(11 nodes) Tissue factor, and Regulation of IFNG signaling network (Neophocaena asiaeorientalis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	IFNG	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. (166 aa)
	IL22	Interleukin-22. (189 aa)
	LOC112395033	Interferon omega-1-like. (250 aa)
	LOC112403081	LOW QUALITY PROTEIN: interferon lambda-1-like. (191 aa)
	IL10RA	Interleukin-10 receptor subunit alpha isoform X1. (594 aa)
	IFNGR2	Interferon gamma receptor 2 isoform X2. (364 aa)
	IL10RB	Interleukin-10 receptor subunit beta isoform X1. (361 aa)
	IFNGR1	Interferon gamma receptor 1 isoform X1. (468 aa)
	JAK1	Tyrosine-protein kinase. (1153 aa)
	IL22RA1	Interleukin-22 receptor subunit alpha-1. (581 aa)
	IFNLR1	Interferon lambda receptor 1. (517 aa)

Your Current Organism:

Neophocaena asiaeorientalis

NCBI taxonomy Id: 1706337
Other names: N. asiaeorientalis asiaeorientalis, Neophocaena asiaeorientalis asiaeorientalis, Yangtze finless porpoise

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
IFNG	IFNGR1	A0A341APD9	A0A341CIY8	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	Interferon gamma receptor 1 isoform X1.	0.992
IFNG	IFNGR2	A0A341APD9	A0A341CH98	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	Interferon gamma receptor 2 isoform X2.	0.998
IFNG	IFNLR1	A0A341APD9	A0A341D6S7	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	Interferon lambda receptor 1.	0.876
IFNG	IL10RA	A0A341APD9	A0A341C0K3	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	Interleukin-10 receptor subunit alpha isoform X1.	0.882
IFNG	IL10RB	A0A341APD9	A0A341CHM8	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	Interleukin-10 receptor subunit beta isoform X1.	0.874
IFNG	IL22	A0A341APD9	A0A341ATC2	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	Interleukin-22.	0.758
IFNG	IL22RA1	A0A341APD9	A0A341D6E9	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	Interleukin-22 receptor subunit alpha-1.	0.853
IFNG	JAK1	A0A341APD9	A0A341D0I0	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	Tyrosine-protein kinase.	0.968
IFNG	LOC112395033	A0A341APD9	A0A341AV42	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	Interferon omega-1-like.	0.666
IFNG	LOC112403081	A0A341APD9	A0A341BW75	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	LOW QUALITY PROTEIN: interferon lambda-1-like.	0.478
IFNGR1	IFNG	A0A341CIY8	A0A341APD9	Interferon gamma receptor 1 isoform X1.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.992
IFNGR1	IFNGR2	A0A341CIY8	A0A341CH98	Interferon gamma receptor 1 isoform X1.	Interferon gamma receptor 2 isoform X2.	0.969
IFNGR1	IL10RB	A0A341CIY8	A0A341CHM8	Interferon gamma receptor 1 isoform X1.	Interleukin-10 receptor subunit beta isoform X1.	0.694
IFNGR1	IL22	A0A341CIY8	A0A341ATC2	Interferon gamma receptor 1 isoform X1.	Interleukin-22.	0.627
IFNGR1	JAK1	A0A341CIY8	A0A341D0I0	Interferon gamma receptor 1 isoform X1.	Tyrosine-protein kinase.	0.974
IFNGR1	LOC112395033	A0A341CIY8	A0A341AV42	Interferon gamma receptor 1 isoform X1.	Interferon omega-1-like.	0.624
IFNGR1	LOC112403081	A0A341CIY8	A0A341BW75	Interferon gamma receptor 1 isoform X1.	LOW QUALITY PROTEIN: interferon lambda-1-like.	0.709
IFNGR2	IFNG	A0A341CH98	A0A341APD9	Interferon gamma receptor 2 isoform X2.	Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.	0.998
IFNGR2	IFNGR1	A0A341CH98	A0A341CIY8	Interferon gamma receptor 2 isoform X2.	Interferon gamma receptor 1 isoform X1.	0.969
IFNGR2	IFNLR1	A0A341CH98	A0A341D6S7	Interferon gamma receptor 2 isoform X2.	Interferon lambda receptor 1.	0.440