cadherin- 2 function as receptors. Mouse cadherin-1 is not a receptor, however mutating a single surface-exposed residue (Glu-172 to Pro in mouse) allows cadherin-1 to act as a receptor for InlA ; Belongs to the internalin family. (800 aa) | ||||
inlB | Internalin B; Mediates the entry of L.monocytogenes into normally non- phagocytic mammalian host cells. Its host receptor is hepatocyte growth factor receptor (HGF receptor, a tyrosine kinase, MET) which is tyrosine-phosphorylated in response to InlB. Downstream targets MAPK1/MAPK3 (Erk1/2) and AKT are phosphorylated in response to InlB, which also causes cell colony scattering. Complement component 1 Q subcomponent-binding protein (gC1q-R, C1QBP) has been suggested to also act an InlB receptor, but this is less certain. Stimulation of Tyr-phosphorylation of MET by InlB is potentiated [...] (630 aa) | ||||
lmo0438 | Listeria nuclear targeted protein A; Relieves the repression of host cell immune response genes (interferon-stimulated genes) by blocking the recruitment of host BAHD1 to these genes. May modulate interferon-mediated immune response to control bacterial colonization of the host. (205 aa) | ||||
lmo0463 | Lmo0463 protein. (101 aa) | ||||
lmo0514 | Similar to internalin protein, putative peptidoglycan bound protein (LPXTG motif). (605 aa) | ||||
iap | P60 extracellular protein, invasion associated protein Iap; This major extracellular protein may be involved in the invasion of non-professional phagocytic cells by Listeria; Belongs to the peptidase C40 family. (482 aa) | ||||
lmo0610 | Similar to internalin proteins, putative peptidoglycan bound protein (LPXTG motif). (589 aa) | ||||
lmo0627 | Peptidoglycan bound protein (LPXTG motif) similar to adhesin. (1582 aa) | ||||
flaA | Flagellin protein; Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella. (287 aa) | ||||
lmo0705 | Similar to flagellar hook-associated protein FlgK. (506 aa) | ||||
lmo0707 | Flagellar hook-associated protein 2; Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end. (429 aa) | ||||
lmo0880 | Similar to wall associated protein precursor (LPXTG motif). (462 aa) | ||||
lmo1115 | Lmo1115 protein; Similar to fibrinogen-binding protein (LPXTG motif). (862 aa) |