STRINGSTRING
ALE06598.1 ALE06598.1 folD folD ALE05117.1 ALE05117.1 kbl kbl metXA metXA ALE07642.1 ALE07642.1 lipA lipA dxs dxs ALE05625.1 ALE05625.1 ALE05658.1 ALE05658.1 ALE05778.1 ALE05778.1 ALE05890.1 ALE05890.1 ALE07754.1 ALE07754.1 mshC mshC metK metK metE metE ALE06138.1 ALE06138.1 ALE06153.1 ALE06153.1 ALE06377.1 ALE06377.1 ALE06378.1 ALE06378.1 thiL thiL ALE06576.1 ALE06576.1 ALE07891.1 ALE07891.1 ALE06635.1 ALE06635.1 ALE06683.1 ALE06683.1 ALE06735.1 ALE06735.1 thiG thiG ALE06742.1 ALE06742.1 ALE06743.1 ALE06743.1 thiE thiE ALE06831.1 ALE06831.1 bioD bioD ALE07955.1 ALE07955.1 ALE06837.1 ALE06837.1 bioB bioB ALE06981.1 ALE06981.1 mshD mshD ALE07064.1 ALE07064.1 ALE07097.1 ALE07097.1 ALE07098.1 ALE07098.1 ALE08008.1 ALE08008.1 ALE07168.1 ALE07168.1 ackA ackA acsA acsA metZ metZ ALE07361.1 ALE07361.1 ALE08062.1 ALE08062.1 ALE08066.1 ALE08066.1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ALE06598.1Cysteine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (360 aa)
folDMethenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. (294 aa)
ALE05117.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (265 aa)
kbl2-amino-3-ketobutyrate CoA ligase; Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. (403 aa)
metXAHomoserine acetyltransferase; Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. (371 aa)
ALE07642.1Pyruvate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (364 aa)
lipALipoyl synthase; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (338 aa)
dxs1-deoxy-D-xylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily. (662 aa)
ALE05625.1Homoserine dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (350 aa)
ALE05658.1Cupin; Derived by automated computational analysis using gene prediction method: Protein Homology. (377 aa)
ALE05778.1Hypothetical protein; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily. (256 aa)
ALE05890.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (453 aa)
ALE07754.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (467 aa)
mshCL-cysteine:1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside ligase; Catalyzes the ATP-dependent condensation of GlcN-Ins and L- cysteine to form L-Cys-GlcN-Ins; Belongs to the class-I aminoacyl-tRNA synthetase family. MshC subfamily. (428 aa)
metKS-adenosylmethionine synthetase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (394 aa)
metE5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (771 aa)
ALE06138.15,10-methylenetetrahydrofolate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the methylenetetrahydrofolate reductase family. (322 aa)
ALE06153.1Hydroxymethylpyrimidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (494 aa)
ALE06377.1Cysteine synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the cysteine synthase/cystathionine beta- synthase family. (311 aa)
ALE06378.1Serine acetyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (195 aa)
thiLThiamine-monophosphate kinase; Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1; Belongs to the thiamine-monophosphate kinase family. (338 aa)
ALE06576.1Homoserine dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (449 aa)
ALE07891.1Glyoxalase; Derived by automated computational analysis using gene prediction method: Protein Homology. (170 aa)
ALE06635.1AMP-dependent synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology. (555 aa)
ALE06683.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (368 aa)
ALE06735.1Molybdopterin biosynthesis-like protein MoeZ; The proteins in this cluster have high sequence similarity to MoeB and are possibly involved in the synthesis of molybdopterin, but there has been no biochemical or physiological characterization. There is also no genetic linkage to other molybdopterin cofactor synthesis proteins. These proteins are similar to a Pseudomonas stutzeri protein which is essential to pyridine-2,6-bis(thiocarboxylic acid) synthesis that possibly activates a substrate by adenylation; Derived by automated computational analysis using gene prediction method: Protein [...] (398 aa)
thiGThiazole synthase; Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S. (269 aa)
ALE06742.1Thiamine biosynthesis protein ThiS; Derived by automated computational analysis using gene prediction method: Protein Homology. (79 aa)
ALE06743.1Glycine oxidase; Derived by automated computational analysis using gene prediction method: Protein Homology. (414 aa)
thiEThiamine-phosphate pyrophosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. (226 aa)
ALE06831.1Cystathionine gamma-synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (390 aa)
bioDDethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. (231 aa)
ALE07955.18-amino-7-oxononanoate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (374 aa)
ALE06837.1Adenosylmethionine-8-amino-7-oxononanoate aminotransferase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (457 aa)
bioBBiotin synthase; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. (360 aa)
ALE06981.1D-inositol 3-phosphate glycosyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (414 aa)
mshDMycothiol acetyltransferase; Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol. (328 aa)
ALE07064.1Aspartate-semialdehyde dehydrogenase; Catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the aspartate-semialdehyde dehydrogenase family. (378 aa)
ALE07097.1Cystathionine gamma-synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (386 aa)
ALE07098.1Cystathionine beta-synthase; Derived by automated computational analysis using gene prediction method: Protein Homology. (458 aa)
ALE08008.1Sulfate adenylyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (295 aa)
ALE07168.1Pyruvate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (386 aa)
ackAAcetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. (380 aa)
acsAacetyl-CoA synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA; Belongs to the ATP-dependent AMP-binding enzyme family. (658 aa)
metZO-succinylhomoserine sulfhydrylase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide. (403 aa)
ALE07361.13-demethylubiquinone-9 3-methyltransferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (139 aa)
ALE08062.1Pyruvate dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (390 aa)
ALE08066.1Thiamine biosynthesis protein ThiS; Derived by automated computational analysis using gene prediction method: Protein Homology. (93 aa)
Your Current Organism:
Arthrobacter sp. ERGS101
NCBI taxonomy Id: 1704044
Other names: A. sp. ERGS1:01, Arthrobacter sp. ERGS1:01
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