node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
codY | glnR | gene:17593937 | gene:17593955 | GTP-sensing transcriptional pleiotropic repressor CodY; DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor; Belongs to the CodY family. | GlnR protein; Similar to glutamine synthetase repressor. | 0.602 |
dnaK | mutL | gene:17594130 | gene:17594061 | Class I heat-shock protein (molecular chaperone) DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | DNA mismatch repair protein; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. | 0.501 |
dnaK | pfk | gene:17594130 | gene:17594228 | Class I heat-shock protein (molecular chaperone) DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | ATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. | 0.410 |
dnaK | recA | gene:17594130 | gene:17594055 | Class I heat-shock protein (molecular chaperone) DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | Recombination protein recA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.684 |
dnaK | rplA | gene:17594130 | gene:17592900 | Class I heat-shock protein (molecular chaperone) DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | Ribosomal protein L1; Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release. | 0.470 |
dnaK | rpmA | gene:17594130 | gene:17594197 | Class I heat-shock protein (molecular chaperone) DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | Ribosomal protein L27; Belongs to the bacterial ribosomal protein bL27 family. | 0.458 |
dnaK | rpsB | gene:17594130 | gene:17594315 | Class I heat-shock protein (molecular chaperone) DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 30S ribosomal protein S2; Belongs to the universal ribosomal protein uS2 family. | 0.887 |
glnR | codY | gene:17593955 | gene:17593937 | GlnR protein; Similar to glutamine synthetase repressor. | GTP-sensing transcriptional pleiotropic repressor CodY; DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor; Belongs to the CodY family. | 0.602 |
infC | ldh | gene:17594470 | gene:17592846 | Translation initiation factor IF-3; IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins. | L-lactate dehydrogenase 1; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family. | 0.534 |
infC | recA | gene:17594470 | gene:17594055 | Translation initiation factor IF-3; IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins. | Recombination protein recA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.524 |
infC | rplA | gene:17594470 | gene:17592900 | Translation initiation factor IF-3; IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins. | Ribosomal protein L1; Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release. | 0.989 |
infC | rpmA | gene:17594470 | gene:17594197 | Translation initiation factor IF-3; IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins. | Ribosomal protein L27; Belongs to the bacterial ribosomal protein bL27 family. | 0.938 |
infC | rpsB | gene:17594470 | gene:17594315 | Translation initiation factor IF-3; IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins. | 30S ribosomal protein S2; Belongs to the universal ribosomal protein uS2 family. | 0.993 |
ldh | infC | gene:17592846 | gene:17594470 | L-lactate dehydrogenase 1; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family. | Translation initiation factor IF-3; IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins. | 0.534 |
mutL | dnaK | gene:17594061 | gene:17594130 | DNA mismatch repair protein; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. | Class I heat-shock protein (molecular chaperone) DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.501 |
mutL | recA | gene:17594061 | gene:17594055 | DNA mismatch repair protein; This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. | Recombination protein recA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.831 |
pfk | dnaK | gene:17594228 | gene:17594130 | ATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. | Class I heat-shock protein (molecular chaperone) DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.410 |
pfk | recA | gene:17594228 | gene:17594055 | ATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. | Recombination protein recA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.509 |
pfk | rplA | gene:17594228 | gene:17592900 | ATP-dependent 6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis. | Ribosomal protein L1; Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release. | 0.415 |
recA | dnaK | gene:17594055 | gene:17594130 | Recombination protein recA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | Class I heat-shock protein (molecular chaperone) DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.684 |