STRINGSTRING
lmo0745 lmo0745 lmo0752 lmo0752 lmo0755 lmo0755 lmo0783 lmo0783 uhpT uhpT inlC inlC lmo2158 lmo2158 lmo2391 lmo2391 lmo2484 lmo2484 lmo2673 lmo2673 lmo2684 lmo2684 lmo0096 lmo0096 plcA plcA hly hly mpl mpl actA actA plcB plcB lmo0206 lmo0206 lmo0207 lmo0207 inlA inlA inlB inlB lmo0444 lmo0444
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
lmo0745Lmo0745 protein. (167 aa)
lmo0752Lmo0752 protein; Weakly similar to a putative haloacetate dehalogenase. (278 aa)
lmo0755Similar to unknown proteins. (273 aa)
lmo0783Lmo0783 protein; Similar to mannose-specific phosphotransferase system (PTS) component IIB. (161 aa)
uhpTUhpT protein; Highly similar to hexose phosphate transport protein. (461 aa)
inlCInternalin C. (296 aa)
lmo2158Similar to B. subtilis YwmG protein. (61 aa)
lmo2391Conserved hypothetical protein similar to B. subtilis YhfK protein. (209 aa)
lmo2484Lmo2484 protein; Similar to B. subtilis YvlD protein. (117 aa)
lmo2673Lmo2673 protein. (156 aa)
lmo2684Permease IIC component; The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. (435 aa)
lmo0096Lmo0096 protein; Similar to PTS system mannose-specific, factor IIAB. (321 aa)
plcAPhosphatidylinositol-specific phospholipase c; Cleaves glycosylphosphatidylinositol (GPI) and phosphatidylinositol (PI) anchors but not PI phosphates. Important factor in pathogenesis, PI-PLC activity is present only in virulent listeria species. It may participate in the lysis of the phagolysosomal membrane. (317 aa)
hlyListeriolysin O precursor; Sulfhydryl-activated pore-forming toxin, which is a major virulence factor required for the escape of bacteria from phagosomal vacuoles and entry into the host cytosol. After binding to target membranes, the protein undergoes a major conformation change, leading to its insertion in the host membrane and formation of an oligomeric pore complex. Listeriolysin O activates mitogen-activated protein (MAP) kinase activity in host cells, most likely as a result of the permeabilization of the host cell membrane. Also induces a proteasome- independent degradation of U [...] (529 aa)
mplZinc metalloproteinase precursor; Probably linked to the pathogenesis of listerial infection; Belongs to the peptidase M4 family. (510 aa)
actAActin-assembly inducing protein precursor; Virulence factor required for host cell microfilament interaction. It induces actin assembly around the bacteria to allow it to move within the cytoplasm. It is involved in the actin polymerization process. It seems to act as a nucleator that induces the reorganization of the actin cytoskeleton. (639 aa)
plcBPhospholipase C; Important role in the infectious process. May contribute to efficient lysis of the two-membrane vacuoles that surround the bacteria after direct cell-to-cell spread. (289 aa)
lmo0206Uncharacterized protein Lmo0206. (107 aa)
lmo0207Uncharacterized lipoprotein Lmo0207; Hypothetical lipoprotein. (153 aa)
inlAInternalin A; Mediates the entry of L.monocytogenes into host intestinal epithelial cells; transformation with inlA alone allows L.innocua (a non-invasive species) to be taken up by host cells. Binds to human receptor cadherin-1 (E-cadherin, CDH1); the chicken homolog of cadherin-1 but not cadherin- 2 function as receptors. Mouse cadherin-1 is not a receptor, however mutating a single surface-exposed residue (Glu-172 to Pro in mouse) allows cadherin-1 to act as a receptor for InlA ; Belongs to the internalin family. (800 aa)
inlBInternalin B; Mediates the entry of L.monocytogenes into normally non- phagocytic mammalian host cells. Its host receptor is hepatocyte growth factor receptor (HGF receptor, a tyrosine kinase, MET) which is tyrosine-phosphorylated in response to InlB. Downstream targets MAPK1/MAPK3 (Erk1/2) and AKT are phosphorylated in response to InlB, which also causes cell colony scattering. Complement component 1 Q subcomponent-binding protein (gC1q-R, C1QBP) has been suggested to also act an InlB receptor, but this is less certain. Stimulation of Tyr-phosphorylation of MET by InlB is potentiated [...] (630 aa)
lmo0444Lmo0444 protein. (926 aa)
Your Current Organism:
Listeria monocytogenes
NCBI taxonomy Id: 169963
Other names: L. monocytogenes EGD-e, Listeria monocytogenes ATCC BAA-679, Listeria monocytogenes EGD-e, Listeria monocytogenes EGDe, Listeria monocytogenes str. EGD-e, Listeria monocytogenes strain EGD-e
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