(14 nodes) SUMO is proteolytically processed, and SUMO activating enzyme complex network (Neophocaena asiaeorientalis)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC112391341	Small ubiquitin-related modifier. (95 aa)
	UBA2	SUMO-activating enzyme subunit 2; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. Belongs to the ubiquitin-activating E1 family. (640 aa)
	RANGAP1	Ran GTPase-activating protein 1. (569 aa)
	LOC112394878	Small ubiquitin-related modifier. (114 aa)
	SENP1	Sentrin-specific protease 1 isoform X1. (690 aa)
	LOC112396080	Small ubiquitin-related modifier 2-like. (75 aa)
	LOC112397112	Small ubiquitin-related modifier. (101 aa)
	PIAS4	E3 SUMO-protein ligase PIAS4 isoform X1. (529 aa)
	LOC112402711	Small ubiquitin-related modifier. (95 aa)
	SUMO1	Small ubiquitin-related modifier. (101 aa)
	SUMO3	LOW QUALITY PROTEIN: small ubiquitin-related modifier 3. (142 aa)
	UBE2I	SUMO-conjugating enzyme UBC9; Belongs to the ubiquitin-conjugating enzyme family. (158 aa)
	KCTD2	BTB/POZ domain-containing protein KCTD2. (208 aa)
	SAE1	SUMO-activating enzyme subunit 1. (346 aa)

Your Current Organism:

Neophocaena asiaeorientalis

NCBI taxonomy Id: 1706337
Other names: N. asiaeorientalis asiaeorientalis, Neophocaena asiaeorientalis asiaeorientalis, Yangtze finless porpoise

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
KCTD2	LOC112391341	A0A341CNL3	A0A341AFV1	BTB/POZ domain-containing protein KCTD2.	Small ubiquitin-related modifier.	0.803
KCTD2	LOC112394878	A0A341CNL3	A0A341ASU2	BTB/POZ domain-containing protein KCTD2.	Small ubiquitin-related modifier.	0.897
KCTD2	LOC112396080	A0A341CNL3	A0A341AXY1	BTB/POZ domain-containing protein KCTD2.	Small ubiquitin-related modifier 2-like.	0.803
KCTD2	LOC112397112	A0A341CNL3	A0A341B5G3	BTB/POZ domain-containing protein KCTD2.	Small ubiquitin-related modifier.	0.897
KCTD2	LOC112402711	A0A341CNL3	A0A341BUL6	BTB/POZ domain-containing protein KCTD2.	Small ubiquitin-related modifier.	0.803
KCTD2	PIAS4	A0A341CNL3	A0A341BG04	BTB/POZ domain-containing protein KCTD2.	E3 SUMO-protein ligase PIAS4 isoform X1.	0.858
KCTD2	RANGAP1	A0A341CNL3	A0A341AS16	BTB/POZ domain-containing protein KCTD2.	Ran GTPase-activating protein 1.	0.965
KCTD2	SAE1	A0A341CNL3	A0A341DCU9	BTB/POZ domain-containing protein KCTD2.	SUMO-activating enzyme subunit 1.	0.959
KCTD2	SUMO1	A0A341CNL3	A0A341CES0	BTB/POZ domain-containing protein KCTD2.	Small ubiquitin-related modifier.	0.897
KCTD2	SUMO3	A0A341CNL3	A0A341CHQ5	BTB/POZ domain-containing protein KCTD2.	LOW QUALITY PROTEIN: small ubiquitin-related modifier 3.	0.803
KCTD2	UBA2	A0A341CNL3	A0A341AGW6	BTB/POZ domain-containing protein KCTD2.	SUMO-activating enzyme subunit 2; The heterodimer acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. Belongs to the ubiquitin-activating E1 family.	0.972
LOC112391341	KCTD2	A0A341AFV1	A0A341CNL3	Small ubiquitin-related modifier.	BTB/POZ domain-containing protein KCTD2.	0.803
LOC112391341	LOC112394878	A0A341AFV1	A0A341ASU2	Small ubiquitin-related modifier.	Small ubiquitin-related modifier.	0.765
LOC112391341	LOC112396080	A0A341AFV1	A0A341AXY1	Small ubiquitin-related modifier.	Small ubiquitin-related modifier 2-like.	0.620
LOC112391341	LOC112397112	A0A341AFV1	A0A341B5G3	Small ubiquitin-related modifier.	Small ubiquitin-related modifier.	0.763
LOC112391341	PIAS4	A0A341AFV1	A0A341BG04	Small ubiquitin-related modifier.	E3 SUMO-protein ligase PIAS4 isoform X1.	0.904
LOC112391341	RANGAP1	A0A341AFV1	A0A341AS16	Small ubiquitin-related modifier.	Ran GTPase-activating protein 1.	0.895
LOC112391341	SAE1	A0A341AFV1	A0A341DCU9	Small ubiquitin-related modifier.	SUMO-activating enzyme subunit 1.	0.916
LOC112391341	SENP1	A0A341AFV1	A0A341ATX0	Small ubiquitin-related modifier.	Sentrin-specific protease 1 isoform X1.	0.892
LOC112391341	SUMO1	A0A341AFV1	A0A341CES0	Small ubiquitin-related modifier.	Small ubiquitin-related modifier.	0.765