STRINGSTRING
SPINT1 SPINT1 HECTD1 HECTD1 LOC112391874 LOC112391874 SPINT2 SPINT2 SUFU SUFU IFT57 IFT57 BMP4 BMP4 RARG RARG CELSR1 CELSR1 PLXNB2 PLXNB2 TWIST1 TWIST1 CITED2 CITED2 PRICKLE1 PRICKLE1 CC2D2A CC2D2A SCRIB SCRIB SEC24B SEC24B RARA RARA GLMN GLMN TRIM71 TRIM71 KDM6A KDM6A SEMA4C SEMA4C LMO4 LMO4 TBXT TBXT FZD6 FZD6 CTHRC1 CTHRC1 KAT2A KAT2A PRKACB PRKACB FUZ FUZ ARHGAP35 ARHGAP35 PRKACA PRKACA VASP VASP TGFB1 TGFB1 DVL3 DVL3 TEAD2 TEAD2 BCL10 BCL10 FZD3 FZD3 WNT5A WNT5A MTHFD1L MTHFD1L MTHFR MTHFR SALL4 SALL4 RALA RALA MTHFD1 MTHFD1 SETD2 SETD2 OPA1 OPA1 TRAF6 TRAF6 PTCH1 PTCH1 SHROOM3 SHROOM3 GRHL2 GRHL2 LRP2 LRP2 ST14 ST14 LOC112407979 LOC112407979 NOG NOG MKS1 MKS1 MED12 MED12 LOC112407988 LOC112407988 KDM2B KDM2B APAF1 APAF1 DVL1 DVL1 CLUAP1 CLUAP1 FZD2 FZD2 BBS4 BBS4 LOC112411262 LOC112411262 ABL1 ABL1 TSC1 TSC1 LHX2 LHX2 COBL COBL SFRP1 SFRP1 LRRC1 LRRC1 GRHL3 GRHL3 BRD2 BRD2 PHACTR4 PHACTR4 PTK7 PTK7 DVL2 DVL2 LOC112390775 LOC112390775 LIAS LIAS TULP3 TULP3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SPINT1Kunitz-type protease inhibitor 1. (510 aa)
HECTD1E3 ubiquitin-protein ligase HECTD1 isoform X1. (2610 aa)
LOC112391874Cat eye syndrome critical region protein 2 isoform X2. (1222 aa)
SPINT2Kunitz-type protease inhibitor 2. (249 aa)
SUFUSuppressor of fused homolog; Negative regulator in the hedgehog signaling pathway. Down- regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of [...] (469 aa)
IFT57Intraflagellar transport protein 57 homolog. (427 aa)
BMP4Bone morphogenetic protein 4 isoform X1. (420 aa)
RARGRetinoic acid receptor gamma isoform X2. (458 aa)
CELSR1Cadherin EGF LAG seven-pass G-type receptor 1; Belongs to the G-protein coupled receptor 2 family. (2288 aa)
PLXNB2plexin-B2. (1799 aa)
TWIST1LOW QUALITY PROTEIN: twist-related protein 1. (152 aa)
CITED2Cbp/p300-interacting transactivator 2. (263 aa)
PRICKLE1Prickle-like protein 1 isoform X1. (874 aa)
CC2D2ACoiled-coil and C2 domain-containing protein 2A. (1619 aa)
SCRIBLOW QUALITY PROTEIN: protein scribble homolog. (1575 aa)
SEC24BProtein transport protein Sec24B isoform X1. (1168 aa)
RARALOW QUALITY PROTEIN: retinoic acid receptor alpha. (572 aa)
GLMNGlomulin. (592 aa)
TRIM71E3 ubiquitin-protein ligase TRIM71. (596 aa)
KDM6ALysine-specific demethylase 6A isoform X1. (1278 aa)
SEMA4Csemaphorin-4C; Belongs to the semaphorin family. (833 aa)
LMO4LIM domain transcription factor LMO4. (165 aa)
TBXTBrachyury protein isoform X1. (435 aa)
FZD6Frizzled-6; Belongs to the G-protein coupled receptor Fz/Smo family. (712 aa)
CTHRC1Collagen triple helix repeat-containing protein 1. (244 aa)
KAT2AHistone acetyltransferase KAT2A. (872 aa)
PRKACBcAMP-dependent protein kinase catalytic subunit beta isoform X1; Belongs to the protein kinase superfamily. (397 aa)
FUZProtein fuzzy homolog isoform X1. (440 aa)
ARHGAP35Rho GTPase-activating protein 35. (1500 aa)
PRKACAcAMP-dependent protein kinase catalytic subunit alpha. (293 aa)
VASPVasodilator-stimulated phosphoprotein isoform X1; Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. Belongs to the Ena/VASP family. (380 aa)
TGFB1Transforming growth factor beta; Belongs to the TGF-beta family. (391 aa)
DVL3Segment polarity protein dishevelled homolog DVL-3 isoform X1. (716 aa)
TEAD2Transcriptional enhancer factor TEF-4 isoform X1. (462 aa)
BCL10B-cell lymphoma/leukemia 10. (233 aa)
FZD3Frizzled-3; Belongs to the G-protein coupled receptor Fz/Smo family. (468 aa)
WNT5AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (380 aa)
MTHFD1LMonofunctional C1-tetrahydrofolate synthase, mitochondrial isoform X1. (867 aa)
MTHFRMethylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. (696 aa)
SALL4Sal-like protein 4 isoform X1. (1055 aa)
RALARas-related protein Ral-A. (206 aa)
MTHFD1C-1-tetrahydrofolate synthase, cytoplasmic isoform X1. (961 aa)
SETD2Histone-lysine N-methyltransferase SETD2 isoform X1. (2547 aa)
OPA1Dynamin-like 120 kDa protein, mitochondrial isoform X1; Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. (1022 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (570 aa)
PTCH1Protein patched homolog 1 isoform X1. (1297 aa)
SHROOM3Protein Shroom3 isoform X2. (1794 aa)
GRHL2Grainyhead-like protein 2 homolog isoform X1. (625 aa)
LRP2Low-density lipoprotein receptor-related protein 2 isoform X1. (4651 aa)
ST14Suppressor of tumorigenicity 14 protein. (877 aa)
LOC112407979Secreted frizzled-related protein 2-like. (105 aa)
NOGNoggin; Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite. (232 aa)
MKS1Meckel syndrome type 1 protein isoform X2. (607 aa)
MED12Mediator of RNA polymerase II transcription subunit 12. (2097 aa)
LOC112407988Secreted frizzled-related protein 2. (294 aa)
KDM2BLysine-specific demethylase 2B. (1309 aa)
APAF1Apoptotic protease-activating factor 1 isoform X1. (1301 aa)
DVL1Segment polarity protein dishevelled homolog DVL-1. (706 aa)
CLUAP1Clusterin-associated protein 1 isoform X1. (457 aa)
FZD2Frizzled-2; Belongs to the G-protein coupled receptor Fz/Smo family. (709 aa)
BBS4Bardet-Biedl syndrome 4 protein isoform X1. (519 aa)
LOC112411262LOW QUALITY PROTEIN: transcriptional enhancer factor TEF-4-like. (282 aa)
ABL1Tyrosine-protein kinase. (1148 aa)
TSC1Hamartin isoform X1. (1169 aa)
LHX2LIM/homeobox protein Lhx2. (406 aa)
COBLProtein cordon-bleu isoform X1. (1274 aa)
SFRP1Secreted frizzled-related protein 1. (296 aa)
LRRC1Leucine-rich repeat-containing protein 1. (443 aa)
GRHL3Grainyhead-like protein 3 homolog. (602 aa)
BRD2Bromodomain-containing protein 2 isoform X1. (803 aa)
PHACTR4Phosphatase and actin regulator. (747 aa)
PTK7Inactive tyrosine-protein kinase 7; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1070 aa)
DVL2Segment polarity protein dishevelled homolog DVL-2 isoform X1. (785 aa)
LOC112390775Folate receptor alpha-like. (251 aa)
LIASLipoyl synthase, mitochondrial; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. (372 aa)
TULP3Tubby-like protein; Belongs to the TUB family. (464 aa)
Your Current Organism:
Neophocaena asiaeorientalis
NCBI taxonomy Id: 1706337
Other names: N. asiaeorientalis asiaeorientalis, Neophocaena asiaeorientalis asiaeorientalis, Yangtze finless porpoise
Server load: low (12%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.