(12 nodes) Mixed, incl. Activation of AKT2, and FOXO protein, transactivation domain network (Neophocaena asiaeorientalis)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC112392089	RAC-alpha serine/threonine-protein kinase. (138 aa)
	PHLPP2	PH domain leucine-rich repeat-containing protein phosphatase 2. (1319 aa)
	TRIB3	Tribbles homolog 3. (357 aa)
	LOC112398198	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (490 aa)
	FOXO6	Forkhead box protein O6. (374 aa)
	SGK2	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (383 aa)
	AKT3	Non-specific serine/threonine protein kinase. (531 aa)
	PHLPP1	PH domain leucine-rich repeat-containing protein phosphatase 1. (1604 aa)
	FOXO1	Forkhead box protein O1. (511 aa)
	FOXO4	Forkhead box protein O4. (512 aa)
	LOC112409111	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (445 aa)
	AKT2	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (481 aa)

Your Current Organism:

Neophocaena asiaeorientalis

NCBI taxonomy Id: 1706337
Other names: N. asiaeorientalis asiaeorientalis, Neophocaena asiaeorientalis asiaeorientalis, Yangtze finless porpoise

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKT2	AKT3	A0A341DDW1	A0A341C5C6	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase.	0.757
AKT2	FOXO1	A0A341DDW1	A0A341CA23	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Forkhead box protein O1.	0.921
AKT2	FOXO4	A0A341DDW1	A0A341CIX0	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Forkhead box protein O4.	0.899
AKT2	FOXO6	A0A341DDW1	A0A341BCB3	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Forkhead box protein O6.	0.899
AKT2	LOC112398198	A0A341DDW1	A0A341B8A3	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.480
AKT2	LOC112409111	A0A341DDW1	A0A341CIZ7	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.589
AKT2	PHLPP1	A0A341DDW1	A0A341C778	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	PH domain leucine-rich repeat-containing protein phosphatase 1.	0.877
AKT2	PHLPP2	A0A341DDW1	A0A341ANH1	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	PH domain leucine-rich repeat-containing protein phosphatase 2.	0.850
AKT2	SGK2	A0A341DDW1	A0A341BIT3	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.583
AKT2	TRIB3	A0A341DDW1	A0A341B745	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	Tribbles homolog 3.	0.962
AKT3	AKT2	A0A341C5C6	A0A341DDW1	Non-specific serine/threonine protein kinase.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.757
AKT3	FOXO1	A0A341C5C6	A0A341CA23	Non-specific serine/threonine protein kinase.	Forkhead box protein O1.	0.970
AKT3	FOXO4	A0A341C5C6	A0A341CIX0	Non-specific serine/threonine protein kinase.	Forkhead box protein O4.	0.953
AKT3	FOXO6	A0A341C5C6	A0A341BCB3	Non-specific serine/threonine protein kinase.	Forkhead box protein O6.	0.953
AKT3	LOC112392089	A0A341C5C6	A0A341AFJ6	Non-specific serine/threonine protein kinase.	RAC-alpha serine/threonine-protein kinase.	0.756
AKT3	LOC112398198	A0A341C5C6	A0A341B8A3	Non-specific serine/threonine protein kinase.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.481
AKT3	LOC112409111	A0A341C5C6	A0A341CIZ7	Non-specific serine/threonine protein kinase.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.583
AKT3	PHLPP1	A0A341C5C6	A0A341C778	Non-specific serine/threonine protein kinase.	PH domain leucine-rich repeat-containing protein phosphatase 1.	0.925
AKT3	PHLPP2	A0A341C5C6	A0A341ANH1	Non-specific serine/threonine protein kinase.	PH domain leucine-rich repeat-containing protein phosphatase 2.	0.960
AKT3	SGK2	A0A341C5C6	A0A341BIT3	Non-specific serine/threonine protein kinase.	Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily.	0.582