(32 nodes) Mixed, incl. Interleukin-20 family signaling, and Regulation of IFNG signaling network (Neophocaena asiaeorientalis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	STAT1	Signal transducer and activator of transcription. (749 aa)
	STAT4	Signal transducer and activator of transcription. (748 aa)
	SOCS4	Suppressor of cytokine signaling 4. (440 aa)
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
	STAT6	Signal transducer and activator of transcription. (859 aa)
	STAT2	Signal transducer and activator of transcription. (899 aa)
	IL22	Interleukin-22. (189 aa)
	LOC112395033	Interferon omega-1-like. (250 aa)
	LOC112395025	Interferon omega-1-like. (250 aa)
	STAT5A	Signal transducer and activator of transcription. (726 aa)
	SOCS1	Suppressor of cytokine signaling 1. (214 aa)
	LOC112399174	Signal transducer and activator of transcription. (618 aa)
	STAT3	Signal transducer and activator of transcription. (770 aa)
	TYK2	Non-receptor tyrosine-protein kinase TYK2 isoform X1. (1214 aa)
	CISH	Cytokine-inducible SH2-containing protein. (254 aa)
	TP53BP2	Apoptosis-stimulating of p53 protein 2. (1007 aa)
	LOC112403081	LOW QUALITY PROTEIN: interferon lambda-1-like. (191 aa)
	IL10RA	Interleukin-10 receptor subunit alpha isoform X1. (594 aa)
	IRF9	LOW QUALITY PROTEIN: interferon regulatory factor 9. (478 aa)
	SOCS5	Suppressor of cytokine signaling 5. (536 aa)
	SOCS2	Suppressor of cytokine signaling 2. (198 aa)
	IFNGR2	Interferon gamma receptor 2 isoform X2. (364 aa)
	IFNAR1	Interferon alpha/beta receptor 1 isoform X1. (561 aa)
	IL10RB	Interleukin-10 receptor subunit beta isoform X1. (361 aa)
	IFNGR1	Interferon gamma receptor 1 isoform X1. (468 aa)
	SOCS3	Suppressor of cytokine signaling 3. (237 aa)
	PTPN2	Tyrosine-protein phosphatase non-receptor type. (396 aa)
	JAK1	Tyrosine-protein kinase. (1153 aa)
	LOC112413460	Apoptosis-stimulating of p53 protein 2-like. (124 aa)
	IL22RA1	Interleukin-22 receptor subunit alpha-1. (581 aa)
	IFNLR1	Interferon lambda receptor 1. (517 aa)
	JAK3	Tyrosine-protein kinase. (1104 aa)

Your Current Organism:

Neophocaena asiaeorientalis

NCBI taxonomy Id: 1706337
Other names: N. asiaeorientalis asiaeorientalis, Neophocaena asiaeorientalis asiaeorientalis, Yangtze finless porpoise

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CISH	IFNG	A0A341BJY2	A0A341APD9	Cytokine-inducible SH2-containing protein.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.483
CISH	JAK1	A0A341BJY2	A0A341D0I0	Cytokine-inducible SH2-containing protein.	Tyrosine-protein kinase.	0.427
CISH	JAK3	A0A341BJY2	A0A341D8D9	Cytokine-inducible SH2-containing protein.	Tyrosine-protein kinase.	0.429
CISH	LOC112399174	A0A341BJY2	A0A341BE08	Cytokine-inducible SH2-containing protein.	Signal transducer and activator of transcription.	0.929
CISH	SOCS1	A0A341BJY2	A0A341BCH9	Cytokine-inducible SH2-containing protein.	Suppressor of cytokine signaling 1.	0.612
CISH	SOCS2	A0A341BJY2	A0A341C6H4	Cytokine-inducible SH2-containing protein.	Suppressor of cytokine signaling 2.	0.528
CISH	SOCS3	A0A341BJY2	A0A341CRI7	Cytokine-inducible SH2-containing protein.	Suppressor of cytokine signaling 3.	0.443
CISH	SOCS4	A0A341BJY2	A0A341AMZ3	Cytokine-inducible SH2-containing protein.	Suppressor of cytokine signaling 4.	0.548
CISH	SOCS5	A0A341BJY2	A0A341C3A5	Cytokine-inducible SH2-containing protein.	Suppressor of cytokine signaling 5.	0.548
CISH	STAT1	A0A341BJY2	A0A341AFP8	Cytokine-inducible SH2-containing protein.	Signal transducer and activator of transcription.	0.916
CISH	STAT2	A0A341BJY2	A0A341AT06	Cytokine-inducible SH2-containing protein.	Signal transducer and activator of transcription.	0.917
CISH	STAT3	A0A341BJY2	A0A341BEB1	Cytokine-inducible SH2-containing protein.	Signal transducer and activator of transcription.	0.926
CISH	STAT4	A0A341BJY2	A0A341AJY2	Cytokine-inducible SH2-containing protein.	Signal transducer and activator of transcription.	0.916
CISH	STAT5A	A0A341BJY2	A0A341BAX0	Cytokine-inducible SH2-containing protein.	Signal transducer and activator of transcription.	0.925
CISH	STAT6	A0A341BJY2	A0A341AR17	Cytokine-inducible SH2-containing protein.	Signal transducer and activator of transcription.	0.921
CISH	TYK2	A0A341BJY2	A0A341BIN6	Cytokine-inducible SH2-containing protein.	Non-receptor tyrosine-protein kinase TYK2 isoform X1.	0.427
IFNAR1	IFNG	A0A341CHA3	A0A341APD9	Interferon alpha/beta receptor 1 isoform X1.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.969
IFNAR1	IFNGR1	A0A341CHA3	A0A341CIY8	Interferon alpha/beta receptor 1 isoform X1.	Interferon gamma receptor 1 isoform X1.	0.880
IFNAR1	IFNGR2	A0A341CHA3	A0A341CH98	Interferon alpha/beta receptor 1 isoform X1.	Interferon gamma receptor 2 isoform X2.	0.929
IFNAR1	IFNLR1	A0A341CHA3	A0A341D6S7	Interferon alpha/beta receptor 1 isoform X1.	Interferon lambda receptor 1.	0.952