(79 nodes) JAK-STAT signaling pathway network (Neophocaena asiaeorientalis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	IL13RA2	Interleukin-13 receptor subunit alpha-2. (387 aa)
	IL15RA	Interleukin-15 receptor subunit alpha isoform X1. (411 aa)
	STAT1	Signal transducer and activator of transcription. (749 aa)
	USP18	Ubl carboxyl-terminal hydrolase 18 isoform X1; Belongs to the peptidase C19 family. (321 aa)
	IL2RA	Interleukin-2 receptor subunit alpha. (275 aa)
	IL23R	Interleukin-23 receptor. (630 aa)
	STAT4	Signal transducer and activator of transcription. (748 aa)
	JAK2	Tyrosine-protein kinase. (1132 aa)
	IL12RB2	Interleukin-12 receptor subunit beta-2 isoform X1. (859 aa)
	SOCS4	Suppressor of cytokine signaling 4. (440 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
	IL15	Interleukin; Belongs to the IL-15/IL-21 family. (180 aa)
	STAT6	Signal transducer and activator of transcription. (859 aa)
	IL23A	Interleukin-23 subunit alpha. (189 aa)
	STAT2	Signal transducer and activator of transcription. (899 aa)
	IL22	Interleukin-22. (189 aa)
	LOC112395033	Interferon omega-1-like. (250 aa)
	LOC112395020	Interferon alpha-1-like. (189 aa)
	IL6	Interleukin-6. (208 aa)
	LOC112395025	Interferon omega-1-like. (250 aa)
	CSF3R	Granulocyte colony-stimulating factor receptor isoform X1. (847 aa)
	CSF2	Granulocyte-macrophage colony-stimulating factor. (134 aa)
	LOC112397463	Interleukin-3-like. (149 aa)
	STAT5A	Signal transducer and activator of transcription. (726 aa)
	IL21R	Interleukin-21 receptor. (537 aa)
	CSF3	Granulocyte colony-stimulating factor. (195 aa)
	SOCS1	Suppressor of cytokine signaling 1. (214 aa)
	LOC112399174	Signal transducer and activator of transcription. (618 aa)
	EPO	Erythropoietin. (266 aa)
	STAT3	Signal transducer and activator of transcription. (770 aa)
	IL4R	Interleukin-4 receptor subunit alpha isoform X1. (832 aa)
	IL21	Interleukin; Belongs to the IL-15/IL-21 family. (146 aa)
	IL2	Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Belongs to the IL-2 family. (154 aa)
	TYK2	Non-receptor tyrosine-protein kinase TYK2 isoform X1. (1214 aa)
	EPOR	Erythropoietin receptor; Receptor for erythropoietin. (509 aa)
	CISH	Cytokine-inducible SH2-containing protein. (254 aa)
	IL5	Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (135 aa)
	IL4	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Belongs to the IL-4/IL-13 family. (133 aa)
	IL5RA	Interleukin-5 receptor subunit alpha isoform X1. (417 aa)
	IL13	Interleukin-13. (145 aa)
	IL6R	Interleukin-6 receptor subunit alpha. (465 aa)
	IRF7	Interferon regulatory factor 7. (474 aa)
	TP53BP2	Apoptosis-stimulating of p53 protein 2. (1007 aa)
	IL10	Interleukin-10. (178 aa)
	IL13RA1	Interleukin-13 receptor subunit alpha-1. (286 aa)
	LOC112403081	LOW QUALITY PROTEIN: interferon lambda-1-like. (191 aa)
	IL7	Interleukin-7 isoform X1. (226 aa)
	IL10RA	Interleukin-10 receptor subunit alpha isoform X1. (594 aa)
	IL9	Interleukin-9. (141 aa)
	IRF9	LOW QUALITY PROTEIN: interferon regulatory factor 9. (478 aa)
	SOCS5	Suppressor of cytokine signaling 5. (536 aa)
	SOCS2	Suppressor of cytokine signaling 2. (198 aa)
	IL7R	Interleukin-7 receptor subunit alpha. (459 aa)
	IL12A	Interleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated Killer cells, and stimulate the production of IFN-gamma by resting PBMC. (222 aa)
	IFNB1	Interferon beta. (185 aa)
	LOC112407025	Interferon alpha-1-like. (189 aa)
	IL2RG	Cytokine receptor common subunit gamma isoform X1. (381 aa)
	IFNGR2	Interferon gamma receptor 2 isoform X2. (364 aa)
	IFNAR1	Interferon alpha/beta receptor 1 isoform X1. (561 aa)
	IL10RB	Interleukin-10 receptor subunit beta isoform X1. (361 aa)
	IFNAR2	Interferon alpha/beta receptor 2 isoform X1. (533 aa)
	IFNGR1	Interferon gamma receptor 1 isoform X1. (468 aa)
	IL9R	Interleukin-9 receptor. (536 aa)
	CSF2RB	Cytokine receptor common subunit beta isoform X1. (896 aa)
	SOCS3	Suppressor of cytokine signaling 3. (237 aa)
	IL2RB	Interleukin-2 receptor subunit beta. (600 aa)
	PTPN2	Tyrosine-protein phosphatase non-receptor type. (396 aa)
	JAK1	Tyrosine-protein kinase. (1153 aa)
	IL6ST	Interleukin-6 receptor subunit beta. (918 aa)
	LOC112413460	Apoptosis-stimulating of p53 protein 2-like. (124 aa)
	IL22RA1	Interleukin-22 receptor subunit alpha-1. (581 aa)
	IFNLR1	Interferon lambda receptor 1. (517 aa)
	IL12RB1	Interleukin-12 receptor subunit beta-1 isoform X1. (762 aa)
	JAK3	Tyrosine-protein kinase. (1104 aa)
	IL12B	Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (329 aa)
	CSF2RA	Granulocyte-macrophage colony-stimulating factor receptor subunit alpha isoform X1. (430 aa)
	IL3RA	Interleukin-3 receptor subunit alpha isoform X1. (540 aa)
	CRLF2	Cytokine receptor-like factor 2. (367 aa)
	IRF3	Interferon regulatory factor 3. (419 aa)

Your Current Organism:

Neophocaena asiaeorientalis

NCBI taxonomy Id: 1706337
Other names: N. asiaeorientalis asiaeorientalis, Neophocaena asiaeorientalis asiaeorientalis, Yangtze finless porpoise

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CISH	EPOR	A0A341BJY2	A0A341BIU3	Cytokine-inducible SH2-containing protein.	Erythropoietin receptor; Receptor for erythropoietin.	0.728
CISH	IFNG	A0A341BJY2	A0A341APD9	Cytokine-inducible SH2-containing protein.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.483
CISH	IL6	A0A341BJY2	A0A341AW59	Cytokine-inducible SH2-containing protein.	Interleukin-6.	0.405
CISH	JAK1	A0A341BJY2	A0A341D0I0	Cytokine-inducible SH2-containing protein.	Tyrosine-protein kinase.	0.427
CISH	JAK2	A0A341BJY2	A0A341AKB6	Cytokine-inducible SH2-containing protein.	Tyrosine-protein kinase.	0.535
CISH	JAK3	A0A341BJY2	A0A341D8D9	Cytokine-inducible SH2-containing protein.	Tyrosine-protein kinase.	0.429
CISH	LOC112399174	A0A341BJY2	A0A341BE08	Cytokine-inducible SH2-containing protein.	Signal transducer and activator of transcription.	0.929
CISH	SOCS1	A0A341BJY2	A0A341BCH9	Cytokine-inducible SH2-containing protein.	Suppressor of cytokine signaling 1.	0.612
CISH	SOCS2	A0A341BJY2	A0A341C6H4	Cytokine-inducible SH2-containing protein.	Suppressor of cytokine signaling 2.	0.528
CISH	SOCS3	A0A341BJY2	A0A341CRI7	Cytokine-inducible SH2-containing protein.	Suppressor of cytokine signaling 3.	0.443
CISH	SOCS4	A0A341BJY2	A0A341AMZ3	Cytokine-inducible SH2-containing protein.	Suppressor of cytokine signaling 4.	0.548
CISH	SOCS5	A0A341BJY2	A0A341C3A5	Cytokine-inducible SH2-containing protein.	Suppressor of cytokine signaling 5.	0.548
CISH	STAT1	A0A341BJY2	A0A341AFP8	Cytokine-inducible SH2-containing protein.	Signal transducer and activator of transcription.	0.916
CISH	STAT2	A0A341BJY2	A0A341AT06	Cytokine-inducible SH2-containing protein.	Signal transducer and activator of transcription.	0.917
CISH	STAT3	A0A341BJY2	A0A341BEB1	Cytokine-inducible SH2-containing protein.	Signal transducer and activator of transcription.	0.926
CISH	STAT4	A0A341BJY2	A0A341AJY2	Cytokine-inducible SH2-containing protein.	Signal transducer and activator of transcription.	0.916
CISH	STAT5A	A0A341BJY2	A0A341BAX0	Cytokine-inducible SH2-containing protein.	Signal transducer and activator of transcription.	0.925
CISH	STAT6	A0A341BJY2	A0A341AR17	Cytokine-inducible SH2-containing protein.	Signal transducer and activator of transcription.	0.921
CISH	TYK2	A0A341BJY2	A0A341BIN6	Cytokine-inducible SH2-containing protein.	Non-receptor tyrosine-protein kinase TYK2 isoform X1.	0.427
CRLF2	CSF2	A0A341DAG7	A0A341B3K7	Cytokine receptor-like factor 2.	Granulocyte-macrophage colony-stimulating factor.	0.844